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| 1 | NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis显示文摘AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression analysis.RESULTS: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, 'NAT2*4', was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity. | Norihide Higuchi Naoko Tahara Katsunori Yanagihara Kiyoyasu Fukushima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazaki Tsutomu Kobayashi Koh-ichiro Yoshiura Norio Niikawa, Chun-Yang Wen, Hajime Isomoto,Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Kazuhiro Tsukamoto Norio Niikawa Chun-Yang Wen Hajime Isomoto Saburou Shikuwa Katsuhisa Omagari Yohei Mizuta Shigeru Kohno Kazuhiro Tsukamoto | 2007 | World Journal of Gastroenterology2007，13，45： | 21 |
| 2 | Intraductal papillary neoplasm of the bile duct in liver cirrhosis with hepatocellular carcinoma显示文摘A case of intraductal papillary neoplasm of the bile duct (IPNB) arising in a patient with hepatitis B-related liver cirrhosis with hepatocellular carcinoma (HCC) is reported. A 76-year-old man was admitted to our hospital with recurrent HCC. Laboratory data showed that levels of carcinoembryonic antigen and carbohydrate antigen 19-9 were elevated. He died of progressive hepatic failure. At autopsy,in addition to HCCs,an intraductal papillary proliferation of malignant cholangiocytes with fibrovascular cores was found in the dilated large bile ducts in the left lobe,and this papillary carcinoma was associated with an invasive mucinous carcinoma (invasive IPNB). Interestingly,extensive intraductal spread of the cholangiocarcinoma was found from the reactive bile ductular level to the interlobular bile ducts and septal bile ducts and to the large bile ducts in the left lobe. Neural cell adhesion molecule,a hepatic progenitor cell marker,was detected in IPNB cells. It seems possible in this case that hepatic progenitor cells located in reactive bile ductules in liver cirrhosis may have been responsible for the development of the cholangiocarcinoma and HCC,and that the former could have spread in the intrahepatic bile ducts and eventually formed grossly visible IPNB. | Jing Xu Yasunori Sato Kenichi Harada Norihide Yoneda Yasuni Nakanuma Teruyuki Ueda Atsushi Kawashima Akishi Ooi | 2011 | World Journal of Gastroenterology2011，17，14： | 4 |
| 3 | Removal of selected pharmaceuticals and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) during sand filtration and ozonation at a municipal sewage treatment plant 显示文摘 | Norihide N Hiroyuki S Ayako M | 2007 | Water Research2007，41，19： | 1 |
| 4 | Removal of selected pharmaceuticals and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) during sand filtration and Qzonation at a municipal sewage treatment plant显示文摘 | NORIHIDE N HIROYUKI S AYAKO M | 2007 | Water Research2007，41，19： | 1 |
| 5 | Depth-resolving THz imaging with tomosynthesis 显示文摘 | Naoki Sunaguchi Yoshiaki Sasaki Norihide Maikusa | 2009 | Optics Express2009，17，12： | 1 |
| 6 | Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats显示文摘 | Hitoshi Suhara Yoshiki Sawa Norihide Fukushima Koji Kagisaki Chieko Yokoyama Tadashi Tanabe Shigeaki Ohtake Hikaru Matsuda | 2002 | The Journal of Thoracic and Cardiovascular Surgery2002，，5： | 1 |
| 7 | Molecular Cloning and Characterization of a Microsatellite Locus Found in an RAPD Marker of a Spider Mite, Panonychus Citri (Acari: Tetranychidae)显示文摘 | Mh. Osakabe Norihide Hinomoto Satoshi Toda Shinkichi Komazaki Koichi Goka | 2000 | Experimental and Applied Acarology (-)2000，，5： | 1 |
| 8 | Presence of Intraplaque Hemorrhage Stimulates Progression of Carotid Atherosclerotic Plaques:a High-resolution Magnetic Resonance Imaging Study显示文摘 | Norihide T Chun Y Baocheng C | 2005 | Circulation2005，111，21： | 1 |
| 9 | Evaluation of the sensitivity of marine microalgal strains to the heavy metals,Cu,As,Sb,Pb and Cd显示文摘 | Akira S Litiana Q V Norihide K | 2005 | Environment Intemational2005，31，5： | 1 |
| 10 | Mass balance of anti-influenza drugs discharged into the Yodo River system, Japan, under an influenza outbreak显示文摘 | Takashi Azuma Norihide Nakada Naoyuki Yamashita Hiroaki Tanaka | 2013 | Chemosphere2013，，： | 1 |
| 11 | Analysis of Real-Word Driver's Frustration 显示文摘 | Malta Lucas Chiyomi Miyajima Norihide Kitaoka | 2011 | IEEE Transactions on intelligent transportation systems2011，1，12： | 1 |
| 12 | Clinicopathologic Significance of Combined Hepatocellular-Cholangiocarcinoma With Stem Cell Subtype Components With Reference to the Expression of Putative Stem Cell Markers显示文摘 | Hiroko Ikeda Kenichi Harada Yasunori Sato Motoko Sasaki Norihide Yoneda Seiko Kitamura Yoshiko Sudo Akishi Ooi Yasuni Nakanuma | 2013 | American Journal of Clinical Pathology2013，，3： | 1 |
| 13 | Aluminization of high purity iron and stainless steel by powder liquid coating显示文摘 | Murakami Koji Nishida Norihide Osamura Kozo | 2004 | Acta Materialia2004，52，： | 1 |
| 14 | Presence of intraptaque hemorrhage stimulates progression of carotid atheroselerotic plaques:a high-resolution magnetic resonance imaging study显示文摘 | Norihide T Chun Y Baocheng C | 2005 | Circulation2005，11，27： | 1 |
| 15 | Late Complications of Gelatin-Resorcin-Formalin Glue in the Repair of Acute Type A Aortic Dissection显示文摘 | Hiroki Hata Hiroshi Takano Goro Matsumiya Norihide Fukushima Naomasa Kawaguchi Yoshiki Sawa | 2007 | The Annals of Thoracic Surgery2007，，5： | 1 |
| 16 | Abnormalities of cerebral blood flow in multiple sclerosis: A pseudocontinuous arterial spin labeling MRI study显示文摘 | Miho Ota Noriko Sato Yasuhiro Nakata Kimiteru Ito Kouhei Kamiya Norihide Maikusa Masafumi Ogawa Tomoko Okamoto Satoko Obu Takamasa Noda Manabu Araki Takashi Yamamura Hiroshi Kunugi | 2013 | Magnetic Resonance Imaging2013，，6： | 1 |
| 17 | Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its appli cation to microarray显示文摘 | MOTOI NISHIMURA NORIHIDE YOKOI | 2004 | DNA Research2004，11，： | 1 |
| 18 | Rapid Determination of Free and Conjugated Estrogen in Different Water Matrices by Liq- uid Chromatography-Tandem Mass Spectrometry 显示文摘 | VIMAL K NORIHIDE N MAKOTO Y | 2009 | Chemo- sphere2009，77，10： | 1 |
| 19 | Generating Lane-change Trajectories of Individual Drivers显示文摘 | Yoshihiro Nishiwaki Chiyomi Miyajima Norihide Kitaoka etc | 2008 | Proeeedings of the 2008 IEEE International Conference on Vehicular Electronics and Safety Columbus2008，，： | 1 |
| 20 | Analytical studies on local damage to reinforced concrete structures under impact loading by discrete element method显示文摘 | Yoshikazu Sawamoto Haruji Tsubota Yoshiyuki Kasai Norihide Koshika Hiroshi Morikawa | 1998 | Nuclear Engineering and Design1998，，2： | 1 |
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