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| 1 | Transcatheter embolization therapy in liver cancer:an update of clinical evidences显示文摘Transarterial chemoembolization(TACE) is a form of intra-arterial catheter-based chemotherapy that selectively delivers high doses of cytotoxic drug to the tumor bed combining with the effect of ischemic necrosis induced by arterial embolization.Chemoembolization and radioembolization are at the core of the treatment of liver hepatocellular carcinoma(HCC) patients who cannot receive potentially curative therapies such as transplantation,resection or percutaneous ablation.TACE for liver cancer has been proven to be useful in local tumor control,to prevent tumor progression,prolong patients' life and control patient symptoms.Recent evidence showed in patients with single-nodule HCC of 3 cm or smaller without vascular invasion,the5-year overall survival(OS) with TACE was similar to that with hepatic resection and radiofrequency ablation.Although being used for decades,Lipiodol~(Lipiodol~ Ultra Fluid~,Guerbet,France) remains important as a tumor-seeking and radio-opaque drug delivery vector in interventional oncology.There have been efforts to improve the delivery of chemotherapeutic agents to tumors.Drug-eluting bead(DEB) is a relatively novel drug delivery embolization system which allows for fixed dosing and the ability to release the anticancer agents in a sustained manner.Three DEBs are available,i.e.,Tandem~(CeloNova Biosciences Inc.,USA),DC-Beads~(BTG,UK) and HepaSphere~(BioSphere Medical,Inc.,USA).Transarterial radioembolization(TARE) technique has been developed,and proven to be efficient and safe in advanced liver cancers and those with vascular complications.Two types of radioembolization microspheres are available i.e.,SIR-Spheres~(Sirtex Medical Limited,Australia) and TheraSphere~(BTG,UK).This review describes the basic procedure of TACE,properties and efficacy of some chemoembolization systems and radioembolization agents which are commercially available and/or currendy under clinical evaluation.The key clinical trials of transcatheter arterial therapy for liver cancer are summarized. | Yi-Xiang J.Wang Thierry De Baere Jean-Marc Idee Sebastien Ballet | 2015 | Chinese Journal of Cancer Research2015,27,2: | 72 |
| 2 | Portal Triad Clamping or Hepatic Vascular Exclusion for Major Liver Resection: A Controlled Study显示文摘 | Jacques Belghiti Roger Noun Evelyne Zante Thierry Ballet Alain Sauvanet | 1996 | Annals of Surgery1996,,2: | 2 |
| 3 | 经导管动脉栓塞术治疗肝癌:最新临床证据显示文摘对不能接受根治性治疗如肝移植、肿瘤切除术或经皮射频消融术(radiofrequency ablation,RFA)的肝细胞肝癌(hepatocellular carcinoma,HCC)患者,经导管动脉化疗栓塞术(transarterial chemoembolization,TACE)或放疗栓塞术(transarterial radioembolization,TARE)是治疗的核心手段。近期研究证据显示:对于无血管侵犯、3 cm及以下单结节型HCC患者,TACE与肿瘤切除术及RFA后的5年总生存率相似。尽管已应用数十年,碘油(超液化碘油®,Lipiodol®Ultra Fluid,Guerbet,France)作为一种亲肿瘤性且不透射线的药物运输载体在肿瘤介入治疗中的地位依然重要。药物缓释微球(drug-eluting bead,DEB)是栓塞术中一种较新型的药物输送方式,既可维持药物浓度,也可持续释放抗癌药。现有三种DEB可供临床选择使用,即Tandem®(Celo Nova Biosciences Inc.),DC-Beads®(BTG,UK)和Hepa Sphere®(Bio Sphere Medical,Inc.,USA)。经动脉TARE已被证实可安全有效地运用于晚期肝癌及有肝血管侵犯的患者。两种放射性栓塞微粒可供临床选择使用,即SIR-Spheres®(Sirtex Medical Limited,Australia)和Thera Sphere®(BTG,UK)。本文总结肝癌经导管动脉治疗的关键临床试验。 | Yì-Xiáng J.Wáng Thierry De Baere Jean-Marc Idée Sébastien Ballet 邓敏 王毅翔 | 2015 | 临床与病理杂志2015,35,7: | 2 |
| 4 | Duodenal intraepithelial T lymphocytes in patients with functional dyspepsia显示文摘AIM: To quantify the intraepithelial lymphocytes (IELs) and to document the membrane expression of CD4, CD8, TCRγδ and adhesion and/or activation-associated molecules (CD103, CD28, CD44, CD69, HLA-DR, CD95/ Fas) in the duodenal mucosa of patients with functional dyspepsia (FD) in order to provide arguments for an immunological process in FD. METHODS: Twenty-six FD patients according to Rome Ⅱ criteria (20 were H pylori negative) were studied and compared to 12 healthy adults. IELs were isolated from five duodenal biopsy samples, then quantified by microscopy and flow cytometry while the membrane phenotypes were determined by cytofluorometry. RESULTS: Duodenal histological examination was normal. In H pylori negative patients, the number of IELs was not different from that in healthy controls. Median percentage expression of CD4, CD8, or TCRγδ and CD103, CD44, CD28, CD69 on CD3+ IELs, among the adhesion/activation associated molecules tested, was not different from that in healthy controls. In contrast, the median percentage expression of CD95/ Fas [22 (9-65) vs 45 (19-88), P = 0.03] and HLA- DR expressing CD3+ IELs [4 (0-30) vs 13 (4-42), P = 0.04] was significantly lower in the H pylori negative FD group than in healthy controls, respectively. The number of IELs was significantly greater in H pylori positive FD patients than in healthy controls [median ratiofor 100 enterocytes 27.5 (6.7-62.5) vs 10.8 (3-33.3), P = 0.02] due to a higher number of CD8+ CD3+ IELs. CONCLUSION: In H pylori negative FD patients, the phenotypic characterization of IELs suggests that we cannot exclude a role of IELs in FD. | Gilles Gargala Stéphane Lecleire Arnaud Franois Serge Jacquot Pierre Déchelotte Jean Jacques Ballet Loic Favennec Philippe Ducrotté | 2007 | World Journal of Gastroenterology2007,13,16: | 2 |
| 5 | Levels of C-reactive Protein Are Associated With Response to Infliximab Therapy in Patients With Crohn’s Disease显示文摘 | Matthias Jürgens Jestinah M. Mahachie John Isabelle Cleynen Fabian Schnitzler Herma Fidder Wouter van Moerkercke Vera Ballet Maja Noman Ilse Hoffman Gert van Assche Paul J. Rutgeerts Kristel van Steen Severine Vermeire | 2011 | Clinical Gastroenterology and Hepatology2011,,5: | 2 |
| 6 | Hydrogen peroxidegas plasma sterilization is effective against Cryptosporidium parvumoocysts显示文摘 | VASSAL S FAVENNEC L BALLET J J | 1998 | Am J Infect Control1998,26,2: | 1 |
| 7 | Effect of vasodilators on hepatic vasnconstriction:Astudy of the inhibition of norepinephrine-induced vasnconstriction in the isolated perfused rat liver显示文摘 | Marteau P Ballet F Chretien Y | 1998 | Hepatology1998,8,2: | 1 |
| 8 | The novel analgesic,cizolirtine,inhibits the spinal release of substance P and CGRP in rats显示文摘 | Ballet S Aubel B Mauborgne A | 2001 | Neuropharmacology2001,40,4: | 1 |
| 9 | Magnetic resonance molec- ular imaging of thrombosis in an araehidonic acid mouse model u- sing an activated platelet targeted probe显示文摘 | Klink A Lancelot E Ballet S | 2010 | Arteriosecler Thromb Vasc Biol2010,30,3: | 1 |
| 10 | Influence of operation conditions on the retention of phosphate in water by nanofiltration显示文摘 | Guy Tiama Ballet Amor Haflane Mahmoud Dhahbi | 2007 | Journal of Membrane Science2007,290,: | 1 |
| 11 | SPARC represses E- eadherin and induces mesenchymal transition during melanoma development 显示文摘 | Robert G Gaggioli C Ballet O | 2006 | Cancer Res2006,66,15: | 1 |
| 12 | TV/4 Dual-Band HgCdTe Infrared Focal Plane Arrays with a 25-mm Pitch and Spatial Coherence 显示文摘 | BAYLET J BALLET P CASTELEIN P | 2006 | Journal of Electronic Materials (S0361-5235)2006,35,6: | 1 |
| 13 | Intluence of beta - glucanase supplementation on growth pertormances and digestive organs weights of broiler chickens fed corn, wheat and barley- based diet显示文摘 | Mathlouthi N Ballet N Larbier M | 2011 | International Journal of Pouhry Science2011,10,2: | 1 |
| 14 | Association between chronic urticaria and thyroid autoimmunity: a prospective study involving 99 patients 显示文摘 | Verneuil L Leconte C Ballet JJ | 2004 | Dermatology2004,208,2: | 1 |
| 15 | Gastric inhibitory pol- ypeptide and glucagon-like peptide-1 in the pathogene- sis of type 2 diabetes显示文摘 | Nauck MA Ballet B Meier JJ | 2004 | Diabetes2004,53,3: | 1 |
| 16 | Influence of operating conditions on the retention of phosphate in water by nanofiltration显示文摘 | Ballet G T Hafiane A Dhahbi M | 2007 | J Membr Sci2007,290,: | 1 |
| 17 | Latest Devel- opments of HgCdTe e-APDs at CEALETI-Minatec 显示文摘 | Rothman J Perrais G Ballet P | 2008 | Journal of Electronic Materials2008,37,9: | 1 |
| 18 | The novel analgesic,cizolirtine,inhibits the spinal release of substance P and CGRPin rats显示文摘 | Ballet S Aubel B Mauborgne A | 2001 | J Neuropharmacol2001,40,4: | 1 |
| 19 | Synovial chondromatosis of the distal radioulnar joint显示文摘 | Ballet FL Watson HK Ryu J | 1984 | J Hand Surg Am1984,9,: | 1 |
| 20 | Hg Cd Te p-on-n Focal-Plane Array Fabrication Using Arsenic Incorporation During MBE Growth显示文摘 | Gravrand O Ballet P Baylet J | 2009 | Journal of electrical materials2009,38,8: | 1 |