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| 1 | Management of negative pressure wound therapy in the treatment of diabetic foot ulcers显示文摘Diabetic foot(DF) is a common complication of diabetes and the first cause of hospital admission in diabetic patients. In recent years several guidelines have been proposed to reinforce the the management of DF with a notable increase in diabetes knowledge and an overall reduction of amputations. Significant improvements have been reached in the treatment of diabetic foot ulcers(DFUs) and nowadays clinicians have several advanced medications to apply for the best local therapy. Among these, negative pressure wound therapy(NPWT) is a useful adjunct in the management of chronic and complex wounds to promote healing and wound bed preparation for surgical procedures such as skin grafts and flap surgery. NPWT has shown remarkable results although its mechanisms of action are not completely understood. In this paper, we offer a complete overview of this medication and its implication in the clinical setting. We have examined literature related to NPWT concerning human, animal and in vitro studies, and we have summarized why, when and how we can use NPWT to treat DFUs. Further we have associated our clinical experience to scientific evidence in the field of diabetic foot to identify a defined strategy that could guide clinician in the use of NPWT approaching to DFUs. | Marco Meloni Valentina Izzo Erika Vainieri Laura Giurato Valeria Ruotolo Luigi Uccioli | 2015 | World Journal of Orthopedics2015，6，4： | 33 |
| 2 | Growth hormone regulates intestinal ion transport through a modulation of the constitutive nitric oxide synthase-nitric oxide-cAMP pathway显示文摘瞄准:生长激素(GH ) 直接与刺激离子吸收并且减少营地的收缩筋导致的离子分泌物的 enterocyte 交往。后来氮的氧化物(没有) 为 GH 血液动力学的效果作为第二个送信人涉及 transepithelial 离子运输和行为的规定,我们测试了可以不在肠的离子运输上涉及 GH 的产生效果的假设。方法:反映 trans 上皮的离子运输的电的参数在房间单层在 Ussing 房间装了并且独自或在联合暴露了到 GH 和霍乱毒素(CT ) 的 Caco-2 被测量,当面或 NO 的缺席 synthase (NOS ) 禁止者, Nomega-nitro-L-arginine 甲基酉旨(L 名字) 。类似的实验被进行决定营地和亚硝酸根 / 硝酸盐集中。NOS 表示是由西方的污点分析的 assayed。结果:L 名字原因在肠的离子运输上由 GH 总计吸收性、反能分泌的效果的废除。另外, L 名字能在基础条件下面并且响应 CT 在细胞内部的营地集中上禁止 GH 效果。GH 导致了 Ca (2+) 亚硝酸根 / 硝酸盐生产的依赖增加,显示参与组成而非可诱导的 NOS 对碘氧基苯甲醚,它被西方的污点分析直接证实。结论:这些结果建议在基础条件下面或面对刺激营地的离子分泌物,肠的离子运输上的 GH 效果被 cNOS 的活动在细胞内部的水平调停。 | Roberto Berni Canani Pia Cirillo Giuseppe Mallardo Vittoria Buccigrossi Annalisa Passariello Serena Ruotolo Giulio De Marco Francesco Porcaro Alfredo Guarino | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 3 | Serum insulin-like growth factor-1 level is independently associated with coronary artery disease progression in young male survivors of myocardial infarction:beneficial effects of bezafibrate treatment显示文摘 | Ruotolo G Bavenholm P Brismar K | 2000 | J Am Coll Cardiol2000，35，： | 1 |
| 4 | 接受最佳治疗的高危血管病患者中C反应蛋白对脂蛋白(a)相关心血管病风险的影响显示文摘脂蛋白(a)是动脉粥样硬化性心血管病的遗传致病危险因素,但目前还不清楚哪些动脉粥样硬化性心血管病患者从脂蛋白(a)降低中受益最大。在二级预防中炎症是否会调节与脂蛋白(a)相关的心血管病风险也未知。该文旨在确定在接受最佳治疗的高危心血管病患者中,脂蛋白(a)相关的心血管病风险是否受到全身炎症的调节。 | 周卫(译) 刘莉(摘/审校) Puri R Nissen SE Arsenault BJ St John J Riesmeyer JS Ruotolo G McErlean E Menon V Cho L Wolski K Lincoff AM Nicholls SJ | 2020 | 中华高血压杂志2020，28，11： | 1 |
| 5 | Insights into pulsed electrodeposition of GMR multilayered nanowires显示文摘 | Pullini D Busquets D Ruotolo A | 2007 | J Magn Magn Mater2007，316，2： | 1 |
| 6 | Dyslipidemia of the metabolic syndrome显示文摘 | Ruotolo G Howard BV | 2002 | Curr Cardiol Rep2002，4，： | 1 |
| 7 | Treatment effect on serumlipoprotine lipids, apolipoproteins and low density liporotine particle size and relationships of lipoprotine variables to progression of coronary artery disease in the Bezafibrate Cotonary Atherosclerosis Intervention Trial(BECAIT) 显示文摘 | Ruotolo G Ericsson CG Tettarmanti C | 1998 | J Am Coll Cardiol1998，32，： | 1 |
| 8 | Gene expression profiling in human age-related nuclear cataract 显示文摘 | Ruotolo R Grassi F Percudani R | 2003 | Mol Vis2003，9，： | 1 |
| 9 | Using SVD to detect damage in structures with different operational conditions显示文摘 | Ruotolo R Surace C | 1999 | Journal of Sound and Vibration1999，，3： | 1 |
| 10 | Insulin resistance,the metabolic syndrome,and risk of incident cardiovascular disease in nondiabetic American indians:The strong heart study显示文摘 | RESNICK HE JONES K RUOTOLO G | 2003 | Diabetes Care2003，26，3： | 1 |
| 11 | Insulin resistance ,the metabolic syndrome, and the risk of incident cardiovascular disease in nondiabetic American Indians显示文摘 | Resnick HE Jones K Ruotolo G | 2003 | Diabetes Care2003，26，： | 1 |
| 12 | Evidence for macromoleeular protein rings in the absence of bulk water显示文摘 | RUOTOLO B T GILES K CAMPUZANO I | 2005 | Science2005，310，5754： | 1 |
| 13 | Zinc inhibits calcium-mediated and nitric oxide-mediated ion secretion in human enterocytes显示文摘 | Roberto Berni Canani Agnese Secondo Annalisa Passariello Vittoria Buccigrossi Lorella Maria Teresa Canzoniero Serena Ruotolo Cuono Puzone Francesco Porcaro Manuela Pensa Antonio Braucci Monica Pedata Lucio Annunziato Alfredo Guarino | 2009 | European Journal of Pharmacology2009，，2： | 1 |
| 14 | Electrochemical treatment of effluents containing Cr(VI): Influence of PH and current on the kinetics显示文摘 | Ruotolo L A M Santos-Junior J D S Gubulin J C | 2006 | Water Research2006，40，8： | 1 |
| 15 | Domain organization of phytochelatln synthase显示文摘 | Ruotolo R Peracchi A Bolchi A | 2004 | The Journal of Biological Chemistry2004，279，14： | 1 |
| 16 | The diagnosis of fond allergyin children显示文摘 | Canani RB Ruotolo S Discepolo V | 2008 | Curr Opin Pediatr2008，20，4： | 1 |
| 17 | The diagnosis of food allergy in children显示文摘 | Berni Canani R Ruotolo S Discepolo V | 2008 | Current Opinion in Pediatrics2008，20，： | 1 |
| 18 | The diagnosis of food allergy in children显示文摘 | Canani RB Ruotolo S Discepolo V | 2008 | Curr Opin Pediatr2008，20，4： | 1 |
| 19 | Structural basis for the inhibition of activin signaling by follistatin 显示文摘 | Harrington AE Morris - Triggs SA Ruotolo BT | 2006 | EMBO2006，，25： | 1 |
| 20 | All-arthroscopic versus mini-open rotator cuff repair:A long-term retrospective outcome comparison显示文摘 | Severud EL Ruotolo C Abbott DD | 2003 | Arthroscopy2003，19，： | 1 |
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