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| 1 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 2 | Three Hundred and One Consecutive Extended Right Hepatectomies: Evaluation of Outcome Based on Systematic Liver Volumetry显示文摘 | Yoji Kishi Eddie K. Abdalla Yun Shin Chun Daria Zorzi David C. Madoff Michael J. Wallace Steven A. Curley Jean-Nicolas Vauthey | 2009 | Annals of Surgery2009，，4： | 4 |
| 3 | Bioreduction of nitrate in groundwater using a pilot-scale hydrogen-based membrane biofilm reactor显示文摘A long-term pilot-scale H_(2)-based membrane biofilm reactor(MBfR)was tested for removal of nitrate from actual groundwater.A key feature of this secondgeneration pilot MBfR is that it employed lower cost polyester hollow fibers and still achieved high loading rate.The steady-state maximum nitrate surface loading at which the effluent nitrate and nitrite concentrations were below the Maximum Contaminant Level(MCL)was at least 5.9 g·N·(m^(2)·d)^(–1),which corresponds to a maximum volumetric loading of at least 7.7 kg·N·(m^(3)·d)^(–1).The steady-state maximum nitrate surface area loading was higher than the highest nitrate surface loading reported in the firstgeneration MBfRs using composite fibers(2.6 g·N·(m^(2)·d)^(–1)).This work also evaluated the H_(2)-utilization efficiency in MBfR.The measured H_(2)supply rate was only slightly higher than the stoichiometric H_(2)-utilization rate.Thus,H_(2)utilization was controlled by diffusion and was close to 100%efficiency,as long as biofilm accumulated on the polyester-fiber surface and the fibers had no leaks. | Youneng TANG Michal ZIV-EL Chen ZHOU Jung Hun SHIN Chang Hoon AHN Kerry MEYER Daniel CANDELARIA David FRIESE Ryan OVERSTREET Rick SCOTT Bruce ERITTMANN | 2010 | Frontiers of Environmental Science & Engineering2010，4，3： | 4 |
| 4 | Nonpolypoid neoplastic lesions of the colorectal mucosa显示文摘 | Shin ei Kudo René Lambert John I. Allen Hiroaki Fujii Takahiro Fujii Hiroshi Kashida Takahisa Matsuda Masaki Mori Hiroshi Saito Tadakazu Shimoda Shinji Tanaka Hidenobu Watanabe Joseph J. Sung Andrew D. Feld John M. Inadomi Michael J. O’Brien David A. Lieb | 2008 | Gastrointestinal Endoscopy2008，，4： | 3 |
| 5 | Rotor-Rotor Interaction for Counter-Rotating Fans,Part1:Three-Dimensional Flowfield Measurements显示文摘 | Hyoun-Woo Shin Charlotte E Whitrield David C Wisler | 1994 | AIAAJournal1994，32，11： | 1 |
| 6 | Treatment Options for the Infertile Male With Cancer显示文摘 | Lo KC Lipshultz LI | 2005 | Journal of the National Cancer Institute Monographs2005，34，： | 1 |
| 7 | Structural Property Effect of Nanoparticle Agglomerates on Particle Penetration through Fibrous Filter显示文摘 | Seong C. Kim Jing Wang Mark S. Emery Weon Gyu Shin George W. Mulholland David Y. H. Pui | 2009 | Aerosol Science and Technology2009，，4： | 1 |
| 8 | Classification Cramer-Rao Bounds on Stock Price Prediction显示文摘 | Frances B Shin David H Kil | 1998 | Journal of Forecasting1998，17，： | 1 |
| 9 | Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosis显示文摘 | Soomin Shin Katharine A. Walz Angela S. Archambault Julia Sim Bryan P. Bollman Jessica Koenigsknecht-Talboo Anne H. Cross David M. Holtzman Gregory F. Wu | 2014 | Journal of Neuroimmunology (-)2014，，1： | 1 |
| 10 | Fibroblast growth factor‐2/brain‐derived neurotrophic factor—associated maturation of new neurons generated from adult human subependymal cells显示文摘 | David W.Pincus H. MichaelKeyoung CatherineHarrison‐Restelli Robert R.Goodman Richard A. R.Fraser MarkEdgar Shin‐IchiSakakibara HideyukiOkano MaikenNedergaard Steven A.Goldman | 2004 | Ann Neurol2004，，5： | 1 |
| 11 | SIRT3 Reverses Aging-Associated Degeneration显示文摘 | Katharine Brown Stephanie Xie Xiaolei Qiu Mary Mohrin Jiyung Shin Yufei Liu Dan Zhang David T. Scadden Danica Chen | 2013 | Cell Reports2013，，2： | 1 |
| 12 | Technological relatedness, boundary - spanning combination of knowledge and the impact of inno- vation: Evidence of an inverted- U relationship显示文摘 | Jongtae Shin David Jalajas | 2010 | Journal of High Technology Management Research2010，21，2： | 1 |
| 13 | 七氟醚抑制突触后胆碱能突触传递而不影响短时程增强显示文摘 | Hiroaki Naruo Shin Onizuka David Prince Mayumi Takasaki Naweed I.Syed 方波 王俊科 | 2005 | 国外医学(麻醉学与复苏分册)2005，26，3： | 1 |
| 14 | Stacked auto-encoders for unsu-pervised feature learning and multiple organ detection in a pilot studyusing 4D patient data 显示文摘 | Shin H C Matthew R 0 David J C | 2013 | Pattern Analysis and Machine Intelli-gence2013，35，8： | 1 |
| 15 | Service-oriented Architectures显示文摘 | Shin David | 2004 | Scientific Computing and Instrumentation2004，，： | 1 |
| 16 | Technological relatedness, boundary - spanning combination of knowledge and the impact of innovation: evidence of an inverted - U rela- tionship 显示文摘 | Jongtae Shin David Jalajas | 2010 | Journal of High Technology Management Research2010，21，2： | 1 |
| 17 | Treadmill Exercise Training Modulates Hepatic Cholesterol Metabolism and Circulating PCSK9 Concentration in High-Fat-Fed Mice显示文摘 | Shin Wen Kavita S. Jadhav David L. Williamson Todd C. Rideout Sampath Parthasarathy | 2013 | Journal of Lipids2013，，： | 1 |
| 18 | Melody Valve Implantation Into the Branch Pulmonary Arteries for Treatment of Pulmonary Insufficiency in an Ovine Model of Right Ventricular Outflow Tract Dysfunction Following Tetralogy of Fallot Repair显示文摘 | J. Daniel Robb Matthew A. Harris Masahito Minakawa Evelio Rodriguez Kevin J. Koomalsingh Takashi Shuto David C. Shin Yoav Dori Andrew C. Glatz Jonathan J. Rome Robert C. Gorman Joseph H. Gorman Matthew J. Gillespie | 2011 | Circulation: Cardiovascular Interventions2011，，1： | 1 |
| 19 | Flockhart effect of antipsychotic drugs on human liver cytochrome P-450(CYP) isoforms in vitro:preferential inhibition of CYP2D6显示文摘 | Nadia Soukhova David A | 1999 | Drug Metabolism and Disposition1999，27，9： | 1 |
| 20 | Sevoflurane blocks cholinergic synaptic transmission postsynaptically but does not affect short-term potentiation 显示文摘 | Hiroaki N Shin O David P | 2005 | Anesthesiology2005，102，5： | 1 |
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