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| 1 | Clinical implications of fatty pancreas:Correlations between fatty pancreas and metabolic syndrome显示文摘AIM:To investigate the clinical implications of lipid deposition in the pancreas(fatty pancreas). METHODS:The subjects of this study were 293 patients who had undergone abdominal computed tomography(CT)and sonography.Fatty pancreas was diagnosed by sonographic findings and subdivided into mild,moderate,and severe fatty pancreas groups comparing to the retroperitoneal fat echogenicity. RESULTS:Fatty pancreas was associated with higher levels for visceral fat,waist circumference,aspartate aminotransferase(AST),alanine aminotransferase (ALT),total cholesterol,triglyceride,high density lipoprotein,free fatty acid,γ-GTP,insulin,and the homeostasis model assessment of insulin resistance (HOMA-IR)than the control group(P<0.05).HOMAIR,visceral fat,triglyceride,and ALT also tended to increase with the degree of fat deposition in the pancreas on sonography.In a multivariate logistic regression analysis,HOMA-IR,visceral fat,and ALT level were independently related to fatty pancreas after adjustment for age,body mass index,and lipid profile.The incidence of metabolic syndrome in the fatty pancreas group was significantly higher than in the control group,and the numbers of metabolic syndrome parameters were significantly higher in the fatty pancreas group(P<0.05).CONCLUSION:Sonographic fatty pancrease showed higher insulin resistance,visceral fat area,triglyceride, and ALT levels than normal pancreases.Fatty pancreas also showed a strong correlation with metabolic syndrome. | Jun Seok Lee Sang Heum Kim Dae Won Jun Jee Hye Han Eun Chul Jang Ji Young Park Byung Kwan Son Seong Hwan Kim Yoon Ju Jo Young Sook Park Yong Soo Kim | 2009 | World Journal of Gastroenterology2009，15，15： | 40 |
| 2 | Degradation of intestinal mRNA:A matter of treatment显示文摘AIM: To characterize the influence of location, species and treatment upon RNA degradation in tissue samples from the gastrointestinal tract. METHODS: The intestinal samples were stored in different medium for different times under varyingconditions: different species(human and rat), varying temperature(storage on crushed ice or room temperature), time point of dissection of the submucous-mucous layer from the smooth muscle(before or after storage), different rinsing methods(rinsing with Medium, PBS, RNALater or without rinsing at all) and different regions of the gut(proximal and distal small intestine, caecum, colon and rectum). The total RNA from different parts of the gut(rat: proximal and distal small intestine, caecum, colon and rectum, human: colon and rectum) and individual gut layers(muscle and submucosal/mucosal) was extracted. The quality of the RNA was assessed by micro capillary electrophoresis. The RNA quality was expressed by the RNA integrity number which is calculated from the relative height and area of the 18 S and 28 S RNA peaks. From rat distal small intestine q PCR was performed for neuronal and glial markers.RESULTS: RNA obtained from smooth muscle tissue is much longer stable than those from submucosal/mucosal tissue. At RT muscle RNA degrades after one day, on ice it is stable at least three days. Cleaning and separation of gut layers before storage and use of RNALater, maintains the stability of muscle RNA at RT for much longer periods. Different parts of the gut show varying degradation periods. RNA obtained from the submucosal/mucosal layer always showed a much worse amplification rate than RNA from muscle tissue. In general RNA harvested from rat tissue, either smooth muscle layer or submucosal/mucosal layer is much longer stable than RNA from human gut tissue, and RNA obtained from smooth muscle tissue shows an increased stability compared to RNA from submucosal/mucosal tissue. At RT muscle RNA degrades after one day, while the stability on ice lasts at least three days. Cleaning and separation of gut layers before storage and use of RNALater, maintains the stability of muscle RNA at RT for much longer periods. Different parts of the gut show varying degradation periods. The RNA from muscle and submucosal/mucosal tissue of the proximal small intestine degrades much faster than the RNA of distal small intestine, caecum or colonwith rectum. RNA obtained from the submucosal/mucosal layer always showed a much more reduced amplification rate than RNA from muscle tissue [β-Tubulin Ⅲ for muscle quantification cycle(Cp): 22.07 ± 0.25, for β-Tubulin Ⅲ submucosal/mucosal Cp: 27.42 ± 0.19].CONCLUSION: Degradation of intestinal m RNA depends on preparation and storage conditions of the tissue. Cooling, rinsing and separating of intestinal tissue reduce the degradation of m RNA. | Sabine Heumüller-Klug Carsten Sticht Karin Kaiser Elvira Wink Cornelia Hagl Lucas Wessel Karl-Herbert Schafer | 2015 | World Journal of Gastroenterology2015，21，12： | 2 |
| 3 | Distant skeletal muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome显示文摘Intrahepatic cholangiocarcinoma is a malignant neoplasm arising from the biliary epithelium, which frequently invades adjacent organs or metastasizes to other visceral organs such as the lungs, bones, adrenals, and brain. However, distant skeletal muscle metastasis of cholangiocarcinoma has never been described before to the best of our knowledge and, furthermore, Budd-Chiari syndrome secondary to intrahepatic cholangiocarcinoma is also extremely rare. Here we present the first case overall of distant muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome. A 44-year-old man admitted to the hospital with complaints of abdominal distension, edema of both legs, back pain and anorexia of 30 d' duration. Computed tomography and ultrasonography-guided percutaneous muscle biopsy established intrahepatic cholangiocarcinoma with disseminated thrombosis from inferior vena cava to bilateral iliac and femoral veins, and multiple skeletal muscle metastases in bilateral buttock and erector spinal muscle. | Oh Sung Kwon Dae Won Jun Sang Heum Kim Mee Yeon Chung Nam In Kim Moon Hee Song Han Hyo Lee Seung Hwan Kim Yoon Ju Jo Young Sook Park Jong Eun Joo | 2007 | World Journal of Gastroenterology2007，13，22： | 2 |
| 4 | Transplantation of an adipose stem cell cluster in a spinal cord injury显示文摘 | Jin Soo Oh In Su Park Keung Nyun Kim Do Heum Yoon Sang-Heon Kim Yoon Ha | 2012 | NeuroReport2012，，5： | 2 |
| 5 | Hypoxia-preconditioned adipose tissue-derived mesenchymal stem cell increase the survival and gene expression of engineered neural stem cells in a spinal cord injury model显示文摘 | Jin Soo Oh Yoon Ha Sung Su An Momin Khan William A. Pennant Hyo Jin Kim Do Heum Yoon Minhyung Lee Keung Nyun Kim | 2010 | Neuroscience Letters2010，，3： | 2 |
| 6 | 糖尿病下肢血管病变的介入治疗显示文摘约有2%-37%的糖尿病病人有周围神经.缺血问题。有关糖尿病足病介入治疗的研究很少。在文献复习的基础上,介绍了52例糖尿病合并下肢血管病变病人的临床特点和接受不同治疗的随访结果。52例病人中94%有下肢动脉粥样硬化阻塞性改变,34例有显著的股、胭、胫动脉病变,65%的病人的下肢动脉狭窄程度大于70%。其中12例进行了球囊扩张、18例支架治疗。治疗后的近期结果为手术成功26例(87%),失败4例。随访7个月的伤口愈合率只有42%。 | Won Heum Shim 王玉珍 | 2004 | 国外医学(内分泌学分册)2004，24，5： | 2 |
| 7 | Papillary balloon dilation is not itself a cause of post‐endoscopic retrograde cholangiopancreatography pancreatitis; results of anterograde and retrograde papillary balloon dilation显示文摘 | Yu Ri Seo Jong Ho Moon Hyun Jong Choi Dong Choon Kim Tae Hoon Lee Sang‐Woo Cha Young Deok Cho Sang‐Heum Park Sun‐Joo Kim | 2013 | J Gastroenterol Hepatol2013，，8： | 2 |
| 8 | Robotic and laparo- scopic total mesorectal excision for rectal cancer: a case - matched study 显示文摘 | Back Jeong- Heum Carlos Pastor | 2011 | Surgical Endoscopy2011，25，2： | 1 |
| 9 | Preparation and evaluation of the chitin derivatives for wastewater treatments显示文摘 | Aly Sayed Aly Byong Dae Jeon Yun Heum Park | 1997 | Jourmal of Applied Polymer Science1997，65，10： | 1 |
| 10 | Coprecipitation synthesis and sintering of yttrium aluminum garnet (YAG) powders:The effect of precipitant显示文摘 | Li Jiguang Ikegami Takayasu Lee Jong Heum | 2000 | J Eur Ceram Soc2000，20，1415： | 1 |
| 11 | Kidney donation from children after cardiac death显示文摘 | de Vries EE Snoeijs MG van Heum E | 2010 | Crit Care Med2010，38，1： | 1 |
| 12 | A Randomized, Multi-Center, Clinical Trial to Assess the Efficacy and Safety of Alginate Carboxymethylcellulose Hyaluronic Acid Compared to Carboxymethylcellulose Hyaluronic Acid to Prevent Postoperative Intrauterine Adhesion显示文摘 | Tak Kim Ki Hoon Ahn Doo Seok Choi Kyung Joo Hwang Byoung Ick Lee Min Hyung Jung Jae Weon Kim Jong Hyuk Kim Sun Hee Cha Ki Hwan Lee Kyu Sup Lee Sung Tack Oh Chi Heum Cho Jeong Ho Rhee | 2012 | The Journal of Minimally Invasive Gynecology2012，，6： | 1 |
| 13 | Effects of precarbonization on porosity development of ac- tivated carbons forms rice straw显示文摘 | Chang Hun Yun Yun Heum Park Chong Rae Park | 2001 | Carbon2001，3，4： | 1 |
| 14 | Cholangitis after hepatic portoenterostomy for biliary atresia: a multivariate a- nalysis of risk factors显示文摘 | Ernest van Heum LW Saing H Tam PK | 2003 | J Pediatr2003，142，5： | 1 |
| 15 | Effects of precarbonization on porosity development of activated carbons form rice straw显示文摘 | Chang Hun Yun Yun Heum Park Chong Rae Park | 2001 | Carbon2001，39，4： | 1 |
| 16 | Enhancement of thermal stability and cycling performance in lithium-ion cells through the use of ceramic-coated separators显示文摘 | Ji-Ae Choi Sa Heum Kim Dong-Won Kim | 2009 | Journal of Power Sources2009，，18： | 1 |
| 17 | Preparation and evaluation of the chitin derivatives for wastewater treat- ments显示文摘 | Sayed A A Jeon Byong Dae Park Yun Heum | 1997 | J Appl Polym Sci1997，65，10： | 1 |
| 18 | Screen Design Guidelines for Motivation in Interactive Multimedia Instruction: A Survey and Framework for Designers显示文摘 | Lee Sung Heum Boling Elizabeth | 1999 | Educational Technology1999，39，3： | 1 |
| 19 | Effect of electrotransport treatment on susceptibility of high-strength low alloy steel to hydrogen embrittlement显示文摘 | Jin Seok Park Tae Heum Nam Jong Sung Kim Jung Gu Kim | 2013 | International Journal of Hydrogen Energy2013，，： | 1 |
| 20 | Preparation and evaluation of the chitin derivatives for wastewater treatments显示文摘 | Sayed A A Jeon Byong Dae Park Yun Heum | 1997 | JAppl Polym Sci1997，65，： | 1 |
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