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| 1 | Potential beneficial effects of butyrate in intestinal and extraintestinal diseases显示文摘The multiple beneficial effects on human health of the short-chain fatty acid butyrate,synthesized from nonabsorbed carbohydrate by colonic microbiota,are well documented.At the intestinal level,butyrate plays a regulatory role on the transepithelial fluid transport,ameliorates mucosal inflammation and oxidative status,reinforces the epithelial defense barrier,and modulates visceral sensitivity and intestinal motility.In addition,a growing number of studies have stressed the role of butyrate in the prevention and inhibition of colorectal cancer.At the extraintestinal level,butyrate exerts potentially useful effects on many conditions,including hemoglobinopathies,genetic metabolic diseases,hypercholesterolemia,insulin resistance,and ischemic stroke.The mechanisms of action of butyrate are different;many of these are related to its potent regulatory effects on gene expression.These data suggest a wide spectrum of positive effects exerted by butyrate,with a high potential for a therapeutic use in human medicine. | Roberto Berni Canani Margherita Di Costanzo Ludovica Leone Monica Pedata Rosaria Meli Antonio Calignano | 2011 | World Journal of Gastroenterology2011，17，12： | 52 |
| 2 | Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms显示文摘 | Anna Iacono Giuseppina Mattace Raso Roberto Berni Canani Antonio Calignano Rosaria Meli | 2011 | The Journal of Nutritional Biochemistry2011，，8： | 4 |
| 3 | Growth hormone regulates intestinal ion transport through a modulation of the constitutive nitric oxide synthase-nitric oxide-cAMP pathway显示文摘瞄准:生长激素(GH ) 直接与刺激离子吸收并且减少营地的收缩筋导致的离子分泌物的 enterocyte 交往。后来氮的氧化物(没有) 为 GH 血液动力学的效果作为第二个送信人涉及 transepithelial 离子运输和行为的规定,我们测试了可以不在肠的离子运输上涉及 GH 的产生效果的假设。方法:反映 trans 上皮的离子运输的电的参数在房间单层在 Ussing 房间装了并且独自或在联合暴露了到 GH 和霍乱毒素(CT ) 的 Caco-2 被测量,当面或 NO 的缺席 synthase (NOS ) 禁止者, Nomega-nitro-L-arginine 甲基酉旨(L 名字) 。类似的实验被进行决定营地和亚硝酸根 / 硝酸盐集中。NOS 表示是由西方的污点分析的 assayed。结果:L 名字原因在肠的离子运输上由 GH 总计吸收性、反能分泌的效果的废除。另外, L 名字能在基础条件下面并且响应 CT 在细胞内部的营地集中上禁止 GH 效果。GH 导致了 Ca (2+) 亚硝酸根 / 硝酸盐生产的依赖增加,显示参与组成而非可诱导的 NOS 对碘氧基苯甲醚,它被西方的污点分析直接证实。结论:这些结果建议在基础条件下面或面对刺激营地的离子分泌物,肠的离子运输上的 GH 效果被 cNOS 的活动在细胞内部的水平调停。 | Roberto Berni Canani Pia Cirillo Giuseppe Mallardo Vittoria Buccigrossi Annalisa Passariello Serena Ruotolo Giulio De Marco Francesco Porcaro Alfredo Guarino | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 4 | Diarrhea in neonatal intensive care unit显示文摘AIM:To investigate the frequency,etiology,and current management strategies for diarrhea in newborn.METHODS:Retrospective,nationwide study involving 5801 subjects observed in neonatal intensive care units during 3 years.The main anamnesis and demographic characteristics,etiology and characteristics of diarrhea,nutritional and therapeutic management,clinical outcomes were evaluated.RESULTS:Thirty-nine cases of diarrhea(36 acute,3 chronic) were identified.The occurrence rate of diarrhea was 6.72 per 1000 hospitalized newborn.Etiology was defined in 29 of 39 newborn(74.3%):food allergy(20.5%),gastrointestinal infections(17.9%),antibiotic-associated diarrhea(12.8%),congenital defects of ion transport(5.1%),withdrawal syndrome(5.1%),Hirschsprung's disease(2.5%),parenteral diarrhea(2.5%),cystic fibrosis(2.5%),and metabolic disorders(2.5%).Three patients died due to complications related to diarrhea(7.7%).In 19 of 39 patients(48.7%),rehydration was performed exclusively by the enteral route.CONCLUSION:Diarrhea in neonates is a challenging clinical condition due to the possible heterogeneous etiologies and severe outcomes.Specific guidelines are advocated in order to optimize management of diarrhea in this particular setting. | Annalisa Passariello Gianluca Terrin Maria Elisabetta Baldassarre Mario De Curtis Roberto Paludetto Roberto Berni Canani | 2010 | World Journal of Gastroenterology2010，16，21： | 2 |
| 5 | Diagnostic value of faecal calprotectin in paediatric gastroenterology clinical practice显示文摘 | R. Berni Canani L. Rapacciuolo M.T. Romano L. Tanturri de Horatio G. Terrin F. Manguso P. Cirillo F. Paparo R. Troncone | 2004 | Digestive and Liver Disease2004，，7： | 1 |
| 6 | Faecal calprotectin as reliable non-invasive marker to assess the severity of mucosal inflammation in children with inflammatory bowel disease显示文摘 | R. Berni Canani G. Terrin L. Rapacciuolo E. Miele M.C. Siani C. Puzone L. Cosenza A. Staiano R. Troncone | 2008 | Digestive and Liver Disease2008，，7： | 1 |
| 7 | Cardiovascular autonomic neuropathy in type 2 diabetes mellitus patients with peripheral artery disease显示文摘 | Canani LH Copstein E Pecis M | 2013 | Diabetol Metab Syndr2013，5，1： | 1 |
| 8 | Growth hormone stimulate,through tyrosine kinase,ion transport and proliferation in human intestinal cell 显示文摘 | Bisceglia M Brazzese E Mallardo G Ganrino A | 1999 | J Pediatr Gastrcenterol Nutr1999，28，3： | 1 |
| 9 | Aggregation of features of the metabolic syndrome is associated with increased prevalence of chronic complications in type 2 diabetes显示文摘 | Costa LA Canani LH Lisboa HRK | 2004 | Diabetic Med2004，21，： | 1 |
| 10 | Aggregation of features of the metabolic syndrome is associated with increased prevalence of chronic complications in type 2 diabetes显示文摘 | Costa LA Canani LH Lisboa HR | 2004 | Diabet Med2004，21，： | 1 |
| 11 | Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children显示文摘 | Roberto Berni Canani Pia Cirillo Paola | 2006 | Pediatrics2006，117，5： | 1 |
| 12 | Probiotics as prevention and treatment for diarrhea显示文摘 | Guuarino A Lo Vecchio A Canani RB | 2009 | Curr Opin Gastroenterol2009，25，1： | 1 |
| 13 | Gastric acidity inhibitors and the risk of intestinal infections显示文摘 | Canani RB Terrin G | 2010 | Curr Opin Gastroenterol2010，26，1： | 1 |
| 14 | Diabetic nephropathy:diagnosis,prevention,and treatment显示文摘 | Gross IL Silveiro SP Canani LH et a1 | | 0，，01： | 1 |
| 15 | Nutritional recommendations for the prevention of ischemic stroke显示文摘 | Berni Canani R Barba G | 2004 | Nutr Metab Cardiovasc Dis2004，14，： | 1 |
| 16 | The optimal diagnostic workup for children with suspected food allergy显示文摘 | Berni Canani R Di Costanzo M Troncone R | | 0，，10： | 1 |
| 17 | Minimal enteral feeding reduces the risk of sepsis in feed-intolerant very low birth weight newborns 显示文摘 | Terrin G Passariello A Canani RB | 2009 | Acta Paediatr2009，98，1： | 1 |
| 18 | Masked hypertension,nocturnal blood pressure and retinopathy in normotensive patients with type 1 diabetes显示文摘 | Rodrigues T C Canani L H Viatroski R S | 2010 | Diabetes Res Clin Pract2010，87，2： | 1 |
| 19 | Physical Therapy Reduces Bone Resorption and Increases Bone Formation in Preterm Infants显示文摘 | Carine Vignochi Rita Silveira Ernani Miura Luis Canani Renato Procianoy | 2012 | Amer J Perinatol2012，，08： | 1 |
| 20 | Probiotics for treatment of acute diarrhoea in children : randomised clinical trial of five different preparations显示文摘 | CANANI R B CIRILLO P TERRIN G | 2007 | BMJ2007，335，7615： | 1 |
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