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| 1 | Superior in vitro anticancer effect of biomimetic paclitaxel and triptolide co-delivery system in gastric cancer显示文摘As a well-known anticancer drug,paclitaxel(PTX),a first-line chemotherapeutic agent,remains unsatisfactory for gastric cancer therapy.It is reported that triptolide(TPL)could enhance the anti-gastric cancer effect of PTX.Considering the poor solubility of both drugs,we developed a red blood cell membrane-biomimetic nanosystem,an emerging tool in drug delivery,to co-load paclitaxel and triptolide(red blood cell membrane coated PTX and TPL co-loaded poly(lactic-co-glycolic acid)[PLGA]nanoparticles,RP(P/T)).The successful preparation was confirmed in terms of particle size,morphology,and surface markers assays.This biomimetic system could prolong circulation and escape immune surveillance.And these properties were verified by stability,in vitro drug release,and cellular uptake assays.Moreover,the MTT and colony formation assays demonstrated the superior anti-proliferation effect of the RP(P/T)to free drugs.The enhanced antitumor effects of RP(P/T)on migration and invasion were also evaluated by wound-healing and transwell assays.Overall,the bionic co-delivery nanoplatform with improved efficacy in vitro is a promising therapy for gastric cancer. | Siwan Wang Hui Jiang Jia Wang Haisi Wu Ting Wu Mengnan Ni Qianqian Zhao You Ji Ziting Zhang Chunming Tang Huae Xu | 2021 | The Journal of Biomedical Research2021，35，4： | 5 |
| 2 | Training and transfer of colonoscopy skills: a multinational, randomized, blinded, controlled trial of simulator versus bedside training显示文摘 | Adam Haycock Arjun D. Koch Pietro Familiari Foke van Delft Evelien Dekker Lucio Petruzziello Jelle Haringsma Siwan Thomas-Gibson | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 3 | Factors associated with failed polyp retrieval at screening colonoscopy显示文摘 | Yoriaki Komeda Noriko Suzuki Marshall Sarah Siwan Thomas-Gibson Margaret Vance Chris Fraser Kinesh Patel Brian P. Saunders | 2012 | Gastrointestinal Endoscopy2012，，： | 1 |
| 4 | Training and transfer of colonoscopy skills: a multinational, randomized, blinded, controlled trial of simulator versus bedside training显示文摘 | Adam Haycock Arjun D. Koch Pietro Familiari Foke van Delft Evelien Dekker Lucio Petruzziello Jelle Haringsma Siwan Thomas-Gibson | 2010 | Gastrointestinal Endoscopy2010，，2： | 1 |
| 5 | The Role of Competencies in Shaping the Leadership Style of Female Entrepreneurs: The Case of North West of E ngland, Y orkshire, and N orth W ales显示文摘 | Vassiliki Bamiatzi Sally Jones Siwan Mitchelmore Konstantinos Nikolopoulos | 2015 | Journal of Small Business Management2015，，3： | 1 |
| 6 | Rational Colonoscopy, Realistic Simulation, and Accelerated Teaching显示文摘 | Christopher B. Williams Siwan Thomas-Gibson | 2006 | Gastrointestinal Endoscopy Clinics of North Americ2006，，3： | 1 |
| 7 | Colorectal Stenting for Malignant and Benign Disease: Outcomes in Colorectal Stenting显示文摘 | Noriko Suzuki M.D. Brian P. Saunders M.D. Siwan Thomas-Gibson M.R.C.P. Charles Akle F.R.C.S. Michele Marshall F.R.C.R. Steve Halligan F.R.C.R | 2004 | Diseases of the Colon & Rectum2004，，7： | 1 |
| 8 | What determines female autonomy? Evidence from Bangladesh显示文摘 | Siwan Anderson Mukesh Eswaran | 2008 | Journal of Development Economics2008，，2： | 1 |
| 9 | Calculation of the intake retention fraction and dose coefficients in ^99mTc-labelled compound for internal exposure for medical workers显示文摘 | Tae-Eun Kwon Siwan Noh Sol Jeong Jai-Ki Lee | 2014 | Nuclear Science and Techniques2014，25，A01： | 1 |
| 10 | Factors associated with failed polyp retrieval at screening colonoscopy显示文摘 | Yoriaki Komeda Noriko Suzuki Marshall Sarah Siwan Thomas-Gibson Margaret Vance Chris Fraser Kinesh Patel Brian P. Saunders | 2012 | Gastrointestinal Endoscopy2012，，： | 1 |
| 11 | Simulator training improves practical skills in therapeutic GI endoscopy: results from a randomized, blinded, controlled study显示文摘 | Adam V. Haycock Philippa Youd Paul Bassett Brian P. Saunders Paris Tekkis Siwan Thomas-Gibson | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 12 | Development and validation of a novel method for assessing competency in polypectomy: direct observation of polypectomy skills显示文摘 | Sachin Gupta John Anderson Pradeep Bhandari Brian McKaig Pullan Rupert Bjorn Rembacken Stuart Riley Matt Rutter Roland Valori Margaret Vance Cees P.M. van der Vleuten Brian P. Saunders Siwan Thomas-Gibson | 2011 | Gastrointestinal Endoscopy2011，，6： | 1 |
| 13 | How we can measure quality in colonoscopy?显示文摘Measuring quality is a current need of medical services either to assess their cost-effectiveness or to identify discrepancies requiring refinement. With the advent of bowel cancer screening and increasing patient awareness of bowel symptoms, there has been an unprecedented increase in demand for colonoscopy.Consequently, there is an expanding open-discussion on missed rates of cancer or precancerous polyps during diagnostic/screening colonoscopy and on the rate of adverse events related to therapeutic colonoscopy.Delivering a quality colonoscopy service is therefore a healthcare priority. Colonoscopy is a multi-step process and therefore assessment of all aspects of the procedure must be addressed. Quality in colonoscopy refers to a combination of many patient-centered technical and non-technical skills and knowledge aiming to patient's safety and satisfaction through a continuous effort for improvement. The benefits of this endless process are hiding behind small details which can eventually make the difference in colonoscopy.Identifying specific quality metrics help to define and shape an optimal service and forms a secure basis of improvement. Τhis paper does not aim to give technical details on how to perform colonoscopy but to summarize what to measure and when, in accordance with the current identified quality indicators and standards for colonoscopy. | Leonidas A Bourikas Zacharias P Tsiamoulos Adam Haycock Siwan Thomas-Gibson Brian P Saunders | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，10： | 1 |
| 14 | The Development of a Virtual Reality Training Curriculum for Colonoscopy显示文摘 | Colin Sugden Rajesh Aggarwal Amrita Banerjee Adam Haycock Siwan Thomas-Gibson Christopher B. Williams Ara Darzi | 2012 | Annals of Surgery2012，，1： | 1 |
| 15 | Endoscopic non-technical skills team training:The next step in quality assurance of endoscopy training显示文摘AIM:To investigate whether novel,non-technical skills training for Bowel Cancer Screening(BCS)endoscopy teams enhanced patient safety knowledge and attitudes.METHODS:A novel endoscopy team training intervention for BCS teams was developed and evaluated as a pre-post intervention study.Four multi-disciplinary BCS teams constituting BCS endoscopist(s),specialist screening practitioners,endoscopy nurses and administrative staff(A)from English BCS training centres participated.No patients were involved in this study.Expert multidisciplinary faculty delivered a single day’s training utilising real clinical examples.Pre and post-course evaluationcomprised participants’patient safety awareness,attitudes,and knowledge.Global course evaluations were also collected.RESULTS:Twenty-three participants attended and their patient safety knowledge improved significantly from43%-55%(P≤0.001)following the training intervention.12/41(29%)of the safety attitudes items significantly improved in the areas of perceived patient safety knowledge and awareness.The remaining safety attitude items:perceived influence on patient safety,attitudes towards error management,error management actions and personal views following an error were unchanged following training.Both qualitative and quantitative global course evaluations were positive:21/23(91%)participants strongly agreed/agreed that they were satisfied with the course.Qualitative evaluation included mandating such training for endoscopy teams outside BCS and incorporating team training within wider endoscopy training.Limitations of the study include no measure of increased patient safety in clinical practice following training.CONCLUSION:A novel comprehensive training package addressing patient safety,non-technical skills and adverse event analysis was successful in improving multi-disciplinary teams’knowledge and safety attitudes. | Manmeet Matharoo Adam Haycock Nick Sevdalis Siwan Thomas-Gibson | 2014 | World Journal of Gastroenterology2014，20，46： | 1 |
| 16 | Development and validation of a training module on the use of narrow-band imaging in differentiation of small adenomas from hyperplastic colorectal polyps显示文摘 | Ana Ignjatovic Siwan Thomas-Gibson James E. East Adam Haycock Paul Bassett Pradeep Bhandari Ripple Man Noriko Suzuki Brian P. Saunders | 2011 | Gastrointestinal Endoscopy2011，，1： | 1 |
| 17 | The Development of a Virtual Reality Training Curriculum for Colonoscopy显示文摘 | Colin Sugden Rajesh Aggarwal Amrita Banerjee Adam Haycock Siwan Thomas-Gibson Christopher B. Williams Ara Darzi | 2012 | Annals of Surgery2012，，1： | 1 |
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