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| 1 | Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion显示文摘Development of a novel in vivo lung perfusion(IVLP)procedure allows localized delivery of high-dose doxorubicin(DOX)for targeting residual micrometastatic disease in the lungs.However,DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent remain in the therapeutic window.A small dimension nitinol wire coated with a sorbent of biocompatible morphology(Bio-SPME)has been clinically evaluated for in vivo lung tissue extraction and determination of DOX and its key metabolites.The in vivo Bio-SPME-IVLP experiments were performed on pig model over various(150 and 225 mg/m^(2))drug doses,and during human clinical trial.Two patients with metastatic osteosarcoma were treated with a single 5 and 7 μg/mL(respectively)dose of DOX during a 3-h IVLP.In both pig and human cases,DOX tissue levels presented similar trends during IVLP.Human lung tissue concentrations of drug ranged between 15 and 293 μg/g over the course of the IVLP procedure.In addition to DOX levels,Bio-SPME followed by liquid chromatography-mass spectrometry analysis generated 64 metabolic features during endogenous metabolite screening,providing information about lung status during drug administration.Real-time monitoring of DOX levels in the lungs can be performed effectively throughout the IVLP procedure by in vivo Bio-SPME chemical biopsy approach.Bio-SPME also extracted various endogenous molecules,thus providing a real-time snapshot of the physiology of the cells,which might assist in the tailoring of personalized treatment strategy. | Barbara Bojko Nikita Looby Mariola Olkowicz Anna Roszkowska Bogumiła Kupcewicz Pedro Reck dos Santos Khaled Ramadan Shaf Keshavjee Thomas K.Waddell German Goomez-Rios Marcos Tascon Krzysztof Gorynski Marcelo Cypel Janusz Pawliszyn | 2021 | Journal of Pharmaceutical Analysis2021，11，1： | 3 |
| 2 | Solitary fibrous tumors of the pleura显示文摘 | Marc de Perrot Stefan Fischer Marie-Anne Bründler Yasuo Sekine Shaf Keshavjee | 2002 | The Annals of Thoracic Surgery2002，，1： | 2 |
| 3 | XB130, a Novel Adaptor Protein, Promotes Thyroid Tumor Growth显示文摘 | Atsushi Shiozaki Monika Lodyga Xiao-Hui Bai Jeya Nadesalingam Takeshi Oyaizu Daniel Winer Sylvia L. Asa Shaf Keshavjee Mingyao Liu | 2011 | The American Journal of Pathology2011，，1： | 2 |
| 4 | The superiority of an extracellular fluid solution over Euro-Collins solution for pulmonary preservation 显示文摘 | Yamazaki R Yokomise H Keshavjee SH | 1990 | Transplantation1990，49，： | 1 |
| 5 | Treatment of extensively drug-resistant tuberculosis in Tomsk,Russia:a retrospective cohort study显示文摘 | Keshavjee S Gelmanova IY Farmer PE | | 0，，9647： | 1 |
| 6 | The role of dextran 40 and potassium in extended hypothermic lung preservation for transplantation显示文摘 | Keshavjee SH Yamazaki MSc Yokomise H | 1992 | Thoral Cardiovasc Surg1992，103，： | 1 |
| 7 | Hepatotoxicity during treatment for multidrug-resistant tuberculosis : occurrence, management and outcome 显示文摘 | Keshavjee S Gelmanova IY Shin SS | 2012 | Int J Tuberc Lung Dis2012，16，5： | 1 |
| 8 | Adenoid cystic carcinoma of the airway: thirty-two-year experience 显示文摘 | Maziak DE Todd TR Keshavjee SH | 1996 | J Thorac Cardiovasc Surg1996，112，6： | 1 |
| 9 | Ischemia - reperfusion decreases protein phosphorylation and p38 mitogen - activated protein kinase phosphorylation in rat lung transplants 显示文摘 | Sakiyama S dePerrot M Hart B Wadded TK Keshavjee S Liu M | 2003 | J Heart Lung Transplantation2003，22，： | 1 |
| 10 | Adenoid cystic carcinoma of the airway:thirty-two year experience显示文摘 | Maziak DE Todd TRJ Keshavjee SH | | 0，，06： | 1 |
| 11 | Solitary fibrous tumors of the pleura显示文摘 | Marc de Perrot Stefan Fischer Marie-Anne Bründler Yasuo Sekine Shaf Keshavjee | 2002 | The Annals of Thoracic Surgery2002，，1： | 1 |
| 12 | Ischemia reperfusion - induced dynamic changes of protein tyrosinephosphorylation during human lung transplantation显示文摘 | Keshavjee S Zhang XM Fischer S Liu M | 2000 | Transplantation2000，70，： | 1 |
| 13 | Outcomes afterlung retransplantation in the modem era 显示文摘 | Kawut SM Lederer DJ Keshavjee S | 2008 | Am J Respir Crit Care Med2008，177，1： | 1 |
| 14 | Innate immunity and organ transplantation:the potential role of toll-like receptors 显示文摘 | Andrade CF Waddell TK Keshavjee S | 2005 | Am J Transplant2005，5，5： | 1 |
| 15 | Barriers to successful tuberculosis treatment in Tomsk, Russian Federa- tion: non-adherence, default and the acquisition of multidrug re- sistance 显示文摘 | Gelmanova IY Keshavjee S Golubchikova VT | 2007 | Bull World Health Organ2007，85，9： | 1 |
| 16 | Solitary fibrous tumors of the pleura显示文摘 | Marc de Perrot Stefan Fischer Marie-Anne Bründler Yasuo Sekine Shaf Keshavjee | 2002 | The Annals of Thoracic Surgery2002，，1： | 1 |
| 17 | Accommodation after lung xenografting from hamster to rat显示文摘 | Tabata T de Perrot M Keshavjee S | 2003 | Transplantation2003，75，5： | 1 |
| 18 | Adenoid cystic carcinoma of the airway: Thirty-two-year experience 显示文摘 | Maziak DE Todd TR Keshavjee SH | 1996 | J Thorac and Cardiovasc Surg1996，112，6： | 1 |
| 19 | Multidrug-Resistant tu- berculosis and extensively Drug-Resistant tuberculosis显示文摘 | Seung KJ Keshavjee S Rich ML | 2015 | Cold Spring Harb Perspect Med2015，5，01： | 1 |
| 20 | Prevention of ra-pid reperfusion-induced lung injury with prostaglandin E1 during the intial period of reperfusion 显示文摘 | Keshavjee S Liu M | 1998 | J Heart Lung Transplant1998，17，： | 1 |
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