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| 1 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 2 | Early detection and prevention of pancreatic cancer:Is it really possible today?显示文摘Pancreatic cancer is the 4th leading cause of cancerrelated death in Western countries.Considering the low incidence of pancreatic cancer,population-based screening is not feasible.However,the existence of a group of individuals with an increased risk to develop pancreatic cancer has been well established.In particular,individuals suffering from a somatic or genetic condition associated with an increased relative risk of more than 5-to 10-fold seem to be suitable for enrollment in a surveillance program for prevention or early detection of pancreatic cancer.The aim of such a program is to reduce pancreatic cancer mortality through early or preemptive surgery.Considering the risk associated with pancreatic surgery,the concept of preemptive surgery cannot consist of a prophylactic removal of the pancreas in high-risk healthy individuals,but must instead aim at treating precancerous lesions such as intraductal papillary mucinous neoplasms or pancreatic intraepithelial neoplasms,or early cancer.Currently,results from clinical trials do not convincingly demonstrate the efficacy of this approach in terms of identification of precancerous lesions,nor do they define the outcome of the surgical treatment of these lesions.For this reason,surveillance programs for individuals at risk of pancreatic cancer are thus far generally limited to the setting of a clinical trial.However,the acquisition of a deeper understanding of this complex area,together with the increasing request for screening and treatment by individuals at risk,will usher pancreatologists into a new era of preemptive pancreatic surgery.Along with the growing demand to treat individuals with precancerous lesions,the need for low-risk investigation,lowmorbidity operation and a minimally invasive approach becomes increasingly pressing.All of these considerations are reasons for preemptive pancreatic surgery programs to be undertaken in specialized centers only. | Marco Del Chiaro Ralf Segersvrd Matthias Lohr Caroline Verbeke | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 3 | Challenges and prospects for consumer acceptance of cultured meat显示文摘Consumer acceptance of cultured meat is expected to depend on a wide diversity of determinants ranging from technologyrelated perceptions to product-specific expectations, and including wider contextual factors like media coverage, public involvement, and trust in science, policy and society. This paper discusses the case of cultured meat against this multitude of possible determinants shaping future consumer acceptance or rejection. The paper also presents insights from a primary exploratory study performed in April 2013 with consumers from Flanders(Belgium)(n=180). The concept of cultured meat was only known(unaided) by 13% of the study participants. After receiving basic information about what cultured meat is, participants expressed favorable expectations about the concept. Only 9% rejected the idea of trying cultured meat, while two thirds hesitated and about quarter indicated to be willing to try it. The provision of additional information about the environmental benefits of cultured meat compared to traditional meat resulted in 43% of the participants indicating to be willing to try this novel food, while another 51% indicated to be ‘maybe' willing to do so. Price and sensory expectations emerged as major obstacles. Consumers eating mostly vegetarian meals were less convinced that cultured meat might be healthy, suggesting that vegetarians may not be the ideal primary target group for this novel meat substitute. Although exploratory rather than conclusive, the findings generally underscore doubts among consumers about trying this product when it would become available, and therefore also the challenge for cultured meat to mimic traditional meat in terms of sensory quality at an affordable price in order to become acceptable for future consumers. | Wim Verbeke Pierre Sans Ellen J Van Loo | 2015 | Journal of Integrative Agriculture2015，14，2： | 10 |
| 4 | Effects of cereal fiber on bowel function: A systematic review of intervention trials显示文摘AIM: To comprehensively review and quantitatively summarize results from intervention studies that examined the effects of intact cereal dietary fiber on parameters of bowel function. METHODS: A systematic literature search was conducted using Pub Med and EMBASE. Supplementary literature searches included screening reference lists from relevant studies and reviews. Eligible outcomes were stool wet and dry weight, percentage water in stools, stool frequency and consistency, and total transit time. Weighted regression analyses generated mean change(± SD) in these measures per g/d of dietary fiber. RESULTS: Sixty-five intervention studies among generally healthy populations were identified. A quantitative examination of the effects of non-wheat sources of intact cereal dietary fibers was not possible due to an insufficient number of studies. Weighted regression analyses demonstrated that each extra g/d of wheat fiber increased total stool weight by 3.7 ± 0.09 g/d(P < 0.0001; 95%CI: 3.50-3.84), dry stool weight by 0.75 ± 0.03 g/d(P < 0.0001; 95%CI: 0.69-0.82), and stool frequency by 0.004 ± 0.002 times/d(P = 0.0346; 95%CI: 0.0003-0.0078). Transittime decreased by 0.78 ± 0.13 h per additional g/d(P < 0.0001; 95%CI: 0.53-1.04) of wheat fiber among those with an initial transit time greater than 48 h.CONCLUSION: Wheat dietary fiber, and predominately wheat bran dietary fiber, improves measures of bowel function. | Jan de Vries Paige E Miller Kristin Verbeke | 2015 | World Journal of Gastroenterology2015，21，29： | 5 |
| 5 | European experts consensus statement on cystic tumours of the pancreas显示文摘 | Marco Del Chiaro Caroline Verbeke Roberto Salvia Gunter Kl?ppel Jens Werner Colin McKay Helmut Friess Riccardo Manfredi Eric Van Cutsem Matthias L?hr Ralf Segersv?rd | 2013 | Digestive and Liver Disease2013，，： | 3 |
| 6 | Intraductal papillary-mucinous neoplasia of the pancreas:Histopathology and molecular biology显示文摘Intraductal papillary-mucinous neoplasm(IPMN) of the pancreas is a clinically and morphologically distinctive precursor lesion of pancreatic cancer,characterized by gradual progression through a sequence of neoplastic changes.Based on the nature of the constituting neoplastic epithelium,degree of dysplasia and location within the pancreatic duct system,IPMNs are divided in several types which differ in their biological properties and clinical outcome.Molecular analysis and recent animal studies suggest that IPMNs develop in the context of a field-defect and reveal their possible relationship with other neoplastic precursor lesions of pancreatic cancer. | Caroline S Verbeke | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 3 |
| 7 | Vegetation change detection using artificial neural networks with ancillary data in Xishuangbanna,Yunnan Province,China显示文摘地球的及时、精确的变化察觉“ s 表面特征为更好计划,管理和环境研究提供基础。在这个学习 ANN 变化,察觉被用来执行植被变化察觉,并且与分类以后的方法相比。以前分类以后被执行 ANN 分类被用来产出多时间的植被地图。ANN 也被用来在 2003 和 2004 为图象执行一个一个通行证分类。DEM 和斜坡被用作二条额外的隧道。在训练阶段期间,训练数据包括 36 个变化子类和 46 个没有变化子类被分开成 82 个子类。而且 NDVI differencing 方法被用来开发变化面具。当鉴别参考区域能为 ANN 那个生产更精确的变化察觉结果时,结果显示出那把 NDVI differencing 方法与视觉解释相结合通行证变化分类。而且,和 PCA 部件把举起和斜坡用作额外的隧道是有效的,在多山的学习区域执行基于 ANN 的变化察觉。把植被转变类分开成子类基于也是重要的光谱反应模式,特别为多山的地面。这个处理能减少地志的效果并且改进变化察觉精确性。 | ZHANG ZhiMing Lieven VERBEKE Eva De CLERCQ OU XiaoKun Robert De WULF | 2007 | Chinese Science Bulletin2007，52，A02： | 2 |
| 8 | Consumer interest in information cues denoting quality, traceability and origin: An application of ordered probit models to beef labels显示文摘 | Wim Verbeke Ronald W. Ward | 2005 | Food Quality and Preference2005，，6： | 2 |
| 9 | Resection Margins in Pancreatic Cancer显示文摘 | Caroline S. Verbeke | 2013 | Surgical Clinics of North America2013，，3： | 2 |
| 10 | Modulating the microbiota in inflammatory bowel diseases: prebiotics, probiotics or faecal transplantation?显示文摘 | Kristin A. Verbeke Leen Boesmans Eef Boets | 2014 | Proceedings of the Nutrition Society2014，，4： | 2 |
| 11 | Sa1922 Pilot Study on the Safety and Efficacy of Faecal Microbiota Transplantation in Refractory Crohn’s Disease显示文摘 | Severine Vermeire Marie Joossens Kristin Verbeke Falk Hildebrand Kathleen Machiels Karolien Van den Broeck Gert Van Assche Paul J. Rutgeerts Jeroen Raes | 2012 | Gastroenterology2012，，5： | 2 |
| 12 | Microencapsulation of apomorphine HCI with gelatin显示文摘 | Ugwoke M I Verbeke N Kinget R | 1997 | Inter J Pharm1997，148，1： | 1 |
| 13 | Consumer acceptance of functional foods: socio -demographic, cognitive and attitudinal determinants 显示文摘 | Wim Verbeke | 2005 | Food Quality and Preference2005，16，： | 1 |
| 14 | Redefining the R1 resec- tion in pancreatic cancer显示文摘 | Verbeke C Leitch D Menon K | 2006 | Br J Surg2006，93，10： | 1 |
| 15 | Amgional analysis of tourist flows within Europe 显示文摘 | Jansen - Verbeke M | 1995 | Tourism Management1995，，1： | 1 |
| 16 | Brain-derivedneurotrophic factor and neurotrophin-4/5 are expressed in breastcancer and can be targeted to inhibit tumor cell survival显示文摘 | Vanhecke E Adriaenssens E Verbeke S | 2011 | ClinCancer Res2011，17，7： | 1 |
| 17 | Expression of survivin, a novel inhibitor of apoptosis and cell cycle regulatory protein, in pancreatic adenocarcinoma显示文摘 | Sarela AI Verbeke CS Ramsdale J | 2002 | Br J Cancer2002，86，6： | 1 |
| 18 | Redefining the R1 resection in pancreatic cancer显示文摘 | Verbeke CS Leitch D Menon KV | 2006 | Br J Surg2006，93，10： | 1 |
| 19 | Prognostic value of aortic stiffness and calcification for cardiovascular events and mortality in dialysis patients: outcome of the calcification outcome in renal disease (CORD) study显示文摘 | Verbeke F Van Biesen W Honkanen E | 2011 | Clin J Am Soc Nephrol2011，6，1： | 1 |
| 20 | Postprandial symptoms originating from the stomach in functional dyspepsia显示文摘 | H. Vanheel T. Vanuytsel L. Oudenhove R. Farré K. Verbeke J. Tack | 2013 | Neurogastroenterol. Motil2013，，11： | 1 |
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