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| 1 | 冠状动脉内皮功能障碍患者循环MOTS-c水平下调显示文摘MOTS-c是一种新发现的线粒体衍生肽,其在调节代谢稳态中起作用。该研究旨在研究在没有显著冠状动脉结构性病变的患者中循环MOTS-c水平是否也与内皮功能障碍相关。方法:纳入无冠状动脉结构性病变的复发性心绞痛并接受冠状动脉造影和内皮功能检测的患者40例。 | Qin Q Delrio S Wan J Jay Widmer R Cohen P Lerman LO Lerman A 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 14 |
| 2 | Role of endoscopic ultrasonography in the loco-regional staging of patients with rectal cancer显示文摘The prognosis of rectal cancer(RC) is strictly related to both T and N stage of the disease at the time of diagnosis. RC staging is crucial for choosing the best multimodal therapy: patients with high risk locally advanced RC(LARC) undergo surgery after neoadjuvant chemotherapy and radiotherapy(NAT); those with low risk LARC are operated on after a preoperative short-course radiation therapy; finally, surgery alone is recommended only for early RC. Several imaging methods are used for staging patients with RC: computerized tomography, magnetic resonance imaging, positron emission tomography, and endoscopic ultrasound(EUS). EUS is highly accurate for the loco-regional staging of RC, since it is capable to evaluate precisely the mural infiltration of the tumor(T), especially in early RC. On the other hand, EUS is less accurate in restaging RC after NAT and before surgery. Finally, EUS is indicated for follow-up of patients operated on for RC, where there is a need for the surveillance of the anastomosis. The aim of this review is to highlight the impact of EUS on the management of patients with RC, evaluating its role in both preoperative staging and follow-up of patients after surgery. | Pietro Marone Mario de Bellis Valentina D'Angelo Paolo Delrio Valentina Passananti Elena Di Girolamo Giovanni Battista Rossi Daniela Rega Maura Claire Tracey Alfonso Mario Tempesta | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，7： | 11 |
| 3 | Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis显示文摘AIM:To investigated the molecular cause of very early-onset ulcerative colitis(UC)in an 18-mo-old affected child.METHODS:We analysed the interleukin-10(IL10)receptor genes at the DNA and RNA level in the proband and his relatives.Beta catenin and tumor necrosis factor-α(TNFα)receptors were analysed in the proteins extracted from peripheral blood cells of the proband,his relatives and familial adenomatous polyposis(FAP)and PTEN hamartoma tumor syndrome(PHTS)patients.Samples were also collected from the proband’s inflamed colorectal mucosa and compared to healthy and tumour mucosa collected from a FAP patient and patients affected by sporadic colorectal cancer(CRC).Finally,we examined mesalazine and azathioprine effects on primary fibroblasts stabilised from UC and FAP patients.RESULTS:Our patient was a compound heterozygote for the IL10RB E47K polymorphism,inherited from his father,and for a novel point mutation within the IL10RA promoter(the-413G->T),inherited from his mother.Beta catenin and tumour necrosis factorαreceptors-Ⅰ(TNFRI)protein were both over-expressed in peripheral blood cells of the proband’s relatives more than the proband.However,TNFRII was over-expressed only in the proband.Finally,both TNFα-receptors were shown to be under-expressed in the inflamed colon mucosa and colorectal cancer tissue compared to healthy colon mucosa.Consistent with this observation,mesalazine and azathioprine induced,in primary fibroblasts,IL10RB and TNFRII over-expression and TNFRI and TNFαunder-expression.We suggest thatβ-catenin and TNFRI protein expression in peripheral blood cells could represent molecular markers of sub-clinical disease in apparently healthy relatives of patients with early-onset UC.CONCLUSION:A synergistic effect of several variant alleles of the IL10 receptor genes,inherited in a Mende-lian manner,is involved in UC onset in this young child. | Martina Galatola Erasmo Miele Caterina Strisciuglio Lorella Paparo Daniela Rega Paolo Delrio Francesca Duraturo Massimo Martinelli Giovanni Battista Rossi Annamaria Staiano Paola Izzo Marina De Rosa | 2013 | World Journal of Gastroenterology2013，19，46： | 7 |
| 4 | Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies:results in 123 patients显示文摘 | Curley SA Izzo F Delrio P | | 0，，： | 3 |
| 5 | Radiofiequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients显示文摘 | Curley SA Izzo F Delrio P | 1999 | Ann Surg1999，230，1： | 2 |
| 6 | Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients显示文摘 | Curley SA Izzo F Delrio P | 1999 | Ann Surg1999，230，1： | 2 |
| 7 | Radiofrequency ablation of unresectahle primary and metastatic hepatic malignancies: results in 123 patients显示文摘 | Izzo F Delrio P | 1999 | Arn Surg1999，230，1： | 1 |
| 8 | Radiofrequency ablation of unre- sectable primary and metastatic hepatic malignancies: results in 123 patienrs显示文摘 | Curley SA Izzo F Delrio P | 1999 | Ann Surg1999，230，1： | 1 |
| 9 | Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies显示文摘 | Curley SA Izzo F Delrio P | 1999 | Ann Surg1999，230，1： | 1 |
| 10 | Post-operative complications after completion thyroidectomy for differentiated thyroid cancer显示文摘 | Pezzullo L Delrio P Losito NS | 1997 | Eur J Surg Oncol1997，23，3： | 1 |
| 11 | Radiofrequency ablation of unresectableprimary and metastatic hepatic malignancies:results in 123 patients显示文摘 | Curley SA Izzo F Delrio P | 1999 | Ann Surg1999，230，1： | 1 |
| 12 | Radiofrequency ablation in patients with primary breast carcinoma: a pilot study in 26 patients显示文摘 | Izzo F Thomas R Delrio P | 2001 | Cancer2001，92，8： | 1 |
| 13 | Oxaliplatin plus dual in- hibition of thymidilate synthase duIing preoperative pelvic radio- therapy for locally advanced rectal carcinoma: long-term outcome 显示文摘 | Avallone A Delrio P Pecori B | 2011 | Int J Radiat Oncol Biol Phys2011，79，3： | 1 |
| 14 | Oxaliplatin Plus Dual Inhibition of Thymidilate Synthase During Preoperative Pelvic Radiotherapy for Locally Advanced Rectal Carcinoma: Long-Term Outcome显示文摘 | Antonio Avallone Paolo Delrio Biagio Pecori Fabiana Tatangelo Antonella Petrillo Nigel Scott Pietro Marone Luigi Aloi Claudia Sandomenico Secondo Lastoria Vincenzo Rosario Iaffaioli Dario Scala Giovanni Iodice Alfredo Budillon Pasquale Comella | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，3： | 1 |
| 15 | Sentinel node biopsy in gastric cancer显示文摘 | Palaia R Cremona F Delrio P | 1999 | J Chemother1999，11，3： | 1 |
| 16 | Infective endocarditis and cardiac surgery in intravenous drug abusers and HIV-1 infected patients显示文摘 | Miro JM DelRio A Mestres CA | 2003 | Cardiol Clin2003，21，2： | 1 |
| 17 | Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies:results in123 patients显示文摘 | Curley SA Lzzo F Delrio P | | 0，，01： | 1 |
| 18 | Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies:results in 123 patients显示文摘 | Curley SA Izzo F Delrio P | 1999 | Ann Surg1999，230，1： | 1 |
| 19 | Radiofrequency ablation in patients with primary breast carcinoma:a pilot study in 26 patients显示文摘 | Thomas R Delrio P | 2001 | Cancer2001，92，8： | 1 |
| 20 | Soluble interleukin-2 receptor level in hepatocellular cancer:a more sensitive marker than alpha-fetorprotein显示文摘 | Izzo F Cremona F Delrio P | | 0，，02： | 1 |
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