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| 1 | Significance of adverse outcome pathways in biomarker-based environmental risk assessment in aquatic organisms显示文摘In environmental risk assessments(ERA), biomarkers have been widely used as an early warning signal of environmental contamination. However, biomarker responses have limitation due to its low relevance to adverse outcomes(e.g., fluctuations in community structure, decreases in population size, and other similar ecobiologically relevant indicators of community structure and function). To mitigate these limitations, the concept of adverse outcome pathways(AOPs) was developed. An AOP is an analytical, sequentially progressive pathway that links a molecular initiating event(MIE) to an adverse outcome. Recently, AOPs have been recognized as a potential informational tool by which the implications of molecular biomarkers in ERA can be better understood. To demonstrate the utility of AOPs in biomarker-based ERA, here we discuss a series of three different biological repercussions caused by exposure to benzo(a)pyrene(Ba P), silver nanoparticles(Ag NPs), and selenium(Se). Using mainly aquatic invertebrates and selected vertebrates as model species, we focus on the development of the AOP concept. Aquatic organisms are suitable bioindicator species whose entire lifespans can be observed over a short period; moreover, these species can be studied on the molecular and population levels.Also, interspecific differences between aquatic organisms are important to consider in an AOP framework, since these differences are an integral part of the natural environment.The development of an environmental pollutant-mediated AOP may enable a better understanding of the effects of environmental pollutants in different scenarios in the diverse community of an ecosystem. | Jin Wuk Lee Eun-Ji Won Sheikh Raisuddin Jae-Seong Lee | 2015 | Journal of Environmental Sciences2015，27，9： | 7 |
| 2 | Pro-apoptotic effect of fly ash leachates in hepatocytes of freshwater fish ( Channa punctata Bloch)显示文摘 | Mehboob Ali Shakilur Rahman Hasibur Rehman Kanchan Bhatia Rizwan A. Ansari Sheikh Raisuddin | 2006 | Toxicology in Vitro2006，，1： | 1 |
| 3 | Beneficial effects of lamivudine in hepatitis B virus-related decompensated cirrhosis显示文摘 | Dharmesh Kapoor Rajkumar C Guptan Salma M Wakil Syed N Kazim Rachna Kaul Shri Ram Agarwal Sheikh Raisuddin Seyed E Hasnain Shiv K Sarin | 2000 | Journal of Hepatology2000，，2： | 1 |
| 4 | Beneficial effects of lamivudine in hepatitis B virus-related decompensated cirrhosis显示文摘 | Dharmesh Kapoor Rajkumar C Guptan Salma M Wakil Syed N Kazim Rachna Kaul Shri Ram Agarwal Sheikh Raisuddin Seyed E Hasnain Shiv K Sarin | 2000 | Journal of Hepatology2000，，2： | 1 |
| 5 | FoxO proteins’ nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells显示文摘 | Shatrunajay Shukla Fatima Rizvi Sheikh Raisuddin Poonam Kakkar | 2014 | Free Radical Biology and Medicine2014，，： | 1 |
| 6 | A corticotropin-releasing hormone binding protein ( CRH-BP ) gene from the intertidal copepod, Tigriopus japonicus显示文摘 | Kyun-Woo Lee Jae-Sung Rhee Sheikh Raisuddin Heum Gi Park Jae-Seong Lee | 2008 | General and Comparative Endocrinology2008，，1： | 1 |
| 7 | Molecular cloning, expression, biochemical characteristics, and biomarker potential of theta class glutathione S -transferase (GST-T) from the polychaete Neanthes succinea显示文摘 | Jae-Sung Rhee Young-Mi Lee Dae-Sik Hwang Eun-Ji Won Sheikh Raisuddin Kyung-Hoon Shin Jae-Seong Lee | 2007 | Aquatic Toxicology2007，，2： | 1 |
| 8 | In vivo cytogenetic and oxidative stress-inducing effects of cypermethrin in freshwater fish, Channa punctata Bloch显示文摘 | Rizwan A. Ansari Shakilur Rahman Manpreet Kaur Sameya Anjum Sheikh Raisuddin | 2010 | Ecotoxicology and Environmental Safety2010，，1： | 1 |
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