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| 1 | Increased susceptibility of aging gastric mucosa to injury:The mechanisms and clinical implications显示文摘This review updates the current views on aging gastric mucosa and the mechanisms of its increased susceptibility to injury.Experimental and clinical studies indicate that gastric mucosa of aging individuals-'aging gastropathy'-has prominent structural and functional abnormalities vs young gastric mucosa.Some of these abnormalities include a partial atrophy of gastric glands,impaired mucosal defense(reduced bicarbonate and prostaglandin generation,decreased sensory innervation),increased susceptibility to injury by a variety of damaging agents such as ethanol,aspirin and other non-steroidal anti-inflammatory drugs(NSAIDs),impaired healing of injury and reduced therapeutic efficacy of ulcer-healing drugs.Detailed analysis of the above changes indicates that the following events occur in aging gastric mucosa:reduced mucosal blood flow and impaired oxygen delivery cause hypoxia,which leads to activation of the early growth response-1(egr-1)transcription factor.Activation of egr-1,in turn,upregulates the dual specificity phosphatase,phosphatase and tensin homologue deleted on chromosome ten(PTEN)resulting in activation of pro-apoptotic caspase-3 and caspase-9 and reduced expression of the anti-apoptosis protein,survivin.The imbalance between pro-and anti-apoptosis mediators results in increased apoptosis and increased susceptibility to injury.This paradigm has human relevance since increased expression of PTEN and reduced expression of survivin were demonstrated in gastric mucosa of aging individuals.Other potential mechanisms operating in aging gastric mucosa include reduced telomerase activity,increase in replicative cellular senescence,and reduced expression of vascular endothelial growth factor and importin-α-a nuclear transport protein essential for transport of transcription factors to nucleus.Aging gastropathy is an important and clinically relevant issue because of:(1)an aging world population due to prolonged life span;(2)older patients have much greater risk of gastroduodenal ulcers and gastrointestinal complications(e.g.,NSAIDs-induced gastric injury)than younger patients;and(3)increased susceptibility of aging gastric mucosa to injury can be potentially reduced or reversed pharmacologically. | Andrzej S Tarnawski Amrita Ahluwalia Michael K Jones | 2014 | World Journal of Gastroenterology2014，20，16： | 16 |
| 2 | 肾茶对UUO大鼠肾组织FaS、FasL表达的影响显示文摘目的:探讨肾茶对UUO大鼠肾组织Fas(Fas蛋白)、FasL(FasL蛋白)表达的影响。方法:将清洁级SD大鼠随机分为模型组、假手术组、肾茶组。模型组、肾茶组分离、结扎左侧输尿管,并离断;假手术组只分离左侧输尿管,不结扎、离断。肾茶组给予剂量为8g/kg的肾茶煎剂灌胃,模型组、假手术组给予等体积的生理盐水灌胃,分别于术后3d,7d,14d在每组大鼠中随机取8只,麻醉后心脏取血测定血尿素氮、血肌酐,处死大鼠,摘取左侧(术侧)肾脏后采用免疫组化方法检测大鼠肾组织中Fas和FasL的表达。结果:同模型组相比,术后3d、7d、14d肾茶组血尿素氮、血肌酐下降,肾间质纤维化程度减轻,Fas、FasL表达下调,各组间差异有统计学意义(P<0.05)。结论:肾茶能够延缓单侧输尿管结扎大鼠肾间质纤维化程度,其疗效可能是使进行性纤维化的肾组织Fas、FasL的表达降低。 | 王丽敏 田玉凤 谭振香 郭佳丽 Amrita Shrestha 王超 | 2014 | 黑龙江医药科学2014，37，3： | 9 |
| 3 | Increased susceptibility of aging gastric mucosa to injury and delayed healing:Clinical implications显示文摘In this editorial we comment on the article by Fukushi K et al published in the recent issue of the World Journal of Gastroenterology 2018; 24(34): 3908-3918. We focus specifically on the mechanisms of the anti-thrombotic action of aspirin, gastric mucosal injury and aging-related increased susceptibility of gastric mucosa to injury. Aspirin is widely used not only for the management of acute and chronic pain and arthritis, but also importantly for the primary and secondary prevention of cardiovascular events such as myocardial infarcts and strokes. Clinical trials have consistently shown that antiplatelet therapy with long term, low dose aspirin(LDA)-75 to 325 mg daily, dramatically reduces the risk of non-fatal myocardial infarcts, stroke and mortality in patients with established arterial diseases. However, such treatment considerably increases the risk of gastrointestinal(GI) ulcerations and serious bleeding by > 2-4 fold, especially in aging individuals. This risk is further increased in patients using LDA together with other antiplatelet agents, other nonsteroidal anti-inflammatory agents(NSAIDs) and/or alcohol, or in patients with Helicobacter pylori(H. pylori) infection. Previous studies by our group and others have demonstrated prominent structural and functional abnormalities in gastric mucosa of aging individuals(which we refer to as aging gastric mucosa or 'aging gastropathy') compared to the gastric mucosa of younger individuals. Aging gastric mucosa has impaired mucosal defense, increased susceptibility to injury by a variety of noxious agents such as aspirin, other NSAIDs and ethanol, and delayed and impaired healing of injury. The mechanism underlying these abnormalities of aging gastric mucosa include reduced mucosal blood flowcausing hypoxia, upregulation of PTEN, activation of proapoptotic caspase-3 and caspase-9, and reduced survivin(anti-apoptosis protein), importin-α(nuclear transport protein), vascular endothelial growth factor, and nerve growth factor. The decision regarding initiation of a long-term LDA therapy should be made after a careful consideration of both cardiovascular and GI risk factors. The latter include a previous history of GI bleeding and/or ulcers, age ≥ 70, male gender, concurrent use of other NSAIDs, alcohol consumption and H. pylori infection. Furthermore, the incidence of GI ulcers and bleeding can be reduced in patients on long term LDA treatment by several measures. Clinicians treating such patients should test for and eradicate H. pylori, instruct patients to avoid alcohol and non-aspirin NSAIDs, including cyclooxygenase-2-selective NSAIDs, and prescribe proton pump inhibitors in patients on LDA therapy. In the future, clinicians may be able to prescribe one of several potential new drugs, which include aspirin associated with phosphatidylcholine(PL2200), which retains all property of aspirin but reduces by approximately 50% LDA-induced GI ulcerations. | Andrzej S Tarnawski Amrita Ahluwalia | 2018 | World Journal of Gastroenterology2018，24，42： | 8 |
| 4 | Modified chitosan hydrogels as drug delivery and tissue engineering systems:present status and applications显示文摘Chitosan,a natural cationic polysaccharide,is prepared industrially by the hydrolysis of the aminoacetyl groups of chitin,a naturally available marine polymer.Chitosan is a non-toxic,biocompatible and biodegradable polymer and has attracted considerable interest in a wide range of biomedical and pharmaceutical applications including drug delivery,cosmetics,and tissue engineering.The primary hydroxyl and amine groups located on the backbone of chitosan are responsible for the reactivity of the polymer and also act as sites for chemical modification.However,chitosan has certain limitations for use in controlled drug delivery and tissue engineering.These limitations can be overcome by chemical modification.Thus,modified chitosan hydrogels have gained importance in current research on drug delivery and tissue engineering systems.This paper reviews the general properties of chitosan,various methods of modification,and applications of modified chitosan hydrogels. | Tapan Kumar Giri Amrita Thakur Amit Alexander Ajazuddin Hemant Badwaik Dulal Krishna Tripathi | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 7 |
| 5 | Therapeutic neovascularization promoted by injectable hydrogels显示文摘The aim of therapeutic neovascularization is to repair ischemic tissues via formation of new blood vessels by delivery of angiogenic growth factors,stem cells or expansion of pre-existing cells.For efficient neovascularization,controlled release of growth factors is particularly necessary since bolus injection of molecules generally lead to a poor outcome due to inadequate retention within the injured site.In this regard,injectable hydrogels,made of natural,synthetic or hybrid biomaterials,have become a promising solution for efficient delivery of angiogenic factors or stem and progenitor cells for in situ tissue repair,regeneration and neovascularization.This review article will broadly discuss the state-of-the-art in the development of injectable hydrogels from natural and synthetic precursors,and their applications in ischemic tissue repair and wound healing.We will cover a wide range of in vitro and in vivo studies in testing the functionalities of the engineered injectable hydrogels in promoting tissue repair and neovascularization.We will also discuss some of the injectable hydrogels that exhibit self-healing properties by promoting neovascularization without the presence of angiogenic factors. | Amrita Pal Brent L.Vernon Mehdi Nikkhah | 2018 | Bioactive Materials2018，3，4： | 6 |
| 6 | 网络信息生态系统中的虚假信息:检测、缓解与挑战显示文摘随着互联网的迅速发展及网络社会媒体中用户的增加,通过社会媒体发布和传播信息的真实性和质量受到日益广泛的关注.目前大部分公众已习惯从社会媒体平台与互联网获取新闻,甚至是获取受到高度关注的话题(如新冠病毒感染症状)的信息.鉴于网络信息生态系统非常嘈杂,充斥着错误和虚假信息并经常受到恶意媒介的污染,从中识别真实的信息成为一项艰巨任务.对此,研究者们已开始致力于虚假信息检测和减缓虚假信息传播影响方面的工作.讨论了网络信息生态系统中的虚假信息问题,特别是随着新冠病毒大爆发而来的“信息疫情”.随后,简述了虚假信息检测方法,分析了减缓虚假信息影响的方法,并探讨了虚假信息研究中的固有挑战.最后从跨学科角度阐述了检测和减缓虚假信息影响的方法和未来研究展望. | Amrita Bhattacharjee 舒凯 高旻 刘欢 | 2021 | 计算机研究与发展2021，58，7： | 5 |
| 7 | Preeclampsia and eclampsia: Etiopathogenesis and perioperative management显示文摘Preeclampsia is a pregnancy specific syndrome of elusive etiology, developing in 2nd trimester and associated with high maternal and perinatal morbidity and mortality. The spectrum ranges from mild preeclampsia with no systemic involvement to multi-system involvement. The course is unpredictable and delivery is the only curative treatment. Elevated blood pressure(> 160/110 mm Hg) should be reduced gradually to a safe level(140/90) using antihypertensive drugs. Prophylaxis and treatment of convulsions using Mg SO4 is indicated for severe preeclampsia. Fluid therapy is controversial due to potential delicate balance between constricted plasma volume and risk of fluid overload and pulmonary oedema secondary to increased capillary permeability and reduced colloid osmotic pressure. Single shot spinal anaesthesia is the technique of choice for caesarean delivery unless contraindicated. General anaesthesia is indicated in patients with coagulopathy or eclampsia but is associated with risk of difficult airway and exaggerated sympathetic response during laryngoscopy. Epidural analgesia and anaesthesia is safe in absence of coagulopathy. | Uma Srivastava Veena Asthana Amrita Gupta | 2014 | World Journal of Anesthesiology2014，3，2： | 3 |
| 8 | Utilization of metabolomics to identify serum biomarkers for hepatocellular carcinoma in patients with liver cirrhosis显示文摘 | Habtom W. Ressom Jun Feng Xiao Leepika Tuli Rency S. Varghese Bin Zhou Tsung-Heng Tsai Mohammad R. Nezami Ranjbar Yi Zhao Jinlian Wang Cristina Di Poto Amrita K. Cheema Mahlet G. Tadesse Radoslav Goldman Kirti Shetty | 2012 | Analytica Chimica Acta2012，，： | 2 |
| 9 | Pre‐ and post‐training session evaluation for interobserver agreement and diagnostic accuracy of probe‐based confocal laser endomicroscopy for biliary strictures显示文摘 | Jayant P. Talreja Brian G. Turner Frank G. Gress Sammy Ho Savreet Sarkaria Naveen Paddu Nikola Natov Sheila Bharmal Monica Gaidhane Amrita Sethi Michel Kahaleh | 2014 | Digestive Endoscopy2014，，4： | 2 |
| 10 | Two-dimensional finite element model to study unsteady state Ca^2+ diffusion in neuron involving ER LEAK and SERCA显示文摘 | Amrita Jha Neeru Adlakha | 2015 | International Journal of Biomathematics2015，8，1： | 2 |
| 11 | 吉林省健康儿童的冠状动脉Z值的调查研究显示文摘目的:探讨并得出吉林省健康儿童经体表面积(BSA)调整的冠状动脉的Z值,运用Z值来判断冠状动脉是否异常,从而指导可能影响冠状动脉的疾病的临床诊治.方法:研究收录了2009-05~2012-10吉林大学第一医院儿科超声门诊检查的15岁以下健康儿童,共998例.将其分成6组,分别为≤1岁、1~3岁、3~6岁、6~9岁、9~12岁、12~15岁.使用东芝SSH-880CV仪器分别测量左冠状动脉主干(LMCA)和右冠状动脉(RCA)内径.将测量的内径值转换为经BSA调整的Z值.结果:在不同年龄组的健康儿童之间经BSA调整的LMCA和RCA内径Z值存在明显差异.Z值在低年龄组之间以及高年龄组之间没有统计学意义.结论:该研究建立了吉林健康儿童冠状动脉Z值的正常区间,运用Z值来判断冠状动脉是否扩张,对于指导川崎病以及其他可能影响冠状动脉的疾病的临床诊治工作有着重要的意义. | 王丽敏 Amrita Shrestha Shrestha 徐阳 王淑静 李春玉 赵冬梅 朴金花 | 2014 | 黑龙江医药科学2014，37，5： | 2 |
| 12 | Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair显示文摘Macrophage plasticity is critical for normal tissue repair following injury.In pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are unknown.Here,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJD3 in diabetic wound macrophages,resulting in increased inflammatory gene expression.Mechanistically,we report that in wound healing,JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 signaling.However,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 mechanism.Interestingly,RNA sequencing of wound macrophages isolated from mice with JMJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJD3 in wound macrophages.STING limits inflammatory cytokine production by wound macrophages during healing.However,in diabetic mice,its role changes to limit wound repair and enhance inflammation.This finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time points.Finally,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and STING.Taken together,this work highlights the central role of JMJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds. | Christopher O.Audu William J.Melvin Amrita D.Joshi Sonya J.Wolf Jadie Y.Moon Frank M.Davis Emily C.Barrett Kevin D.Mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 13 | Oxidative stress in lymphocytes, neutrophils, and serum of oral cavity cancer patients: modulatory array of l -glutamine显示文摘 | Subhasis Das Santanu Kar Mahapatra N. Gautam Amrita Das Somenath Roy | 2007 | Supportive Care in Cancer2007，，12： | 2 |
| 14 | Development of microsponges for topical delivery of mupirocin 显示文摘 | Netal Amrutiya Amrita Bajaj Madhu Madan | 2009 | AAPS Pharm Sci Tech2009，10，2： | 1 |
| 15 | Artificial neural net- work modeling of the river water quality-A ease study 显示文摘 | Kunwar P Singh Ankita Basant Amrita Malik | 2009 | Ecological Modeling2009，，6： | 1 |
| 16 | Secondary cooling control model for continuous casting - direct rolling process 显示文摘 | Kawasaki S Amrita H | 1984 | Seitetsu Kenkyu1984，313，： | 1 |
| 17 | Functionality study of santalin as tyrosinase inhibitor:a potential depigmentation agent显示文摘 | Hemachandran H Amrita A Mohan S | 2016 | Int J Biol Macromol2016，86，5： | 1 |
| 18 | Characterization of a dimeric unfolding intermediate of bovine serum albumin under mildly acidic condition 显示文摘 | Amrita Brahma Chhabinath Mandal Debasish Bhattacharyya | 2005 | Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics2005，1751，2： | 1 |
| 19 | Protective role of l-ascorbic acid on antioxidant defense system in erythrocytes of albino rats exposed to nickel sulfate显示文摘 | Kusal K. Das Amrita Das Gupta Salim A. Dhundasi Ashok M. Patil Swastika N. Das Jeevan G. Ambekar | 2007 | BioMetals2007，，2： | 1 |
| 20 | Nancy Fraser 显示文摘 | Amrita Chhachhi Nancy Fraser | 2011 | Development and Change2011，42，1： | 1 |
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