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| 1 | Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion显示文摘Development of a novel in vivo lung perfusion(IVLP)procedure allows localized delivery of high-dose doxorubicin(DOX)for targeting residual micrometastatic disease in the lungs.However,DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent remain in the therapeutic window.A small dimension nitinol wire coated with a sorbent of biocompatible morphology(Bio-SPME)has been clinically evaluated for in vivo lung tissue extraction and determination of DOX and its key metabolites.The in vivo Bio-SPME-IVLP experiments were performed on pig model over various(150 and 225 mg/m^(2))drug doses,and during human clinical trial.Two patients with metastatic osteosarcoma were treated with a single 5 and 7 μg/mL(respectively)dose of DOX during a 3-h IVLP.In both pig and human cases,DOX tissue levels presented similar trends during IVLP.Human lung tissue concentrations of drug ranged between 15 and 293 μg/g over the course of the IVLP procedure.In addition to DOX levels,Bio-SPME followed by liquid chromatography-mass spectrometry analysis generated 64 metabolic features during endogenous metabolite screening,providing information about lung status during drug administration.Real-time monitoring of DOX levels in the lungs can be performed effectively throughout the IVLP procedure by in vivo Bio-SPME chemical biopsy approach.Bio-SPME also extracted various endogenous molecules,thus providing a real-time snapshot of the physiology of the cells,which might assist in the tailoring of personalized treatment strategy. | Barbara Bojko Nikita Looby Mariola Olkowicz Anna Roszkowska Bogumiła Kupcewicz Pedro Reck dos Santos Khaled Ramadan Shaf Keshavjee Thomas K.Waddell German Goomez-Rios Marcos Tascon Krzysztof Gorynski Marcelo Cypel Janusz Pawliszyn | 2021 | Journal of Pharmaceutical Analysis2021，11，1： | 3 |
| 2 | Solitary fibrous tumors of the pleura显示文摘 | Marc de Perrot Stefan Fischer Marie-Anne Bründler Yasuo Sekine Shaf Keshavjee | 2002 | The Annals of Thoracic Surgery2002，，1： | 2 |
| 3 | XB130, a Novel Adaptor Protein, Promotes Thyroid Tumor Growth显示文摘 | Atsushi Shiozaki Monika Lodyga Xiao-Hui Bai Jeya Nadesalingam Takeshi Oyaizu Daniel Winer Sylvia L. Asa Shaf Keshavjee Mingyao Liu | 2011 | The American Journal of Pathology2011，，1： | 2 |
| 4 | Primary nonHodgkin's lymphoma of the liver显示文摘 | Noronha V Shaf NQ Obando JA | | 0，，： | 1 |
| 5 | Solitary fibrous tumors of the pleura显示文摘 | Marc de Perrot Stefan Fischer Marie-Anne Bründler Yasuo Sekine Shaf Keshavjee | 2002 | The Annals of Thoracic Surgery2002，，1： | 1 |
| 6 | Experimental use of the obtnrator intemus muscle as a functioning pelvic floor muscle in dogs显示文摘 | Shaf ik A E I-SibaiO Shaf ik A A | 2001 | Eur J Surg2001，167，10： | 1 |
| 7 | Climatic-related e- valuations of the summer peak-hours' electric load in Is- rael 显示文摘 | Segal M Shaf'lr H Mandel M | 1992 | Journal of Applied Meteorology1992，31，12： | 1 |
| 8 | Solitary fibrous tumors of the pleura显示文摘 | Marc de Perrot Stefan Fischer Marie-Anne Bründler Yasuo Sekine Shaf Keshavjee | 2002 | The Annals of Thoracic Surgery2002，，1： | 1 |
| 9 | 15 years single center experience with surgical resection of the superior vena cava for non-small cell lung cancer显示文摘 | Yaron Shargall Marc de Perrot Shaf Keshavjee | 2004 | Lung Cancer2004，45，： | 1 |
| 10 | Cell Death in Human Lung Transplantation: Apoptosis Induction in Human Lungs During Ischemia and After Transplantation显示文摘 | Stefan Fischer Stephen D. Cassivi Alexandre M. Xavier Jonathan A. Cardella Ernest Cutz Vern Edwards Mingyao Liu Shaf Keshavjee | 2000 | Annals of Surgery2000，，3： | 1 |
| 11 | Anal Submucosal injection:a new route for drug administration,VI, chronic prostatitis:a mew modality of treatment with report of II cases 显示文摘 | Shaf KA | 1991 | Urology1991，37，： | 1 |
| 12 | The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups显示文摘 | Michael T. Jaklitsch Francine L. Jacobson John H.M. Austin John K. Field James R. Jett Shaf Keshavjee Heber MacMahon James L. Mulshine Reginald F. Munden Ravi Salgia Gary M. Strauss Scott J. Swanson William D. Travis David J. Sugarbaker | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，1： | 1 |
| 13 | Rad iosurgeryin the treatment of spinal metastases : tumorcontro,lsurviva,land quality of life after helical tomotherapy显示文摘 | Sheehan JP Shaf frey CI Schlesinger D et a1 | 2009 | Neuro Surgery2009，65，6： | 1 |
| 14 | The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups显示文摘 | Michael T. Jaklitsch Francine L. Jacobson John H.M. Austin John K. Field James R. Jett Shaf Keshavjee Heber MacMahon James L. Mulshine Reginald F. Munden Ravi Salgia Gary M. Strauss Scott J. Swanson William D. Travis David J. Sugarbaker | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，1： | 1 |
| 15 | INTESTINAL ISCHEMIA-REPERFUSION-INDUCED ACUTE LUNG INJURY AND ONCOTIC CELL DEATH IN MULTIPLE ORGANS显示文摘 | Marco Mura Cristiano F. Andrade Bing Han Rashmi Seth Yu Zhang Xiao-Hui Bai Thomas K. Waddell David Hwang Shaf Keshavjee Mingyao Liu | 2007 | Shock2007，，2： | 1 |
| 16 | Clinical depression versus distress among patients with type 2 diabetes : Not just a question of semantics 显示文摘 | Fisher L Shaf MM Mullah JT | 2007 | Diabetes Care2007，30，： | 1 |
| 17 | Lithe: lightweight secure CoAP for the Internet of Things显示文摘 | RAZA S SHAF AGH H HEWAGE K | 2013 | IEEE SensorsJournal2013，13，1： | 1 |
| 18 | Lung preservation显示文摘 | Marc P Shaf K | 2001 | Curr Opin Organ Transplant2001，6，1： | 1 |
| 19 | Role of external bacterial flora in the pathogenesis of acute postoperative endophthalmitis显示文摘 | Milch FA Shaf MK | 1991 | Ophthalmology1991，98，： | 1 |
| 20 | Lung preservation显示文摘 | Marc de Perrot and Shaf Keshavjee | 2001 | Curent opinion in oran transplantation2001，6，： | 1 |
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