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| 1 | Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis显示文摘The 'a disintegrin and metalloprotease' (ADAM) family contributes to regulation of the cell-cell and cell-matrix interactions that are critical determinants of malignancy. To determine the relationship between metastasis and ADAM proteins, we compared the mRNA levels of ADAM9,-10,-12,-15, and-17 in sublines of an EBC-1 lung cancer cell line that were highly metastatic to either brain or bone. ADAM9 mRNA levels were significantly higher in highly brain-metastatic sublines than in the parent or highly bonemetastalic sublines. To elucidate the role ofADAM9 in brain metastasis, we stably transfected A549 and EBC-1 cells with a fulllength ADAM9 expression vector. Compared with mock-transfectants, ADAM9 overexpression resulted in increased invasive capacity | Shintani Y Higashiyama S Ohta M Hirabayashi H Yamamoto S Yoshimasu T Matsuda H Matsuura N | 2004 | 中国神经肿瘤杂志2004，2，2： | 36 |
| 2 | Acquisition of LURE-Binding Activity at the Pollen Tube Tip of Torenia fournieri显示文摘 | Satohiro Okuda Takamasa Suzuki Masahiro M. Kanaoka Hitoshi Moric Narie Sasaki Tetsuya Higashiyama | 2013 | Molecular Plant2013，6，4： | 3 |
| 3 | Effect of nitrogen source on mycelial morphology and arachidonic acid production in cultures of Mortierella alpina显示文摘 | PARK E Y KOIKE Y HIGASHIYAMA K | 1999 | J Biosci Bioeng1999，88，： | 1 |
| 4 | KAI1/CD82 expression in non-small cell lung carcinoma is a novel, favorable prognostic factor: an immunohistochemical analysis显示文摘 | Higashiyama M Kadama K Yokouchi H | 1998 | Cancer1998，83，3： | 1 |
| 5 | Identification of a phosphopaeptide in bovine ctsl-casein digest as a factor influencing proliferation and immunoglobu- lin production in lymphocyte cultures 显示文摘 | Hata I Higashiyama S | 1998 | J Dairy Res1998，65，： | 1 |
| 6 | Primary and metastatic pulmonary meningioma显示文摘 | Kodama K Doi O Higashiyama M | 1991 | Cancer1991，7，5： | 1 |
| 7 | Risk factors for recurrence to the lymph node in papillary thyroid carcinoma patients without preoperatively detectable lateral node metastasis: validity of prophylactic modified radical neck dissection 显示文摘 | Ito Y Higashiyama T Takamura Y | 2007 | World J Surg2007，31，11： | 1 |
| 8 | Pollen tube attraction by the synergid cell显示文摘 | Higashiyama T Yabe S Sasaki N Nishimura Y Miyagishima S Kuroiwa H Kuroiwa T | 2001 | Science2001，293，24： | 1 |
| 9 | Defensin-like polypeptide LUREs are pollen tube attractants secreted from synergid ceils显示文摘 | Okuda S Tsutsui H Shiina K Sprunck S Takeuchi H Yui R Kasahara R D HamamuraY Mizukami A S usaki D Kawano N Sakakibara T Namiki S Itoh K Otsuka K Matsuzaki M Nozaki H Kuroiwa T Nakano A Kanaoka M M Dresselhaus T Sasaki N Higashiyama T | | 0，，7236： | 1 |
| 10 | Scanning electron microscopic study on the catalytic gasification of coal显示文摘 | Tomita A Higashiyama K Tamai Y | 1981 | Fuel1981，60，21： | 1 |
| 11 | Immunohistochemically detected expression of motilityrelated protein-1 (MRP-1/CD9) in lung adenocarcinoma and its relation to prognosis 显示文摘 | Higashiyama M Doi O Kodama K | 1997 | Int J Cancer1997，74，2： | 1 |
| 12 | Natural history of pure ground-glass opacity after long-term follow-up of more than 2 years显示文摘 | Kodama K Higashiyama M Yokouchi H | 2002 | Ann Thorac Surg2002，73，： | 1 |
| 13 | Serum 1,5-anhydro- D-glucitol levels predict first-ever eardiovaseular disease : an 11-year population-based cohort study in Japan, the Suita study 显示文摘 | Watanabe M Kokubo Y Higashiyama A | 2011 | Athere- sclerosis2011，216，2： | 1 |
| 14 | Effect of consumed carbon to nitrogen ratio on mycelial morphology and arachidonic acid production in cultures of MortiereUa alpina显示文摘 | KOIKE Y CAI H J HIGASHIYAMA K | 2001 | J Biosci Bioeng2001，91，： | 1 |
| 15 | KAI1/CD82 expression in non-small cell lung carcinoma is a novel favorable prognostic factor:an immunohistochemical analysis 显示文摘 | Higashiyama M Kodama K Yokouchi H | 1998 | Cancer1998，83，3： | 1 |
| 16 | Effects of mineral addition on the growth morphology of an arachidonic acid production by Mortierella alpina 1S-4 显示文摘 | Higashiyama K Yaguchi T Akimoto K | 1998 | Journal of the American oil chemists society1998，75，12： | 1 |
| 17 | The motion of charged metal particles within parallel and tilted electrodes显示文摘 | Asano Kazutoshi Yatsuzuka Kyoko Higashiyama Yoshio | 1993 | Journal of Electrostatics1993，30，： | 1 |
| 18 | Effects of mineral addition on the growth morphology of and arachidonic acid production by Mortierella alpina 1S-4显示文摘 | HIGASHIYAMA K YAGYCHI T AKIMOTO K | 1998 | J Am Oil Chem Soe1998，75，： | 1 |
| 19 | Immunokinetics in severe pneumonia due to influenza virus and bacteria coinfection in mice 显示文摘 | Seki M Yanagihara K Higashiyama Y | 2004 | Eur Respir J2004，24，1： | 1 |
| 20 | Localization of heparin-binding EGF-like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques 显示文摘 | MIYAGAWA J HIGASHIYAMA S KAWATA S | 1995 | J Clin Invest1995，95，1： | 1 |
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