|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 2 | 对两种不同饲养条件下猪生长和胴体性状的遗传与表型参数的研究显示文摘本文对自由采食和限制喂料两群猪的平均日增重(DG)、平均日采食量(FI)、饲料转化率(FCR)、P_2点背膘厚(BF)和后腿瘦肉量(HL)作了遗传分析和比较。试验猪为合成品系,主要的遗传血统为大白猪和长白猪以及少量的巴克夏猪。限制采食猪各性状的平均数和标准差为:DG 729±48.45g,FI 1.85±0.043kg,FCR 2.56±0.15,BF 15.3±1.90mlmHL 6.07±0.36kg,自由采食猪相应为:821±85.87g,2.31±0.16 kg,2.85±0.31,16.8±2.43mm,6.07±0.56kg。限制采食猪各性状的遗传力:DG 0.399,FI 0.410,FC R0.403,BF 0.619,HL 0.446,而自由采食猪分别为0.307,0.480,0.129,0.315和0.350。在限制采食下,日增重与饲料转化率、日增重与后腿瘦肉量、饲料转化率与后腿瘦肉量有很强的遗传相关,分别为-0.94,0.95和-0.97;而在自由采食下这三个相关分别为-0.46,0.97和-0.46。 | 胡锦平 Chris Haley Cam Mcphee | 1990 | 畜牧兽医学报1990，21，2： | 3 |
| 3 | Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)显示文摘 | Fiona McPhee Amy K. Sheaffer Jacques Friborg Dennis Hernandez Paul Falk Guangzhi Zhai Steven Levine Susan Chaniewski Fei Yu Diana Barry Chaoqun Chen Min S. Lee Kathy Mosure Li-Qiang Sun Michael Sinz Nicholas A. Meanwell Richard J. Colonno Jay Knipe Paul S | 2012 | Antimicrobial Agents and Chemotherapy2012，，10： | 2 |
| 4 | Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options显示文摘 | Yoshiyuki Suzuki Kenji Ikeda Fumitaka Suzuki Joji Toyota Yoshiyasu Karino Kazuaki Chayama Yoshiiku Kawakami Hiroki Ishikawa Hideaki Watanabe Wenhua Hu Timothy Eley Fiona McPhee Eric Hughes Hiromitsu Kumada | 2012 | Journal of Hepatology2012，，： | 2 |
| 5 | A deformation field for Euler-Bernoulli beams with applications to flexible multibody dynamics显示文摘 | Shi P McPhee J Heppler G R | 2001 | Multibody System Dynamics2001，5，： | 1 |
| 6 | Randomized study of percutaneous endoscopic gastrostomy versus nasogastric tubesfor enteral feeding in head and neck cancer patients treated with (chemo) radiation显示文摘 | CorryJ Poon W Mcphee N | | 0，，： | 1 |
| 7 | A description of virologic escape in HCV genotype 1 -infected patients trea- ted with daclatasvir (BMS -790052) in combination with ribavirin and peginterferon alfa -2a or peinterferon alfa -2b 显示文摘 | MCPHEE F HERNANDEZ D YU F | 2012 | J Hepatol2012，56，： | 1 |
| 8 | Translation of the Alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untrsnated region sequences 显示文摘 | Rogers J T Leiter L M Mcphee J | 1999 | J Biol chem1999，294，： | 1 |
| 9 | The formula for healthand well-being in individuals with cerebral palsy: physical activity,sleep, and nutrition显示文摘 | Verschuren 0 McPhee P Rosenbaum P | 2016 | Dev Med Child Neurol2016，589，： | 1 |
| 10 | HIV-1 Nef:a critical factor in viral-induced pathogenesis显示文摘 | Greenway A L Holloway G McPhee D A | 2000 | Adv Pharmacol2000，48，： | 1 |
| 11 | Idiopathic scoliosis and pineal lesions in Australian children 显示文摘 | Day GA McPhee IB Tuffley J | 2007 | J Orthop Surg2007，15，3： | 1 |
| 12 | The Effect of Automated Calls With Telephone Nurse Follow-Up on Patient-Centered Outcomes of Diabetes Care: A Randomized, Controlled Trial显示文摘 | John D. Piette Morris Weinberger Stephen J. McPhee | 2000 | Medical Care2000，，2： | 1 |
| 13 | Automated type synthesis planar mechanisms using numeric optimization with genetic algorithms 显示文摘 | Liu Yi Mcphee John | 2005 | ASME : Journal of Mechanical Design2005，127，5： | 1 |
| 14 | A comparison of insemination techniques in Corridale ewes 显示文摘 | KERTON D J McPHEE S R DAVIS I F | 1984 | Process Australia Society Animal Production1984，15，： | 1 |
| 15 | Carodd endarterectomy was performed with lower stroke and darth rates than carotid artery stenting in the United Stakes in 2003 and 2004显示文摘 | McPhee JT Hill JS Ciocca RG | | 0，，06： | 1 |
| 16 | Function and therapeutic potential of host defence peptides显示文摘 | Mcphee J B | 2005 | J Peptide Sci2005，11，： | 1 |
| 17 | The midterm results ofstent graft treatment of thoracic aortic injuries显示文摘 | McPhee J T Asham E H Rohrer M J | 2007 | J Surg Res2007，138，2： | 1 |
| 18 | Automated type synthesis of planar mechanisms using numeric optimization with genetic algorithms显示文摘 | Liu Yi John McPhee | 2005 | ASME J Mech Des2005，128，12： | 1 |
| 19 | Off-label use of medicines:consensus recommendations for evaluating appropriateness显示文摘 | Gazarian M Kelly M McPhee JR | 2006 | Med J Aust2006，185，10： | 1 |
| 20 | Maximizing the benefits of autopsy for clinicians and families显示文摘 | MCPHEE S J | 1996 | Arch of Pathol and lab med1996，120，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员