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| 1 | Significance of adverse outcome pathways in biomarker-based environmental risk assessment in aquatic organisms显示文摘In environmental risk assessments(ERA), biomarkers have been widely used as an early warning signal of environmental contamination. However, biomarker responses have limitation due to its low relevance to adverse outcomes(e.g., fluctuations in community structure, decreases in population size, and other similar ecobiologically relevant indicators of community structure and function). To mitigate these limitations, the concept of adverse outcome pathways(AOPs) was developed. An AOP is an analytical, sequentially progressive pathway that links a molecular initiating event(MIE) to an adverse outcome. Recently, AOPs have been recognized as a potential informational tool by which the implications of molecular biomarkers in ERA can be better understood. To demonstrate the utility of AOPs in biomarker-based ERA, here we discuss a series of three different biological repercussions caused by exposure to benzo(a)pyrene(Ba P), silver nanoparticles(Ag NPs), and selenium(Se). Using mainly aquatic invertebrates and selected vertebrates as model species, we focus on the development of the AOP concept. Aquatic organisms are suitable bioindicator species whose entire lifespans can be observed over a short period; moreover, these species can be studied on the molecular and population levels.Also, interspecific differences between aquatic organisms are important to consider in an AOP framework, since these differences are an integral part of the natural environment.The development of an environmental pollutant-mediated AOP may enable a better understanding of the effects of environmental pollutants in different scenarios in the diverse community of an ecosystem. | Jin Wuk Lee Eun-Ji Won Sheikh Raisuddin Jae-Seong Lee | 2015 | Journal of Environmental Sciences2015，27，9： | 7 |
| 2 | Analysis and implementation for a walking support system /'or visually impaired people显示文摘 | Hossain E Khan Md Raisuddin Muhida R | 2011 | International Journal of Intelligent Mechatronics and Robotics2011，1，3： | 1 |
| 3 | Differential expression of metallothionein(MT)gene by trace metals and endocrine disrupting chemicals in the hermaphroditic mangrove killifish,Kryptolebias marmoratus显示文摘 | Rhee J S Raisuddin S Hwang D S | 2009 | Ecotoxicology and Environmental Safety2009，72，1： | 1 |
| 4 | Expression of glutathione S-transferase(GST)genes in the marine copepod Tigriopus japonicus exposed to trace metals显示文摘 | Lee K W Raisuddin S Rhee J S | 2008 | Aquatic Toxicology2008，89，3： | 1 |
| 5 | Effect of Endosulfan on Antioxidants of Freshwater Fish Channa punctatus Bloch: 1. Protection Against Lipid Peroxidation in Liver by Copper Preexposure显示文摘 | S. Pandey I. Ahmad S. Parvez B. Bin-Hafeez R. Haque S. Raisuddin | 2001 | Archives of Environmental Contamination and Toxicology2001，，3： | 1 |
| 6 | A corticotropin re- leasing hormone binding protein (CRH-BP) gene from the intertidal copepod, Tigriopus jqoonicus 显示文摘 | Lee K W Rhee J S Raisuddin S eta/ | 2008 | General and Comparative Endocrinology2008，158，1： | 1 |
| 7 | Pro-apoptotic effect of fly ash leachates in hepatocytes of freshwater fish ( Channa punctata Bloch)显示文摘 | Mehboob Ali Shakilur Rahman Hasibur Rehman Kanchan Bhatia Rizwan A. Ansari Sheikh Raisuddin | 2006 | Toxicology in Vitro2006，，1： | 1 |
| 8 | Molecular cloning and beta-naphthoflavone-induced expression of a cytochrome P450 1A (CYP1A) gene from an anadromous river pufferfish, Takifugu obscurus 显示文摘 | Kim J H Raisuddin S Ki J S | 2008 | Marl Pollut Bull2008，57，： | 1 |
| 9 | Acute toxicities of trace metals and common xenobiotics to the marine cope- pod Tigriopus j~onicus : Evaluation of its use as a bench- mark species for routine ecotoxicity tests in Western Pacific coastal regions 显示文摘 | Lee K W Raisuddin S Hwang D S | 2007 | Environmental Toxicology2007，22，5： | 1 |
| 10 | A new approach to instability testing of shells显示文摘 | RAISUDDIN M D KHANA M A SALAM AKANDA B | 1998 | International Journal of Pressure Vessels and Piping1998，75，1： | 1 |
| 11 | The copepod Tigriopus: a promising marine model organism for ecotoxieology and environmental genomies 显示文摘 | Raisuddin S Kwok K W H Leung K M Y | 2007 | Aquatic Toxicology2007，83，： | 1 |
| 12 | Heat shock protein(rsp) gene responses of the intertidal copepod Tigriopus japonicusto environmental toxicants显示文摘 | Rhee J S Raisuddin S Lee K W | 2009 | Comparative Biochemistry and Physiology Part C:Toxicology & Pharmacology2009，149，1： | 1 |
| 13 | Genotoxic effects of arsenic:preven-tion by functional food-jaggery显示文摘 | Singh N Kumar D Raisuddin S | | 0，，02： | 1 |
| 14 | Beneficial effects of lamivudine in hepatitis B virus-related decompensated cirrhosis显示文摘 | Dharmesh Kapoor Rajkumar C Guptan Salma M Wakil Syed N Kazim Rachna Kaul Shri Ram Agarwal Sheikh Raisuddin Seyed E Hasnain Shiv K Sarin | 2000 | Journal of Hepatology2000，，2： | 1 |
| 15 | Heat shock protein(Hsp ) gene responses of the intertidal copepod Tigriopusjaponicus to environmental toxicants 显示文摘 | Rhee J S Raisuddin S Lee K W ei al | 2009 | ComparativeBiochemistry and Physiology Part C :Toxicology & Pharmacology2009，149，1： | 1 |
| 16 | Genotoxic effects of arsenic:prevention by functional food-jaggery显示文摘 | Singh N Kumar D Raisuddin S | 2008 | Cancer Lett2008，268，2： | 1 |
| 17 | Heat stress-induced alterations of antioxidants in the freshwater fish Channa punctata Bloch 显示文摘 | Kaur M Atif F Ali M Rehman H Raisuddin S | 2005 | Journal of Fish Biology2005，67，： | 1 |
| 18 | Beneficial effects of lamivudine in hepatitis B virus-related decompensated cirrhosis显示文摘 | Dharmesh Kapoor Rajkumar C Guptan Salma M Wakil Syed N Kazim Rachna Kaul Shri Ram Agarwal Sheikh Raisuddin Seyed E Hasnain Shiv K Sarin | 2000 | Journal of Hepatology2000，，2： | 1 |
| 19 | FoxO proteins’ nuclear retention and BH3-only protein Bim induction evoke mitochondrial dysfunction-mediated apoptosis in berberine-treated HepG2 cells显示文摘 | Shatrunajay Shukla Fatima Rizvi Sheikh Raisuddin Poonam Kakkar | 2014 | Free Radical Biology and Medicine2014，，： | 1 |
| 20 | A corticotropin-releasing hormone binding protein ( CRH-BP ) gene from the intertidal copepod, Tigriopus japonicus显示文摘 | Kyun-Woo Lee Jae-Sung Rhee Sheikh Raisuddin Heum Gi Park Jae-Seong Lee | 2008 | General and Comparative Endocrinology2008，，1： | 1 |
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