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| 1 | Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?显示文摘AIM:To evaluate the effectiveness of hepatic arterial infusion chemotherapy(HAIC) for advanced hepatocellular carcinoma(HCC) resistant to transarterial chemoembolization(TACE).METHODS:This study was conducted on 42 patients who received HAIC for advanced HCC between 2001and 2010 at our hospital.5-fluorouracil(5-FU) was administered continuously for 24 h from day 1 to day 5 every 2-4 wk via an injection reservoir.Intra-arterial cisplatin or subcutaneous interferon was administered in combination with the 5-FU.The patients enrolled in this retrospective study were divided into two groups according to whether or not they fulfilled the criteria for resistance to TACE proposed by the Japan Society of Hepatology in 2010(written in Japanese);one group of patients who did not fulfill the criteria for TACE resistance(group A,n = 23),and another group who fulfilled the criteria for TACE resistance(group B,n = 19).We compared the outcomes in terms of the response and survival rates between the two groups.RESULTS:Both the response rate and tumor suppression rate following HAIC were significantly superior in group A than in group B(response rate:48% vs 16%,P = 0.028,tumor suppression rate:87% vs 53%,P = 0.014).Furthermore,both the progression-free survival rate and survival time were significantly superior in group A than in group B(3-,6-,12-,and 24-mo = 83%,70%,29% and 20% vs 63%,42%,16% and 0%,respectively,P = 0.040,and 9.8 mo vs 6.2 mo,P = 0.040).A multivariate analysis(Cox proportional hazards regression model) showed that resistance to TACE was an independent predictor of poor survival(P = 0.007).CONCLUSION:HAIC administrating 5-FU was not effective against advanced HCC resistant to TACE.Other tools for treatment,i.e.,molecular-targeting agents may be considered for these cases. | Hiroyuki Kirikoshi Masato Yoneda Hironori Mawatari Koji Fujita Kento Imajo Shingo Kato Kaori Suzuki Noritoshi Kobayashi Kensuke Kubota Shin Maeda Atsushi Nakajima Satoru Saito | 2012 | World Journal of Gastroenterology2012，18，16： | 9 |
| 2 | Early effects of oral administration of omeprazole and roxatidine on intragastric pH显示文摘Objective:The ideal medication for the treatment of acid-related diseases,e.g.,peptic ulcers,stress-related gastric bleeding,functional dyspepsia,and gastroesophageal reflux disease,should have a rapid onset of action to promote hemostasis and relieve the symptoms.The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor,omeprazole 20 mg,and an H2-receptor antagonist,roxatidine 75 mg.Methods:Ten Helicobacter pylori-negative male subjects participated in this randomized,two-way crossover study.Intragastric pH was monitored continuously for 6 h after single oral administration of omeprazole 20 mg and roxatidine 75 mg.Each administration was separated by a 7-d washout period.Results:During the 6-h study period,the average pH after administration of roxatidine was higher than that after administration of omeprazole(median:4.45 vs.2.65;P=0.0367).Also during the 6-h study period,a longer duration of maintenance at pH above 2,5,and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg(median:90.6% vs.55.2%,P=0.0284;43.7% vs.10.6%,P=0.0125;40.3% vs.3.3%,P=0.0125;respectively).Conclusions:In Helicobacter pylori-negative healthy male subjects,oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg. | Hiroshi IIDA Shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke KUBOTA Eiji GOTOH Shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 6 |
| 3 | BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts显示文摘Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation.Osteocytes or osteoblasts express receptor activator of nuclear factor k-B ligand(Rankl)or osteoprotegerin(Opg)to promote or inhibit osteoclastogenesis,respectively.Bone morphogenetic protein(BMP)is a potent bone inducer,but its major role in adult bone is to induce osteocytes to upregulate sclerostin(Sost)and increase the Rankl/Opg expression ratio,resulting in promotion of osteoclastogenesis.However,the precise effect of BMP-target gene(s)in osteoblasts on the Rankl/Opg expression ratio remains unclear.In the present study,we identified atonal homolog 8(Atoh8),which is directly upregulated by the BMPSmadl axis in osteoblasts.In vivo,Atoh8 was detected in osteoblasts but not osteocytes in adult mice.Although global Atoh8-knockout mice showed only a mild phenotype in the neonate skeleton,the bone volume was decreased and osteoclasts were increased in the adult phase.Atoh8-null marrow stroma cells were more potent than wild-type cells in inducing osteoclastogenesis in marrow cells.Atoh8 loss in osteoblasts increased Runx2 expression and the Rankl/Opg expression ratio,while Runx2 knockdown normalized the Rankl/Opg expression ratio.Moreover,Atoh8 formed a protein complex with Runx2 to inhibit Runx2 transcriptional activity and decrease the Rankl/Opg expression ratio.These results suggest that bone remodeling is regulated elaborately by BMP signaling;while BMP primarily promotes bone resorption,it simultaneously induces Atoh8 to inhibit Runx2 and reduce the Rankl/Opg expression ratio in osteoblasts,suppressing osteoclastogenesis and preventing excessive BMP-mediated bone resorption. | Yuhei Yahiro Shingo Maeda Masato Morikawa Daizo Koinuma Go Jokoji Toshiro ljuin Setsuro Komiya Ryoichiro Kageyama Kohei Miyazono Noboru Taniguchi | 2020 | Bone Research2020，8，3： | 6 |
| 4 | Notes on Extended-Range Atmospheric Prediction in the Northern Hemisphere Winter显示文摘NotesonExtended-RangeAtmosphericPredictionintheNorthernHemisphereWinterShingoYamadaForecastDivision,JapanMeteorologicalAgency... | Shingo Yamada Forecast Division, Japan Meteorological Agency, Tokyo, 100, Japan Shuhei Maeda Administration Division, Climate and Marine Department, Japan Meteorological Agency, Tokyo, 100, Japan K. Gambo c/o Department of Earth and Planetary Physi | 1997 | Advances in Atmospheric Sciences1997，14，1： | 3 |
| 5 | Clinical benefit of surgery for stage IV colorectal cancer with synchronous peritoneal metastasis显示文摘 | Hirotoshi Kobayashi Kenjiro Kotake Kimihiko Funahashi Kazuo Hase Koichi Hirata Tsuneo Iiai Shingo Kameoka Yukihide Kanemitsu Koutarou Maeda Akihiko Murata Masayuki Ohue Kazuo Shirouzu Keiichi Takahashi Toshiaki Watanabe Hideaki Yano Toshimasa Yatsuoka Yoj | 2014 | Journal of Gastroenterology2014，，4： | 2 |
| 6 | Soft computing-based predictive modeling of flexible electrohydrodynamic pumps显示文摘Flexible electrohydrodynamic(EHD)pumps have been developed and applied in many fields due to no transmission structure,no wear,easy manipulation,and no noise.Physical simulation is often used to predict the output performance of flexible EHD pumps.However,this method neglects fluid–solid interaction and energy loss caused by flexible materials,which are both difficult to calculate when the flexible pumps deform.Therefore,this study proposes a flexible pump output performance prediction using machine learning algorithms.We used three different types of machine learning:random forest regression,ridge regression,and neural network to predict the critical parameters(pressure,flow rate,and power)of the flexible EHD pump.Voltage,angle,gap,overlap,and channel height are selected as five input data of the neural network.In addition,we optimized essential parameters in the three networks.Finally,we adopt the best predictive model and evaluate the significance of five input parameters to the output performance of the flexible EHD pumps.Among the three methods,the MLP model has exceptionally high accuracy in predicting pressure and flow.Our work is beneficial for the design process of fluid sources in flexible soft actuators and soft hydraulic sources in microfluidic chips. | Zebing Mao Yanhong Peng Chenlong Hu Ruqi Ding Yuhei Yamada Shingo Maeda | 2023 | Biomimetic Intelligence & Robotics2023，3，3： | 2 |
| 7 | Comparison of Autologous Hematopoietic Cell Transplantation and Chemotherapy as Postremission Treatment in Non-M3 Acute Myeloid Leukemia in First Complete Remission显示文摘 | Kensuke Usuki Saiko Kurosawa Naoyuki Uchida Kazuaki Yakushiji Fusako Waki Eijo Matsuishi Kumiko Kagawa Tatsuo Furukawa Yoshinobu Maeda Manabu Shimoyama Hiroatsu Ago Yujiro Yamano Shingo Yano Naohito Fujishima Yasushi Takamatsu Tetsuya Eto Michihiro Hidaka | 2012 | Clinical Lymphoma Myeloma and Leukemia2012，，6： | 1 |
| 8 | Gender-specific haplotype association of collagen á2 (Ⅺ) gene in ossification of the posterior longitudinal ligament of the spine显示文摘 | Shingo Maeda Hiroaki Koga Shunji Matsunaga | 2001 | J Hum Genet2001，46，： | 1 |
| 9 | Changes with Age in Proteoglycan Synthesis in Cells Cultured In Vitro From the Inner and Outer Rabbit Annulus Fibrosus: Responses to Interleukin-1 and Interleukin-1 Receptor Antagonist Protein显示文摘 | Shingo Maeda Shoichi Kokubun | 2000 | Spine2000，，2： | 1 |
| 10 | Dyeing Polyester Fabrics with Indigo显示文摘 | Katsushi Kunttou Setsuaki Hongyo Shingo Maeda | 2005 | Textile Research Journal2005，75，2： | 1 |
| 11 | One- Bath Dyeing of Polyester/Cotton Blends with Reactive Disperse Dyes in Supercritical Carbon Dioxide显示文摘 | Maeda Shingo Kunitnu Katsushi Hihara Toshio | 2004 | Textile Research Jour- nal2004，74，11： | 1 |
| 12 | Characteristics of recurrence and surveillance tools after curative resection for colorectal cancer: A multicenter study显示文摘 | Hirotoshi Kobayashi Hidetaka Mochizuki Kenichi Sugihara Takayuki Morita Kenjiro Kotake Tatsuo Teramoto Shingo Kameoka Yukio Saito Keiichi Takahashi Kazuo Hase Masatoshi Oya Koutarou Maeda Takashi Hirai Masao Kameyama Kazuo Shirouzu Tetsuichiro Muto | 2007 | Surgery2007，，1： | 1 |
| 13 | Endogenous TGF-β1 signaling supresses maturation of osteoblastic mesenchymal cells显示文摘 | Shingo Maeda Makoto Hayashi Setsuro Komiya | | 0，，03： | 1 |
| 14 | Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcomacell growth显示文摘 | Naoya Kawabata Kosei Ijiri Yasuhiro Ishidou Takuya Yamamoto Hiroko Nagao Satoshi Nagano Shingo Maeda Setsuro Komiya Takao Setoguchi | 2011 | International Journal of Oncology2011，，4： | 1 |
| 15 | Changes with age in proteoglycan synthesis in cells cultured in vitro from the inner and outer rabbit annulus fibrosus responses to interleukin-1 and interleukin-1 receptor antagonist protein显示文摘 | Shoichi Kokubun | 2000 | Spine2000，25，： | 1 |
| 16 | Outcome of surgical resection for recurrent pulmonary metastasis from colorectal carcinoma显示文摘 | Ryu Kanzaki Masahiko Higashiyama Kazuyuki Oda Ayako Fujiwara Toshiteru Tokunaga Jun Maeda Jiro Okami Koji Tanaka Tatsushi Shingai Shingo Noura Masayuki Ohue Ken Kodama | 2011 | The American Journal of Surgery2011，，4： | 1 |
| 17 | Sessile serrated adenoma shares similar genetic and epigenetic featureswith microsatellite unstable colon cancer in a location-dependent manner显示文摘 | Takafumi Maeda Koichi Suzuki Kazutomo Togashi Mitsuhiro Nokubi Masaaki Saito Shingo Tsujinaka Hidenori Kamiyama Fumio Konishi | 2011 | Experimental and Therapeutic Medicine2011，，4： | 1 |
| 18 | Expression of osterix inhibits bone morphogenetic protein-induced chondrogenic differentiation of mesenchymal progenitor cells显示文摘 | Hiroyuki Tominaga Shingo Maeda Hiroyuki Miyoshi Kohei Miyazono Setsuro Komiya Takeshi Imamura | 2009 | Journal of Bone and Mineral Metabolism2009，，1： | 1 |
| 19 | Catalytic activity of oxide-supported Pd catalysts on a honeycomb for low-temperature methane oxidation显示文摘 | KIKUCHI Ryuji MAEDA Shingo SASAKI Kazunari | 2003 | Applied Catalysis A:General2003，239，12： | 1 |
| 20 | Low-temperature methane oxidation over oxide-supported Pd catalysts: inhibitory effect of water vapor显示文摘 | Ryuji Kikuchi Shingo Maeda Kazunari Sasaki Stefan Wennerstr?m Koichi Eguchi | 2002 | Applied Catalysis A General2002，，1： | 1 |
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