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| 1 | Removal of diminutive colorectal polyps: A prospective randomized clinical trial between cold snare polypectomy and hot forceps biopsy显示文摘AIM To compare the efficacy and safety of cold snare polypectomy(CSP) and hot forceps biopsy(HFB) for diminutive colorectal polyps.METHODS This prospective, randomized single-center clinical trial included consecutive patients ≥ 20 years of age with diminutive colorectal polyps 3-5 mm from December 2014 to October 2015. The primary outcome measures were en-bloc resection(endoscopic evaluation) and complete resection rates(pathological evaluation). The secondary outcome measures were the immediate bleeding or immediate perforation rate after polypectomy, delayed bleeding or delayed perforation rate after polypectomy, use of clipping for bleeding or perforation, and polyp retrieval rate. Prophylactic clipping after polyp removal wasn't routinely performed.RESULTS Two hundred eight patients were randomized into the CSP(102), HFB(106) and 283 polyps were evaluated(CSP: 148, HFB: 135). The en-bloc resection rate was significantly higher with CSP than with HFB [99.3%(147/148) vs 80.0%(108/135), P < 0.0001]. The complete resection rate was significantly higher with CSP than with HFB [80.4%(119/148) vs 47.4%(64/135), P < 0.0001]. The immediate bleeding rate was similar between the groups [8.6%(13/148) vs 8.1%(11/135), P = 1.000], and endoscopic hemostasis with hemoclips was successful in all cases. No cases of perforation or delayed bleeding occurred. The rate of severe tissue injury to the pathological specimen was higher HFB than CSP [52.6%(71/135) vs 1.3%(2/148), P < 0.0001]. Polyp retrieval failure was encountered CSP(7), HFB(2).CONCLUSION CSP is more effective than HFB for resecting diminutive polyps. Further long-term follow-up study is required. | Yoriaki Komeda Hiroshi Kashida Toshiharu Sakurai George Tribonias Kazuki Okamoto Masashi Kono Mitsunari Yamada Teppei Adachi Hiromasa Mine Tomoyuki Nagai Yutaka Asakuma Satoru Hagiwara Shigenaga Matsui Tomohiro Watanabe Masayuki Kitano Takaaki Chikugo Yasutaka Chiba Masatoshi Kudo | 2017 | World Journal of Gastroenterology2017，23，2： | 20 |
| 2 | Efficacy of treatment with rebamipide for endoscopic submucosal dissection-induced ulcers显示文摘AIM:To prospectively compare the healing rates of endoscopic submucosal dissection(ESD)-induced ulcers treated with either a proton-pump inhibitor(PPI)or rebamipide.METHODS:We examined 90 patients with early gastric cancer who had undergone ESD.All patients were administered an intravenous infusion of the PPI lansoprazole(20 mg)every 12 h for 2 d,followed by oral administration of lansoprazole(30 mg/d,5 d).After7-d treatment,the patients were randomly assigned to 2 groups and received either lansoprazole(30 mg/d orally,n=45;PPI group)or rebamipide(300 mg orally,three times a day;n=45;rebamipide group).At 4and 8 wk after ESD,the ulcer outcomes in the 2 groups were compared.RESULTS:No significant differences were noted in patient age,underlying disease,tumor location,Helicobacter pylori infection rate,or ESD-induced ulcersize between the 2 groups.At both 4 and 8 wk,the healing rates of ESD-induced ulcers were similar in the PPI-treated and the rebamipide-treated patients(4 wk:PPI,27.2%;rebamipide,33.3%;P=0.5341;8 wk:PPI,90.9%;rebamipide,93.3%;P=0.6710).At 8 wk,the rates of granulation lesions following ulcer healing were significantly higher in the PPI-treated group(13.6%)than in the rebamipide-treated group(0.0%;P=0.0103).Ulcer-related symptoms were similar in the2 treatment groups at 8 wk.The medication cost of 8-wk treatment with the PPI was 10945 yen vs 4889 yen for rebamipide.No ulcer bleeding or complications due to the drugs were observed in either treatment group.CONCLUSION:The healing rate of ESD-induced ulcers was similar with rebamipide or PPI treatment;however,rebamipide treatment is more cost-effective and prevents granulation lesions following ulcer healing. | Masaki Takayama Shigenaga Matsui Masanori Kawasaki Yutaka Asakuma Toshiharu Sakurai Hiroshi Kashida Masatoshi Kudo | 2013 | World Journal of Gastroenterology2013，19，34： | 15 |
| 3 | Effective use of the Japan Narrow Band Imaging Expert Team classification based on diagnostic performance and confidence level显示文摘Five years have passed since the Japan Narrow Band Imaging Expert Team (JNET) classification was proposed in 2014. However, the diagnostic performance of this classification has not yet been established. We conducted a retrospective study and a systematic search of Medical Literature Analysis and Retrieval System On-Line. There were three retrospective single center studies about the diagnostic performance of this classification. In order to clarify this issue, we reviewed our study and three previous studies. This review revealed the diagnostic performance in regards to three important differentiations.(1) Neoplasia from non-neoplasia;(2) malignant neoplasia from benign neoplasia;and (3) deep submucosal invasive cancer (D-SMC) from other neoplasia. The sensitivity in differentiating neoplasia from non-neoplasia was 98.1%-99.8%. The specificity in differentiating malignant neoplasia from benign neoplasia was 84.7%-98.2% and the specificity in the differentiation D-SMC from other neoplasia was 99.8%-100.0%. This classification would enable endoscopists to identify almost all neoplasia, to appropriately determine whether to perform en bloc resection or not, and to avoid unnecessary surgery. This article is the first review about the diagnostic performance of the JNET classification. Previous reports about the diagnostic performance have all been retrospective single center studies. A large-scale prospective multicenter evaluation study is awaited for the validation. | Daizen Hirata Hiroshi Kashida Mineo Iwatate Tomomasa Tochio Akira Teramoto Yasushi Sano Masatoshi Kudo | 2019 | World Journal of Clinical Cases2019，7，18： | 6 |
| 4 | Risk factors for local recurrence and appropriate surveillance interval after endoscopic resection显示文摘BACKGROUND Risk factors for local recurrence after polypectomy, endoscopic mucosal resection(EMR), and endoscopic submucosal dissection(ESD) have not been identified.Additionally, the appropriate interval for endoscopic surveillance of colorectal tumors at high-risk of local recurrence has not been established.AIM To clarify the clinicopathological characteristics of recurrent lesions after endoscopic colorectal tumor resection and determine the appropriate interval.METHODS Three hundred and sixty patients(1412 colorectal tumors) who underwent polypectomy, EMR, or ESD and received endoscopic surveillance subsequently for more than one year to detect local recurrence were enrolled in this study. The clinicopathological factors associated with local recurrence were determined via univariate and multivariate analyses.RESULTS Local recurrence was observed in 31 of 360(8.6%) patients [31 of 1412(2.2%)lesions] after colorectal tumor resection. Piecemeal resection, tumor size of more than 2 cm, and the presence of villous components were associated with colorectal tumor recurrence after endoscopic resection. Of these three factors, the piecemeal resection procedure was identified as an independent risk factor for recurrence. Colorectal tumors resected into more than five pieces were associated with a high risk of recurrence since the average period from resection torecurrence in these cases was approximately 3 mo. The period to recurrence in cases resected into more than 5 pieces was much shorter than that in those resected into less than 4 pieces(3.8 ± 1.9 mo vs 7.9 ± 5.0 mo, P < 0.05).CONCLUSION Local recurrence of endoscopically treated colorectal tumors depends upon the outcome of first endoscopic procedure. Piecemeal resection was the only significant risk factor associated with local recurrence after endoscopic resection. | Yoriaki Komeda Tomohiro Watanabe Toshiharu Sakurai Masashi Kono Kazuki Okamoto Tomoyuki Nagai Mamoru Takenaka Satoru Hagiwara Shigenaga Matsui Naoshi Nishida Naoko Tsuji Hiroshi Kashida Masatoshi Kudo | 2019 | World Journal of Gastroenterology2019，25，12： | 4 |
| 5 | Nonpolypoid neoplastic lesions of the colorectal mucosa显示文摘 | Shin ei Kudo René Lambert John I. Allen Hiroaki Fujii Takahiro Fujii Hiroshi Kashida Takahisa Matsuda Masaki Mori Hiroshi Saito Tadakazu Shimoda Shinji Tanaka Hidenobu Watanabe Joseph J. Sung Andrew D. Feld John M. Inadomi Michael J. O’Brien David A. Lieb | 2008 | Gastrointestinal Endoscopy2008，，4： | 3 |
| 6 | JGES guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection显示文摘 | Shinji Tanaka Hiroshi Kashida Yutaka Saito Naohisa Yahagi Hiroo Yamano Shoichi Saito Takashi Hisabe Takashi Yao Masahiko Watanabe Masahiro Yoshida Shin‐ei Kudo Osamu Tsuruta Ken‐ichi Sugihara Toshiaki Watanabe Yusuke Saitoh Masahiro Igarashi Takashi Toyon | 2015 | Digestive Endoscopy2015，，4： | 2 |
| 7 | Dynamic fracture initiation in brittle materials under combined mode I /II loading显示文摘 | Nakano M Kashida K Yamauchi Y | 1994 | Journal De Physique IV1994，4，8： | 1 |
| 8 | lntracytoplasmic localization of cathepsin D reflects the invasive potential of gastric carcinoma显示文摘 | Kashida H Kawamata H Ichikawa K | 2001 | J Gastroenteorl2001，36，12： | 1 |
| 9 | Endoscopic diagnosis and treatment of earlycolorectal cancer显示文摘 | Kudo S Kashida H Nakajima T | 1997 | World J Surg1997，21，： | 1 |
| 10 | Colonoscopic diagnosis and management of nonpolypoid early eolorectal cancer 显示文摘 | Kudo S Kashida H Tamura T | 2000 | World J Surg2000，24，9： | 1 |
| 11 | Observation and treatment of small bowel diseases using single balloon endoscope 显示文摘 | Ohtsuka K Kashida H kodama k | 2008 | Gastrointest Endose2008，67，5： | 1 |
| 12 | Difference among angiotensin-converting enzyme inhibitors in potentiating effects on bradykinlin-induced microvasucular leakage in guinea pig airways显示文摘 | Murata T Matsumoto Y Kashida T | 1995 | Jpn J Pharmacol1995，69，1： | 1 |
| 13 | Expression of Bcl-2 and Bax in the human corpus luteum during the menstrual cycle and in early pregnancy:regulation by human chorionic gonadotropin显示文摘 | SUGINO N SUZUKI T KASHIDA S | 2000 | J Clin Endocrinol Metab2000，85，： | 1 |
| 14 | Virtual Histology of Colorectal Lesions Using Laser-Scanning Confocal Microscopy显示文摘 | M. Sakashita H. Inoue H. Kashida J. Tanaka J. Cho H. Satodate E. Hidaka T. Yoshida N. Fukami Y. Tamegai A. Shiokawa S. Kudo | 2003 | Endoscopy2003，，12： | 1 |
| 15 | Expression of cascular endothelial growth factor (VEGF) and its resceptors in human endometrium throughout the menstrual cycle and in early pregnancy 显示文摘 | SUGINO N KASHIDA S KARUBE-HARADA A | 2002 | Reproduction2002，123，5： | 1 |
| 16 | ExPression of vaseular endothelial growth factor and its recepteor in the human endometrium throughout menstrual cycle and in early pregnancy显示文摘 | Sugino N Kashida S Karabe Harada A | 2002 | ReProduc-tion2002，123，3： | 1 |
| 17 | Difference among angiotensin-converting enzyme inhibitors in potentiating effects on bradykinin-induced microvascular leakage in guinea pig airways显示文摘 | Murata T Matsumoto Y Kashida T | 1995 | Jpn J Pharmacol1995，69，： | 1 |
| 18 | Pit Pattern in Colorectal Neoplasia: Endoscopic Magnifying View显示文摘 | S. Kudo C. Rubino C. Teixeira H. Kashida E. Kogure | 2001 | Endoscopy2001，，04： | 1 |
| 19 | Regulation and role of vascular endothelial growth factor in the corpus luteum during mid-pregnancy in rats显示文摘 | Kashida S Sugino N Takiguchi S | 2001 | Biol Reprod2001，64，1： | 1 |
| 20 | Valence band photoemission study of the copper chalcogenide compounds,Cu2S,Cu2Se and Cu2Te显示文摘 | Kashida S Shimosaka W Mori M | 2003 | Journal of Physics and Chemistry of Solids2003，64，12： | 1 |
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