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| 1 | Pathways of China's PM;air quality 2015–2060 in the context of carbon neutrality显示文摘Clean air policies in China have substantially reduced particulate matter(PM;) air pollution in recent years,primarily by curbing end-of-pipe emissions.However,reaching the level of the World Health Organization(WHO) guidelines may instead depend upon the air quality co-benefits of ambitious climate action.Here,we assess pathways of Chinese PM;air quality from 2015 to 2060 under a combination of scenarios that link global and Chinese climate mitigation pathways(i.e.global 2℃-and 1.5℃-pathways,National Determined Contributions(NDC) pledges and carbon neutrality goals) to local clean air policies.We find that China can achieve both its near-term climate goals(peak emissions) and PM;air quality annual standard(35 μg/m;) by 2030 by fulfilling its NDC pledges and continuing air pollution control policies.However,the benefits of end-of-pipe control reductions are mostly exhausted by 2030,and reducing PM;exposure of the majority of the Chinese population to below 10 μg/m;by 2060 will likely require more ambitious climate mitigation efforts such as China’ s carbon neutrality goals and global1.5℃-pathways.Our results thus highlight that China’s carbon neutrality goals will play a critical role in reducing air pollution exposure to the level of the WHO guidelines and protecting public health. | Jing Cheng Dan Tong Qiang Zhang Yang Liu Yu Lei Gang Yan Liu Yan Sha Yu Ryna Yiyun Cui Leon Clarke Guannan Geng Bo Zheng Xiaoye Zhang Steven JDavis Kebin He | 2021 | National Science Review2021，8，12： | 23 |
| 2 | On-the-fly active learning of interpretable Bayesian force fields for atomistic rare events显示文摘Machine learned force fields typically require manual construction of training sets consisting of thousands of first principles calculations,which can result in low training efficiency and unpredictable errors when applied to structures not represented in the training set of the model.This severely limits the practical application of these models in systems with dynamics governed by important rare events,such as chemical reactions and diffusion.We present an adaptive Bayesian inference method for automating the training of interpretable,low-dimensional,and multi-element interatomic force fields using structures drawn on the fly from molecular dynamics simulations.Within an active learning framework,the internal uncertainty of a Gaussian process regression model is used to decide whether to accept the model prediction or to perform a first principles calculation to augment the training set of the model.The method is applied to a range of single-and multi-element systems and shown to achieve a favorable balance of accuracy and computational efficiency,while requiring a minimal amount of ab initio training data.We provide a fully opensource implementation of our method,as well as a procedure to map trained models to computationally efficient tabulated force fields. | Jonathan Vandermause Steven B.Torrisi Simon Batzner Yu Xie Lixin Sun Alexie M.Kolpak Boris Kozinsky | 2020 | npj Computational Materials2020，，1： | 17 |
| 3 | Chinese Tuina Downregulates the Elevated Levels of Tissue Plasminogen Activator in Sciatic Nerve Injured Sprague-Dawley Rats显示文摘Objective:To elucidate the mechanism of Chinese tuina in treating sciatic nerve crush injury,and to detect the levels of tissue plasminogen activator(t PA)and plasminogen activator inhibitor-1(PAI-1),which is thought to play an important role in nerve regeneration.Methods:Thirty-two adult male Sprague-Dawley rats were subjected to sciatic nerve crush injury and 16 rats(sham-operated group)went through a sham operation.Control group was given no treatment while tuina group received tuina therapy since day 7 post-surgery.Tuina treatment was performed once a day and lasted for 20 days.The sciatic functional index was examined every 5days during the treatment session.The rats'gastrocnemius muscles were evaluated for changes in mass and immunohistochemistry techniques were performed to detect the levels of tP A and PAI-1.Results:Tuina therapy improved the motor function of sciatic nerve injured rats(P<0.05),however,it did not increase muscle volume(P<0.05).Tuina downregulated the levels of t PA and PAI-1(P<0.05).Conclusions:The present study implies that tuina treatment could accelerate rehabilitation of peripheral nerve injury. | PAN Fan YU Tian-yuan Steven Wong XIAN Si-tong LU Meng-qian WU Jian-cong GAO Yu-feng LI Xiao-qin GENG Nan YAO Bin-bin | 2017 | Chinese Journal of Integrative Medicine2017，23，8： | 16 |
| 4 | “Three Methods and Three Points” regulates p38 mitogen-activated protein kinase in the dorsal horn of the spinal cord in a rat model of sciatic nerve injury显示文摘Tuina is a traditional Chinese treatment for sensory disturbances caused by peripheral nerve injury and related diseases. Our previous studies showed that tuina regulates relevant regions and indices of the spinal dorsal horn using the Dian, Bo, and Rou method in Yinmen(BL37), Yanglingquan(GB34), and Weizhong(BL40). Treatment prevents muscle atrophy, protects spinal cord neurons, and promotes sciatic nerve repair. The mechanisms of action of tuina for treating peripheral nerve injury remain poorly understood. This study established rat models of sciatic nerve injury using the crushing method. Rats received Chinese tuina in accordance with the principle of 'Three Methods and Three Points,' once daily for 20 days. Tuina intervention reduced paw withdrawal latency and improved wet weight of the gastrocnemius muscle, as well as promoting morphological recovery of sciatic nerve fibers, Schwann cells, and axons. The protein expression levels of phospho-p38 mitogen-activated protein kinase, tumor necrosis factor-α, and interleukin-1β also decreased. These findings indicate that 'Three Methods and Three Points' promoted morphological recovery and improved behavior of rats with peripheral nerve injury. | Xin Guo Tian-yuan Yu Wong Steven Wen-duan Jia Chi Ma Yan-hong Tao Chao Yang Tao-tao Lv Shuai Wu Meng-qian Lu Jia-li Liu | 2016 | Neural Regeneration Research2016，11，12： | 7 |
| 5 | Parallel transjugular intrahepatic portosystemic shunt with Viatorr^(®)? stents for primary TIPS insufficiency:Case series and review of literature显示文摘BACKGROUND Transjugular intrahepatic portosystemic shunts(TIPS) can alleviate complications of portal hypertension such as ascites and variceal bleeding by decreasing the portosystemic gradient.In limited clinical situations,parallel TIPS may be only solution to alleviate either variceal bleeding or ascites secondary to portal hypertension when the primary TIPS fails to do so.Data specifically addressing the use of this partially polytetrafluoroethylene covered nitinol stent(Viatorr~?) is largely lacking despite Viatorr~? being the current gold standard for modern TIPS placement.CASE SUMMARY All three patients had portal hypertension and already had a primary Viatorr~?TIPS placed previously.All patients have undergone failed endoscopy to manage acute variceal bleeding before referral for a parallel stent(PS).PS were placed in patients presenting with recurrent variceal bleeding despite existence of a widely patent primary TIPS.Primary stent patency was verified with either Doppler ultrasound or intra-procedural TIPS stent venography.Doppler ultrasound follow-up imaging demonstrated complete patency of both primary and parallel TIPS.All three patients did well on clinical follow-up of up to six months and no major complications were recorded.A review of existing literature on the role of PS in the management of portal hypertension complications is discussed.There are three case reports of use of primary and PS Viatorr~? stents placement,only one of which is in a patient with gastrointestinal variceal bleeding despite a patent primary Viatorr~? TIPS.CONCLUSION Viatorr~? PS placement in the management of variceal hemorrhage is feasible with promising short term patency and clinical follow-up data. | Driss Raissi Qian Yu Michael Nisiewicz Steven Krohmer | 2019 | World Journal of Hepatology2019，11，2： | 5 |
| 6 | A Lunar-based Soft X-ray Imager(LSXI)for the Earth's magnetosphere显示文摘We propose to use the Moon as a platform to obtain a global view of Earth's magnetosphere by a Lunar-based Soft X-ray Imager(LSXI).LSXI is a wide field-of-view Soft X-ray telescope,which can obtain X-ray images of Earth's magnetosphere based on the solar wind charge exchange(SWCX)X-ray emission.Global perspective is crucial to understand the overall interaction of the solar wind with magnetosphere.LSXI is capable of continuously monitoring the evolution of geospace conditions under the impact of the solar wind by simultaneous observation of the bow shock,magnetosheath,magnetopause and cusps for the first time.This proposal is answering the call for the Chinese Lunar Exploration Program Phase IV. | Yihong GUO Chi WANG Fei WEI Tianran SUN Xizheng YU Songwu PENG Graziella BRANDUARDI-RAYMONT Steven SEMBAY | 2021 | Science China Earth Sciences2021，64，7： | 5 |
| 7 | SUPPRESSOR OF VARIEGATION4, a New var2 Suppressor Locus, Encodes a Pioneer Protein that Is Required for Chloroplast Biogenesis显示文摘VAR2 是不可分的 thylakoid 膜蛋白质和在初核质和优核质的 metalloproteases 的万用的 FtsH 班的一个成员。在 VAR2 地点的后退的变化产生与正常出现的叶绿体与反常质体和绿部门包含白部门的使成杂色的植物(var2 ) 。在孤立 var2 上色的秒地点 suppressors 的一个持续努力,我们在这报告 ems2505 描绘,在 At4g28590 由于一个错误感觉变化有带绿色的显型的一个 suppressor 种类,为先驱蛋白质的基因。我们指明了这基因 SVR4 (为 VARIEGATION4 的 SUPPRESSOR ) 并且在 ems2505 的变异的等位基因作为 svr4-1。我们证明 SVR4 位于叶绿体并且 svr4-1 单身者异种关于叶绿体解剖和 thylakoid 膜蛋白质累积是正常的。然而,他们平常地在光化学的几个方面被损害并且提高了非光化学的熄灭(NPQ ) 能力。SVR4 的 T-DNA 插入等位基因, svr4-2,由于叶绿体开发的早阻塞是幼苗致命的。我们断定 SVR4 为叶绿体生物的续生说是必要的,并且假设那 SVR4 调停控制 NPQ 的 thylakoid 结构或功能的某方面。我们建议在 suppressor 紧张, VAR2 的缺乏引起的 photoinhibitory 压力被减少的 SVR4 活动引起的提高的 NPQ 能力在叶绿体开发早改善。这将导致能克服必要的阀值避免相片损坏并且从而发展成功能的叶绿体的叶绿体的数字的增加。 | Fei Yu ung-Soon Park Xiayan Liu Andrew Foudree Aigen Fu Marta Powikrowska Anastassia Khrouchtchova Poul Erik Jensen Jillian N. Kriger Gordon RI Gray Steven R. Rodermel | 2011 | Molecular Plant2011，4，2： | 5 |
| 8 | Evaluation of a point of care ultrasound curriculum for Indonesian physicians taught by fi rst-year medical students显示文摘BACKGROUND: The purpose of this study was to assess the short-term efficacy of a 4-week ultrasound curriculum taught by American first-year medical students to general practitioners working in public health care clinics, or puskesmas, in Bandung, Indonesia.METHODS: We performed a prospective, observational study of Indonesian health care practitioners from public clinics in Bandung, Indonesia. These practitioners were enrolled in a 4-week ultrasound training course taught by first-year American medical students. A total of six sessions were held comprising of 38 ultrasound milestones. A pre-course and post-course written exam and practical exam was taken by each participant.RESULTS: We enrolled 41 clinicians in the course. The average pre-course exam score was 35.2% with a 2.4% pass rate, whereas the average post-course exam score was 82.0% with a 92.7% pass rate. The average practical score at the completion of the course was 83.2%(SD=0.145) with 82.9% of the class passing(score above 75.0%).CONCLUSION: Our data suggests that first-year medical students can effectively teach ultrasound to physicians in Indonesia using a 4-week intensive ultrasound training course. Future studies are needed to determine the amount of training required for proficiency and to evaluate the physicians' perceptions of the student-instructors' depth of knowledge and skill in point of care ultrasound. | Jonathan B.Lee Christina Tse Thomas Keown Michael Louthan Christopher Gabriel Alexander Anshus Bima Hasjim Katrina Lee Esther Kim Luke Yu Allen Yu Shadi Lahham Steven Bunch Maili Alvarado Abdulatif Gari John C.Fox | 2017 | World Journal of Emergency Medicine2017，8，4： | 4 |
| 9 | Epigenetic states and expression of imprinted genes in human embryonic stem cells显示文摘AIM: To investigate the epigenetic states and expres- sion of imprinted genes in five human embryonic stem cell (hESC) lines derived in Taiwan. METHODS: The heterozygous alleles of single nucleo- tide polymorphisms (SNPs) at imprinted genes were analyzed by sequencing genomic DNAs of hESC lines and the monoallelic expression of the imprinted genes were confirmed by sequencing the cDNAs. The expres- sion profiles of 32 known imprinted genes of five hESC lines were determined using Affymetrix human genome U133 plus 2.0 DNA microarray. RESULTS: The heterozygous alleles of SNPs at seven imprinted genes, IPW , PEG10 , NESP55 , KCNQ1 , ATP10A ,TCEB3C and IGF2 , were identified and the monoallelic expression of these imprinted genes except IGF2 were confirmed. The IGF2 gene was found to be imprinted in hESC line T2 but partially imprinted in line T3 and not imprinted in line T4 embryoid bodies. Ten imprinted genes, namely GRB10 , PEG10 , SGCE, MEST , SDHD , SN- RPN , SNURF , NDN , IPW and NESP55 , were found to be highly expressed in the undifferentiated hESC lines and down-regulated in differentiated derivatives. The UBE3A gene abundantly expressed in undifferentiated hESC lines and further up-regulated in differentiated tissues. The expression levels of other 21 imprinted genes were relatively low in undifferentiated hESC lines and five of these genes (TP73 , COPG2 , OSBPL5 , IGF2 and ATP10A ) were found to be up-regulated in differentiated tissues. CONCLUSION: The epigenetic states and expression of imprinted genes in hESC lines should be thoroughly studied after extended culture and upon differentiation in order to understand epigenetic stability in hESC lines before their clinical applications. | Steven Shoei-Lung Li Sung-Liang Yu Sher Singh | 2010 | World Journal of Stem Cells2010，2，4： | 3 |
| 10 | 2013年ISMRM年会前列腺MRI研究进展显示文摘第21届国际医学磁共振学会(ISMRM2013)在美国犹他州盐湖城举行,此次会议共收录与前列腺相关的论文91篇,这些论文主要关注磁共振功能成像技术,如扩散加权成像(DWI)、磁共振波谱成像(MRS)、标记靶分子成像和动态增强图像(DCE)等在前列腺癌诊断、鉴别诊断中的应用。本文对以上的研究现状进行综述,旨在提高我国对前列腺磁共振成像研究的新认识。 | 冯朝燕 李亮 胡道予 夏黎明 陈敏 Jinxing Yu Steven Eberhard 王良 | 2013 | 放射学实践2013，28，7： | 3 |
| 11 | Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)显示文摘 | Fiona McPhee Amy K. Sheaffer Jacques Friborg Dennis Hernandez Paul Falk Guangzhi Zhai Steven Levine Susan Chaniewski Fei Yu Diana Barry Chaoqun Chen Min S. Lee Kathy Mosure Li-Qiang Sun Michael Sinz Nicholas A. Meanwell Richard J. Colonno Jay Knipe Paul S | 2012 | Antimicrobial Agents and Chemotherapy2012，，10： | 2 |
| 12 | Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors显示文摘Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal cancer.It has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient prognosis.TST001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human Claudin18.2.In this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell lines.The[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),respectively.The radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h p.i.with[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging groups.Immunohistochemistry results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine research.Taken together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors. | Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue Liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang Hua Zhu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 2 |
| 13 | Precision Phenotyping Reveals Novel Loci for Quantitative Resistance to Septoria Tritici Blotch显示文摘Accurate,high-throughput phenotyping for quantitative traits is a limiting factor for progress in plant breeding.We developed an automated image analysis to measure quantitative resistance to septoria tritici blotch(STB),a globally important wheat disease,enabling identification of small chromosome intervals containing plausible candidate genes for STB resistance.335 winter wheat cultivars were included in a replicated field experiment that experienced natural epidemic development by a highly diverse but fungicide-resistant pathogen population.More than 5.4 million automatically generated phenotypes were associated with 13,648 SNP markers to perform the GWAS.We identified 26 chromosome intervals explaining 1.9-10.6%of the variance associated with four independent resistance traits.Sixteen of the intervals overlapped with known STB resistance intervals,suggesting that our phenotyping approach can identify simultaneously(i.e.,in a single experiment)many previously defined STB resistance intervals.Seventeen of the intervals were less than 5 Mbp in size and encoded only 173 genes,including many genes associated with disease resistance.Five intervals contained four or fewer genes,providing high priority targets for functional validation.Ten chromosome intervals were not previously associated with STB resistance,perhaps representing resistance to pathogen strains that had not been tested in earlier experiments.The SNP markers associated with these chromosome intervals can be used to recombine different forms of quantitative STB resistance that are likely to be more durable than pyramids of major resistance genes.Our experiment illustrates how high-throughput automated phenotyping can accelerate breeding for quantitative disease resistance. | Steven Yates Alexey Mikaberidze Simon GKrattinger Michael Abrouk Andreas Hund Kang Yu Bruno Studer Simone Fouche Lukas Meile Danilo Pereira Petteri Karisto Bruce A.McDonald | 2019 | Plant Phenomics2019，1，1： | 2 |
| 14 | Characteristics and health impacts of VOCs and carbonyls associated with residential cooking activities in Hong Kong显示文摘 | Yu Huang Steven Sai Hang Ho Kin Fai Ho Shun Cheng Lee Jian Zhen Yu Peter K.K. Louie | 2010 | Journal of Hazardous Materials2010，，1： | 2 |
| 15 | Hepatitis C Infection and Related Factors in Hemodialysis Patients in China: Systematic Review and Meta-Analysis显示文摘 | Jinghua Sun Rongbin Yu Bei Zhu Jianqing Wu Steven Larsen Weihong Zhao | 2009 | Renal Failure2009，，7： | 2 |
| 16 | Multicenter analysis of soluble A xl reveals diagnostic value for very early stage hepatocellular carcinoma显示文摘 | Patrick Reichl Meng Fang Patrick Starlinger Katharina Staufer Rudolf Nenutil Petr Muller Kristina Greplova Dalibor Valik Steven Dooley Christine Brostjan Thomas Gruenberger Jiayun Shen Kwan Man Michael Trauner Jun Yu Chun Fang Gao Wolfgang Mikulits | 2015 | Int. J. Cancer2015，，2： | 2 |
| 17 | The chemical composition of inorganic and carbonaceous materials in PM25 in Nanjing, China 显示文摘 | YANG Hong YU Jianzhen STEVEN Sai Hang Ho | 2005 | Atmospheric Environment2005，39，20： | 1 |
| 18 | Mechanisms of sodium, calcium and hydrogen removal from an aluminum melt in a stirred tank reactor-The ALCOA 622 Process 显示文摘 | Stevens J G Yu H | 1988 | Light Metals1988，，： | 1 |
| 19 | RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity显示文摘 | Yu W Liu-Bryyan R Stevens | 2012 | Atherosclerosis2012，222，2： | 1 |
| 20 | Saturation and comparative mapping of the genomic region harboring Hessian fly resistance gene H26 in wheat显示文摘 | Guo Tai Yu Xiwen Cai Marion O. Harris Yong Qiang Gu Ming-Cheng Luo Steven S. Xu | | 0，2009，： | 1 |
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