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| 1 | Role of microRNAs in the immune system,inflammation and cancer显示文摘MicroRNAs,a key class of gene expression regulators,have emerged as crucial players in various biological processes such as cellular proliferation and differentiation,development and apoptosis.In addition,microRNAs are coming to light as crucial regulators of innate and adaptive immune responses,and their abnormal expression and/or function in the immune system have been linked to multiple human diseases including inflammatory disorders,such as inflammatory bowel disease,and cancers.In this review,we discuss our current understanding of microRNAs with a focus on their role and mode of action in regulating the immune system during inflammation and carcinogenesis. | Jennifer Raisch Arlette Darfeuille-Michaud Hang Thi Thu Nguyen | 2013 | World Journal of Gastroenterology2013，19，20： | 17 |
| 2 | Role of bacteria in the etiopathogenesis of inflammatory bowel disease显示文摘Increased numbers of mucosa-associated Escherichia coli are observed in both of the major inflammatory bowel diseases,Crohn's disease(CD)and ulcerative colitis(UC).A potential pathophysiological link between the presence of pathogenic invasive bacteria and genetic host susceptibility of patients with ileal CD is suspected.In CD patients,with increased ileal expression of the CEACAM6 molecule acting as a receptor recognized by type 1 pilus bacterial adhesin,and with the identification of mutations in the NOD2-encoding gene,the presence of pathogenic invasive bacteria could be the link between abnormal ileal bacterial colonization and innate immune responses to invasive bacteria.In a susceptible host,the sequential etiological steps of the disease induced by adherent-invasive E.coli(AIEC)are:(1)abnormal colonization via binding to the CEACAM6 receptor,which is overexpressed in the ileal mucosa of CD patients;(2)ability to adhere to and to invade intestinal epithelial cells,which allows bacteria to cross the mucosal barrier;(3)survival and replication within infected macrophages in the lamina propria;and(4)induction of tumor necrosis factor-α secretion and granuloma formation. | Nicolas Barnich Arlette Darfeuille-Michaud | 2007 | World Journal of Gastroenterology2007，13，42： | 15 |
| 3 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 4 | The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases显示文摘 | Benoit Chassaing Arlette Darfeuille–Michaud | 2011 | Gastroenterology2011，，6： | 6 |
| 5 | Infectious etiopathogenesis of Crohn's disease显示文摘Important advances during the last decade have been made in understanding the complex etiopathogenesis of Crohn’s disease(CD).While many gaps in our knowledge still exist,it has been suggested that the etiology of CD is multifactorial including genetic,environmental and infectious factors.The most widely accepted theory states that CD is caused by an aggressive immune response to infectious agents in genetically predisposed individuals.The rise of genome-wide association studies allowed the identification of loci and genetic variants in several components of host innate and adaptive immune responses to microorganisms in the gut,highlighting an implication of intestinal microbiota in CD etiology.Moreover,numerous independent studies reported a dysbiosis,i.e.,a modification of intestinal microbiota composition,with an imbalance between the abundance of beneficial and harmful bacteria.Although microorganisms including viruses,yeasts,fungi and bacteria have been postulated as potential CD pathogens,based on epidemiological,clinicopathological,genetic and experimental evidence,their precise role in this disease is not clearly defined.This review summarizes the current knowledge of the infectious agents associated with an increased risk of developing CD.Therapeutic approaches to modulate the intestinal dysbiosis and to target the putative CD-associated pathogens,as well as their potential mechanisms of action are also discussed. | Jessica Carriere Arlette Darfeuille-Michaud Hang Thi Thu Nguyen | 2014 | World Journal of Gastroenterology2014，20，34： | 4 |
| 6 | Plasma phospholipid transfer protein (PLTP) modulates adaptive immune functions through alternation of T helper cell polarization显示文摘客观:血浆 phospholipid 转移蛋白质(PLTP ) 是脂蛋白新陈代谢的一个关键决定因素,并且动物和人的研究收敛显示 PLTP 支持 atherogenesis 和它的 thromboembolic 复杂并发症。而且, PLTP 调制发炎和有免疫力的回答,这最近被报导了。尽管从我们的组的更早的研究证明 PLTP 能修改巨噬细胞激活,在 T-cell-mediated 有免疫力的回答的调整的 PLTP 的含意从来没被调查过并且因此在现在的学习被探讨。途径和结果:在现在的学习,我们证明在老鼠的那 PLTP 缺乏在 CD4 + Th0 房间极化上有深刻效果,与向在正常、病理学的条件下面的反煽动性的 Th2 显型的移动。在接触超敏性的一个模型,对有 hapten-2,4-dinitrofluorobenzene (DNFB ) 的皮肤促进感受性的显著地损害的回答在 PLTP 缺乏的老鼠被观察与相比野类型(WT ) 老鼠。有趣地,在老鼠的 PLTP 缺乏没在外部血在全部的白血房间,淋巴细胞, granulocytes,或单核白血球的计数上施加效果。而且, PLTP 缺乏没修改 CD4 + 和 CD8 + T 淋巴细胞子集的数量。然而, PLTP 缺乏,与 Th2 显型的 upregulation 联系了,被重要减少在 pro-Th1 cytokine interleukin 的生产伴随 18 由附件房间。结论:第一次,这个工作向支持 inflammatory Th1 显型在 CD4 + T 房间的极化为 PLTP 报导一个生理的角色。 | Catherine Desrumau Stephanie Lemaire-Ewing Nicolas Ogier Akadiri Yessoufou Arlette Hammann Anabelle Sequeira-Le Grand Valerie Deckert Jean-Paul Pais de Barros Naig Le Guern Julien Guy Naim A Khan Laurent Lagrost | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 7 | Crohn’s Disease–Associated Adherent Invasive Escherichia coli Modulate Levels of microRNAs in Intestinal Epithelial Cells to Reduce Autophagy显示文摘 | Hang Thi Thu Nguyen Guillaume Dalmasso Stefan Müller Jessica Carrière Frank Seibold Arlette Darfeuille–Michaud | 2014 | Gastroenterology2014，，2： | 3 |
| 8 | Protective effect of Bifidobacterium pseudocatenulatum CECT 7765 against induced bacterial antigen translocation in experimental cirrhosis显示文摘 | Alba Moratalla Isabel Gómez‐Hurtado Arlette Santacruz ángela Moya Gloria Peiró Pedro Zapater José M. González‐Navajas Paula Giménez José Such Yolanda Sanz Rubén Francés | 2014 | Liver Int2014，，6： | 2 |
| 9 | 猪呼吸道病综合征的复杂性与防控策略显示文摘猪呼吸道病综合征(PRDC)是一种由多种传染性因子和环境因子互相作用导致的多因子疾病,在生长肥育猪阶段常见,表现为生长迟缓和死亡率增加。其关键性病原为猪肺炎支原体,同时普遍:每在细菌继发感染和病毒混合感染。由PRDC引发的经济损失巨大,因此值得我们尽一切可能来有效控制该病。 | Arlette Laval 张晓梅(译) 腾峰(校) | 2008 | 养猪2008，，6： | 2 |
| 10 | Two New Cembrane diterpenes from a Madagascan Soft Coral of thegenus ,Sarcophyton 显示文摘 | Arlette L Kondracki MB and Guyot M | 2002 | Tetrahedron Letters2002，43，： | 1 |
| 11 | Mohs micrographic surgery and dermatofibrosarcoma protuberans:A multidisciplinary approach in 44 patients显示文摘 | Nelson RA Arlette JP | 2008 | Ann Plast Surg2008，60，6： | 1 |
| 12 | Structure du venusol,nouvelle substance,isole de Umbilicus Pendulinus DC显示文摘 | Arlette Proliac Michel Desage Jean Favre-Bonvin | 1981 | Tetrahedron Leu1981，22，37： | 1 |
| 13 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 14 | A novel splice vari- ant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum显示文摘 | Abbaszadeh F Clingen PH Arlett CF | 2010 | J Med Genet2010，47，3： | 1 |
| 15 | Recombinant fl phage particles can transfect monkey COS-7 cell by DEAE dex- tran method 显示文摘 | MacGregor GR James MR Arlett CF | 1993 | Biochem Biophys Res Commun1993，192，2： | 1 |
| 16 | Identification of Monosaccharides by High-performance Liquid Chromatography Using Methanolysis and a Light-scattering Detector显示文摘 | Myriam T Arlette E B Danielle B F | 1990 | J Chromatogr1990，514，1： | 1 |
| 17 | Benefits of obstructive sleep apnoea treatment in coronary artery disease:a long-term follow-up study显示文摘 | Olivier M Remy Arlette F | 2004 | European Heart Journal2004，25，9： | 1 |
| 18 | Mohs micrographic surgery, and dermatofibrosareoma protuberans:a multidiseiplinar7 ap- proach in 44 patients 显示文摘 | Nelson RA Arlette JP | 2008 | Ann Plast Surg2008，60，6： | 1 |
| 19 | Predictive in vitro methods for identifying photo sensitizing drugs: A report 显示文摘 | Arlett C Earl L Ferguson J | 1995 | Br J Dermatol1995，132，： | 1 |
| 20 | Removal of Phenol from Water by Adsorption Using Zeolites显示文摘 | Khalid Mohamed Joly Guy Renaud Arlette | 2004 | Industrial&Engineering Chemistry Research2004，43，17： | 1 |
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