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| 1 | Watch and wait approach in rectal cancer:Current controversies and future directions显示文摘According to the main international clinical guidelines,the recommended treatment for locally-advanced rectal cancer is neoadjuvant chemoradiotherapy followed by surgery.However,doubts have been raised about the appropriate definition of clinical complete response(cCR)after neoadjuvant therapy and the role of surgery in patients who achieve a cCR.Surgical resection is associated with significant morbidity and decreased quality of life(QoL),which is especially relevant given the favourable prognosis in this patient subset. Accordingly, therehas been a growing interest in alternative approaches with less morbidity,including the organ-preserving watch and wait strategy, in which surgery isomitted in patients who have achieved a cCR. These patients are managed with aspecific follow-up protocol to ensure adequate cancer control, including the earlyidentification of recurrent disease. However, there are several open questionsabout this strategy, including patient selection, the clinical and radiologicalcriteria to accurately determine cCR, the duration of neoadjuvant treatment, therole of dose intensification (chemotherapy and/or radiotherapy), optimal followupprotocols, and the future perspectives of this approach. In the present review,we summarize the available evidence on the watch and wait strategy in thisclinical scenario, including ongoing clinical trials, QoL in these patients, and thecontroversies surrounding this treatment approach. | Fernando López-Campos Margarita Martín-Martín Roberto Fornell-Pérez Juan Carlos García-Pérez Javier Die-Trill Raquel Fuentes-Mateos Sergio López-Durán JoséDomínguez-Rullán Reyes Ferreiro AlejandroRiquelme-Oliveira Asunción Hervás-Morón Felipe Couñago | 2020 | World Journal of Gastroenterology2020，26，29： | 10 |
| 2 | Synthesis of Large Area, Homogeneous, Single Layer Graphene Films by Annealing Amorphous Carbon on Co and Ni显示文摘大区域,钴(公司) 上的同质的、单个层 graphene 和镍(Ni ) 的合成被报导。这个过程包含真空在公司 / 蓝宝石或 Ni/sapphire 底层上扔的劈啪作响的非结晶的碳(交流) 退火。金属电影的改进 crystallinity,由蓝宝石底层帮助了,证明是成长得当的 graphene 的质量的关键电影。公司和 Ni 金属电影的 crystallinity 被劈啪作响改进在被 X 光检查衍射(XRD ) 验证的提高的温度的金属。在交流劈啪作响并且退火以后,大区域,几乎占据底层的全部区域的单个层 graphene 被生产。与这个方法, 100 mm2 区域单身者层 graphene 能被综合并且仅仅由底层和真空房间尺寸是有限的。graphene 电影的同质不依赖于冷却的率,与用多晶的金属电影和常规化学蒸汽免职(CVD ) 的综合体相对照生长。我们在公司和 Ni 金属电影上生产单个层 graphene 的灵巧的方法应该导致大规模基于 graphene 的应用。 | Carlo M. Orofeo Hiroki Ago Baoshan Hu Masaharu Tsuji | 2011 | Nano Research2011，4，6： | 5 |
| 3 | Magnetic resonance imaging for prostate cancer before radical and salvage radiotherapy: What radiation oncologists need to know显示文摘External beam radiotherapy(EBRT) is one of the principal curative treatments for patients with prostate cancer(PCa). Risk group classification is based on prostate-specific antigen(PSA) level, Gleason score, and T-stage. After risk group determination, the treatment volume and dose are defined and androgen deprivation therapy is prescribed, if appropriate. Traditionally, imaging has played only a minor role in T-staging due to the low diagnostic accuracy of conventional imaging strategies such as transrectal ultrasound, computed tomography, and morphologic magnetic resonance imaging(MRI). As a result, a notable percentage of tumours are understaged, leading to inappropriate and imprecise EBRT. The development of multiparametric MRI(mp MRI), an imaging technique that combines morphologic studies with functional diffusion-weighted sequences and dynamic contrastenhanced imaging, has revolutionized the diagnosis and management of PCa. As a result, mpM RI is now used in staging PCa prior to EBRT, with possible implications for both risk group classification and treatment decisionmaking for EBRT. mpM RI is also being used in salvageradiotherapy(SRT), the treatment of choice for patients who develop biochemical recurrence after radical prostatectomy. In the clinical context of biochemical relapse, it is essential to accurately determine the site of recurrence-pelvic(local, nodal, or bone) or distant-in order to select the optimal therapeutic management approach. Studies have demonstrated the value of mpM RI in detecting local recurrences-even in patients with low PSA levels(0.3-0.5 ng/m L)-and in diagnosing bone and nodal metastasis. The main objective of this review is to update the role of mpM RI prior to radical EBRT or SRT. We also consider future directions for the use and development of MRI in the field of radiation oncology. | Felipe Cou?ago Gemma Sancho Violeta Catalá Diana Hernández Manuel Recio Sara Montemui?o Jhonathan Alejandro Hernández Antonio Maldonado Elia del Cerro | 2017 | World Journal of Clinical Oncology2017，8，4： | 4 |
| 4 | 吸烟状况与急性缺血性脑卒中后功能结局的关系显示文摘吸烟是脑卒中的既定危险因素;然而,脑卒中前吸烟状态是否会影响急性缺血性脑卒中的临床预后尚不确定。该研究旨在阐明吸烟状态与急性缺血性脑卒中后功能预后的关系。研究者获取一项基于日本多中心医院的脑卒中登记资料,调查了2007年7-12月期间住院的10825例急性缺血性脑卒中患者,这些患者在脑卒中发作之前生活能够自理。吸烟状况分为从未吸烟者(不吸烟者),曾经吸烟者和现在吸烟者。临床结局包括3个月时功能转归不良(改良的Rankin量表评分≥2)和功能性依赖(改良的Rankin量表评分2~5)。 | 刘青(译) 刘莉(摘、审校) Matsuo R Ago T Kiyuna F Sato N Nakamura K Kuroda J Wakisaka Y Kitazono T | 2020 | 中华高血压杂志2020，28，2： | 4 |
| 5 | 涵周土性状对高填方盖板涵涵顶应力影响分析显示文摘山区高等级公路建设时盖板涵为常设建筑物,但由于对涵洞外界面受力规律认识不完善导致的涵洞病害频繁发生。本文依托包茂高速(粤境段)公路工程,通过现场原位试验及数值模拟,研究高填方盖板涵涵顶应力分布及涵顶集中应力影响因素。结果表明:涵顶承担了两侧填土的部分附加应力,造成侧墙顶处测点PG-14、PG-18处压力大于涵顶其他位置处;涵顶土压力随填土高度变化呈正相关,土压力集中系数随填土高度的增长有峰值现象,填土初期快速增长,到峰值后缓慢下降直至趋于稳定;涵顶填土模量、地基土模量的增加显著增强涵顶压力集中现象,两侧填土模量增加可降低涵顶压力集中现象;涵周土抗剪强度指标c、φ值改变对涵顶压力影响不大。本研究反映了涵周土体土性参数的改变对高填方盖板涵受力规律的影响,对涵洞工程具有重要意义。 | 米帅奇 陈伟 苏彤 AGO Cadnel | 2021 | 粉煤灰综合利用2021，35，6： | 4 |
| 6 | Effects of substrate and transfer on CVD-grown graphene over sapphire-induced Cu films显示文摘We differentiated the effects of Cu films deposited on single crystalline a-,r-,and c-plane sapphire substrates upon graphene films synthesized with atmospheric pressure chemical vapor deposition(CVD).The data illustrate that the realization of high-crystalline Cu film is dependent not only on the crystallinity of underlying substrate,but also on the symmetric match of crystallographic geometry between metal film and substrate.We also systematically investigated the effects of PMMA removal on the Raman ID/IG and IG/I2D values of transferred graphene.The results reveal that different PMMA removal methods do not alter the ID/IG values;instead,the residue of PMMA increases the IG/I2D values and the thermal decomposition of PMMA leads to higher IG/I2D values than the removal of PMMA with acetone.The effects of PMMA removal on variations of the Raman spectra are also discussed. | HU BaoShan WEI ZiDong AGO Hiroki JIN Yan XIA MeiRong LUO ZhengTang PAN QingJiang LIU YunLing | 2014 | Science China Chemistry2014，57，6： | 4 |
| 7 | New standard in locally advanced rectal cancer显示文摘In the following review we intend to ascertain the optimal neoadjuvant therapy inpatients with locally advanced rectal cancer. In 2004, a study revealed thatchemoradiotherapy (CRT) resulted in better local control when performedpreoperatively rather than postoperatively, thus neoadjuvant treatment wasestablished as a standard treatment. Subsequently, the Polish study and the Trans-Tasman Radiation Oncology Group showed no statistically significant differencebetween concomitant CRT over 5 wk vs short-course radiotherapy (RT).Therefore, both were established as standard neoadjuvant treatments. Later, theStockholm III study demonstrated that short-course RT had a higher completepathological response than long-course RT. It also showed that a delay betweenRT and surgery presented fewer complications. This opened a window of time toprovide an early and effective systemic treatment to prevent distant metastases.Studies show that short-course RT plus oxaliplatin-based chemotherapy couldachieve this. When comparing this total neoadjuvant treatment (TNT) vsconcomitant CRT, the former showed greater complete pathological response andlower acute toxicity. Studies presented during 2020 have also shown the benefitsof TNT in terms of complete pathological response, as well as disease andmetastasis-free survival. Our review suggests that probably TNT should be thenew standard treatment for these patients. However, we will have to wait for thefull text publications of these studies to confirm this statement. | Sebastián Solé Ramón Baeza Carolina Gabler Felipe Couñago | 2020 | World Journal of Clinical Oncology2020，11，12： | 2 |
| 8 | 枢纽港投资方案与安全运输通道同步优化模型显示文摘针对西非大陆独特特性,考虑货主与港口经营者博弈、各枢纽港间相互关系以及西非地缘风险等因素的影响,基于用户均衡原理,以区域综合运输成本最低为目标,构建混合整数规划模型,协同优化枢纽港投资方案(包括枢纽港投资对象选择,投资港口数,投资额度)以及内陆安全通道设计方案.基于遗传算法提出一种遗传Frank-Wolf混合算法.计算结果表明,模型能够在考虑安全风险因素的要求下,同步优化枢纽港投资对象选择、投资额度以及相应的内陆安全运输通道网络. | 陈康 王滋承 Evans Ago TETTEH 杨华龙 杨忠振 | 2018 | 系统工程理论与实践2018，38，9： | 2 |
| 9 | GDF15, a Cardioprotective TGF-β Superfamily Protein显示文摘 | Tetsuro Ago Junichi Sadoshima | 2006 | Circulation Research2006，，3： | 2 |
| 10 | GOECP/SEOR clinical guidelines on radiotherapy for malignant pleural mesothelioma显示文摘Malignant pleural mesothelioma(MPM)is a rare tumor with poor prognosis and rising incidence.Palliative care is common in MPM as radical treatment with curative intent is often not possible due to metastasis or extensive locoregional involvement.Numerous therapeutic advances have been made in recent years,including the use of less aggressive surgical techniques associated with lower morbidity and mortality(e.g.,pleurectomy/decortication),technological advancements in the field of radiotherapy(intensity-modulated radiotherapy,image-guided radiotherapy,stereotactic body radiotherapy,proton therapy),and developments in systemic therapies(chemotherapy and immunotherapy).These improvements have had as yet only a modest effect on local control and survival.Advances in the management of MPM and standardization of care are hampered by the evidence to date,limited by high heterogeneity among studies and small sample sizes.In this clinical guideline prepared by the oncological group for the study of lung cancer of the Spanish Society of Radiation Oncology,we review clinical,histologic,and therapeutic aspects of MPM,with a particular focus on all aspects relating to radiotherapy,including the current evidence base,associations with chemotherapy and surgery,treatment volumes and planning,technological advances,and reradiation. | Javier Luna Andrea Bobo Joaquín José Cabrera-Rodriguez María Pagola Margarita Martín-Martín María Ángeles González Ruiz Miguel Montijano Aurora Rodríguez Lira Pelari-Mici Almudena Corbacho Marta Moreno Felipe Couñago | 2021 | World Journal of Clinical Oncology2021，12，8： | 2 |
| 11 | NOX4 as the major catalytic component of an endothelial NAD(P)H oxidase显示文摘 | Ago T Kitazono T Ouboshi H Iyama T Han YH Takada J | 2004 | Circulation2004，109，2： | 1 |
| 12 | Metabotropic glutamate 2/3 receptor antagonists improve behavioral and prefrontal dopaminergicaherations in the chronic corticosterone - induced depression model in mice 显示文摘 | Ago Y Yano K Araki R | 2013 | N europharmacology2013，65，2： | 1 |
| 13 | GDF15,a cardioprotective TGF-beta superfamily protein显示文摘 | Ago T Sadoshima J | 2006 | Circ Pies2006，98，3： | 1 |
| 14 | PPARgamma ligands attenuate mesangial contractile dysfunction in high glucose 显示文摘 | Ueta M Wakisaka M Ago T | 2004 | Kidney Int2004，65，3： | 1 |
| 15 | Epitaxial growth of large-area single-layer graphene over Cu(111)/sapphire by atmospheric pressure CVD 显示文摘 | HUA Baoshan AGO H ITO Y | 2012 | Carbon2012，50，1： | 1 |
| 16 | Crystalline transformation of native cellulose from cellulose I to celluloseⅡpolymorph by a ball-milling method with a specific amount of water显示文摘 | AGO M ENDO T HIROMU T | 2004 | Cellulose2004，11，2： | 1 |
| 17 | Development of an aerobic cultivation system by using a microbubble aeration technology显示文摘 | Ago K Nagasawa K Takita J | 2005 | Journal of Chemical Engineering of Japan2005，38，9： | 1 |
| 18 | Thioredoxin 1 negatively regulates an-giotensinⅡ-induced cardiac hypertrophy through upregulation of miR-98/let-7显示文摘 | Yang Y Ago T Zhai P | 2011 | Circ Res2011，108，3： | 1 |
| 19 | Pharmacological aspects of the acetylcholinesterase inhibitor galantamine显示文摘 | Ago Y Koda K Takuma K etal | 2011 | J Pharma- col Sci2011，116，： | 1 |
| 20 | Stereotactic body radiation therapy:A good dance partner of oligometastatic non-small cell lung cancer to the sound of SINDAS study显示文摘The European Organization for Research on Treatment of Cancer Research published a consensus statement to establish the key criteria to define oligometastatic disease(OMD).According to those criteria,all lesions(both primary and metastatic)should be amenable to radical intent treatment with acceptable toxicity.Several retrospective studies have shown that adding local ablative therapy to the treatment of OMD improves outcomes;however,due to the diverse selection criteria and treatment strategies used in those studies,it is difficult to compare directly results to draw definitive conclusions.In recent years,prospective phase II trials,such as the SABR-COMET and'Oligomez'trials,have shown that stereotactic body radiation therapy(SBRT)improves outcomes in patients with OMD.More recently,interim results of the randomised phase 3 SINDAS trial were reported at the annual meeting of the American Society of Clinical Oncology 2020 demonstrating that upfront SBRT added to systemic treatment with tyrosine kinase inhibitors yielded a significant benefit in both progression-free survival and overall survival in patients with epidermal growth factor receptor-mutant oligometastatic non-small cell lung cancer.In the present editorial,we review the definition and historical context of advanced non-small cell lung cancer with OMD.In addition,we review the scientific evidence for local ablative therapy and SBRT and discuss the results of recently published prospective studies.We also discuss in depth the results of the SINDAS study,including the strengths and weaknesses of the study and the barriers to extrapolating these results to routine clinical practice. | Xabier Mielgo-Rubio Javier Garde-Noguera Oscar Juan Felipe Couñago | 2020 | World Journal of Clinical Oncology2020，11，12： | 1 |
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