|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Aberrant glycosylation of the anti-Thomsen-Friedenreich glycotope immunoglobulin G in gastric cancer patients显示文摘AIM: To study whether alterations in the glycosylation of immunoglobulin G (IgG) specific to the ThomsenFriedenreich glycotope (TF) have diagnostic and prognostic potential in gastric cancer. METHODS: Serum samples were obtained from patients with histologically verified gastric carcinoma (n = 89), healthy blood donors (n = 40), and patients with benign stomach diseases (n = 22). The lectin-enzymelinked immunosorbent assay-based glycoprofiling of TF-specific IgG (anti-TF IgG) was performed using synthetic TF-polyacrylamide conjugate as antigen, total IgG purified by affinity chromatography on protein G sepharose, and lectins of various sugar specificities: mannose-specific concanavalin A (ConA), fucose-specificAleuria aurantia lectin (AAL) and sialic acid-specific Sambucus nigra agglutinin (SNA). The sensitivity and specificity of the differences between cancer patients and controls were evaluated by receiver operator characteristic (ROC) curve analysis. Overall survival was analyzed by the Kaplan-Meier method. Time-dependent ROC curve statistics were applied to determine cut-off values for survival analysis. All calculations and comparisons were performed using the GraphPad Prism 5 and SPSS 15.0 software.RESULTS: The level of TF-specific IgG was significantly increased in cancer patients compared with non-cancer controls (P < 0.001). This increase was pronounced mostly in stage 1 of the disease. Cancer patients showed a higher level of ConA binding to antiTF-IgG (P < 0.05) and a very low level of SNA lectin binding (P = 0.0001). No appreciable stage-dependency of the binding of any lectin to anti-TF IgG was found. A strong positive correlation between the binding of AAL and SNA was found in all groups studied (r = 0.71-0.72; P < 0.0001). The changes in ConA reactivity were not related to those of the fucoseor sialic acid-specific lectin. Changes in the SNA binding index and the ConA/SNA binding ratio demonstrated good sensitivity and specificity for stomach cancer: sensitivity 78.79% (95%CI: 61.09-91.02) and 72.73% (95%CI: 57.21-85.04); specificity 79.17 (95%CI: 65.01-89.53) and 88.64% (95%CI: 71.8-96.6), for the SNA binding index and the ConA/SNA binding ratio, respectively. The other combinations of lectins did not improve the accuracy of the assay. The low level of ConA-positive anti-TF IgG was associated with a survival benefit in cancer patients (HR = 1.56; 95%CI: 0.78-3.09; P = 0.19), especially in stages 3-4 of the disease (HR = 2.17; 95%CI: 0.98-4.79; P = 0.048). A significantly better survival rate was found in all cancer patients with a low reactivity of anti-TF IgG to the fucose-specific AAL lectin (HR = 2.39; 95%CI: 1.0-5.7;P = 0.038).CONCLUSION: The changes in the TF-specific IgG glycosylation pattern can be used as a biomarker for stomach cancer detection, and to predict patient survival. | Kristel Kodar Jelena Izotova Kersti Klaamas Boris Sergeyev Lilian Jrvekülg Oleg Kurtenkov | 2013 | World Journal of Gastroenterology2013，19，23： | 3 |
| 2 | Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells显示文摘 | Kristel Kemper Pramudita R. Prasetyanti Wim De Lau Hans Rodermond Hans Clevers Jan Paul Medema | 2012 | STEM CELLS2012，，11： | 2 |
| 3 | Bcl-2 Gene Family and Related Proteins in Mammary Gland Involution and Breast Cancer显示文摘 | Kristel Schorr Minglin Li Stanislaw Krajewski John C. Reed Priscilla A. Furth | 1999 | Journal of Mammary Gland Biology and Neoplasia1999，，2： | 2 |
| 4 | Postoperative change of anti-Thomsen-Friedenreich and Tn IgG level: The follow-up study of gastrointestinal cancer patients显示文摘AIM: To study the influence of tumor removal on the serum level of IgG antibodies to tumor-associated Thomsen-Friedenreich (TF), Tn carbohydrate epitopes and xenogeneic αGal, and to elucidate on the change of the level during the follow-up as well as its association with the stage and morphology of the tumor and the values of blood parameters in gastrointestinal cancer. METHODS: Sixty patients with gastric cancer and 34 patients with colorectal cancer in stages Ⅰ-Ⅳ without distant metastases were subjected to follow- up. The level of antibodies in serum was determined by the enzyme-linked immunosorbent assay (ELISA) using synthetic polyacrylamide (PAA) glycoconjugates. Biochemical and haematological analyses were performed using automated equipment. RESULTS: In gastrointestinal cancer, the TF antibody level was found to have elevated significantly after the removal of G3 tumors as compared with the preoperative level (u = 278.5, P < 0.05). After surgery, the TF and Tn antibody level was elevated in the majority of gastric cancer patients (sign test, 20 vs 8, P < 0.05, and 21 vs 8, P < 0.05, respectively). In gastrointestinal cancer, the elevated postoperative level of TF, Tn and αGal antibodies was noted in most patients with G3 tumors (sign test, 22 vs 5, P < 0.01; 19 vs 6, P < 0.05; 24 vs 8, P < 0.01, respectively), but the elevation was not significant in patients with G1 + G2 resected tumors. The postoperative follow-up showed that the percentage of patients with G3 resected tumors of the digestive tract, who had a mean level of anti-TF IgG above the cut- off value (1.53), was significantly higher than that of patients with G1 + G2 resected tumors (χ2 = 3.89, all patients; χ2 = 5.34, patients without regional lymph node metastases; P < 0.05). The percentage of patients with a tumor in stage I, whose mean anti-TF IgG level remained above the cut-off value (1.26), was significantly higher than that of patients with the cancer in stages Ⅲ-Ⅳ (χ2 = 4.71, gastric cancer; χ2 = 4.11, gastrointestinal cancer; P < 0.05). The correlation was observed to exist between the level of anti-TF IgG and the count of lymphocytes (r = 0.517, P < 0.01), as well as between the level of anti- Tn IgG and that of serum CA 19-9 (r = 0.481, P < 0.05). No positive delayed-type hypersensitivity reaction in skin test challenges with TF-PAA in any of the fifteen patients, including those with a high level of anti-TF IgG, was observed. CONCLUSION: The surgical operation raises the level of anti-carbohydrate IgG in most patients, especially in those with the G3 tumor of the gastrointestinal tract. The follow-up demonstrates that after surgery the low preoperative level of TF antibodies may be considerably increased in patients with the carcinoma in its early stage but remains low in its terminal stages. The stage- and morphology-dependent immunosuppression affects the TF-antibody response and may be one of the reasons for unresponsiveness to the immunization with TF-antigens. | Eugeniy P Smorodin Oleg A Kurtenkov Boris L Sergeyev Kristel E Kodar Valentin I Chuzmarov Vladimir P Afanasyev | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 5 | Laparoscopic versus open resection of gastrointestinal stromal tumors of the stomach显示文摘 | Kristel Vogelaere Anne Hoorens Patrick Haentjens Georges Delvaux | 2013 | Surgical Endoscopy2013，，5： | 2 |
| 6 | Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells显示文摘 | Kristel Kemper Pramudita R. Prasetyanti Wim De Lau Hans Rodermond Hans Clevers Jan Paul Medema | 2012 | STEM CELLS2012，，11： | 2 |
| 7 | Histone H3 lysine 4 monomethylation modulates long- range chromatin interactions at enhancers显示文摘在 enhancers 和倡导者之间的远程的染色质相互作用为在哺乳动物和另外的 metazoans 的许多发展地控制的基因的抄写是必要的。当前,把远侧的 enhancers 连接到他们的特定的目标倡导者的准确机制尚待充分被阐明。这里,我们证明 4 monomethylation (H3K4me1 )(MLL3/4 ) 和 histone methyltransferases MLL3 和 MLL4 玩的提高特定的 histone H3 离氨酸在这个过程的一个活跃角色。我们在区分老鼠表明那胚胎的干细胞,在 enhancers 的 H3K4me1 的 MLL3/4-dependent 免职与染色质相互作用的增加的层次相关,而这 histone 修正的损失在区别期间在基因激活导致染色质相互作用和缺点的减少的层次。H3K4me1 便于 Cohesin 建筑群的招募,染色质组织的一个已知的管理者到在 vitro 并且在 vivo 的染色质,提供潜在的机制让 MLL3/4 支持在 enhancers 和倡导者之间的染色质相互作用。一起拿,我们的结果在在哺乳动物的房间在 enhancers 安排远程的染色质相互作用为 MLL3/4-dependent H3K4me1 支持一个角色。 | Jian Yan Shi-An A Chen Andrea Local Tristin Liu Yunjiang Qiu Kristel M Dorighi Sebastian Preissl Chloe M Rivera Chaochen Wang Zhen Ye Kai Ge Ming Hu Joanna Wysocka Bing Ren | 2018 | Cell Research2018，28，2： | 2 |
| 8 | Genetic Risk Profiling and Prediction of Disease Course in Crohn’s Disease Patients显示文摘 | Liesbet Henckaerts Kristel Van Steen Isabel Verstreken Isabelle Cleynen Andre Franke Stefan Schreiber Paul Rutgeerts Séverine Vermeire | 2009 | Clinical Gastroenterology and Hepatology2009，，9： | 2 |
| 9 | Levels of C-reactive Protein Are Associated With Response to Infliximab Therapy in Patients With Crohn’s Disease显示文摘 | Matthias Jürgens Jestinah M. Mahachie John Isabelle Cleynen Fabian Schnitzler Herma Fidder Wouter van Moerkercke Vera Ballet Maja Noman Ilse Hoffman Gert van Assche Paul J. Rutgeerts Kristel van Steen Severine Vermeire | 2011 | Clinical Gastroenterology and Hepatology2011，，5： | 2 |
| 10 | Comparative effectiveness of a mindful eating intervention to a diabetes self-management intervention among adults with type 2diabetes:a pilot study显示文摘 | Miller CK Kristeller JL Headings A | 2012 | J Acad Nutr Diet2012，112，11： | 1 |
| 11 | Overexpression of Cyclin D1indicates a poor prognosis in squamous cell carcinoma of the head and neck显示文摘 | Michalides RJ van Veelen NM Kristel PM | 1997 | Arch Otolaryngol Head Neck Surg1997，123，5： | 1 |
| 12 | Agrobacterium - mediated transformation of apple( Malus × Domestica Borkh) : an assessment of factors affecting regeneration of transgenic plants 显示文摘 | An De Bondt Kristel Eggermont Iris Penninckx | 1996 | Plant Cell Report1996，15，： | 1 |
| 13 | Fluoxetine versus placebo in advanced cancer outpatients: a double-blinded trial of the Hoosier Oncology Group显示文摘 | Fisch M J Loehrer PJ Kristeller J | 2003 | J Clin Oncol2003，21，10： | 1 |
| 14 | Benefits and risks of aprotininuse during cardiac surgery 显示文摘 | Kristeller JL Roslund BP Stahl RF | 2008 | Pharmacotherapy2008，28，1： | 1 |
| 15 | Quantifying the formation of carcinogens during food processing: acrylamide显示文摘 | Wendie L. Claeys Kristel De Vleeschouwer Marc E. Hendrickx | 2005 | Trends in Food Science & Technology2005，，5： | 1 |
| 16 | Developmental- and food-dependent foraging transcript levels in the desert locust显示文摘在环境的激烈的变化在一生期间要求发展、生理的灵活性保证动物幸存。荒芜的蝗虫, Schistocerca gregaria,住在极其可变的环境,它在降雨和丰富的食物的时期和干旱和饥饿的时期之间轮流出现。以便幸存,蝗虫显示允许他们很快由从一个神秘 solitarious 阶段变换成聚集应付这些变化条件的 phenotypic 粘性的一种极端形式,贪婪群居的阶段。完成这,蝗虫拥有 phenotypic 的不同保存调停人粘性。最近,注意在这个过程被引起了到蛋白质 kinases 的可能的角色。除了周期的安培依赖者蛋白质 kinase (PKA ) ,也周期的 GMP 依赖的蛋白质 kinase (PKG ) 被显示在许多昆虫涉及食物相关的行为的变化,与蝗虫 phenotypic 粘性被联系了。在这篇文章,我们学习 S 的抄本层次。把 PKG 编码为不同食物相关的、发展、挤满的条件的 foraging 基因的 gregaria orthologue。S 的抄本层次。gregaria foraging orthologue 在内脏的不同部分是最高的并且不同在之间孤立并且饲养人群的蝗虫。当食物的可获得性被改变,在一根脱毛以后与高水平显示一个不同模式并且与在 postembryonic 开发期间的年龄减少时,他们变化。 | Julie Tobback Heleen Verlinden Kristel Vuerinckx Rut Vleugels Jozef Vanden Broeck Roger Huybrechts | 2013 | Insect Science2013，20，6： | 1 |
| 17 | Expression of the breast cancer resistance protein in breast cancer显示文摘 | Faneyte IF Kristel PM Maliepaard M | 2002 | Clin Cancer Res2002，8，4： | 1 |
| 18 | The nursing process in community nursing 显示文摘 | Kristel K H | 1993 | Krankenpfl-J1993，31，12： | 1 |
| 19 | Expression of the breast cancer resistance protein in breast cancer显示文摘 | Faneyte IF Kristel PM Maliepaard M | 2002 | Clin Cancer Res2002，8，4： | 1 |
| 20 | Associa- tion of C-MYC amplification with progression from the in situ to the invasive stage in C-MYC-amplified breast carcinomas 显示文摘 | Robanus-Maandag E C Bosch C A Kristel P M | 2003 | J Pathol2003，201，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员