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| 1 | Nature:骨髓微环境发生突变可导致造血干细胞异常显示文摘白血病骨髓微环境中支持血液发育的某些DNA突变可以驱动周围造血干细胞形成白血病,来自艾默里大学温希普癌症研究所和亚特兰大儿童健康中心的研究人员在国际学术期刊Nature上公布了他们的最新研究进展。许多致癌突变都作用于细胞自身。让细胞自身生长更快。相比之下,努南综合征小鼠模型上可以观察到间接的邻近细胞效应,努南综合征是一种能够增加白血病患病风险的遗传紊乱。 | Lei Dong, Wen-Mei Yu, Hong Zheng, Melinda Pauly, Muxiang Zhou Cheng-Kui Qu Mignon L. Loh Silvia T. Bunting Gang Huang Hal E. Broxmeyer David T. Scadden | 2016 | 现代生物医学进展2016，16，35： | 18 |
| 2 | Polyoma virus nephropathy in kidney transplantation显示文摘BK virus(BKV) is a polyomavirus that is able to cause renal dysfunction in transplanted grafts via BK virusassociated nephritis(BKVAN).This condition was misdiagnosed in the past due to clinical and histopthological similarities with acute rejection.Due to the prevalence of the virus in the population,it is an important pathogen in this context,and so it is important to understand how this virus functions and its' relationship with the pathogenesis of BKVN.Screening for BKV often reveals viruria and/or viremia,which then manifests as BKVN,which can be asymptomatic or result in clinical features namely renal dysfunction.The pathogenesis of BKV infection is still unclear and needs to be further investigated; nevertheless there are a variety of hypotheses that indicate that there are a host of factors that play important roles.Treatments for BKVAN include a reduction in immunosuppression,the use of antiviral therapy or the combination of both treatment options. | Jacob RW Scadden Adnan Sharif Kassi Skordilis Richard Borrows | 2017 | World Journal of Transplantation2017，7，6： | 5 |
| 3 | Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo显示文摘 | Heather E. Fleming Viktor Janzen Cristina Lo Celso Jun Guo Kathleen M. Leahy Henry M. Kronenberg David T. Scadden | 2008 | Cell Stem Cell2008，，3： | 2 |
| 4 | Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration显示文摘 | Dongsu Park Joel A. Spencer Bong Ihn Koh Tatsuya Kobayashi Joji Fujisaki Thomas L. Clemens Charles P. Lin Henry M. Kronenberg David T. Scadden | 2012 | Cell Stem Cell2012，，3： | 2 |
| 5 | SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin显示文摘 | Petra Simic Kayvan Zainabadi Eric Bell David B. Sykes Borja Saez Sutada Lotinun Roland Baron David Scadden Ernestina Schipani Leonard Guarente | 2013 | EMBO Mol Med2013，，3： | 2 |
| 6 | The stem-cell niche as an entity of action 显示文摘 | Scadden DT | 2006 | Nature2006，441，7097： | 1 |
| 7 | Prospects for stem cell-based thera-py显示文摘 | Daley G Q Scadden D T | | 0，，04： | 1 |
| 8 | Stem-cell ecology and stem cells in motion显示文摘 | Papayannopoulou T Scadden DT | 2008 | Blood2008，111，8： | 1 |
| 9 | The leukemicstem cell niche : current concepts and therapeuticopportunities显示文摘 | Lane S W Scadden DT Gilliland DG | 2009 | Blood2009，114，6： | 1 |
| 10 | The stem-cell niche as an entity of action显示文摘 | Scadden DT | 2006 | Nature2006，441，7097： | 1 |
| 11 | Cancer stem cells refined显示文摘 | Scadden D T | 2004 | Nat Immunol2004，5，： | 1 |
| 12 | The bone marrow at the crossroads of blood and immunity显示文摘 | Mercier F E Ragu C Scadden D T | 2012 | Nat Rev Immunol2012，12，1： | 1 |
| 13 | Biomimetic Platforms for Human Stem Cell Research显示文摘 | Gordana Vunjak-Novakovic David T. Scadden | 2011 | Cell Stem Cell2011，，3： | 1 |
| 14 | Haematological aspects of HIV infection显示文摘 | EVANS R H SCADDEN D T | 2000 | Baillieres Best Pract Res Clin Haematol2000，13，2： | 1 |
| 15 | Intramedullary fixation of Neer type 2 fractures of the distal clavicle with an AO/ASIF screw显示文摘 | JE Scadden R Richards | 2005 | Injyry2005，36，10： | 1 |
| 16 | Nervous activity in a stem cell niche显示文摘 | Larsson J Scadden D | 2006 | Cell2006，124，2： | 1 |
| 17 | The bone marrow niche for hematopoietic stem cells显示文摘 | MorrisonSJ Scadden DT | 2014 | Nature2014，505，7483： | 1 |
| 18 | Ex vivo targeting of p21 Cipl/Wafl permits relative expansion of human hematopoietic stem cells 显示文摘 | Dombkowski DM Zhang JL Scadden DT | 2003 | Blood2003，102，4： | 1 |
| 19 | Stem-cel ecology and stem cel s in motion显示文摘 | Papayannopoulou T Scadden DT | | 0，，08： | 1 |
| 20 | In vivo and in vitro effects of a novel anti-Dkk1 neutralizing antibody in multiple myeloma显示文摘 | Samantha Pozzi Mariateresa Fulciniti Hua Yan Sonia Vallet Homare Eda Kishan Patel Loredana Santo Diana Cirstea Teru Hideshima Linda Schirtzinge Stuart Kuhstoss Kenneth C. Anderson Nikhil Munshi David Scadden Henry M. Kronenberg Noopur Raje | 2013 | Bone2013，，2： | 1 |
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