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| 1 | The treatment of Parkinson's disease with deep brain stimulation: current issues显示文摘Deep brain stimulation has become a well-established symptomatic treatment for Parkinson's disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients' mobility, activities of daily living, emotional well-being and health-related quality of life have been recognized. Apart from that, numerous clinical trials analyzed effects on non-motor symptoms and side effects of deep brain stimulation. Several technical issues and stimulation paradigms have been and are still being developed to optimize the therapeutic effects, minimize the side effects and facilitate handling. This review summarizes current therapeutic issues, i.e., patient and target selection, surgical procedure and programming paradigms. In addition it focuses on neuropsychological effects and side effects of deep brain stimulation. | Alexia-Sabine Moldovan Stefan Jun Groiss Saskia Elben Martin Südmeyer Alfons Schnitzler Lars Wojtecki | 2015 | Neural Regeneration Research2015，10，7： | 8 |
| 2 | Entecavir as treatment for reactivation of hepatitis B in immunosuppressed patients显示文摘AIM: To study the efficacy and safety of entecavir (ETV) as first-line therapy for hepatitis B virus (HBV) reactivation due to immunosuppression. METHODS: Four patients that were treated with different immunosuppressive regimens for hematological malignancies, who presented with HBV reactivation were treated with ETV. Clinical outcome, biochemical and virological factors, including quantitative hepatitis B surface antigen (HBsAg) were studied. RESULTS: In all patients, ETV induced suppression of HBV, and rapid clinical improvement without side effects. In one patient with an alanine aminotransferase (ALT) flare, tenofovir was added after 3 mo of treatment. Until death from disease progression at 6 mo after treatment initiation, this patient did not clear HBV infection. Retrospectively, it is highly probable that thepatient had been non-adherent. In the other three patients, the virological responses were associated with an expeditious decrease in quantitative HBsAg titers with negativity after 2 mo, and all three had HBsAg seroconversion. In one patient, HBV DNA reached a plateau after 3 mo, before becoming undetectable after 1 year, despite early ALT normalization and undetectable quantitative HBsAg. CONCLUSION: ETV seems to be effective and safe treatment for HBV reactivation. Monitoring of quantitative HBsAg might be an additional useful tool to monitor treatment response. | Sylvia Brost Paul Schnitzler Wolfgang Stremmel Christoph Eisenbach | 2010 | World Journal of Gastroenterology2010，16，43： | 7 |
| 3 | Levels of C-reactive Protein Are Associated With Response to Infliximab Therapy in Patients With Crohn’s Disease显示文摘 | Matthias Jürgens Jestinah M. Mahachie John Isabelle Cleynen Fabian Schnitzler Herma Fidder Wouter van Moerkercke Vera Ballet Maja Noman Ilse Hoffman Gert van Assche Paul J. Rutgeerts Kristel van Steen Severine Vermeire | 2011 | Clinical Gastroenterology and Hepatology2011，，5： | 2 |
| 4 | Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status显示文摘 | Johannes Stallhofer Matthias Friedrich Astrid Konrad-Zerna Martin Wetzke Peter Lohse Jürgen Glas Cornelia Tillack-Schreiber Fabian Schnitzler Florian Beigel Stephan Brand | 2015 | Inflammatory Bowel Diseases2015，，10： | 2 |
| 5 | Suppression of distortion product emissions(DPOAE) near 2f1 - f2 removes DP-gram fine structure-Evidence for a secondary generator 显示文摘 | Heitmann J Waldman B Schnitzler H U | 1998 | J Acoust Soc Am1998，103，： | 1 |
| 6 | ATP-sensitive potassium channels in capillaries isolated from guinea-pig heart显示文摘 | Schnitzler Michael Mederos Y Derst Christian Daut Jurgen | 2000 | The journal of physiology2000，525，2： | 1 |
| 7 | Successful treatment of severe acute intestinal graft versus host resistant to systemic and topical steroids with alemtuzumab显示文摘 | Schnitzler M Hasskarl J Egger M | 2009 | Biol Blood Marrow Transplant2009，15，8： | 1 |
| 8 | Antiviral activity ofAustralian tea tree oil and eucalyptus oil against herpes simplexvims in cellculture显示文摘 | SCHNITZLER P SCHON K REICHLING J | 2001 | Pharmazie2001，56，4： | 1 |
| 9 | A Retro- spective Analysis of Immunosuppression Compliance, Dose Reduction and Discontinuation in Kidney Transplant Recipi- ents显示文摘 | Takemoto S K Pinsky B W Schnitzler M A | 2007 | Am J Transplant2007，7，12： | 1 |
| 10 | The patho-physiology of echopraxia/echolalia : relevance toGilles de la Tourette syndrome 显示文摘 | Ganos C Ogrzal T Schnitzler A | 2012 | MovementDisord2012，27，10： | 1 |
| 11 | A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation显示文摘 | Irish WD Ilsley JN Schnitzler MA | 2010 | Am J Transplant2010，10，10： | 1 |
| 12 | The genetic basis for the antigenicity of the VP2 protein of the infectious bursal disease virus显示文摘 | Schnitzler D Bernstein F Muller H | 1993 | J GenVirol1993，74，： | 1 |
| 13 | Hepatitis B virus infec- tion and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph显示文摘 | Becker N Schnitzler P Boffetta P | 2012 | J Cancer Res Clin Oncol2012，138，12： | 1 |
| 14 | Susceptibility of Drug-Resistant Clinical Herpes Simplex Vires Type 1 Strains to Essential Oils of Ginger,Thyme,Hyssop,and Sandalwood显示文摘 | Christine Koch Jurgen Reichling | 2007 | Antimicrobial Agent and Chemotherapy2007，51，5： | 1 |
| 15 | Scperation of cardiomyocytes and coronary endothelial cells for cell-specific RT-PCR显示文摘 | Prcisig Muller R Moderos Y Schnitzler M | 1999 | Am J Physiol Heart Circ Physiol1999，277，： | 1 |
| 16 | Suitability of wood fiber substrates for pro- duction of vegetable transplants Ⅱ 显示文摘 | Gruda N Schnitzler W H | 2004 | Scientia Horticultural2004，100，： | 1 |
| 17 | 显示文摘 | Eggers R | 1999 | J Supercrit Fluids1999，16，1： | 1 |
| 18 | CD40L induces matrix-metalloproteinase-9 but not tissue inhibitor of metalloproteinases-1 in cervical carcinoma cells:imbalance between NF-κB and STAT3 activation显示文摘 | SMOLA-HESS S SCHNITZLER R HADASCHIK D | 2001 | Exp Cell Res2001，267，2： | 1 |
| 19 | Physieoehemieal properties of cassava starch oxidized by sodium hypoehlorite显示文摘 | GARRIDO L SCHNITZLER E de BOFF S | 2014 | Journal of Food Science and Technology2014，51，10： | 1 |
| 20 | Jugular venous oxygen saturation or arteriovenous difference of lactate content and outcome in children with severe traumatic brain injury显示文摘 | Perez A Minces PG Schnitzler EJ | 2003 | Pediatr Crit Care Med2003，4，1： | 1 |
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