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| 1 | Impact of metastatic lymph node ratio in node-positive colorectal cancer显示文摘Colorectal cancer(CRC) is one of the most common malignant diseases in the world.Presently,the most widely used staging system for CRC is the tumor nodes metastasis classification system,which classifies patients into prognostic groups according to the depth of the primary tumor,presence of regional lymph node(LN) metastases,and evidence of distant metastatic spread.The number of LNs with confirmed metastasis is related to the severity of the disease,but this number depends on the number of LNs retrieved,which varies depending on patient age,tumor grade,surgical extent,and tumor site.Numerous studies and a recent structured review have demonstrated associated improvements in the survival of CRC patients with increasing numbers of LNs retrieved for examination.Hence,the impact of lymph node ratio(LNR),defined as the number of metastatic LNs divided by the number of LNs retrieved,has been investigated in various malignancies,including CRC.In this editorial,we review the literature demonstrating the clinicopathological significance of LNR in CRC pati-ents.Some reports have indicated the advantage of considering the LNR compared to the number of LNs retrieved and/or LN status.When the LNR is taken into consideration for survival analysis,the number of LNs retrieved and/or the LN status is not always found to be a prognostic factor.The cut-off points for LNRs were proposed in numerous studies.However,optimal thresholds for LNRs have not yet received consensus.It is still unclear whether the LNR has more prognostic validity than N stage.For all these reasons,the potential advantages of LNRs in the staging system should be investigated in large prospective data sets. | Shingo Noura Masayuki Ohue Shingo Kano Tatsushi Shingai Terumasa Yamada Isao Miyashiro Hiroaki Ohigashi Masahiko Yano Osamu Ishikawa | 2010 | World Journal of Gastrointestinal Surgery2010，2，3： | 7 |
| 2 | NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type 1 IFN induction显示文摘 | Sasai M Shingai M Funami K | 2006 | J Immunol2006，177，12： | 1 |
| 3 | The Utility of an Interferon Gamma Release Assay for Diagnosis of Latent Tuberculosis Infection and Disease in Children: A Systematic Review and Meta-analysis显示文摘 | Shingai Machingaidze Charles Shey Wiysonge Yulieth Gonzalez-Angulo Mark Hatherill Sizulu Moyo Willem Hanekom Hassan Mahomed | 2011 | The Pediatric Infectious Disease Journal2011，，8： | 1 |
| 4 | Pressure-Induced Structural Phase Transition from Relaxor Phase to Antiferroelectric Phase in Disordered Pb(In1/2Nb1/2)O3 显示文摘 | Nomura K Shingai T Yasuda N | 1999 | J Phys Soc Jpn1999，68，： | 1 |
| 5 | Single-incision laparoscopic cecectomy for low-grade appendiceal mucinous neoplasm after laparoscopic rectectomy显示文摘In this case report,we discuss single-incision laparoscopic cecectomy for low-grade appendiceal neoplasm after laparoscopic anterior resection for rectal cancer.The optimal surgical therapy for low-grade appendiceal neoplasm is controversial;currently,the options include appendectomy,cecectomy,right hemicolectomy,and open or laparoscopic surgery.Due to the risk of pseudomyxoma peritonei,complete resection without rupture is necessary.We have encountered 5 cases of lowgrade appendiceal neoplasm and all 5 patients had no lymph node metastasis.We chose the appendectomy or cecectomy without lymph node dissection if preoperative imaging studies did not suspect malignancy.In the present case,we performed cecectomy without lymph node dissection by single-incision laparoscopic surgery(SILS),which is reported to be a reduced port surgery associated with decreased invasiveness and patient stress compared with conventional laparoscopic surgery.We are confident that SILS is a feasible alternative to traditional surgical procedures for borderline tumors,such as low-grade appendiceal neoplasms. | Shiki Fujino Norikatsu Miyoshi Shingo Noura Tatsushi Shingai Yasuhiko Tomita Masayuki Ohue Masahiko Yano | 2014 | World Journal of Gastrointestinal Surgery2014，6，5： | 1 |
| 6 | CEA-Antigen and SCC-Antigen mRNA Expression in Peripheral Blood Predict Hematogenous Recurrence After Resection in Patients with Esophageal Cancer显示文摘 | Koji Tanaka Masahiko Yano Masaaki Motoori Kentaro Kishi Isao Miyashiro Tatsushi Shingai Kunihito Gotoh Shingo Noura Hidenori Takahashi Masayuki Ohue Terumasa Yamada Hiroaki Ohigashi Takashi Yamamoto Tomoyuki Yamasaki Yuichiro Doki Osamu Ishikawa | 2010 | Annals of Surgical Oncology2010，，： | 1 |
| 7 | Fertility of mice receiving vit-rified adult mouse ovaries显示文摘 | Hani T Tachibe T Shingai S | 2006 | Reproduction2006，131，4： | 1 |
| 8 | Fault Location Using Digraph and Inverse Direction Search with Application显示文摘 | Kokawa M Shingai S | 1983 | Automatic1983，19，： | 1 |
| 9 | Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4- mediated IFN-beta induction显示文摘 | Shingai M Azuma M Ebihara T eta | 2008 | Int Immunol2008，20，9： | 1 |
| 10 | A feasibility study of adju- vant therapy with eapecitabine plus oxaliplatin (XELOX) for Japa- nese patients with advanced colorectal cancer显示文摘 | Shingai T Sakai D Sugimoto N | 2015 | Gan To Kagaku Ryoho2015，42，2： | 1 |
| 11 | Combinational rec- ognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily显示文摘 | Higuchi M Matsuo A Shingai M | 2008 | Dev Comp Immunol2008，32，2： | 1 |
| 12 | Tumor immunotherapy using bone marrow-derived dendritic cells over expressing Toll-like receptor adaptors显示文摘 | Akazawa T Shingai M Sasai M | 2007 | FEBS Lett2007，581，18： | 1 |
| 13 | Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily显示文摘 | Higuchi M Matsuo A Shingai M | 2008 | Dev Comp Immunol2008，32，： | 1 |
| 14 | Nectin- like molecule - 2/1GSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell - cell adhesion and transmembrane protein localization in epithelial cells显示文摘 | Tatsushi Shingai Wataru Ikeda Shigeki Kakunaga | 2003 | Biol Chem2003，278，35： | 1 |
| 15 | Combinational recogni- tion of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily显示文摘 | Higuchi M Matsuo A Shingai M | 2008 | Developmental Cornpara-tive Immun-ology2008，32，2： | 1 |
| 16 | Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells显示文摘 | Shingai T Ikeda W Kakunaga S | 2003 | J Biol Chem2003，278，35： | 1 |
| 17 | Combinational recognition of bacterial lipoproteins and peptidoglyean by chicken Toll like receptor 2 subfamily显示文摘 | Higuchi M Matsuo A Shingai M | 2008 | Development and comparative Immunology2008，32，2： | 1 |
| 18 | Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells显示文摘 | Ikeda W Kakunaga S | 2003 | J Biol Chem2003，278，35： | 1 |
| 19 | Sequence and Functional Expression of a Single a-Subunit of an Insect Nicotinic Acetylcholine-receptor显示文摘 | MARSHALL J BUCKINGHAMS D SHINGAI R | 1990 | EMBO J1990，9，： | 1 |
| 20 | Chemotaxis behavior to- ward an odor is regulated by constant sodium chloride stimulus in Caenorhabditis elegans 显示文摘 | Shingai R Ichijo H Wakabayashi T | 2014 | Neurosci Res2014，81，： | 1 |
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