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| 1 | Serrated polyps of the colon and rectum:Remove or not?显示文摘In recent years,the serrated neoplasia pathway where serrated polyps arise as a colorectal cancer has gained considerable attention as a new carcinogenic pathway.Colorectal serrated polyps are histopathologically classified into hyperplastic polyps(HPs),sessile serrated lesions,and traditional serrated adenomas;in the serrated neoplasia pathway,the latter two are considered to be premalignant.In western countries,all colorectal polyps,including serrated polyps,apart from diminutive rectosigmoid HPs are removed.However,in Asian countries,the treatment strategy for colorectal serrated polyps has remained unestablished.Therefore,in this review,we described the clinicopathological features of colorectal serrated polyps and proposed to remove HPs and sessile serrated lesions≥6 mm in size,and traditional serrated adenomas of any size. | Wataru Sano Daizen Hirata Akira Teramoto Mineo Iwatate Santa Hattori Mikio Fujita Yasushi Sano | 2020 | World Journal of Gastroenterology2020，26，19： | 12 |
| 2 | Prognostic significance of perioperative tumor marker levels in stage Ⅱ/Ⅲ gastric cancer显示文摘AIM To evaluate the prognostic significance of perioperative carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) levels in stage Ⅱ/Ⅲ gastric cancer.METHODS From a multi-institutional retrospective database compiled by integrating clinical data from nine institutions, data of 998 patients who underwent curative resection for stage Ⅱ/Ⅲ gastric cancer between 2010 and 2014 were retrieved and analyzed. The prognostic impact of the preoperative and postoperative levels and chronological changes in CEA, CA19-9 and their combination were evaluated. To test whether postoperative adjuvant chemotherapy alters the prognostic impact of perioperative CEA and CA19-9 levels, the hazard ratios for mortality were compared between patients who underwent surgery alone and patients who underwent surgery followed by adjuvant chemotherapy.RESULTS The prognostic impact of postoperative CEA and CA19-9 was superior to that of the preoperative levels. Multivariable analysis identified high postoperative CEA and CA19-9 levels as independent prognostic factors for overall survival.Disease-free survival rates clearly decreased in a stepwise manner in association with postoperative CEA and CA19-9 levels, and patients with high levels of both markers showed significantly poorer prognosis than other patient groups. When we analyzed perioperative changes in serum CEA and CA19-9 levels, patients with high levels before and after surgery had the worst disease-free survival rates among all patient groups. Patients with normalized CEA levels after surgery had a significantly lower disease-free survival rate than those with normal perioperative levels, whereas patients with normalized CA19-9 levels after surgery had equivalent survival to those with normal perioperative levels. The prognostic impact of high CEA levels was observably smaller in patients who underwent adjuvant chemotherapy than in patients who underwent surgery alone, whereas that of high CA19-9 was greater in patients who underwent adjuvant chemotherapy. High postoperative CEA levels were significantly associated with an increased prevalence of liver, lung and bone recurrences, and high postoperative CA19-9 levels were significantly associated with increased frequencies of lymph node and liver recurrences.CONCLUSION The evaluation of serum CEA and CA 19-9 levels both before and after surgery provides useful information for precise risk stratification after curative gastrectomy. | Yasuhito Suenaga Mitsuro Kanda Seiji Ito Yoshinari Mochizuki Hitoshi Teramoto Kiyoshi Ishigure Toshifumi Murai Takahiro Asada Akiharu Ishiyama Hidenobu Matsushita Chie Tanaka Daisuke Kobayashi Michitaka Fujiwara Kenta Murotani Yasuhiro Kodera | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 7 |
| 3 | Effective use of the Japan Narrow Band Imaging Expert Team classification based on diagnostic performance and confidence level显示文摘Five years have passed since the Japan Narrow Band Imaging Expert Team (JNET) classification was proposed in 2014. However, the diagnostic performance of this classification has not yet been established. We conducted a retrospective study and a systematic search of Medical Literature Analysis and Retrieval System On-Line. There were three retrospective single center studies about the diagnostic performance of this classification. In order to clarify this issue, we reviewed our study and three previous studies. This review revealed the diagnostic performance in regards to three important differentiations.(1) Neoplasia from non-neoplasia;(2) malignant neoplasia from benign neoplasia;and (3) deep submucosal invasive cancer (D-SMC) from other neoplasia. The sensitivity in differentiating neoplasia from non-neoplasia was 98.1%-99.8%. The specificity in differentiating malignant neoplasia from benign neoplasia was 84.7%-98.2% and the specificity in the differentiation D-SMC from other neoplasia was 99.8%-100.0%. This classification would enable endoscopists to identify almost all neoplasia, to appropriately determine whether to perform en bloc resection or not, and to avoid unnecessary surgery. This article is the first review about the diagnostic performance of the JNET classification. Previous reports about the diagnostic performance have all been retrospective single center studies. A large-scale prospective multicenter evaluation study is awaited for the validation. | Daizen Hirata Hiroshi Kashida Mineo Iwatate Tomomasa Tochio Akira Teramoto Yasushi Sano Masatoshi Kudo | 2019 | World Journal of Clinical Cases2019，7，18： | 6 |
| 4 | Prospective real-time evaluation of diagnostic performance using endocytoscopy in differentiating neoplasia from nonneoplasia for colorectal diminutive polyps(≤ 5 mm)显示文摘AIM To clarify the diagnostic performance of endocytoscopy for differentiation between neoplastic and nonneoplastic colorectal diminutive polyps.METHODS Patients who underwent endocytoscopy between October and December 2016 at Sano Hospital were prospectively recruited. When diminutive polyps(≤5 mm) were detected, the lesions were evaluated by endocytoscopy after being stained with 0.05% crystal violet and 1% methylene blue. The diminutivepolyps were classified into five categories(EC 1 a, 1 b, 2, 3 a, and 3 b). Endoscopists were asked to take a biopsy from any lesion diagnosed as EC1 b(indicator of hyperplastic polyp) or EC2(indicator of adenoma). We have assessed the diagnostic performance of endocytoscopy for EC2 and EC1 b lesions by comparison with the histopathology of the biopsy specimen. RESULTS A total of 39 patients with 63 diminutive polyps were analyzed. All polyps were evaluated by endocytoscopy. The mean polyp size was 3.3 ± 0.9 mm. Among the 63 diminutive polyps, 60 were flat and 3 were pedunculated. The mean time required for EC observation, including the time for staining with crystal violet and methylene blue, was 3.0 ± 1.9 min. Histopathologic evaluation showed that 13 polyps were hyperplastic and 50 were adenomas. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of EC2 for adenoma compared with EC1 b for hyperplastic polyp were 98.0%, 92.3%, 96.8%, 98.0% and 92.3%, respectively. There were only two cases of disagreement between the endoscopic diagnosis made by endocytoscopy and the corresponding histopathological diagnosis.CONCLUSION Endocytoscopy showed a high diagnostic performance for differentiating between neoplastic and non-neoplastic colorectal diminutive polyps, and therefore has the potential to be used for 'real-time histopathology'. | Takahiro Utsumi Yasushi Sano Mineo Iwatate Hironori Sunakawa Akira Teramoto Daizen Hirata Santa Hattori Wataru Sano Noriaki Hasuike Kazuhito Ichikawa Takahiro Fujimori | 2018 | World Journal of Gastrointestinal Oncology2018，10，4： | 4 |
| 5 | Loss-of-Function of a Ubiquitin-Related Modifier Promotes the Mobilization of the Active MITE mPing显示文摘缩小的转换重复的 transposable 元素(螨) 在原核生物、真核细胞的染色体是普遍的,在他们的拷贝数字能达到几的地方千。然而,很少对影响他们的调换的基因因素被知道。这里,我们证明没有任何外长的压力,显著地编码象 ubiquitin 一样蛋白质的基因的那混乱在未经触动的米饭植物提高螨 mPing 的调换活动。我们发现 mPing 的调换活动在在 Rurm1 怀有非功能的等位基因的线更高是远的(瑞斯 ubiquitin 相关的 modifier-1 ) 地点比在野类型的线。尽管 cytosine methylation 模式的改变在外长的压力条件,在整个染色体的 methylation 度, mPing 身体区域,和胁腹 mPing 下面触发 transposable 元素的激活,非功能的 Rurm1 线的区域是未改变的。这研究为在房间以内的基因事故提高的染色体吃惊理论的模型之一提供试验性的证据 transposable 元素的调换活动。 | Takuji Tsukiyama Shota Teramoto KanakoYasuda Akira Horibata Nanako Mori Yutaka Okumoto Masayoshi Teraishi Hiroki Saito Akiko Onishi Kanako Tamura Takatoshi Tanisaka | 2013 | Molecular Plant2013，6，3： | 3 |
| 6 | A modelling and simulation architecture for virtual manufactring systems 显示文摘 | Iwata K Onosato M Teramoto K | 1995 | Annals of the CIRP1995，44，1： | 2 |
| 7 | Laparoscopic ultralow anterior resection combined withPer Anum intersphincteric rectal dissection for lower rectal cancer显示文摘 | Dr. Masahiko Watanabe M.D. Tatsuo Teramoto M.D. Hirotoshi Hasegawa M.D. Masaki Kitajima M.D | 2000 | Diseases of the Colon & Rectum2000，，10： | 2 |
| 8 | Effects of ambroxol on sponta- neous or stimulated generation of reactive oxygen species by bron- choalveolar lavage ceils harvested from patients with or without chro- nic obstructive pulmonary diseases 显示文摘 | Teramoto S SuzukiM Ohga E | 1999 | Pharmacology1999，59，3： | 1 |
| 9 | A rat fatty liver transplant model显示文摘 | TERAMOTO K BAWERS J L KHETTRY U | 1993 | Transplantation1993，55，4： | 1 |
| 10 | Second-line chemoth- erapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature 显示文摘 | Funakoshi S Hashiguchi A Teramoto K | 2013 | Oncol Lett2013，5，1： | 1 |
| 11 | Biodegradable cellulose diacetate?graft-poly ( L-lactide) s ; thermal treatment effect on the development of supramolecular structures显示文摘 | TERAMOTO Y NISHIO Y | 2004 | Biomacromolecules2004，5，： | 1 |
| 12 | Dominant lethal studies in rats with 1,2-dibromo-3-chloropropane and its structurally related compounds显示文摘 | Saito-Suzuki R Teramoto S Shirasu Y | 1982 | Murat Res1982，101，4： | 1 |
| 13 | Noncoding RNA for CR20, a cytokinin-repressed gene of cucumber显示文摘 | Teramoto H Toyama T Takeba G Tsuji H | 1996 | Plant Mol Biol1996，32，： | 1 |
| 14 | Current progress in the understanding of and therapeutic strategies for ischemia and reperfusion injury of liver显示文摘 | Arii S Teramoto K Kawwmura T | 2003 | J Hepatobiliary Pancreat Surg2003，10，3： | 1 |
| 15 | EGF amplifies the replaeement of parvalbumin- expressing striatal interneurons after isehemia显示文摘 | Teramoto T Qiu J Plumier JC | 2003 | J Clin Invest2003，111，8： | 1 |
| 16 | Biodegradable cellulose diacetate?graft-poly ( L-lactide) s: enzymatic hydrolysis behavior and surface morphological characterization显示文摘 | TERAMOTO Y NISHIO Y | 2004 | Biomacromolecules2004，5，： | 1 |
| 17 | The relation- ship between low-density lipoprotein cholesterol levels and the incidence of cardiovascular disease in high-risk patients treated with pravastatin显示文摘 | Daida H Teramoto T Kitagawa Y | 2014 | Int Heart J2014，55，1： | 1 |
| 18 | 查看详情显示文摘 | Ryo Ono Tobaru C Teramoto Y Oda T | | 0，，： | 1 |
| 19 | Texture and structure of high-pressurefrozen gellan gum gel显示文摘 | Fuchigami M Teramoto A | | 0，，06： | 1 |
| 20 | Plasma C-reactive protein levels are associated with mortality in elderly with acute lung injury显示文摘 | Komiya K Ishii H Teramoto S | 2012 | Crit Care2012，27，5： | 1 |
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