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| 1 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 2 | Spermiogram and sperm head morphometry assessed by multivariate cluster analysis results during adolescence (12-18 years) and the effect of varicocele显示文摘这个工作从精索静脉曲张的 12 ~ 18 岁,和效果在青少年评估精子头 morphometric 特征。在年龄的 150 和 224 个月之间的志愿者(平均数 191, n = 87 ) ,在 12 岁到达了 oigarche,在 Barranquilla 的区域被招募,哥伦比亚。精子头的 Morphometric 分析与主要部件(PC ) 和判别式分析被执行。联合精液和精子参数提供了五 PC:二与精子 morphometry 有关,到精子活动性,并且二到精液部件。精索静脉曲张和 nonvaricocele 组的 morphometric 结果上的判别式分析没提供一个有用分类矩阵。精液相关的 PC,最解释(40%) 与精子活动性有关。包括精子头延伸和尺寸,二 PC 是足够的评估精子 morphometric 特征。大多数 morphometric 变量与年龄被相关,随尺寸的增加和在精子头的延伸的减少。为头尺寸,全部精子人口能被划分成二 morphometric subpopulations, SP1 和 SP2,它没在青春期期间变化。为精索静脉曲张个人,一般来说,更大的有的 SP1 和更多的伸长的精子比 SP2 出发,它有更小并且更多的伸长的头比在 nonvaricocele 人。在摘要, CASA-Morph 和 multivariate 簇分析估计的精子头 morphometry 提供精液结构并且可能的更好的理解精子功能。Morphometric 分析比从常规精液分析获得的数据提供更多信息。 | Fernando Vasquez Caries Soler Patricia Camps Anthony Valverde Almudena Garcia-Molina | 2016 | Asian Journal of Andrology2016，18，6： | 5 |
| 3 | Resection of intrahepatic cholangiocarcinoma: a Western experience显示文摘 | Alain Valverde Nicolas Bonhomme Olivier Farges Alain Sauvanet Jean F. Flejou Jacques Belghiti | 1999 | Journal of Hepato - Biliary - Pancreatic Surgery1999，，2： | 3 |
| 4 | The determinants of bank margins in European banking显示文摘 | Santiago Carbó Valverde Francisco Rodríguez Fernández | 2007 | Journal of Banking and Finance2007，，7： | 2 |
| 5 | The determinants of bank margins in European banking显示文摘 | Santiago Carbó Valverde Francisco Rodríguez Fernández | | Journal of Banking and Finance0，，： | 2 |
| 6 | Quality improvement and extension of shelf life by 1 -methylcyclopropene in plum as affected by ripening stage at harvest显示文摘 | VALERO D MARTINEZ-ROMERO D VALVERDE J M | 2003 | Innovative Food Science and Emerging Technologies2003，4，： | 1 |
| 7 | Acute activation or Maxi-Kchannels (hSlo) by estradiol binding to the beta subunit显示文摘 | Rojas P Amigo J | 1999 | Scince1999，285，： | 1 |
| 8 | Phenotypic analysis of Dlx5 overexpression in post-natal bone显示文摘 | Zhang J Zhu J Valverde P | 2008 | J Dent Res2008，87，1： | 1 |
| 9 | Olfactory bulb ensheathing glia: A unique cell type with axonal growth-promoting properties显示文摘 | Ramon-Cueto A Valverde F | 1995 | Glia1995，14，： | 1 |
| 10 | Analysis of Forchlorfenuron in Alter Extraction with the Buffered QuEChERS Method 显示文摘 | Valverde A Aguilem A Ferret C | 2010 | J Agric Food Chem2010，58，5： | 1 |
| 11 | Detection and identification of Clerodendron golden mosaic China virus in Salvia splendens显示文摘 | Rodrigo A Valverde Raghuwinder Singh Sead Sabanadzovic | 2012 | Eur J Plant Pathol2012，133，： | 1 |
| 12 | Acute activation of Maxi-K channels(h Slo)by estradiol binding to theβsubunit显示文摘 | Valverde MA Rojas P Amigo J | 1999 | Science1999，285，： | 1 |
| 13 | Language networks: Their structure, function, and e- volution显示文摘 | Sole R V Corominas Murtra B Valverde S | 2010 | Complexity2010，15，6： | 1 |
| 14 | Genetic analysis of frust handiness traits in tuber-bearing Solanum species 显示文摘 | Valverde R Chert T H H | 1999 | Journal of Plant Biology1999，42，2： | 1 |
| 15 | Involvement of the endocannabinoid system in drug addiction 显示文摘 | MALDONADO R VALVERDE O BERRENDERO F | 2006 | Trends Neurosci2006，29，4： | 1 |
| 16 | Deterruination of photoirradiated high polar benzoylureas in tomato by HPLC with luminol chemiluminescence detection显示文摘 | Martinez Galera M Gil Gareia M D Santiago Valverde R | 2008 | Talanta2008，76，4： | 1 |
| 17 | Absence of opiate rewarding effects in mice lacking dopamineD2 receptors显示文摘 | Maldonado R Saiardi A Valverde O | 1997 | Nature1997，388，6642： | 1 |
| 18 | Logarithmic growth dynamics in software networks 显示文摘 | VALVERDE S SOLE R V | 2005 | Europhys Lett2005，72，5： | 1 |
| 19 | Hierarchical Small Worlds in Software Architecture, Santa Fe Inst显示文摘 | Valverde S Ferrer-Caneho R Sole R | 2003 | Working Paper2003，，： | 1 |
| 20 | Infuenee of glutathione S transferase M1 and T1 homozy-gous null mutations on the riskofantituberculosis drug-induced hepatotoxieity in a Caucasian population显示文摘 | Virginia Leiro Alberto Fern andez-Villar Diana Valverde | 2008 | Liver Internation-al2008，28，6： | 1 |
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