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| 1 | BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts显示文摘Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation.Osteocytes or osteoblasts express receptor activator of nuclear factor k-B ligand(Rankl)or osteoprotegerin(Opg)to promote or inhibit osteoclastogenesis,respectively.Bone morphogenetic protein(BMP)is a potent bone inducer,but its major role in adult bone is to induce osteocytes to upregulate sclerostin(Sost)and increase the Rankl/Opg expression ratio,resulting in promotion of osteoclastogenesis.However,the precise effect of BMP-target gene(s)in osteoblasts on the Rankl/Opg expression ratio remains unclear.In the present study,we identified atonal homolog 8(Atoh8),which is directly upregulated by the BMPSmadl axis in osteoblasts.In vivo,Atoh8 was detected in osteoblasts but not osteocytes in adult mice.Although global Atoh8-knockout mice showed only a mild phenotype in the neonate skeleton,the bone volume was decreased and osteoclasts were increased in the adult phase.Atoh8-null marrow stroma cells were more potent than wild-type cells in inducing osteoclastogenesis in marrow cells.Atoh8 loss in osteoblasts increased Runx2 expression and the Rankl/Opg expression ratio,while Runx2 knockdown normalized the Rankl/Opg expression ratio.Moreover,Atoh8 formed a protein complex with Runx2 to inhibit Runx2 transcriptional activity and decrease the Rankl/Opg expression ratio.These results suggest that bone remodeling is regulated elaborately by BMP signaling;while BMP primarily promotes bone resorption,it simultaneously induces Atoh8 to inhibit Runx2 and reduce the Rankl/Opg expression ratio in osteoblasts,suppressing osteoclastogenesis and preventing excessive BMP-mediated bone resorption. | Yuhei Yahiro Shingo Maeda Masato Morikawa Daizo Koinuma Go Jokoji Toshiro ljuin Setsuro Komiya Ryoichiro Kageyama Kohei Miyazono Noboru Taniguchi | 2020 | Bone Research2020，8，3： | 6 |
| 2 | Hy-pothermia inhibits ischemia-induced efflux of amino acids and neuronal damage in the hippocampus of aged rats显示文摘 | Hiroaki Ooboshi Setsuro Ibayashi Kentaro Takano | 2000 | Brain Res2000，884，： | 1 |
| 3 | Endogenous TGF-β signaling suppresses maturation of osteoblastic mesenchymal cells 显示文摘 | Shingo M Makoto H Setsuro K | 2004 | EMBO J2004，3，： | 1 |
| 4 | Postischemic gene transfer of interleukin-10 protects against both focal and global brain ischemia 显示文摘 | Hiroaki Setsuro Takashi | 2005 | Circulation2005，111，2： | 1 |
| 5 | Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis 显示文摘 | Sanshiro H Robert LO Setsuro K | 1998 | Arthritis and Rheum1998，41，9： | 1 |
| 6 | Evaluation of Occipitocervical Subluxation in Rheumatoid Arthritis Patients, Using Coronal-View Reconstructive Computed Tomography显示文摘 | Ryusaku Nagayoshi Kosei Ijiri Tsuyoshi Takenouchi Eiji Taketomi Harutoshi Sakakima Setsuro Komiya | 2009 | Spine2009，，24： | 1 |
| 7 | Postischemic gene transfer of interleukin-10 protects against both focal and global brain ischemia显示文摘 | Hiroaki O Setsuro I Takashi S | 2005 | Circulation2005，111，7： | 1 |
| 8 | Postischemic Gene Transfer of Interleukin-10 Protects Against Both Focal and Global Brain Ischemia显示文摘 | Hiroaki Ooboshi Setsuro Ibayashi Takashi Shichita Yasuhiro Kumai Junichi Takada Tetsuro Ago Shuji Arakawa Hiroshi Sugimori Masahiro Kamouchi Takanari Kitazono Mitsuo Iida | 2005 | Circulation2005，，7： | 1 |
| 9 | A novel representation of protein sequences for prediction of subcellular location using support vector machines显示文摘 | Setsuro M Jean-Philippe V Hiroto S | 2005 | Protein Sci2005，14，11： | 1 |
| 10 | A New Low-Brittleness Glass in the Soda-Lime-Silica Glass Family显示文摘 | JEETENDRA SEHGAL SETSURO ITO | 1998 | J Am Ceram Soc1998，81，9： | 1 |
| 11 | Effect of Selective Brain Hypothermia on Regional Cerebral Blood Flow and Tissue Metabolism Using Brain Thermo-Regulator in Spontaneously Hypertensive Rats显示文摘 | Setsuro Ibayashi Kentaro Takano Hiroaki Ooboshi Takanari Kitazono Seizo Sadoshima Masatoshi Fujishima | 2000 | Neurochemical Research2000，，3： | 1 |
| 12 | Decoloration of azo dye using atomic hydrogen permeating through a Pt-modified palladized Pd sheet electrode显示文摘 | Yasuki Yoshida Setsuro Ogata Shuji Nakamatsu Takayuki Shimamune Keiichi Kikawa Hiroshi Inoue Chiaki Iwakura | 1999 | Electrochimica Acta1999，45，： | 1 |
| 13 | Photothrombotic middle cerebral artery occlusion in spontaneously hypertensive rats:influence of substrain gender,and distal middle cerbral artery patterns on infarct size显示文摘 | Hong Cai Hiroshi Yao Setsuro Ibayashi | 1998 | Stroke1998，29，： | 1 |
| 14 | Endogenous TGF-β1 signaling supresses maturation of osteoblastic mesenchymal cells显示文摘 | Shingo Maeda Makoto Hayashi Setsuro Komiya | | 0，，03： | 1 |
| 15 | Amiloride inhibits hydrogen peroxide-induced Ca 2+ responses in human CNS pericytes显示文摘 | Kuniyuki Nakamura Masahiro Kamouchi Takanari Kitazono Junya Kuroda Yuji Shono Noriko Hagiwara Tetsuro Ago Hiroaki Ooboshi Setsuro Ibayashi Mitsuo Iida | 2008 | Microvascular Research2008，，3： | 1 |
| 16 | Effect of selective brain hypothermia on regional cerebral blood flow and tissue metabolism using brain thermo-regulator in spontaneously hypertensive rats显示文摘 | Setsuro Takano | 2000 | neurochemical research2000，25，： | 1 |
| 17 | Deep venous thrombosis after acute intracerebral hemorrhage显示文摘 | Toshiyasu Ogata Masahiro Yasaka Yoshiyuki Wakugawa Tooru Inoue Setsuro Ibayashi Yasushi Okada | 2008 | Journal of the Neurological Sciences2008，，1： | 1 |
| 18 | Postischemic gene transfer of interleukin - 10 protects against both focal and global brain ischemia 显示文摘 | Hiroaki O Setsuro I Takashi S | 2005 | Circulation2005，111，： | 1 |
| 19 | Endogenous Cannabinoids are Candidates for Lipid Mediators of Bone Cement Implantation Syndrome显示文摘 | Takashi Motobe Teruto Hashiguchi Tomonori Uchimura Munekazu Yamakuchi Noboru Taniguchi Setsuro Komiya Ikuro Maruyama | 2004 | Shock2004，，1： | 1 |
| 20 | Osteosarcoma cell apoptosis induced by selenium显示文摘 | Koji H Setsuro K Tetsuya H | 2001 | J Ortho Res2001，19，5： | 1 |
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