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| 1 | Genetic and epigenetic changes associated with cholangiocarcinoma:From DNA methylation to microRNAs显示文摘Cholangiocarcinomas are malignant epithelial liver tumors arising from the intra- and extra-hepatic bile ducts. Little is known about the molecular development of this disease, and very few effective treatment options are available. Thus, prognosis is poor. Genetic and epigenetic changes play an integral role in the neoplastic transformation of human cells to their malignant counterparts. This review summarizes some of the more prevalent genetic alterations (by microRNA expression) and epigenetic changes (hypermethylation of specific gene promoters) that are thought to contribute to the carcinogenic process in cholangiocarcinoma. | Monique Stutes Steven Tran Sharon DeMorrow | 2007 | World Journal of Gastroenterology2007，13，48： | 11 |
| 2 | A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen显示文摘 | Xiao-Jun Ma Zuncai Wang Paula D Ryan Steven J Isakoff Anne Barmettler Andrew Fuller Beth Muir Gayatry Mohapatra Ranelle Salunga J.Todd Tuggle Yen Tran Diem Tran Ana Tassin Paul Amon Wilson Wang Wei Wang Edward Enright Kimberly Stecker Eden Estepa-Sabal Ba | 2004 | Cancer Cell2004，，6： | 1 |
| 3 | Radiolabeled Antibodies in Prostate Cancer: A Case Study Showing the Effect of Host Immunity on Antibody Bio-distribution显示文摘 | Oskar Vilhelmsson-Timmermand Elmer Santos Daniel L.J. Thorek Susan Evans-Axelsson Anders Bjartell Hans Lilja Steven M. Larson Sven-Erik Strand Thuy A. Tran David Ulmert | 2014 | Nuclear Medicine and Biology2014，，： | 1 |
| 4 | Occupational asthma and the paper recycling industry显示文摘 | Steven Tran Helen Francis Jennifer Hoyle | 2009 | Occupational Medicine2009，59，： | 1 |
| 5 | A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen显示文摘 | Xiao-Jun Ma Zuncai Wang Paula D Ryan Steven J Isakoff Anne Barmettler Andrew Fuller Beth Muir Gayatry Mohapatra Ranelle Salunga J.Todd Tuggle Yen Tran Diem Tran Ana Tassin Paul Amon Wilson Wang Wei Wang Edward Enright Kimberly Stecker Eden Estepa-Sabal Ba | 2004 | Cancer Cell2004，，6： | 1 |
| 6 | Association Between Carotid Plaque Characteristics and Subsequent Ischemic Cerebrovascular Events: A Prospective Assessment With MRI—Initial Results显示文摘 | Norihide Takaya Chun Yuan Baocheng Chu Tobias Saam Hunter Underhill Jianming Cai Nam Tran Nayak L. Polissar Carol Isaac Marina S. Ferguson Gwenn A. Garden Steven C. Cramer Kenneth R. Maravilla Beverly Hashimoto Thomas S. Hatsukami | 2006 | Stroke2006，，3： | 1 |
| 7 | Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice显示文摘 | Alessandra Sacco Foteini Mourkioti Rose Tran Jinkuk Choi Michael Llewellyn Peggy Kraft Marina Shkreli Scott Delp Jason H. Pomerantz Steven E. Artandi Helen M. Blau | 2010 | Cell2010，，7： | 1 |
| 8 | Poly(β-hydroxybutyrate) production in oilseed leukoplasts of Brassica napus显示文摘 | Kathryn L. Houmiel Steven Slater Debra Broyles Laura Casagrande Susan Colburn Kathleen Gonzalez Timothy A. Mitsky Steven E. Reiser Devang Shah Nancy B. Taylor Mintien Tran Henry E. Valentin Kenneth J. Gruys | 1999 | Planta1999，，4： | 1 |
| 9 | Characterization of a small molecule PAI-1 inhibitor, ZK4044显示文摘 | Amy Liang Faye Wu Kathy Tran Steven W. Jones Gary Deng Bin Ye Zhuchun Zhao R. Michael Snider William P. Dole John Morser Qingyu Wu | 2004 | Thrombosis Research2004，，4： | 1 |
| 10 | Poly(β-hydroxybutyrate) production in oilseed leukoplasts of Brassica napus显示文摘 | Kathryn L. Houmiel Steven Slater Debra Broyles Laura Casagrande Susan Colburn Kathleen Gonzalez Timothy A. Mitsky Steven E. Reiser Devang Shah Nancy B. Taylor Mintien Tran Henry E. Valentin Kenneth J. Gruys | 1999 | Planta1999，，4： | 1 |
| 11 | Vaccination with a Plasmid Vector Carrying the Rabies Virus Glycoprotein Gene Induces Protective Immunity against Rabies Virus显示文摘 | Zhi Quan Xiang Steven Spitalnik Minh Tran | 1994 | Virology1994，199，： | 1 |
| 12 | 2021皮肤红斑狼疮的诊断、治疗和长期管理指南显示文摘皮肤红斑狼疮(CLE)是一种炎症性自身免疫性疾病,其分型较多,包括急性、亚急性、慢性和间歇性CLE。其中,慢性CLE可以进一步分为红斑狼疮(LE)的几个亚型,如盘状LE、疣状LE、深在性LE、冻疮样LE和Blaschko线状LE等。为了给皮肤科医生和风湿科医生提供CLE的诊断、治疗和长期管理的实用指导建议,本证据和共识指南根据卫生保健实践指南的报告条目(国际RIGHT工作组)目录编制,并在国际实践指南注册平台注册。在亚洲皮肤科学会(ADA)、亚洲皮肤病性病学会(AADV)以及中华医学会皮肤性病学分会(CSD)红斑狼疮研究中心的共同努力下,来自亚洲、美洲、欧洲等16个国家或地区的25名皮肤科医生、7名风湿科医生、1名红斑狼疮领域专家和2名方法学家参与了本指南的制定。所有建议均取得了32名医生中至少80%的同意。作为共识,CLE的诊断主要基于临床和组织病理学表现的评估,并且通过对全身多系统损伤的评估,排除系统性红斑狼疮(SLE)。外用糖皮质激素和钙调磷酸酶抑制剂是局部CLE的一线治疗。对于泛发或严重的CLE皮损和/或局部耐药的病例,可以合并全身治疗,包括抗疟药和/或短期全身使用糖皮质激素。值得注意的是,抗疟药是所有类型CLE的一线全身治疗药物,同样可用于妊娠期患者和儿童。二线治疗用药包括沙利度胺、类维生素A类药物、氨苯砜和甲氨蝶呤,而霉酚酸酯是三线治疗用药。最后,脉冲染料激光或手术可作为四线治疗,用于局部以及发生在不可修饰部位的慢性、难治性CLE皮损。贝利尤单抗亦可作为四线治疗用药,用于活动性SLE患者的泛发性CLE皮损或糖皮质激素逐渐减量期间复发的急性CLE。对于疾病的管理,患者教育和长期随访是必要的。建议在每次随访时适当评估疾病活动度、皮肤和其他器官损伤、生活质量、合并症及可能发生的不良事件。 | Qianjin Lu Hai Long Steven Chow Syarief Hidayat Retno Danarti Yulianto Listiawan Danqi Deng Qing Guo Hong Fang Juan Tao Ming Zhao Leihong Xiang Nan Che Fen Li Hongjun Zhao Chak Sing Lau Fong Cheng Ip King Man Ho Arnelfa C.Paliza Chan Vicheth Kiran Godse Soyun Cho Chew Swee Seow Yoshiki Miyachi Tran Hau Khang Rataporn Ungpakorn Hassan Galadari Rashmikant Shah Kehu Yang Youwen Zhou Carlo Selmi Amr HSawalha Xuan Zhang Yaolong Chen Chrang-Shi Lin 姚文鑫 | 2022 | 中国合理用药探索2022，19，10： | 1 |
| 13 | Concise Review: Maturation Phases of Human Pluripotent Stem Cell‐Derived Cardiomyocytes显示文摘 | Claire Robertson David D. Tran Steven C. George | 2013 | STEM CELLS2013，，5： | 1 |
| 14 | Postoperative mometasone irrigations improve quality of life in skull base tumor patients显示文摘Objectives:The use of topical corticosteroids to manage postoperative sinonasal symptoms after endoscopic skull base surgery (ESBS) has not been well studied.We quantified long‐term impact of postoperative steroid irrigations (SIs) on quality of life of patients after ESBS.Methods:Retrospective review of patients at the University of Pennsylvania undergoing ESBS from 2010 to 2019.Data on patient demographics and postoperative treatment with nasal saline irrigation twice daily with and without dissolved steroids (mometasone or budesonide) was collected.Preoperative,and 1‐,3‐,6‐,12‐,18‐,and 24‐month postoperative Sino‐Nasal Outcome Test (SNOT‐22) scores were assessed.Results:A total of 727 patients were assessed (53.4% males),with 479 patients in the no SI group and 248 patients in the SI group.Preoperative SNOT‐22 scores did not differ significantly (P = 0.19).1‐,3‐,6‐,12‐,18‐,and 24‐month post‐op SNOT‐22 scores did not significantly differ between groups.However,mometasone irrigations resulted in significantly lower postoperative 2‐year SNOT‐22 scores compared to budesonide (P < 0.01) and saline (P = 0.03).Conclusions:Though corticosteroid irrigations are routine in managing inflammatory sinus disease,their role in postoperative management after ESBS for tumors is unclear.Our findings suggest that mometasone irrigation may be effective at improving postoperative quality of life in patients after ESBS. | Mandy K.Salmon Rijul S.Kshirsagar Jacob G.Eide Auddie M.Sweis Kathleen Davin Aman Prasad Heather Ungerer Elizabeth Stevens Kevin Ig‐Izevbekhai Siddhant Tripathi Tran B.Locke Theodore Lin Brian M.Sweis Michael A.Kohanski Nithin D.Adappa James N.Palmer | 2023 | World Journal of Otorhinolaryngology-Head and Neck Surgery2023，9，4： | 0 |
| 15 | Bioactivity‑Guided Isolation of Totarane‑Derived Diterpenes from Podocarpus neriifolius and Structure Revision of 3‑Deoxy‑2α‑hydroxynagilactone E显示文摘Bioactivity-guided phytochemical investigation of Podocarpus neriifolius D.Don.(Podocarpaceae)has led to the isolation of one new(2)and three known(1,3,and 4)B-type podolactones,along with three totarane-type diterpenes(5-7).Their structures were determined by interpretation of High Resolution ElectroSpray Ionization Mass Spectrometry(HRESIMS)and 1D and 2D NMR data,and comparison with the values reported in the literature.The structure of compound 1,previously identifed as 3-deoxy-2α-hydroxynagilactone E(8),was revised as its 2β-epimer,which has been reported recently as a new compound.All of the isolates were evaluated for their antiproliferative activity against a panel of four human cancer cell lines,namely,ovarian(OVCAR3),breast(MDA-MB-231),colon(HT-29),and melanoma(MDA-MB-435),and compounds 1 and 3 were found to be cytotoxic with IC_(50) values in the low micromolar range for most of the cell lines used.The major compound,inumakilactone A(3),was further tested in vivo using the HT-29,MDA-MB-435,and OVCAR3 cells in a murine hollow fber model,for the frst time. | P.Annécie Benatrehina Wei-Lun Chen Austin A.Czarnecki Steven Kurina Hee-Byung Chai Daniel D.Lantvit Tran N.Ninh Xiaoli Zhang Djaja D.Soejarto Joanna E.Burdette A.Douglas Kinghorn L.Harinantenaina Rakotondraibe | 2019 | Natural Products and Bioprospecting2019，9，2： | 0 |
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