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| 1 | Different profile of cytokine synthesis according to the severity of acute pancreatitis显示文摘AIM: To evaluate the cellular synthetic ability of cytokines involved in pro- and anti-inflammatory reactions in patients with AP.METHODS: Sixty-seven patients with AP (16 severe,51 mild) and 10 controls were included in the study.Cultures of whole blood were performed in samples obtained within the first 72 h from the onset of pain.Serum levels of interleukins (IL) 6, 8, 10, and TNF-α were measured at baseline and in the supernatant of cultures with (functional reserve) or without stimulation with phytohemaglutinin.RESULTS: Basal levels of cytokines were significantly higher in patients with severe AP. A significant increase of all pro-inflammatory cytokines vs basal levels was observed in the supernatant after 24 h of whole blood cultures in patients, but not in controls. In contrast, IL-10 increased significantly in the supernatant of cultures only in patients with mild AP. Cells showed a statistically significant functional reserve for all IL in patients with mild, but only for pro-inflammatory cytokines in patients with severe AP.CONCLUSION: A marked activation of immune system may be observed in patients with AP, being balanced between pro- and anti-inflammatory cytokines in patients with mild but not severe AP. A reduced functional reserve for the synthesis of IL-10 may be observed in patients with severe AP, which might lead to a worst prognosis. | Raquel Laveda Juan Martínez Carlos Mu■oz Juan Carlos Penalva Jesus Sáez Germán Belda Salvador Navarro Faust Feu Anton Mas José Ma Palazón José Sánchez-Payá José Such Miguel Pérez-Mateo | 2005 | World Journal of Gastroenterology2005，11，34： | 24 |
| 2 | Gut microbiota-related complications in cirrhosis显示文摘Gut microbiota plays an important role in cirrhosis. The liver is constantly challenged with commensal bacteria and their products arriving through the portal vein in the so-called gut-liver axis. Bacterial translocation from the intestinal lumen through the intestinal wall and to mesenteric lymph nodes is facilitated by intestinal bacterial overgrowth, impairment in the permeability of the intestinal mucosal barrier, and deficiencies in local host immune defences. Deranged clearance of endogenous bacteria from portal and systemic circulation turns the gut into the major source of bacterialrelated complications. Liver function may therefore be affected by alterations in the composition of the intestinal microbiota and a role for commensal flora has been evidenced in the pathogenesis of several complications arising in end-stage liver disease such as hepatic encephalopathy, splanchnic arterial vasodilatation and spontaneous bacterial peritonitis. The use of antibioticsis the main therapeutic pipeline in the management of these bacteria-related complications.However,other strategies aimed at preserving intestinal homeostasis through the use of pre-,pro-or symbiotic formulations are being studied in the last years.In this review,the role of intestinal microbiota in the development of the most frequent complications arising in cirrhosis and the different clinical and experimental studies conducted to prevent or improve these complications by modifying the gut microbiota composition are summarized. | Isabel Gómez-Hurtado José Such Yolanda Sanz Rubén Francés | 2014 | World Journal of Gastroenterology2014，20，42： | 12 |
| 3 | Pathological bacterial translocation in cirrhosis: pathophysiology, diagnosis and clinical implications显示文摘 | Pablo Bellot Rubén Francés Jose Such | 2012 | Liver Int2012，，1： | 4 |
| 4 | Immunomodulating effects of antibiotics used in the prophylaxis of bacterial infections in advanced cirrhosis显示文摘The use of norfloxacin either as primary or secondary prophylaxis of bacterial infections in advanced cirrhosis has improved patient's survival. This may be explained not only due to a significant decrease in the number of infections, but also because of a direct immunomodulatory effect. Selective intestinal decontamination with norfloxacin reduces translocation of either viable bacteria or bacteria-driven products from the intestinal lumen. In addition, norfloxacin directly modulates the systemic inflammatory response. The proinflammatory cytokine profile secreted by neutrophils from these patients shows a close, significant, and inverse correlation with serum norfloxacin levels. Similar effects have been described with other quinolones in different clinical conditions. Although the underlying mechanisms are not well defined for most of the antibiotics, the pathways triggered for norfloxacin to induce such immunomodulatory effects involve the down-regulation of pro-inflammatory inducible nitric oxide synthase, cyclooxygenase-2, and NF-κB and the up-regulation of heme-oxygenase 1 and IL-10 expression. The knowledge of these immunomodulatory effects, additional to their bactericidal role, improves our comprehension of the interaction between antibiotics and the cellular host response and offer new possibilities for the development of new therapeutic strategies to manage and prevent bacterial infections in cirrhosis. | Pedro Zapater José Manuel González-Navajas José Such Rubén Francés | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 5 | Oral probiotic VSL #3 attenuates the circulatory disturbances of patients with cirrhosis and ascites显示文摘 | Diego Rincón Javier Vaquero Ana Hernando Evelyn Galindo Cristina Ripoll Marta Puerto Magdalena Salcedo Rubén Francés Ana Matilla María V. Catalina Gerardo Clemente José Such Rafael Ba?ares | 2014 | Liver Int2014，，10： | 2 |
| 6 | Bacterial DNA Induces the Complement System Activation in Serum and Ascitic Fluid from Patients with Advanced Cirrhosis显示文摘 | Rubén Francés José M. González-Navajas Pedro Zapater Carlos Mu?oz Rocío Ca?o Sonia Pascual Dorkas Márquez Francia Santana Miguel Pérez-Mateo José Such | 2007 | Journal of Clinical Immunology2007，，4： | 2 |
| 7 | Protective effect of Bifidobacterium pseudocatenulatum CECT 7765 against induced bacterial antigen translocation in experimental cirrhosis显示文摘 | Alba Moratalla Isabel Gómez‐Hurtado Arlette Santacruz ángela Moya Gloria Peiró Pedro Zapater José M. González‐Navajas Paula Giménez José Such Yolanda Sanz Rubén Francés | 2014 | Liver Int2014，，6： | 2 |
| 8 | Evidence of neutrophil functional defect despite inflammation in stable cirrhosis显示文摘 | Giovanni Tritto Zois Bechlis Vanessa Stadlbauer Nathan Davies Rubén Francés Naina Shah Rajeshwar P. Mookerjee Jose Such Rajiv Jalan | 2011 | Journal of Hepatology2011，，3： | 2 |
| 9 | Synthesis of a new polyarylenvinylene derivative based on a terstyryl group linked by a maleimide group显示文摘 | YANG N C SUCH D H | 2001 | Polymer Bulletin2001，46，1： | 1 |
| 10 | Anionic polymerization of isocyanates with optical functionalities 显示文摘 | Yang N C Such D H | 2001 | polymer2001，42，19： | 1 |
| 11 | A class of cis-polyarylenevinylene: preparation and optical properties of the oligomeric polyarylenevinylene derivative having an 1,2-diphenylmaleimide moiety 显示文摘 | Yang N C Such D H | 2001 | Polymer2001，42，： | 1 |
| 12 | Next generation, sequentially assembled ultrathin films: beyond electrostatics显示文摘 | Quinn J F Johnston A P R Such G K Zelikin A N Caruso F | | 0，，05： | 1 |
| 13 | Acute and chronic hemodynamic changes after propranolol in patients with cirrhosis under primary and secondary prophylaxis of variceal bleeding: a pilot study显示文摘 | Enrique de-Madaria José María Palazón Flavia Tamara Hernández José Sánchez-Paya Pedro Zapater Javier Irurzun Francisco de Espa?a Sonia Pascual José Such Laura Sempere Fernando Carnicer Antonio García-Herola Jaime Valverde Miguel Pérez-Mateo | 2010 | European Journal of Gastroenterology & Hepatology2010，，5： | 1 |
| 14 | Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites显示文摘 | José Such Rubén Francés Carlos Mu?oz Pedro Zapater Juan A. Casellas Ana Cifuentes Francisco Rodr??guez-Valera Sonia Pascual Javier Sola-Vera Fernando Carnicer Francisco Uceda José M. Palazón Miguel Pérez-Mateo | 2002 | Hepatology2002，，1： | 1 |
| 15 | An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis显示文摘 | Kim Y Such N | 2002 | J Biol Chem2002，277，22： | 1 |
| 16 | A comparison of two different dosages of somatostatin combined with sclerotherapy for the treatment of acute esophageal variceal bleeding:aprospective randomized trial显示文摘 | PALAZN J M SUCH J SNCHEZ-PAYJ | 2006 | Rev Esp Enferm Dig2006，98，： | 1 |
| 17 | Osteoblasts are essential for osteoclast formation显示文摘 | Such T Takahashi N | 1989 | Calcif Tissue Int1989，44，1： | 1 |
| 18 | Norfloxacin Modulates the Inflammatory Response and Directly Affects Neutrophils in Patients With Decompensated Cirrhosis显示文摘 | Pedro Zapater Rocío Ca?o Lucía Llanos Antonio J. Ruiz–Alcaraz Sonia Pascual Claudia Barquero Rocío Moreu Pablo Bellot José F. Horga Carlos Mu?oz Jara Pérez Pilar García–Pe?arrubia Miguel Pérez–Mateo José Such Rubén Francés | 2009 | Gastroenterology2009，，5： | 1 |
| 19 | Primary Prophylaxis of Spontaneous Bacterial Peritonitis Delays Hepatorenal Syndrome and Improves Survival in Cirrhosis显示文摘 | Javier Fernández Miquel Navasa Ramón Planas Silvia Montoliu David Monfort German Soriano Carmen Vila Alberto Pardo Enrique Quintero Victor Vargas Jose Such Pere Ginès Vicente Arroyo | 2007 | Gastroenterology2007，，3： | 1 |
| 20 | O3Tolerance and Ascorbate-dependent H2O2 Decomposing System in Chloroplasts 显示文摘 | Tanaka K Such Y Konda N | 1985 | Plant Cell Physioi1985，26，： | 1 |
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