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| 1 | Personalized immunotherapy in cancer precision medicine显示文摘With the significant advances in cancer genomics using next-generation sequencing technologies,genomic and molecular profilingbased precision medicine is used as a part of routine clinical test for guiding and selecting the most appropriate treatments for individual cancer patients.Although many molecular-targeted therapies for a number of actionable genomic alterations have been developed,the clinical application of such information is still limited to a small proportion of cancer patients.In this review,we summarize the current status of personalized drug selection based on genomic and molecular profiling and highlight the challenges how we can further utilize the individual genomic information.Cancer immunotherapies,including immune checkpoint inhibitors,would be one of the potential approaches to apply the results of genomic sequencing most effectively.Highly cancer-specific antigens derived from somatic mutations,the so-called neoantigens,occurring in individual cancers have been in focus recently.Cancer immunotherapies,which target neoantigens,could lead to a precise treatment for cancer patients,despite the challenge in accurately predicting neoantigens that can induce cytotoxic T cells in individual patients.Precise prediction of neoantigens should accelerate the development of personalized immunotherapy including cancer vaccines and T-cell receptor-engineered T-cell therapy for a broader range of cancer patients. | Kazuma Kiyotani Yujiro Toyoshima Yusuke Nakamura | 2021 | Cancer Biology & Medicine2021，18，4： | 3 |
| 2 | Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study显示文摘 | Yasuo Ohkubo Hideki Kishikawa Eiichi Araki Takao Miyata Satoshi Isami Sadatoshi Motoyoshi Yujiro Kojima Naohiko Furuyoshi Motoaki Shichiri | 1995 | Diabetes Research and Clinical Practice1995，，2： | 3 |
| 3 | Pneumatosis intestinalis with obstructing intussusception:A case report and literature review显示文摘Pneumatosis intestinalis(PI) often represents a benign condition that should not be considered as an argument for surgery. We report a patient with PI and obstructing intussusception who underwent urgent colectomy and review the literatures regarding PI with intussusception. A 20-year-old man presented at our hospital with a 3-d intermittent lower abdominal pain history. He underwent steroid therapy for membranoproliferative glomerulonephritis for 4 years. Computed tomography revealed ascending colon intussusception with air within the wall. Intraoperative colonoscopy revealed numerous soft polypoid masses with normal overlying mucosa and right hemicolectomy was performed. Histological examination of colonic wall sections revealed large cysts in the submucosal layer. The pathological diagnosis was PI. Nine cases of intussusception associated with primary PI have been reported. Although primary PI often represents a benign condition that should not be considered as an argument for surgery,if the case involves intussusception and obstruction,emergent laparotomy should be considered. | Yujiro Itazaki Hironori Tsujimoto Nozomi Ito Hiroyuki Horiguchi Shinsuke Nomura Kyohei Kanematsu Shuichi Hiraki Suefumi Aosasa Junji Yamamoto Kazuo Hase | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 2 |
| 4 | Novel zinc alloys for biodegradable surgical staples显示文摘BACKGROUND The development of biodegradable surgical staples is desirable as non-biodegradable Ti alloy staples reside in the human body long after wound healing, which can cause allergic/foreign-body reactions, adhesion, or other adverse effects. In order to develop a biodegradable alloy suitable for the fabrication of surgical staples, we hypothesized that Zn, a known biodegradable metal, could be alloyed with various elements to improve the mechanical properties while retaining biodegradability and biocompatibility. Considering their biocompatibility, Mg, Ca, Mn, and Cu were selected as candidate alloying elements, alongside Ti, the main material of clinically available surgical staples.AIM To investigate the in vitro mechanical properties and degradation behavior and in vivo safety and feasibility of biodegradable Zn alloy staples.METHODS Tensile and bending tests were conducted to evaluate the mechanical properties of binary Zn alloys with 0.1–6 wt.% Mg, Ca, Mn, Cu, or Ti. Based on the results,three promising Zn alloy compositions were devised for staple applications(wt.%): Zn-1.0Cu-0.2Mn-0.1Ti(Zn alloy 1), Zn-1.0Mn-0.1Ti(Zn alloy 2), and Zn-1.0Cu-0.1Ti(Zn alloy 3). Immersion tests were performed at 37℃ for 4 wk using fed-state simulated intestinal fluid(Fe SSIF) and Hank’s balanced salt solution(HBSS). The corrosion rate was estimated from the weight loss of staples during immersion. Nine rabbits were subjected to gastric resection using each Zn alloy staple, and a clinically available Ti staple was used for another group of nine rabbits. Three in each group were sacrificed at 1, 4, and 12 wk post-operation.RESULTS Additions of ≤1 wt.% Mn or Cu and 0.1 wt.% Ti improved the yield strength without excessive deterioration of elongation or bendability. Immersion tests revealed no gas evolution or staple fracture in any of the Zn alloy staples. The corrosion rates of Zn alloy staples 1, 2, and 3 were 0.02 mm/year in HBSS and 0.12, 0.11, and 0.13 mm/year, respectively, in Fe SSIF. These degradation times are sufficient for wound healing. The degradation rate is notably increased under low pH conditions. Scanning electron microscopy and energy dispersive spectrometry surface analyses of the staples after immersion indicated that the component elements eluted as ions in Fe SSIF, whereas corrosion products were produced in HBSS, inhibiting Zn dissolution. In the animal study, none of the Zn alloy staples caused technical failure, and all rabbits survived without complications. Histopathological analysis revealed no severe inflammatory reaction around the Zn alloy staples.CONCLUSION Staples made of Zn-1.0Cu-0.2Mn-0.1Ti, Zn-1.0Mn-0.1Ti, and Zn-1.0Cu-0.1Ti exhibit acceptable in vitro mechanical properties, proper degradation behavior,and in vivo safety and feasibility. They are promising candidates for biodegradable staples. | Hizuru Amano Koichi Miyake Akinari Hinoki Kazuki Yokota Fumie Kinoshita Atsuko Nakazawa Yujiro Tanaka Yasuhiro Seto Hiroo Uchida | 2020 | World Journal of Clinical Cases2020，8，3： | 2 |
| 5 | Invovement of nitric oxide in the suppressive effect of 17β-estradiol on endothelin-1 overproduction in ischemic acute renal failure 显示文摘 | Yujiro S Masanori T Daisuke M | 2004 | J Cardiovasc Pharmacol2004，44，1： | 1 |
| 6 | Waveform-preserving blind estimation of multiple independent sources 显示文摘 | LANG T YUJIRO I LIU R W | 1993 | IEEE Trans Signal Process1993，41，7： | 1 |
| 7 | Diagnostic approach using endosonography guided fine needle aspiration for lymphadenopathy in primary sclerosing cholangitis显示文摘We report a case of primary sclerosing cholangitis (PSC) with benign lyphadenopathy which was diagnosed with endosonography guided fine needle aspiration (EUS-FNA). A 65-year-old woman was admitted to Jikei University Hospital with severe jaundice. Although endoscopic retrograde cholangiography and liver biopsy revealed the findings consistent with PSC, abdominal computed tomography revealed numerous large perihepatic lymph nodes with a maximum diameter of more than 3 cm. Therefore, EUS-FNA was done in order to exclude malignant lymphadenopathy, and adequate specimens obtained by EUS-FNA showed reactive hyperplasia of lymphnode. The patients were scheduled to undergo liver transplantation. | Shintaro Tsukinaga Hiroo Imazu Yujiro Uchiyama Hiroshi Kakutani Akira Kuramoti Masayuki Kato Keisuke Kanazawa Tsuyoshi Kobayashi Yasuyuki Searashi Hisao Tajiri | 2007 | World Journal of Gastroenterology2007，13，27： | 1 |
| 8 | Efficiency and Equity in Public Research: Rice Breeding in Japan's Economic Development显示文摘 | Masakatsu Akino and Yujiro Hayami | 1975 | American Journal of Agricultural Economies1975，57，4： | 1 |
| 9 | Comparison of Autologous Hematopoietic Cell Transplantation and Chemotherapy as Postremission Treatment in Non-M3 Acute Myeloid Leukemia in First Complete Remission显示文摘 | Kensuke Usuki Saiko Kurosawa Naoyuki Uchida Kazuaki Yakushiji Fusako Waki Eijo Matsuishi Kumiko Kagawa Tatsuo Furukawa Yoshinobu Maeda Manabu Shimoyama Hiroatsu Ago Yujiro Yamano Shingo Yano Naohito Fujishima Yasushi Takamatsu Tetsuya Eto Michihiro Hidaka | 2012 | Clinical Lymphoma Myeloma and Leukemia2012，，6： | 1 |
| 10 | Growth of epitaxial ZnO thin films on lattice-matched buffer layer: Application of InGaO3 ( ZnO ) 6 single-crystalline thin film 显示文摘 | Yujiro Takedaa Kenji Nomurab Hiromichi Ohta | 2005 | Thin Solid Films2005，486，12： | 1 |
| 11 | Arterial conduit shear stress following bypass grafting for intermediate coronary artery stenosis: a comparative study with saphenous vein grafts 显示文摘 | Tsuyoshi Shimizu Shigeki Ito Yujiro Kikuchi | 2004 | Eur J Cardiothorac Surg2004，，25： | 1 |
| 12 | Ephrinb2 reverse signaling protects against capillary rarefaction and fibrosis after kidney injury显示文摘 | Yujiro Kida Nicholas Ieronimakis Claudia Schrimpf | 2013 | J Am Soc Nephrol2013，24，4： | 1 |
| 13 | The direct and enantioselective,one-pot,three-component,cross-Mannich reaction of aldehydes显示文摘 | HAYASHI Yujiro TSUBOI Wataru ASHIMINE Itaru | 2003 | Angew Chem Int Ed2003，42，： | 1 |
| 14 | A Long ncRNA Links Copy Number Variation to a Polycomb/Trithorax Epigenetic Switch in FSHD Muscular Dystrophy显示文摘 | Daphne S. Cabianca Valentina Casa Beatrice Bodega Alexandros Xynos Enrico Ginelli Yujiro Tanaka Davide Gabellini | 2012 | Cell2012，，4： | 1 |
| 15 | Market Price Effects of Techno- logical Change on Income Distribution in Semi Subsistence Agri- culture 显示文摘 | Hayami Yujiro Herdt Robert W | 1977 | American Journal of Agricultural Economics1977，59，2： | 1 |
| 16 | Totally Endoscopic Clo- sure of an Atrial Septal Defect Using the Da Vinci Surgical System: Report of Four Cases显示文摘 | Yujiro K Teruaki U Go W | 2010 | Surg Today2010，40，2： | 1 |
| 17 | Segmentectomy for Reactive Lymphoid Hyperplasia of the Liver: Report of a Case显示文摘 | Naoki Maehara Kazuo Chijiiwa Ichiro Makino Jiro Ohuchida Masahiro Kai Kazuhiro Kondo Sayaka Moriguchi Kousuke Marutsuka Yujiro Asada | 2006 | Surgery Today2006，，11： | 1 |
| 18 | Totally endoscopic closure of an atrial septal defect using the da Vinci surgical system: report of four cases显示文摘 | Yujiro K Teruaki U Go W | 2010 | Surg Today2010，40，2： | 1 |
| 19 | Low-temperature fabrication of dye-sensitized plastic electrodes by electrophoretic preparation of mesoporous TiO2 layers显示文摘 | YUJIRO K | 2004 | Journal of the Electrochemical Society2004，151，11： | 1 |
| 20 | An intercountry comparison of agricultural production efficiency显示文摘 | Toshihiko kawagoe Yujiro hayami | 1985 | American Journal of Agricultural Economics1985，67，1： | 1 |
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