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| 1 | Characterization and assessment of volatile organic compounds (VOCs) emissions from typical industries显示文摘VOCs play an increasingly important role in affecting air quality and threatening human health in China in recent years,where industry activities show a significant contribution to VOCs emission.In this article we report our long term study of industrial VOCs emissions of six major industries (vehicle manufacturing,printing,equipment coating,electronic manufacturing,furniture manufacturing and bio-pharming) on the aspects of emission characteristics,environmental impact and health risk assessment,and control challenge analysis with the purpose to obtain in-depth understanding of industry VOCs emissions and offer some original basements for national control and management of industry VOCs emissions.This study shows that all these industries give middle or low emission with total VOCs concentration less than 1000 mg/m3 at each exhaust pipe.Benzenes,esters,alcohols,ketones,alkanes,chloroalkanes and alkenes were detected as the major emission components and the most frequently monitored VOCs were benzenes,which varied obviously with different processes and industries.The environmental impact assessments indicate that vehicle manufacturing and benzenes should be prior controlled with the purpose to reduce air pollution.While,health risk assessments suggest that furniture manufacturing and chloroalkanes should be firstly controlled.Control analysis indicates that developing technologies with low cost and high efficiency and establishing and completing specific industry emission standards/regulations are the two key issues in VOCs emission management at present stage. | WANG HaiLin NIE Lie LI Jing WANG YuFei WANG Gang WANG JunHui HAO ZhengPing | 2013 | Science China(Technological Sciences)2013，56，3： | 60 |
| 2 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of ischaemic cerebrovascular diseases显示文摘Aim Stroke is the leading cause of disability and death in China.Ischaemic stroke accounts for about 60%-80%of all strokes.It is of considerable significance to carry out multidimensional management of ischaemic cerebrovascular diseases.This evidence-based guideline aims to provide the latest detailed and comprehensive recommendations on the diagnosis,treatment and secondary prevention of ischaemic cerebrovascular diseases.Methods We had performed comprehensive searches of MEDLINE(via PubMed)(before 30 June 2019),and integrated the relevant information into charts and distributed to the writing group.Writing group members discussed and determined the recommendations through teleconference.We used the level of evidence grading algorithm of Chinese Stroke Association to grade each recommendation.The draft was reviewed by the Guideline Writing Committee of Chinese Stroke Association Stroke and finalised.This guideline is fully updated every 3 years.results This evidence-based guideline is based on the treatment,care and prevention of ischaemic cerebrovascular diseases,which emphasises on pathogenesis evaluation,intravenous thrombolysis,endovascular therapy,antiplatelet therapy,prevention and treatment of complications,and risk factor management.Conclusions This updated guideline presents a framework for the management of ischaemic cerebrovascular diseases.Timely first-aid measures,professional care in the acute stage,and proactive secondary prevention will be helpful to patients. | Liping Liu Weiqi Chen Hongyu Zhou Wanying Duan Shujuan Li Xiaochuan Huo Weihai Xu Li'an Huang Huaguang Zheng Jingyi Liu Hui Liu Yufei Wei Jie Xu Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 42 |
| 3 | Analysis of emergy-based metabolic efficiency and environmental pressure on the local coupling and telecoupling between urbanization and the eco-environment in the Beijing-Tianjin-Hebei urban agglomeration显示文摘We use emergy-based urban metabolism analysis in this study to investigate the local coupling and telecoupling between urbanization and the eco-environment in the Beijing-Tianjin-Hebei urban agglomeration. Our analysis encompasses the last 35 years spanning the period between 1980 and 2014. In addition, we analyze urban metabolic efficiency and environmental pressure in these couplings. There are three main conclusions of this study. First, we show that the total metabolic emergy value of the Beijing-Tianjin-Hebei urban agglomeration has increased over the last 35 years, and that external elements have replaced internal ones as the leading contributors to urban metabolism in this region. The proportion of metabolic emergy derived from external elements increased from 30.87% in 1980 to 67.43% in 2014. The emergy extroversion ratio has continued to increase over our study period, while the development of this urban agglomeration had become progressively and more heavily reliant on external elements. Second, over the study period, the metabolic emergy intensity of elements of local coupling and telecoupling in the Beijing-Tianjin-Hebei urban agglomeration has declined at an accelerating rate, from 1.15×10^(21) Sej/100 million RMB in1980 to 9.69×10^(19) Sej/100 million RMB in 2014. This reflects a continuous increase in the economic efficiency of this area.Correspondingly, emergy use per capita increased from 7.8×10^(15) Sej/person in 1980 to 5.83×10^(16) Sej/person in 2014, suggesting a gradual rise in the level of social welfare in this urban agglomeration. However, we also observed a consistently elevated environmental loading ratio(ELR) in our analysis in terms of metabolism of local coupling and telecoupling elements. This result indicates that environmental pressure has also increased constantly within the Beijing-Tianjin-Hebei urban agglomeration. Third,our analysis shows that the ELR of metabolic emergy from internal elements increased from 8.30 in 1980 to 43.46 in 2014, while the ratio from external elements increased from 4.15 to 92.03. Thus, we quantitatively investigated the dependency of development within this urban agglomeration on external elements as well as the resultant environmental load. The conclusions of this study provide the basis for quantitative policy-making in the Beijing-Tianjin-Hebei region, optimizing economic structures, improving economic efficiency, controlling environmental pollution, and promoting the coordinated development of this region. | FANG ChuangLin REN YuFei | 2017 | Science China Earth Sciences2017，60，6： | 22 |
| 4 | Quality Markers of Traditional Chinese Medicine:Concept,Progress,and Perspective显示文摘As the most important complementary medication against a variety of diseases,traditional Chinese medicines(TCMs)have been extensively applied over thousands of years.Current quality control of herbal medicines,however,is in great dispute.Unlike chemical drugs,which have clear and validated quality standards,the content of only one(or a few)compounds of many herbs and preparations is currently assessed as an indicator of quality,even though the assessed compound(s)is neither closely associated with the efficacy nor representative of the medicine as a whole.Based on the clinical use,compatibility of multiple component prescriptions,and manufacturing process of TCM,the new concept of a TCM quality marker that was proposed in previous work is discussed further here.In addition,practical technological approaches are described for the qualitative analysis and quantification of TCMs including herbs,processed products,and preparations,which lead to the discovery and identification of specific chemicals as quality markers and new quality control patterns.The progress that has been made in TCM quality control is also addressed.This work provides useful information for the quality control of herbal medicines in the future. | Yazhuo Li Ying Xie Yufei He Wenbin Hou Maoliang Liao Changxiao Liu | 2019 | Engineering2019，5，5： | 22 |
| 5 | Smart Manufacturing and Intelligent Manufacturing:A Comparative Review显示文摘The application of intelligence to manufacturing has emerged as a compelling topic for researchers and industries around the world.However,different terminologies,namely smart manufacturing(SM)and intelligent manufacturing(IM),have been applied to what may be broadly characterized as a similar paradigm by some researchers and practitioners.While SM and IM are similar,they are not identical.From an evolutionary perspective,there has been little consideration on whether the definition,thought,connotation,and technical development of the concepts of SM or IM are consistent in the literature.To address this gap,the work performs a qualitative and quantitative investigation of research literature to systematically compare inherent differences of SM and IM and clarify the relationship between SM and IM.A bibliometric analysis of publication sources,annual publication numbers,keyword frequency,and top regions of research and development establishes the scope and trends of the currently presented research.Critical topics discussed include origin,definitions,evolutionary path,and key technologies of SM and IM.The implementation architecture,standards,and national focus are also discussed.In this work,a basis to understand SM and IM is provided,which is increasingly important because the trend to merge both terminologies rises in Industry 4.0 as intelligence is being rapidly applied to modern manufacturing and human–cyber–physical systems. | Baicun Wang Fei Tao Xudong Fang Chao Liu Yufei Liu Theodor Freiheit | 2021 | Engineering2021，7，6： | 22 |
| 6 | Attitude tracking control for variable structure near space vehicles based on switched nonlinear systems显示文摘An adaptive robust attitude tracking control law based on switched nonlinear systems is presented for a variable structure near space vehicle (VSNSV) in the presence of uncertainties and disturbances. The adaptive fuzzy systems are employed for approximating unknown functions in the flight dynamic model and their parameters are updated online. To improve the flight robust performance, robust controllers with adaptive gains are designed to compensate for the approximation errors and thus they have less design conservation. Moreover, a systematic procedure is developed for the synthesis of adaptive fuzzy dynamic surface control (DSC) approach. According to the common Lyapunov function theory, it is proved that all signals of the closed-loop system are uniformly ultimately bounded by the continuous controller. The simulation results demonstrate the effectiveness and robustness of the proposed control scheme. | Wang Yufei Jiang Changsheng Wu Qingxian | 2013 | Chinese Journal of Aeronautics2013，26，1： | 21 |
| 7 | Fegeneration of functional alveoli by adult human SOX9^+ airway basal cell transplantation显示文摘 | Qiwang Ma Yu Ma Xiaotian Dai Tao Ren Yingjie Fu Wenbin Liu Yufei Han Yingchuan Wu Yu Cheng Ting Zhang Wei Zuo | 2018 | Protein & Cell2018，9，3： | 20 |
| 8 | Tapped Inductor Quasi-Z-source Inverters显示文摘提出一种高升压比的单级升压逆变器,它在传统准z源逆变器拓扑中引入抽头电感无源网络,因此称为“抽头电感准z源逆变器”(tapped inductor quasi-Z-source inverter,TL-qZSI)。该抽头电感无源网络包括一个抽头电感和两个二极管,替代了原准Z源逆变器中的一个电感。类似于抽头电感Z源逆变器(tapped inductor Z-source inverter,TL-ZSI),所提出的逆变器也能提供高升压能力,但比TL-ZSI略低些。分析电路的工作机理、升压能力和控制策略,讨论设计上的考虑。最后通过基于简单升压控制方法的实验结果验证该拓扑的实际性能。 | ZHOU Yufei HUANG Wenxin ZHAO Jianwu ZHAO Ping | 2012 | 中国电机工程学报2012，32，27： | 17 |
| 9 | Plant pattern-recognition receptors controlling innate immunity显示文摘Plants are exposed to numerous potential pathogenic microbes. To counter the threat, plants have evolved diverse patternrecognition receptors(PRRs), which are receptor kinases(RKs) and receptor proteins(RPs) specialized to detect conserved pathogen/microbe-associated molecular patterns(PAMPs/MAMPs). Although only a handful of RKs and RPs are known PRRs,they belong to the receptor-like kinase(RLK) and receptor-like protein(RLP) superfamilies that undergo lineage-specific expansion, suggesting that many of these RLKs and RLPs are potential PRRs. Analyses of existing PRRs have uncovered ligand-induced RLK-RK or RLK-RP oligomerization as a common mechanism for immune activation. PRRs can recruit additional components to form dynamic receptor complexes, which mediate specific cellular responses. Detailed analyses of these components are shedding light on molecular mechanisms underlying the regulation of PRR activity and downstream signaling. | Lei Li Yufei Yu Zhaoyang Zhou Jian-Min Zhou | 2016 | Science China(Life Sciences)2016，59，9： | 16 |
| 10 | Simultaneous mineralization of CO_2 and recovery of soluble potassium using earth-abundant potassium feldspar显示文摘CO2 capture and storage(CCS) is an important strategy in combatting anthropogenic climate change.However,commercial application of the CCS technique is currently hampered by its high energy expenditure and costs.To overcome this issue,CO2 capture and utilization(CCU) is a promising CO2 disposal method.We,for the first time,developed a promising method to mineralize CO2 using earth-abundant potassium feldspar in order to effectively reduce CO2 emissions.Our experiments demonstrate that,after adding calcium chloride hexahydrate as an additive,the K-feldspar can be transformed to Ca-silicates at 800 C,which can easily mineralize CO2 to form stable calcium carbonate and recover soluble potassium.The conversion of this process reached 84.7%.With further study,the pretreatment temperature can be reduced to 250 C using hydrothermal method by adding the solution of triethanolamine(TEA).The highest conversion can be reached 40.1%.The process of simultaneous mineralization of CO2 and recovery of soluble potassium can be easily implemented in practice and may provide an economically feasible way to tackle global anthropogenic climate change. | XIE HePing WANG YuFei JU Yang LIANG Bin ZHU JiaHua ZHANG Ru XIE LingZhi LIU Tao ZHOU XiangGe ZENG HongMei LI Chun LU HouFang | 2013 | Chinese Science Bulletin2013，58，1： | 16 |
| 11 | The CAMS Climate System Model and a Basic Evaluation of Its Climatology and Climate Variability Simulation显示文摘A new coupled climate system model(CSM) has been developed at the Chinese Academy of Meteorological Sciences(CAMS) by employing several state-of-the-art component models. The coupled CAMS-CSM consists of the modified atmospheric model [ECmwf-HAMburg(ECHAM5)], ocean model [Modular Ocean Model(MOM4)], sea ice model [Sea Ice Simulator(SIS)], and land surface model [Common Land Model(CoLM)]. A detailed model description is presented and both the pre-industrial and 'historical' simulations are preliminarily evaluated in this study.The model can reproduce the climatological mean states and seasonal cycles of the major climate system quantities,including the sea surface temperature, precipitation, sea ice extent, and the equatorial thermocline. The major climate variability modes are also reasonably captured by the CAMS-CSM, such as the Madden–Julian Oscillation(MJO), El Ni?o–Southern Oscillation(ENSO), East Asian Summer Monsoon(EASM), and Pacific Decadal Oscillation(PDO).The model shows a promising ability to simulate the EASM variability and the ENSO–EASM relationship. Some biases still exist, such as the false double-intertropical convergence zone(ITCZ) in the annual mean precipitation field,the overestimated ENSO amplitude, and the weakened Bjerknes feedback associated with ENSO; and thus the CAMS-CSM needs further improvements. | Xinyao RONG Jian LI Haoming CHEN Yufei XIN Jingzhi SU Lijuan HUA Tianjun ZHOU Yanjun QI Zhengqiu ZHANG Guo ZHANG Jianduo LI | 2018 | Journal of Meteorological Research2018，32，6： | 15 |
| 12 | COL4A3 mutations cause focal segmenta glomerulosclerosis显示文摘 | Jingyuan Xie Xiaoxi Wu Hong Ren Weiming Wang Zhaohui Wang Xiaoxia Pan Xu Hao Jun Tong Jun Ma Zhibin Ye Guoyu Meng Yufei Zhu Krzysztof Kiryluk Xiangyin Kong Landian Hu Nan Chen | 2014 | Journal of Molecular Cell Biology2014，8，6： | 15 |
| 13 | SIS accuracy and service performance of the BDS-3 basic system显示文摘On December 27,2018,the basic system of the third-generation BeiDou navigation satellite system(BDS-3)completed the deployment of its constellation of 18 MEO networking satellites as well as the construction of the operation control system(OCS)and began to provide basic navigation services to users worldwide.Compared with BDS-2,BDS-3 aims to offer users better navigation signals and higher precision with a series of new technologies.For example,the spaceborne atomic clock of BDS-3 is upgraded for higher performance,the Ka-band inter-satellite link is adopted for inter-satellite ranging and communication,and new B1C and B2a signals are broadcast in addition to B1I and B3I signals(compatible with BDS-2).In addition,a 9-parameter model based on a spherical harmonic function is employed for ionospheric delay corrections.Using the observation data from 18 satellites of the basic system,this paper conducts a comprehensive evaluation of the pseudorange measurement characteristics,signal-in-space(SIS)accuracy of navigation messages and global service capability of BDS-3.The results indicate that the pseudorange measurement multipath effect and observation noise of BDS-3 satellites are better than those of BDS-2;additionally,with the support of inter-satellite links,the user range error(URE)of the BDS-3 satellite broadcast ephemeris is better than 10 cm,the precision of the broadcast clock parameter is better than 1.5 ns,and the SIS accuracy is better than 0.6 m overall.Different from the traditional Klobuchar model,the BeiDou global broadcast ionospheric delay correction model(BDGIM)can provide ionospheric delay corrections better than 70%for worldwide single-frequency users.The service capability evaluation of the basic system consists mainly of the accuracy improvement of the B1I and B3I signals according to BDS-2 as well as the global positioning accuracy of the new signals.These results prove that the BDS-3 basic system has achieved the design goal;that is,both the horizontal and the vertical global positioning accuracies are better than 10 m(95%).In the future,6 MEO satellites as well as 3 GEO satellites and 3 IGSO satellites for regional enhancement purposes will be deployed for full operation;consequently,BDS-3 will definitely provide a higher SIS accuracy and better service capability. | JinPing Chen XiaoGong Hu ChengPan Tang ShanShi Zhou YuFei Yang JunYang Pan Hui Ren YueXin Ma QiuNing Tian Bin Wu Yang Yu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，6： | 14 |
| 14 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 15 | Responses of Saline Soil Properties and Cotton Growth to Different Organic Amendments显示文摘Application of organic waste to saline alkaline soils is considered to be a good practice for soil remediation. The effects of applying different organic amendments(e.g., cattle dung, vermicompost, biofertilizer) and earthworm inoculations(Eisenia fetida) on saline soils and cotton growth were investigated during 1 year of cotton cultivation. Compared to the control(applied with inorganic NPK fertilizer), applying organic amendments improved soil physicochemical properties. Biofertilizer application improved available nutrient content, reduced short-term soil electrical conductivity, and produced the highest cotton yield, whereas cattle dung and vermicompost applications resulted in higher soil organic matter content. Application of organic amendments significantly increased soil microbial biomass carbon during the flowering period, which sharply declined at harvest. This was especially true for the biofertilizer treatment,which also exhibited lower nematode abundance compared with the other organic materials. Earthworm inoculation following cattle dung application failed to significantly change soil physicochemical properties when compared to the treatments without earthworm inoculation. Results suggest that biofertilizer application to saline soil would improve soil nutrient status in the short-term, whereas cattle dung application would improve soil organic matter content and increase soil organism abundance to a greater extent. However,different strategies might be required for long-term saline soil remediation. | WU Yupeng LI Yufei ZHANG Yi BI Yanmeng SUN Zhenjun | 2018 | Pedosphere2018，28，3： | 13 |
| 16 | A Soft Bionic Gripper with Variable Effective Length显示文摘 | Yufei Hao Zheyuan Gong Zhexin Xie Shaoya Guan Xingbang Yang Tianmiao Wang Li Wen | 2018 | Journal of Bionic Engineering2018，15，2： | 12 |
| 17 | Scientific and Engineering Progress in CO_2 Minerali zation Using Industrial Waste and Natural Minerals显示文摘The issues of reducing CO_2 levels in the atmo-sphere, sustainably utilizing natural mineral resources,and dealing with indus trial waste offer challenging opportunities for sustainable development in energy and the environment. The latest advances in CO_2 mineralization technology involving natural minerals and industrial waste are summarized in this paper, with great emphasis on the advancement of fundamental science, economic evaluation, and engineering applications. We discuss several lead-ing large-scale CO_2 mineralization methodologies from a techn ical and engineering-science perspective. For each technology option, we give an overview of the technical parameters, reaction pathway, reactivity, procedural scheme, and laboratorial and pilot devices. Furthermore, we present a discussion of each technology based on experimental results and the literature. Finally, current gaps in knowledge are identified in the conclusion, and an overview of the challenges and opportunities for future research in this field is provided. | Heping Xie Hairong Yue Jiahua Zhu Bin Liang Chun Li Yufei Wang Lingzhi Xie Xiangge Zhou | 2015 | Engineering2015，1，1： | 12 |
| 18 | Climate Sensitivity and Feedbacks of a New Coupled Model CAMS-CSM to Idealized CO_2 Forcing: A Comparison with CMIP5 Models显示文摘Climate sensitivity and feedbacks are basic and important metrics to a climate system. They determine how large surface air temperature will increase under CO_2 forcing ultimately, which is essential for carbon reduction policies to achieve a specific warming target. In this study, these metrics are analyzed in a climate system model newly developed by the Chinese Academy of Meteorological Sciences(CAMS-CSM) and compared with multi-model results from the Coupled Model Comparison Project phase 5(CMIP5). Based on two idealized CO_2 forcing scenarios, i.e.,abruptly quadrupled CO_2 and CO_2 increasing 1% per year, the equilibrium climate sensitivity(ECS) and transient climate response(TCR) in CAMS-CSM are estimated to be about 2.27 and 1.88 K, respectively. The ECS is near the lower bound of CMIP5 models whereas the TCR is closer to the multi-model ensemble mean(MME) of CMIP5 due to compensation of a relatively low ocean heat uptake(OHU) efficiency. The low ECS is caused by an unusually negative climate feedback in CAMS-CSM, which is attributed to cloud shortwave feedback(λSWCL) over the tropical Indo-Pacific Ocean.The CMIP5 ensemble shows that more negative λSWCL is related to larger increase in low-level(925–700 hPa)cloud over the tropical Indo-Pacific under warming, which can explain about 90% of λSWCL in CAMS-CSM. Static stability of planetary boundary layer in the pre-industrial simulation is a critical factor controlling the low-cloud response and λSWCL across the CMIP5 models and CAMS-CSM. Evidently, weak stability in CAMS-CSM favors lowcloud formation under warming due to increased low-level convergence and relative humidity, with the help of enhanced evaporation from the warming tropical Pacific. Consequently, cloud liquid water increases, amplifying cloud albedo, and eventually contributing to the unusually negative λSWCL and low ECS in CAMS-CSM. Moreover, the OHU may influence climate feedbacks and then the ECS by modulating regional sea surface temperature responses. | Xiaolong CHEN Zhun GUO Tianjun ZHOU Jian LI Xinyao RONG Yufei XIN Haoming CHEN Jingzhi SU | 2019 | Journal of Meteorological Research2019，33，1： | 11 |
| 19 | Drag prediction method of powered-on civil aircraft based on thrust drag bookkeeping显示文摘A drag prediction method based on thrust drag bookkeeping(TDB) is introduced for civil jet propulsion/airframe integration performance analysis.The method is derived from the control volume theory of a powered-on nacelle.Key problem of the TDB is identified to be accurate prediction of velocity coefficient of the powered-on nacelle.Accuracy of CFD solver is validated by test cases of the first AIAA Propulsion Aerodynamics Workshop.Then the TDB method is applied to thrust and drag decomposing of a realistic aircraft.A linear relation between the computations assumed free stream Mach number and the velocity coefficient result is revealed.The thrust losses caused by nozzle internal drag and pylon scrubbing are obtained by the isolated nacelle and mapped on to the in-flight whole configuration analysis.Effects of the powered-on condition are investigated by comparing through-flow configuration with powered-on configuration.The variance on aerodynamic coefficients and pressure distribution is numerically studied. | Zhang Yufei Chen Haixin Fu Song Zhang Miao Zhang Meihong | 2015 | Chinese Journal of Aeronautics2015，28，4： | 11 |
| 20 | Wasserstein GAN-Based Small-Sample Augmentation for New-Generation Artificial Intelligence: A Case Study of Cancer-Staging Data in Biology显示文摘It is essential to utilize deep-learning algorithms based on big data for the implementation of the new generation of artificial intelligence. Effective utilization of deep learning relies considerably on the number of labeled samples, which restricts the application of deep learning in an environment with a small sample size. In this paper, we propose an approach based on a generative adversarial network (GAN) combined with a deep neural network (DNN). First, the original samples were divided into a training set and a test set. The GAN was trained with the training set to generate synthetic sample data, which enlarged the training set. Next, the DNN classifier was trained with the synthetic samples. Finally, the classifier was tested with the test set, and the effectiveness of the approach for multi-classification with a small sample size was validated by the indicators. As an empirical case, the approach was then applied to identify the stages of cancers with a small labeled sample size. The experimental results verified that the proposed approach achieved a greater accuracy than traditional methods. This research was an attempt to transform the classical statistical machine-learning classification method based on original samples into a deep-learning classification method based on data augmentation. The use of this approach will contribute to an expansion of application scenarios for the new generation of artificial intelligence based on deep learning, and to an increase in application effectiveness. This research is also expected to contribute to the comprehensive promotion of new-generation artificial intelligence. | Yufei Liu Yuan Zhou Xin Liu Fang Dong Chang Wang Zihong Wang | 2019 | Engineering2019，5，1： | 11 |
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