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| 1 | PacBio Sequencing and Its Applications显示文摘Single-molecule, real-time sequencing developed by Pacific Bio Sciences offers longer read lengths than the second-generation sequencing(SGS) technologies, making it well-suited for unsolved problems in genome, transcriptome, and epigenetics research. The highly-contiguous de novo assemblies using Pac Bio sequencing can close gaps in current reference assemblies and characterize structural variation(SV) in personal genomes. With longer reads, we can sequence through extended repetitive regions and detect mutations, many of which are associated with diseases. Moreover, Pac Bio transcriptome sequencing is advantageous for the identification of gene isoforms and facilitates reliable discoveries of novel genes and novel isoforms of annotated genes,due to its ability to sequence full-length transcripts or fragments with significant lengths. Additionally, Pac Bio's sequencing technique provides information that is useful for the direct detection of base modifications, such as methylation. In addition to using Pac Bio sequencing alone, many hybrid sequencing strategies have been developed to make use of more accurate short reads in conjunction with Pac Bio long reads. In general, hybrid sequencing strategies are more affordable and scalable especially for small-size laboratories than using Pac Bio Sequencing alone. The advent of Pac Bio sequencing has made available much information that could not be obtained via SGS alone. | Anthony Rhoads Kin Fai Au | 2015 | Genomics, Proteomics & Bioinformatics2015，13，5： | 107 |
| 2 | Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease显示文摘BACKGROUND:Non-alcoholic fatty liver disease(NAFLD)refers to any fatty liver disease that is not due to excessive use of alcohol.NAFLD probably results from abnormal hepatic lipid metabolism and insulin resistance.Aerobic exercise is shown to improve NAFLD.This review aimed to evaluate the molecular mechanisms involved in the beneficial effects of aerobic exercise on NAFLD.DATA SOURCE:We searched articles in English on the role of aerobic exercise in NAFLD therapy in Pub Med. | Rui Guo Emily C Liong Kwok Fai So Man-Lung Fung George L Tipoe | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 16 |
| 3 | Prostate cancer in Asia:A collaborative report显示文摘The incidence of prostate cancer(PCa)within Asian population used to be much lower than in the Western population;however,in recent years the incidence and mortality rate of PCa in some Asian countries have grown rapidly.This collaborative report summarized the latest epidemiology information,risk factors,and racial differences in PCa diagnosis,current status and new trends in surgery management and novel agents for castration-resistant prostate cancer.We believe such information would be helpful in clinical decision making for urologists and oncologists,health-care ministries and medical researchers. | Rui Chen Shancheng Ren 无 Ming Kwong Yiu Ng Chi Fai Wai Sam Cheng Lap Hong Ian Seiji Naito Tadashi Matsuda Elijah Kehinde Ali Kural Jason Yichun Chiu Rainy Umbas Qiang Wei Xiaolei Shi Liqun Zhou Jian Huang Yiran Huang Liping Xie Lulin Ma Changjun Yin Danfeng Xu Kexin Xu Zhangqun Ye Chunxiao Liu Dingwei Ye Xin Gao Qiang Fu Jianquan Hou Jianlin Yuan Dalin He Tiejun Pan Qiang Ding Fengshuo Jin Benkang Shi Gongxian Wang Xiuheng Liu Dongwen Wang Zhoujun Shen Xiangbo Kong Wanhai Xu Yaoliang Deng Haibo Xia Alexa NCohen Xu Gao Chuanliang Xu Yinghao Sun | 2014 | Asian Journal of Urology2014，1，1： | 13 |
| 4 | Emerging role of Hippo pathway in gastric and othergastrointestinal cancers显示文摘More evidence has underscored the importance of Hippo signaling pathway in gastrointestinal tissue homeostasis, whereas its deregulation induces tumorigenesis. Yes-associated protein 1(YAP1) and its close paralog TAZ, transcriptional co-activator with a PDZbinding motif, function as key effectors negatively controlled by the Hippo pathway. YAP1/TAZ exerts oncogenic activities by transcriptional regulation via physical interaction with TEAD transcription factors. In various cancers, Hippo pathway cross-talks with pro- or anti-tumorigenic pathways such as GPCR, Wnt/β-catenin, Notch and TGF-β signaling and is deregulated by multiple factors including cell density/junction and micro RNAs. As YAP1 expression is significantly associated with poor prognosis of gastric and other gastrointestinal cancers, detailed delineation of Hippo regulation in tumorigenesis provides novel insight for therapeutic intervention. In current review, we summarized the recent research progresses on the deregulation of Hippo pathway in the gastrointestinal tract including stomach and discuss the molecular consequences leading to tumorigenesis. | Wei Kang Alfred SL Cheng Jun Yu Ka Fai To | 2016 | World Journal of Gastroenterology2016，22，3： | 11 |
| 5 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 6 | Responses of Soil Microbial Community Structure and Activity to Incorporation of Straws and Straw Biochars and Their Effects on Soil Respiration and Soil Organic Carbon Turnover显示文摘Like straw, biochar incorporation can influence soil microorganisms and enzyme activities and soil carbon(C) responses;however,few studies have compared the various effects of straw and biochar and the underlying mechanisms. An experiment was performed to study the changes in soil respiration(SR) and soil organic C(SOC) fluxes in response to the incorporation of three kinds of straw(reed, smooth cordgrass, and rice) and their pyrolyzed products(biochars) at Chongming Island, China. In addition, the microbial activity and community structure of some amended soils were also analyzed to clarify the mechanisms of these responses. The results showed that all biochar incorporation(BC) induced lower SR than the corresponding unpyrolyzed straw incorporation(ST), and the average SR in the soils following BC and ST during the experimental periods was 21.69 and 65.32 μmol CO2 m^-2s^-1, respectively.Furthermore, the average SOC content was 16.97 g kg-1 following BC, which was higher than that(13.71 g kg-1) following ST,indicating that compared to ST, BC was a low-C strategy, even after accounting for the C loss during biochar production. Among the BC treatments, reed-BC induced the lowest SR(17.04 μmol CO2 m^-2s^-1), whereas smooth cordgrass-BC induced the highest SR(27.02 μmol CO2 m^-2s^-1). Furthermore, in contrast with ST, BC significantly increased the abundance of some bacteria with poorer mineralization or better humification ability, which led to lower SR. The lower easily oxidizable C(EOC) and higher total C contents of biochars induced lower SR and higher SOC in the soil following BC compared to that following ST. Among the BC treatments,the higher total nitrogen content of rice biochar led to significantly higher soil microbial biomass, and the lower EOC content of reed biochar led to lower soil microbial activity and SR. | TIAN Xiaoping WANG Lei HOU Yahong WANG Han TSANG Yiu Fai WU Jihua | 2019 | Pedosphere2019，29，4： | 7 |
| 7 | A proteomic analysis of rice seedlings responding to 1,2,4-trichlorobenzene stress显示文摘回答 to1,2,4-trichlorobenzene (TCB ) 的根和叶子强调的米饭(Oryza sativa L.) 的 proteomic 分析被二维的胶化电气泳动执行,质量度谱(MS ) ,并且蛋白质数据库分析。结果证明 5 mg/L TCB 应力在米饭根和叶子在全球 proteome 上有重要效果。范畴的分析和 TCB 的功能强调可诱导的蛋白质证明回答的不同类型在米饭根和叶子被生产,当稻秧暴露于 5mg/L TCB 应力时。大多数回答为保卫 TCB 应力的损坏的米饭是必要的。这些回答包括有毒的物质,致病相关的蛋白质的表示,细胞壁物质的合成和第二等的混合物的解毒,蛋白质的规定和氨基酸新陈代谢,蛋氨酸的激活抢救小径,并且也包括渗透的规定和植物激素新陈代谢。比较 TCB 压力在二栽培变种,β-葡萄糖苷酶和致病相关的蛋白质之间的可诱导的蛋白质家庭 10 蛋白质被 TCB 应力特别地在米饭栽培变种( Oryza sativa L.)的根导致 Aizaizhan ,并且谷胱甘肽 S-transferase 和 aci-reductone dioxygenase 4 在米饭栽培变种 Shanyou 63 的根被导致。这可以是为比 Aizaizhan 有更高的公差到 TCB 应力的 Shanyou 63 的重要机制之一。 | GE Cailin WAN Dingzhen WANG Zegang DING Yan WANG Yulong SHANG Qi MA Fai LUO Shishi | 2008 | Journal of Environmental Sciences2008，20，3： | 7 |
| 8 | 让肾脏健康人人可享,处处可及——从预防到诊治显示文摘Around 850 million people currently are affected by different types of kidney disorders.Up to 1 in 10 adults worldwide has chronic kidney disease(CKD),which is invariably irreversible and mostly progressive.The global burden of CKD is increasing,and CKD is projected to become the fifth most common cause of years of life lost globally by 2040.If CKD remains uncontrolled and if the affected person survives the ravages of cardiovascular and other complications of the disease,CKD progresses to endstage kidney disease,where life cannot be sustained without dialysis therapy or kidney transplantation.Hence,CKD is a major cause of catastrophic health expenditure. | Philip Kam Tao Guillermo Garcia Garcia Siu Fai Lui Sharon Andreoli Winston Wing Shing Fung Anne Hradsky Latha Kumaraswami Vassilios Liakopoulos Ziyoda Rakhimova Gamal Saadi Luisa Strani Ifeoma Ulasi Kamyar Kalantar Zadeh 无 | 2020 | 肾脏病与透析肾移植杂志2020，29，1： | 6 |
| 9 | 厚板弯曲与拉伸振动精化理论及其求解新途径显示文摘利用弹性动力学中Boussinesq-Galerkin一般解,基于微分算子谱和算子代数理论,采用了适当的规范条件,建立了推演厚板结构动力学方程的新途径.首次给出了考虑横向荷载作用的平板弯曲和拉压振动的两类动力学方程具体形式.为推导动力学方程方便和利用微分算子谱分解理论,引进了虚微分算子(i)的概念.并将本文得到的平板结构振动方程与各种平板结构的弯曲方程作了对比分析.由于本文推导时没有采用任何工程假设,因此本文提出的平板动力学方程是精确的,可用于求解厚壁平板的振动和设计平板振动主动控制策略.本文为不采用几何方法,而是采用分析和代数的方法精确推导低维结构的动力学支配方程提供了一种统一规范的方法. | 胡超 MA Fai 马兴瑞 黄文虎 | 2012 | 中国科学:物理学、力学、天文学2012，42，5： | 6 |
| 10 | A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction显示文摘Hyperhomocysteinemia(HHcy)is an independent risk factor for cardiovascular diseases and increases mortality in type 2 diabetic patients.HHcy induces endoplasmic reticulum(ER)stress and oxidative stress to impair endothelial function.The glucagon-like peptide 1(GLP-1)analog exendin-4 attenuates endothelial ER stress,but the detailed vasoprotective mechanism remains elusive.The present study investigated the beneficial effects of exendin-4 against HHcy-induced endothelial dysfunction.Exendin-4 pretreatment reversed homocysteine-induced impairment of endothelium-dependent relaxations in C57BL/6 mouse aortae ex vivo.Four weeks subcutaneous injection of exendin-4 restored the impaired endothelial function in both aortae and mesenteric arteries isolated from mice with diet-induced HHcy.Exendin-4 treatment lowered superoxide anion accumulation in the mouse aortae both ex vivo and in vivo.Exendin-4 decreased the expression of ER stress markers(e.g.,ATF4,spliced XBP1,and phosphorylated eIF2α)in human umbilical vein endothelial cells(HUVECs),and this change was reversed by cotreatment with compound C(CC)(AMPK inhibitor).Exendin-4 induced phosphorylation of AMPK and endothelial nitric oxide synthase in HUVECs and arteries.Exendin-4 increased the expression of endoplasmic reticulum oxidoreductase(ERO1α),an important ER chaperone in endothelial cells,and this effect was mediated by AMPK activation.Experiments using siRNA-mediated knockdown or adenoviral overexpression revealed that ERO1αmediated the inhibitory effects of exendin-4 on ER stress and superoxide anion production,thus ameliorating HHcy-induced endothelial dysfunction.The present results demonstrate that exendin-4 reduces HHcy-induced ER stress and improves endothelial function through AMPK-dependent ERO1αupregulation in endothelial cells and arteries.AMPK activation promotes the protein folding machinery in endothelial cells to suppress ER stress. | Chak Kwong Cheng Jiang-Yun Luo Chi Wai Lau William Chi-shing Cho Chi Fai Ng Ronald Ching Wan Ma Xiao Yu Tian Yu Huang | 2021 | Acta Pharmacologica Sinica2021，42，10： | 6 |
| 11 | A cross-sectional study on compliance with topical glaucoma medication and its associated socioeconomic burden for a Chinese population显示文摘AIM: To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical treatment.METHODS: This was a retrospective cross-sectional study.Fifty-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication,attitude towards glaucoma and therapy and vision related quality of life.Noncompliance was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the consultation.Relationships between noncompliance and demographics,attitude,disease and treatment status was studied.Cost was estimated with quality of life and direct medical cost involved with noncompliance.Multivariable logistic regression on noncompliance was performed on selected factors.RESULTS: Compliance was calculated as 75%(95% CI: 64%-87%) among 57 subjects(mean age 69 y,female 51%).No statistical significant relationship was established between noncompliance and any single factors or outcomes.Age(P=0.048) and forgetfulness(P=0.064) were found to be marginally significant predictive factors on noncompliance in multivariable logistic regression.Noncompliance might be related(P=0.130) to poorer self-rated vision-associated quality of life.The societal cost of noncompliance was estimated to be over 2510 life-years and US$ 3.7 million territory-wide.CONCLUSION: The compliance of Chinese glaucoma patients in Hong Kong is comparable to other parts in the world,and carries detrimental impacts on individual and societal levels.Age and forgetfulness are two possible independent predictors for noncompliance. | Man-Hin Lui Jason Chun Ho Lam Yi Lee Kwong Tak Siu Wong Pak Long Cheung Sherri Shun Yan Lai Pak Lun Yuen Wai Yiu Lam Ho Yan Chan Yiu Fai Wong Jimmy Shiu Ming Lai Kendrick Co Shih | 2017 | International Journal of Ophthalmology(English edition)2017，10，2： | 5 |
| 12 | 超声波无线电能传输系统电气建模方法(英文)显示文摘基于等效电路的方法,提出一种适用于超声波无线电能传输系统的电气建模方法。首先采用基本压电方程对压电换能器进行建模,接着推导出系统层面的等效电路模型,并获得系统输出特性。实验结果对所提出的模型进行了验证,实验证明利用一对28 k Hz的压电换能器,该系统能通过5 mm厚的铝板向阻性负载传输2.6 W功率的电能。 | Leung Ho Fai 戴欣 呼爱国 | 2015 | 电工技术学报2015，30，19： | 5 |
| 13 | Transfusion-transmitted hepatitis E:What we know so far?显示文摘Hepatitis E virus(HEV)is a major cause of viral hepatitis globally.There is growing concern about transfusion-transmitted HEV(TT-HEV)as an emerging global health problem.HEV can potentially result in chronic infection in immunocompromised patients,leading to a higher risk of liver cirrhosis and even death.Between 0.0013%and 0.281%of asymptomatic blood donors around the world have HEV viremia,and 0.27%to 60.5%have anti-HEV immunoglobulin G.HEV is infectious even at very low blood concentrations of the virus.Immunosuppressed patients who develop persistent hepatitis E infection should have their immunosuppressant regimen reduced;ribavirin may be considered as treatment.Pegylated interferon can be considered in those who are refractory or intolerant to ribavirin.Sofosbuvir,a nucleotide analog,showed modest antiviral activity in some clinical studies but sustained viral response was not achieved.Therefore,rescue treatment remains an unmet need.The need for HEV screening of all blood donations remains controversial.Universal screening has been adopted in some countries after consideration of risk and resource availability.Various pathogen reduction methods have also been proposed to reduce the risk of TT-HEV.Future studies are needed to define the incidence of transmission through transfusion,their clinical features,outcomes and prognosis. | Carmen Ka Man Cheung Sunny Hei Wong Alvin Wing Hin Law Man Fai Law | 2022 | World Journal of Gastroenterology2022，28，1： | 5 |
| 14 | Acaricidal activity of different extracts from Syzygium cumini L.Skeels(Pomposia) against Tetranychus urticae Koch显示文摘Objective:To investigate the acaricidal activity of different extracts from Syzygium cumini(S.cumini)(Pomposia)againsst Tetranyckus urticae Koch(71 urticae)and the biochemical changes in antioxidants enzymes.Methods:Six extracts of S.cumini(Pomposia)at concentrations of 75,150 and 300μg/mL were used to control T.urticae(Koch).Results:The ethanol extract showed the most efficient acaricidal activity agent against T.urticae(98.5%)followed by hexane extract(94.0%),ether and ethyl acetate extract(90.0%).The LC_(50)values of the promising extract-were 85.0,101.0,102.0 and 98.0μ/mL,respectively.The activities of enzymes including ascorbate peroxidase(APX),peroxidase(POD),superoxide dismutase(SOD)and catalase(CAT)in susceptible mites were increased.The activities of all antioxidant enzymes reach the maximum value in mites at LC_(50)with ethanol and ethyl acetate extracts,respectively.Conclusions:The extract of S.cumini has acaricidal acivity against T.urticae,and the ethanol extract is the most efficient. | Abd El-Moneim MR Afify Hossam S El-Beltagi Sayed A Fayed Emad A Shalaby | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，5： | 5 |
| 15 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 16 | Salinity influence on soil microbial respiration rate of wetland in the Yangtze River estuary through changing microbial community显示文摘Estuarine wetland,where freshwater mixes with salt water,comprises different regions(rivers and marine ecosystems)with significantly varying tidal salinities.Two sampling areas,ZXS and JS,were selected to investigate the effect of tidal salinity on soil respiration(SR).ZXS and JS were located in Zhongxia Shoal and Jiangyanan Shoal of Jiuduansha Wetland respectively,with similar elevation and plant species,but significantly different in salinity.The results showed that with almost identical plant biomass,the SR and soil microbial respiration(SMR)of the tidal wetland with lower salinity(JS)were significantly higher than those of the tidal wetland with higher salinity(ZXS)(p<0.05).However,unlike SMR and SR,the difference in the soil microbial biomass(SMB)was not significant(p>0.05)with the SMB of ZXS a little higher than that of JS.The higher SMR and SR of JS may be closely connected to the soil microbial community structures and amount of dominant bacteria.Abundantβ-andγ-Proteobacteria and Actinobacteria in JS soil,which have strong heterotrophic metabolic capabilities,could be the main reason for higher SMR and SR,whereas a high number ofε-Proteobacteria in ZXS,some of which have carbon fixation ability,could be responsible for relatively lower carbon output.Path analysis indicated that soil salinity had the maximum negative total influencing coefficient with SMR among the various soil physical and chemical factors,suggesting that higher soil salinity,restricting highly heterotrophic bacteria,is the principle reason for lower SMR and SR in the ZXS. | Xue Fei Xi Lei Wang Jia Jun Hu Yu Shu Tang Yu Hu Xiao Hua Fu Ying Sun Yiu Fai Tsang Yan Nan Zhang Jin Hai Chen | 2014 | Journal of Environmental Sciences2014，26，12： | 4 |
| 17 | 门槛回归模型中门槛值和回归参数的估计显示文摘门槛模型中有两个关键问题:门槛个数的选择和门槛参数的估计.本文提出的判罚光滑最小二乘方法同时解决这两个问题.本文的方法避免了为确定门槛个数所需的假设检验,计算简单.回归参数估计被证明是n-^(1/2)相合且渐近正态,门槛参数估计被证明是(n/h-)^(1/2)相合且渐近正态.数值模拟和实际例子结果显示本文方法有效可行. | 蒋家坤 林华珍 蒋靓 YIP Paul Siu Fai | 2016 | 中国科学:数学2016，46，4： | 4 |
| 18 | Recurrent intestinal volvulus in midgut malrotation causing acute bowel obstruction: A case report显示文摘Intestinal malrotation occurs when there is a disruption in the normal embryological development of the bowel. The majority of patients present with clinical features in childhood, though rarely a first presentation can take place in adulthood. Recurrent bowel obstruction in patients with previous abdominal operation for midgut malrotation is mostly due to adhesions but very few reported cases have been due to recurrent volvulus. We present the case of a 22-year-old gentleman who had laparotomy in childhood for small bowel volvulus and then presented with acute bowel obstruction. Preoperative computerised tomography scan showed small bowel obstruction and features in keeping with midgut malrotation. Emergency laparotomy findings confirmed midgut malrotation with absent appendix, abnormal location of caecum, ascending colon and small bowel. In addition, there were small bowel volvulus and a segment of terminal ileal stricture. Limited right hemicolectomy was performed with excellent postoperative recovery. This case is presented to illustrate a rare occurrence and raise an awareness of the possibility of dreadful recurrent volvulus even several years following an initial Ladd's procedure for midgut malrotation. Therefore, one will need to exercise a high index of suspicion and this becomes very crucial in order to ensure prompt surgical intervention and thereby preventing an attendant bowel ischaemia with its associated high fatality. | Fayed Sheikh Vickna Balarajah Abraham Abiodun Ayantunde | 2013 | World Journal of Gastrointestinal Surgery2013，5，3： | 3 |
| 19 | Gigantic electric-field-induced second harmonic generation from an organic conjugated polymer enhanced by a band-edge effect显示文摘Electric-field-induced second harmonic generation(EFISH),a third-order nonlinear process,arises from the interaction between the electric field of an external bias and that of two incident photons.EFISH can be used to dynamically control the nonlinear optical response of materials and is therefore promising for active nonlinear devices.However,it has been challenging to achieve a strong modulation with EFISH in conventional nonlinear materials.Here,we report a large tunability of an EFISH signal from a subwavelength-thick polymer film sandwiched between a transparent electrode and a metallic mirror.By exploiting the band-edge-enhanced third-order nonlinear susceptibility of the organic conjugated polymer,we successfully demonstrate a gigantic EFISH effect with a modulation ratio up to 422%V^(−1) at a pumping wavelength of 840 nm.The band-edge-enhanced EFISH opens new avenues for modulating the intensity of SHG signals and for controlling nonlinear electro-optic interactions in nanophotonic devices. | Shumei Chen King Fai Li Guixin Li Kok Wai Cheah Shuang Zhang | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 20 | One New Diterpene Glucoside from the Roots of Rhododendron molle显示文摘One new grayanane diterpene glucoside, rhodomoside A 1 was isolated from the roots of Rhododendron molle G. Don (Ericaceae). Its structure was elucidated on the basis of spectral analysis. | Guan Hu BAO1, Li Quan WANG1, Kin Fai CHENG2, Guo Wei QIN1* 1Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031 2Deprtment of Chemistry, the University of Hong Kong, Hong Kong | 2002 | Chinese Chemical Letters2002，13，10： | 3 |
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