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| 1 | Inflammatory status in chronic renal failure: The role of homocysteinemia and pro-inflammatory cytokines显示文摘AIM: To evaluate determinants of inflammatory markers in chronic renal failure patients according to the level of glomerular filtration rate. METHODS: One hundred fifty four patients(Age; 44 ± 06 years, male/female; 66/88) with chronic renal failure(CRF) were divided into 6 groups according to the National Kidney Foundation(NKF) classification. They included 28 primary stage renal failure patients(CRF 1), 28 moderate stage renal failure patients(CRF 2),28 severe stage renal failure patients(CRF 3), 18 endstage renal failure patients(CRF 4), 40 hemodialysis(HD) patients, and 12 peritoneal dialysis(PD) patients. Tumor necrosis factor-α(TNF-α), interleukin-1β(IL-1β), interleukin-6(IL-6) and C-reactive protein(CRP) were analyzed by immunosorbent assay kit(ELISA)(Cayman Chemical's ACETM EIA kit). Immunoassay methods were used for total homocysteine(tH cy)(fluorescence polarization immunoanalysis HPLC, Perkin Emer 200 series), transferrin(MININEPHTM human transferin kit: ZK070.R), ferritin(ADVIA Centaur) and fibrinogen analysis(ACL 200). Differences between groups were performed using SPSS 20.0 and data are expressed as the mean ± SD.RESULTS: Results showed that in comparison with CRF 1 group and other groups, TNF-α and IL-6 levels were respectively more elevated in HD(16.38 ± 5.52 pg/mL vs 0.39 ± 0.03 pg/mL, 11.05 ± 3.59 pg/mL vs 8.20 ± 0.22 pg/mL, P < 0.001) and PD(14.04 ± 3.40 pg/m L vs 0.39 ± 0.03 pg/m L, 10.15 ± 1.66 pg/m L vs 8.20 ± 0.22 pg/m L, P < 0.001). IL-1β levels were increased in HD(9.63 ± 3.50 pg/m L vs 3.24 ± 0.10 pg/mL, P < 0.001) and CRF 4(7.76 ± 0.66 pg/mL vs 3.24 ± 0.10 pg/m L, P < 0.001) patients than in CRF 1 and in the other groups. Plasma t Hcy levels were higher in HD(32.27 ± 12.08 μmol/L) and PD(28.37 ± 4.98 μmol/L) patients compared to the other groups of CRF(P < 0.001). The serum CRP level was significantly increased in HD(18.17 ± 6.38 mg/L) and PD(17.97 ± 4.85 mg/L) patients compared to the other groups of CRF patients(P < 0.001). The plasma fibrinogen level was more elevated in HD(6.86 ± 1.06 g/L) and CRF 4(6.05 ± 0.57 g/L) than in the other groups(P < 0.001). Furthermore; the ferritin level was higher in HD(169.90 ± 62.16 ng/m L) and PD(90.08 ± 22.09 ng/m L) patients compared to the other groups of CRF(P < 0.001). The serum transferrin value was significantly decreased especially in PD(1.78 ± 0.21 g/L) compared to the other groups(P < 0.001). We found a negative correlationbetween glomerular filtration rate(GFR), TNF-α levels(r =-0.75, P < 0.001), and t Hcy levels(r =-0.68, P < 0.001). We observed a positive correlation between GFR and transferrin levels(r = 0.60, P < 0.001). CONCLUSION: CRF was associated with elevated inflammatory markers. The inflammation was observed at the severe stage of CRF and increases with progression of renal failure. | Hadja Fatima Tbahriti Djamel Meknassi Rachid Moussaoui Amar Messaoudi Lakhdar Zemour Abbou Kaddous Malika Bouchenak Khedidja Mekki | 2013 | World Journal of Nephrology2013，2，2： | 32 |
| 2 | Hepatitis B virus,HBx mutants and their role in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is one of the leading causes of death induced by cancer in the modern world and majority of the cases are related to chronic hepatitis B virus(HBV)infection.HBV-encoded X protein(HBx)is known to play a pivotal role in the pathogenesis of viral induced HCC.HBx is a multifunctional protein of17 kDa which modulates several cellular processes by direct or indirect interaction with a repertoire of host factors resulting in HCC.HBX might interfere with several cellular processes such as oxidative stress,DNA repair,signal transduction,transcription,protein degradation,cell cycle progression and apoptosis.A number of reports have indicated that HBx is one of the most common viral ORFs that is often integrated into the host genome and its sequence variants play a crucial role in HCC.By mutational or deletion analysis it was shown that carboxy terminal of HBx has a likely role in protein-protein interactions,transcriptional transactivation,DNA repair,cell,signaling and pathogenesis of HCC.The accumulated evidence thus far suggests that it is difficult to understand the mechanistic nature of HBx associated HCC,and HBx mediated transcriptional transactivation and signaling pathways may be a major determinant.This article addresses the role of HBx in the development of HCC with particular emphasis on HBx mutants and their putative targets. | Ashraf Ali Hany Abdel-Hafiz Mohd Suhail Amany Al-Mars Mohammad Khalid Zakaria Kaneez Fatima Sultan Ahmad Esam Azhar Adeel Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，30： | 29 |
| 3 | Nosocomial infections:Epidemiology,prevention,control and surveillance显示文摘Nosocomial infections or healthcare associated infections occur in patients under medical care.These infections occur worldwide both in developed and developing countries.Nosocomial infections accounts for 7% in developed and 10% in developing countries.As these infections occur during hospital stay,they cause prolonged stay,disability,and economic burden.Frequently prevalent infections include central line-associated bloodstream infections,catheter-associated urinary tract infections,surgical site infections and ventilator-associated pneumonia.Nosocomial pathogens include bacteria,viruses and fungal parasites.According to WHO estimates,approximately 15% of all hospitalized patients suffer from these infections.During hospitalization,patient is exposed to pathogens through different sources environment,healthcare staff,and other infected patients.Transmission of these infections should be restricted for prevention.Hospital waste serves as potential source of pathogens and about 20%–25% of hospital waste is termed as hazardous.Nosocomial infections can be controlled by practicing infection control programs,keep check on antimicrobial use and its resistance,adopting antibiotic control policy.Efficient surveillance system can play its part at national and international level.Efforts are required by all stakeholders to prevent and control nosocomial infections. | Hassan Ahmed Khan Fatima Kanwal Baig Riffat Mehboob | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，5： | 22 |
| 4 | Potential mechanisms of hepatitis B virus induced liver injury显示文摘Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma.The histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers.The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components.The viral and cellular factors that contribute to liver injury are discussed in this article.Liver injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and maintenance.The consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of nutrients.The identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury. | Mohd Suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，35： | 12 |
| 5 | Dickkopfs and Wnt/β-catenin signalling in liver cancer显示文摘Liver cancer is the fifth and seventh most common cause of cancer in men and women,respectively.Wnt/β-catenin signalling has emerged as a critical player in both the development of normal liver as well as an oncogenic driver in hepatocellular carcinoma(HCC).Based on the current understanding,this article summarizes the possible mechanisms for the aberrant activation of this pathway with specific focus on HCC.Furthermore,we will discuss the role of dickkopfs(DKKs)in regulating Wnt/β-catenin signalling,which is poorly understood and understudied.DKKs are a family of secreted proteins that comprise at least four members,namely DKK1-DKK4,which act as inhibitors of Wnt/β-catenin signalling.Nevertheless,not all members antagonize Wnt/β-catenin signalling.Their functional significance in hepatocarcinogenesis remains to be further characterized for which these studies should provide new insights into the regulatory role of DKKs in Wnt/β-catenin signalling in hepatic carcinogenesis.Because of the important oncogenic roles,there are an increasing number of therapeutic molecules targetingβ-catenin and the Wnt/β-catenin pathway for potential therapy of HCC. | Sarwat Fatima Nikki P Lee John M Luk | 2011 | World Journal of Clinical Oncology2011，2，8： | 11 |
| 6 | Influence of growth time on crystalline structure,conductivity and optical properties of ZnO thin films显示文摘This paper examines the growth of ZnO thin films on glass substrate at 350℃using an ultrasonic spray technique.We have investigated the influence of growth time ranging from 1 to 4 min on structural,optical and electrical properties of ZnO thin films.The as-grown films exhibit a hexagonal structure wurtzite and are(002) oriented.The maximum value of grain size G = 63.99 nm is attained for ZnO films grown at 2 min.The average transmittance is about 80%,thus the films are transparent in the visible region.The optical gap energy is found to increase from 3.26 to 3.37 eV with growth time increased from 1 to 2 min.The minimum value of electrical resistivity of the films is 0.13Ω·cm obtained at 2 min.A systematic study on the influence of growth time on the properties of ZnO thin films deposited by ultrasonic spray at 350℃has been reported. | Said Benramache Foued Chabane Boubaker Benhaoua Fatima Z.Lemmadi | 2013 | Journal of Semiconductors2013，34，2： | 9 |
| 7 | A Genome-Wide Scenario of Terpene Pathways in Self-pollinated Artemisia annua显示文摘到在 Artemisia annua 的代谢物的基因的情形仍然是 uninvestigated。这里,我们报导途径联合 metabolomics, transcriptomics,和基因功能分析在这种的一个 self-pollinating 变化描绘 gene-to-terpene 和萜烯小径情形的 anintegrated 的使用。包括 22 sesquiterpenes 的 88 代谢物(例如, artemisinin ) , 26 monoterpenes,二 triterpenes,一 diterpene 和 38 另外的非极的代谢物从 14 纸巾被识别。这些代谢物是叶子和花生产在的差别对更高的位置更低。从六纸巾的 cDNA 图书馆的序列被装配进 18871 contigsand 在纸巾的染色体宽的基因表示侧面强烈与发展阶段和空间特性被联系。顺序采矿识别了印射到 artemisinin 的 47 基因, non-amorphadiene sesquiterpene, monoterpene, triterpene, 2-C-methyl-D-erythritol 第 4-phosphatea 条 mevalonate 小径。皮尔森关联分析导致了同时在六纸巾描绘了 gene-to-gene 表示模式 andgene expression-to-metabolite 层次的重要关联的网络集成。更重要地, amorpha-4,11-diene synthasegene 表示的操作不仅向 artemisinin, artemisinic 酸,和 arteannuin b 影响了这条小径的活动而且改变了 non-amorphadiene sesquiterpene 和染色体宽的不稳定的侧面。与不同纸巾联系的如此的 gene-to-terpene 风景对 artemisinin 的新陈代谢的工程基本。 | Dong-Ming Ma Zhilong Wang Liangjiang Wang Fatima Alejos-Gonzales1 Ming-An Sun De-Yu Xie | 2015 | Molecular Plant2015，8，11： | 8 |
| 8 | Environmental cues determine the fate of astrocytes after spinal cord injury显示文摘Reactive astrogliosis occurs after central nervous system(CNS) injuries whereby resident astrocytes form rapid responses along a graded continuum. Following CNS lesions, na?ve astrocytes are converted into reactive astrocytes and eventually into scar-forming astrocytes that block axon regeneration and neural repair. It has been known for decades that scarring development and its related extracellular matrix molecules interfere with regeneration of injured axons after CNS injury, but the cellular and molecular mechanisms for controlling astrocytic scar formation and maintenance are not well known. Recent use of various genetic tools has made tremendous progress in better understanding genesis of reactive astrogliosis. Especially, the latest experiments demonstrate environment-dependent plasticity of reactive astrogliosis because reactive astrocytes isolated from injured spinal cord form scarring astrocytes when transplanted into injured spinal cord, but revert in retrograde to naive astrocytes when transplanted into naive spinal cord. The interactions between upregulated type I collagen and its receptor integrin β1 and the N-cadherin-mediated cell adhesion appear to play major roles for local astrogliosis around the lesion. This review centers on the environment-dependent plasticity of reactive astrogliosis after spinal cord injury and its potential as a therapeutic target. | Fatima M.Nathan Shuxin Li | 2017 | Neural Regeneration Research2017，12，12： | 8 |
| 9 | Relationship between Physical and Chemical Soil Attributes and Plant Species Diversity in Tropical Mountain Ecosystems from Brazil显示文摘Although the high diversity of plant species in the rupestrian fields has been primarily attributed to the existence of a set of distinct habitats, few studies support this assertion. The present study aimed to further investigate the relationship between physical and chemical attributes of soils with the diversity of plant species in this unique ecosystem. The rupestrian field is a unique vegetation formation that covers some of the southeastern Brazilian mountains in the transition of the Atlantic rain forest and the Cerrado(savanna). Different habitats occur according to soil characteristics(e.g., presence of rocks, sand, fertility, hydrology, etc.). These attributes ultimately influence the vegetation that is highly adapted to the harsh edaphic and climatic mountain conditions. Five distinct habitats were studied by us: rocky outcrops, peat bogs, sandy bogs, quartz gravel fields, and 'cerrado'(savanna). A floristic survey indicated that four families are found at greater frequency: Poaceae, Asteraceae, Cyperaceae, and Leguminosae. The greatest diversity of plant species was found in the rocky outcrops habitat, followed by cerrado, peat bog, quartz gravel grassland, and sandy bogs, respectively. The main difference in the floristic composition among these habitats was related to the dominant species. Trachypogon spicatus(Poaceae) was the most dominant species in the rocky outcrops, Axonopus siccus(Poaceae) in the peat bogs, Lagenocarpus rigidus(Cyperaceae) in the sandy bogs, Schizachyrium tenerum(Poaceae) in the cerrado, while Vellozia sp. 8(Velloziaceae) dominated the vegetation in the quartz gravel grassland. This study demonstrated that physical and chemical soil properties strongly related the diversity of plant species occurring in the different habitats of rupestrian fields. | Ferna de CARVALHO Edward Luis GODOY Francy J. G. LISBOA Fatima Maria de Souza MOREIRA Francisco Adriano de SOUZA Ricardo Luis Louro BERBARA G Wilson FERNES | 2014 | Journal of Mountain Science2014，11，4： | 7 |
| 10 | Synergistic Effects of Biochar and NPK Fertilizer on Soybean Yield in an Alkaline Soil显示文摘Biochar effects on legume growth and biological nitrogen fixation have been studied extensively, mostly in acidic soils with laboratory produced biochar. In the present study, a pot experiment in a full factorial experimental design was performed to examine soybean yield and nodulation of three genotypes grown with or without biochar and NPK fertilizers in an alkaline soil. We observed synergistic effects of biochar and NPK fertilizer applications on biomass and seed yields for all three soybean genotypes. Total biomass production and seed yield increased on average by 67% and 54%, respectively, with biochar and by 201% and 182% with NPK fertilizer application compared to the control. When applications of biochar and NPK fertilizer were combined, the increases were 391% and367%, respectively. However, the biomass production in the control was very low(692 kg ha-1) due to a high soil p H(8.80). The nodulation increased with biochar and NPK fertilizer applications, and was largest with the combined application. A correlation was found between leaf chlorophyll content(single photon avalanche diode value) and nodule number. We suggested that the synergistic increase in yield was due to a decrease in soil p H caused by biochar and NPK fertilizer applications thereby increasing P availability in this alkaline soil. | Fatima Z.METE Shamim MIA Feike A.DIJKSTRA Md.ABUYUSUF A.S.M.Iqbal HOSSAIN | 2015 | Pedosphere2015，25，5： | 7 |
| 11 | 汞(II)与牛血红蛋白相互作用的研究显示文摘本文采用紫外光谱(UV/VIS)、荧光光谱和圆二色谱等方法,对汞(II)与牛血红蛋白(BHb)的相互作用进行了研究。结果表明:Hg2+处理导致BHb紫外吸收的增加,出现LMCT带,并随Hg2+浓度的增加LMCT带强度显著增强。BHb分子中Soret带的吸收随着Hg2+作用时间的增加而持续降低,表明Hg2+使部分血红素辅基从BHb中脱离出来。蛋白内源荧光光谱显示,Hg2+与BHb的结合会影响蛋白质的三级结构和四级结构。远紫外圆二色谱表明,Hg2+处理会导致BHb蛋白的α-螺旋含量减少。 | 张爽 汪涛 Fatima 杜林方 | 2007 | 化学研究与应用2007，19，6： | 6 |
| 12 | Characterization of lipid parameters in diabetic and non-diabetic atherosclerotic patients显示文摘背景 &在类脂化合物侧面不安和糖尿病之间的 ObjectiveThe 关系联系了复杂并发症长是兴趣的一个区域。Dyslipidemia 在糖尿病的病人是心血管的病态和死亡的一个有势力预言者。现在的学习的目的是在百和 76 个个人(45-75 年年龄) 参予了的糖尿病、非糖尿病的动脉粥样硬化患者 patients.MethodsFive 调查在老化和类脂化合物侧面之间的关系这研究。在这些之中, 192 正在有糖尿病 mellitus 和动脉粥样硬化的历史。个人们在健康的底上被分类(正常、非糖尿病的动脉粥样硬化,糖尿病的动脉粥样硬化) 并且年龄(45-55 年, 56-65 年,和 66-75 年) 。所有参加者受到象详细历史一样的过程,为 fasting 血糖的生物化学的分析,血红素 A1c,全部的胆固醇(TC ) , triglycerides (TG ) ,低密度的脂蛋白 --(LDL ) ,很低密度的脂蛋白(VLDL ) 和高密度的脂蛋白(HDL ) 。所有这些参数在所有三个年龄组的糖尿病、非糖尿病的动脉粥样硬化患者病人之间被比较。TC/HDL 和 LDL/HDL 也是有的 calculated.ResultsDiabetic 动脉粥样硬化患者个人(男性和女性) 与非糖尿病的动脉粥样硬化患者和正常控制个人相比的 HDL 的 TC, TG, LDL, VLDL 和底层高级。在所有三个年龄组之中,脂蛋白反常被观察比男性在女性更经常。在与年龄相比的糖尿病的动脉粥样硬化患者题目 TC/HDL 和 LDL/HDL 比率有重要增加,性别随两性的年龄的增加匹配非糖尿病的动脉粥样硬化患者和 dyslipidemia 增加的正常 control.ConclusionsDegree。女性是对糖尿病的 dyslipidemia 敏感的更多并且因此有与增加年龄开发动脉粥样硬化的更多的风险。 | Fatima Ali Hassan Jamil Sanam Saiqa Anwar Nadia Wajid | 2015 | Journal of Geriatric Cardiology2015，12，1： | 6 |
| 13 | Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors显示文摘 | Fatima Haggar Robin Boushey | 2009 | Clinics in Colon and Rectal Surgery2009，，04： | 6 |
| 14 | The Role of Synapsins in Neurological Disorders显示文摘Synapsins serve as flagships among the presynaptic proteins due to their abundance on synaptic vesicles and contribution to synaptic communication. Several studies have emphasized the importance of this multi-gene family of neuron-specific phosphoproteins in maintaining brain physiology. In the recent times, increasing evidence has established the relevance of alterations in synapsins as a major determinant in many neurological disorders. Here,we give a comprehensive description of the diverse roles of the synapsin family and the underlying molecular mechanisms that contribute to several neurological disorders.These physiologically important roles of synapsins associated with neurological disorders are just beginning to be understood. A detailed understanding of the diversified expression of synapsins may serve to strategize novel therapeutic approaches for these debilitating neurological disorders. | Fatima Javed Mirza Saadia Zahid | 2018 | Neuroscience Bulletin2018，34，2： | 6 |
| 15 | Mechanical and Thermal Properties of Polypropylene Reinforced with Almond Shells Particles: Impact of Chemical Treatments显示文摘 | Fatima Zahra El Mechtali Hamid Essabir Souad Nekhlaoui Mohammed Ouadi Bensalah Mohammad Jawaid Rachid Bouhfid AbouEIkacem Qaiss | 2015 | Journal of Bionic Engineering2015，12，3： | 6 |
| 16 | Anti-bacterial activity and brine shrimp lethality bioassay of methanolic extracts of fourteen different edible vegetables from Bangladesh显示文摘Objective:To investigate the antibacterial and cytotoxic activity of fourteen different edible vegetables methanolic extract from Bangladesh.Methods:The antibacterial activity was evaluated using disc diffusion assay method against 12 bacteria(both gram positive and gram negative).The plant extracts were also screened for cytotoxic activity using the brine shrimp lethality bioassay method and the lethal concentrations(LC_(50))were determined at confidence intervals by analyzing the data on a computer loaded with'Finney Programme??Results:All the vegetable extracts showed low to elevated levels of antibacterial activity against most of the tested strains(zone of inhibition=5-28 mm).The most active extract against all bacterial strains was from Xanthium indicum which showed remarkable antibacterial activity having the diameter of growth inhibition zone ranging from 12 to 28 mm followed by Alternanthera sessilis(zone of inhibition=6-21 mm).All extracts exhibited considerable general toxicity towards brine shrimps.The LC_(50)value of the tested extracts was within the range of 8.447 to 60.323μg/mL with respect to the positive control(vincristine sulphate)which was 0.91μg/mL.Among all studied extracts,Xanthium indicum displayed the highest cytotoxic effect with LC_(50)value of 8.447μg/mL.Conclusions:The results of the present investigation suggest that most of the studied plants are potentially good source of antibacterial and anticancer agents. | M.Obayed Ullah Mahmuda Haque Kaniz Fatima Urmi Abu Hasanat Md.Zulfiker Elichea Synthi Anita Momtaj Begum Kaiser Hamid | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，1： | 5 |
| 17 | 中医药在巴西的发展现状与分析显示文摘巴西医疗保险以统一医疗体系(Unified Health System,SUS)的免费医疗为主、私人保险为补充,已实现全民享有基本医疗服务。导致该国居民死亡的主要疾病是缺血性心脏病、脑卒中、下呼吸道感染,近年来AD、慢性肾脏病及糖尿病的发病率显著增高。以针灸为代表的中医疗法在19世纪初传入巴西,目前针灸治疗已得到较广泛的认可和应用,被纳入SUS,并在多所高校开设相关课程,但中医药整体特色有待加强,从业人员对中药的理解、运用不足,以及中医药教育缺乏规范等问题限制了中医药在巴西的发展。建议通过发挥中医药治未病的特色,加大中药研发力度并扩大市场,规范中医教育等措施,促进两国在中医药领域的广泛合作,推动中医药在巴西的发展与传播。 | 李皓月 党迎迎 Thaís Salles Araujo Fatima Terezinha Pelachini Farias Jaime Amador Soares Graciela Mendonça da Silva de Medeiros 于涛 魏竞竞 赵静 许家杰 曹洪欣 | 2021 | 国际中医中药杂志2021，43，5： | 5 |
| 18 | 培养角膜缘上皮移植后穿透性角膜移植术的早期结果显示文摘目的:描述曾行培养角膜缘上皮移植的患者再行穿透性角膜移植(PKP)的早期结果。
方法:对因化学烧伤造成角膜缘干细胞缺乏而行培养的角膜缘上皮移植后又进行穿透性角膜移植术的患者有关人口统计学、原发病因、角膜缘移植类型、眼表稳定性、视力、移植片透明度和并发症方面的资料进行回顾和复习。对受体角膜片组织病理学特征进行研究,重点观察上皮状态。
结果:在患有角膜缘干细胞缺乏而进行培养的角膜缘上皮移植术的125例患者中,15例接受了穿透性角膜移植术(PKP)。角膜缘上皮移植术后(自体移植组n=11,同种异体移植组n=4)平均间隔时间为7个月(范围2—12个月)。同种异体移植组的4例患者均接受了免疫抑制疗法。15只眼中14只眼(93%)获得了含有稳定的角膜上皮的健全的角膜植片。15只眼中14只眼术前最佳矫正视力低于20/200。PKP后平均随访8.3±5.0个月,8只眼最佳矫正视力高于20/60,5只眼最佳矫正视力20/200至20/60。2只眼低于20/200。15只眼中3只眼发生异体角膜植片的排斥反应但被成功治疗。1只眼发生植片排斥的同时发生了青光眼。同种异体角膜缘上皮移植无一例显示排斥表现。
结论:培养的角膜缘上皮移植后,在形成稳定的眼表后行PKP的早期结果是良好的。为了避免排斥反应,培养的同种异体角膜缘上皮移植者行充分的免疫抑制治疗是必需的。角膜同种异体移植能够单独排斥同种异体角膜缘移植物。 | Virender S. Sangwan Himanshu P. Matalia Geeta K. Vemuganti Ghazala Ifihekar Anees Fatima Shashi Singh, Gullapalli N. Rao 董白霞(译) 马景学(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，4： | 5 |
| 19 | Robust H_∞ Controller Design for Uncertain Neutral Systems via Dynamic Observer Based Output Feedback显示文摘In this paper, the dynamic observer-based controller design for a class of neutral systems with H∞ control is considered. An observer-based output feedback is derived for systems with polytopic parameter uncertainties. This controller assures delay-dependent stabilization and H∞ norm bound attenuation from the disturbance input to the controlled output. Numerical examples are provided for illustration and comparison of the proposed conditions. | Fatima El Haoussi El Houssaine Tissir | 2009 | International Journal of Automation and computing2009，6，2： | 5 |
| 20 | Impact of direct acting antivirals on occurrence and recurrence of hepatocellular carcinoma: Biologically plausible or an epiphenomenon?显示文摘Hepatocellular carcinoma(HCC) is a major cause of morbidity and mortality worldwide. Chronic hepatitis C virus infection(HCV) is the most common cause of HCC in many European countries, Japan and Pakistan. Introduction of the new direct acting antivirals(DAAs) has revolutionized the management of HCV worldwide, with high rates of sustained virologic response in patients who could not have tolerated the previous interferon based treatments. However, recently there have been reports raising caution about the long term effects of DAAs, particularly a possible increased risk of HCC. Therefore this review explores the current molecular studies as well as clinical data that investigate the impact of DAAs on occurrence and recurrence of HCC. | Amna Subhan Butt Fatima Sharif Shahab Abid | 2018 | World Journal of Hepatology2018，10，2： | 4 |
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