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| 1 | Gastric cancer: Current status of lymph node dissection显示文摘D2 procedure has been accepted in Far East as the standard treatment for both early(EGC) and advanced gastric cancer(AGC) for many decades. Recently EGC has been successfully treated with endoscopy by endoscopic mucosal resection or endoscopic submucosal dissection, when restricted or extended Gotoda's criteria can be applied and D1+ surgery is offered only to patients not fitted for less invasive treatment. Furthermore, two randomised controlled trials(RCTs) have been demonstrating the non inferiority of minimally invasive technique as compared to standard open surgery for the treatment of early cases and recently the feasibility of adequate D1+ dissection has been demonstrated also for the robot assisted technique. In case of AGC the debate on the extent of nodal dissection has been open for many decades. While D2 gastrectomy was performed as the standard procedure in eastern countries, mostly based on observational and retrospective studies, in the west the Medical Research Council(MRC), Dutch and Italian RCTs have been conducted to show a survival benefit of D2 over D1 with evidence based medicine. Unfortunately both the MRC and the Dutch trials failed to show a survival benefit after the D2 procedure, mostly due to the significant increase of postoperative morbidity and mortality, which was referred to splenopancreatectomy. Only 15 years after the conclusion of its accrual, the Dutch trial could report a significant decrease of recur-rence after D2 procedure. Recently the long term survival analysis of the Italian RCT could demonstrate a benefit for patients with positive nodes treated with D2 gastrectomy without splenopancreatectomy. As nowadays also in western countries D2 procedure can be done safely with pancreas preserving technique and without preventive splenectomy, it has been suggested in several national guidelines as the recommended procedure for patients with AGC. | Maurizio Degiuli Giovanni De Manzoni Alberto Di Leo Domenico D'Ugo Erica Galasso Daniele Marrelli Roberto Petrioli Karol Polom Franco Roviello Francesco Santullo Mario Morino | 2016 | World Journal of Gastroenterology2016，22，10： | 29 |
| 2 | Giant appendiceal mucocele: Report of a case and brief review显示文摘Mucocele of the appendix is a rare lesion, characterized by distension of the lumen due to accumulation of mucoid substance. This disease is often asymptomatic and pre-operative diagnosis is rare. If untreated, one type of mucocele may rupture producing a potentially fatal entity known as pseudomyxoma peritonei. The type of surgical treatment is related to the dimensions and to histology of the mucocele. Appendectomy is used for simple mucocele or for cystadenoma. Right hemi-colectomy is recommended for cystadenocarcinoma. In this paper, we report a case of a 51-year-old woman with a mobile, painless mass in the right lower quadrant of abdomen caused by a giant appendiceal mucocele. Imaging showed a large, tubular,cystic structure extending below from the inferior wall of the cecum. Surgery revealed a giant retro-cecal appendix measuring 17 cm in length and 4 cm in diameter. The final pathologic diagnosis was mucocele caused by mucinous cystadenoma. | Bernardino Rampone Franco Roviello Daniele Marrelli Enrico Pinto | 2005 | World Journal of Gastroenterology2005，11，30： | 23 |
| 3 | Updates on abdominal desmoid tumors显示文摘Desmoid tumor is a monoclonal, f ibroblastic proliferation arising in musculoaponeurotic structures. This connective tissue hyperplasia inf iltrates locally, recurs frequently after resection but does not metastasize. Abdominal desmoid occurs sporadically, in association with some familial syndromes and often represents a clinical dilemma for surgeons. The enigmatic biology and anatomical location of abdominal desmoids make treatment recommendations diff icult. This distinct pathological entity is reviewed with a specif ic focus on aetiology and management. | Bernardino Rampone Corrado Pedrazzani Daniele Marrelli Enrico Pinto Franco Roviello | 2007 | World Journal of Gastroenterology2007，13，45： | 20 |
| 4 | Multimodal treatment of gastric cancer in the west: Where are we going?显示文摘The incidence of gastric cancer(GC) is decreasing worldwide,especially for intestinal histotype of the distal third of the stomach.On the contrary,proximal location and diffuse Lauren histotype have been reported to be generally stable over time.In the west,no clear improvement in long-term results was observed in clinical and population-based studies.Results of treatment in these neoplasms are strictly dependent on tumor stage.Adequate surgery and extended lymphadenectomy are associated with good long-term outcome in early-stage cancer; however,results are still unsatisfactory for advanced stages(Ⅲ and Ⅳ),for which additional treatments could provide a survival benefit.This implies a tailored approach to GC.The aim of this review was to summarize the main multimodal treatment options in advanced resectable GC.Perioperative or postoperative treatments,including chemotherapy,chemoradiotherapy,targeted therapies,and hyperthermic intraperitoneal chemotherapy have been reviewed,and the main ongoing and completed trials have been analyzed.An original tailored multimodal approach to non-cardia GC has been also proposed. | Daniele Marrelli Karol Polom Giovanni de Manzoni Paolo Morgagni Gian Luca Baiocchi Franco Roviello | 2015 | World Journal of Gastroenterology2015，21，26： | 14 |
| 5 | Impact of age-related comorbidity on results of colorectal cancer surgery显示文摘AIM: To analyze the correlation between preexisting comorbidity and other clinicopathological features, short-term surgical outcome and long-term survival in elderly patients with colorectal cancer (CRC). METHODS: According to age, 403 patients operated on for CRC in our department were divided into group A (< 70 years old) and group B (≥ 70 years old) and analyzed statistically. RESULTS: Rectal localization prevailed in group A (31.6% vs 19.7%, P = 0.027), whereas the percentage of R0 resections was 77% in the two groups. Comorbidity rate was 46.2% and 69.1% for group A and B, respectively (P < 0.001), with a huge difference as regards cardiovascular diseases. Overall, postoperative morbidity was 16.9% and 20.8% in group A and B, respectively (P = 0.367), whereas mortality was limited to group B (4.5%, P = 0.001). In both groups, patients who suffered from postoperative complications had a higher overall comorbidity rate, with preexisting cardiovascular diseases prevailing in group B (P = 0.003). Overall 5-year survival rate was significantly betterfor group A (75.2% vs 55%, P = 0.006), whereas no signif icant difference was observed considering disease-specif ic survival (76.3% vs 76.9%, P = 0.674). CONCLUSION: In spite of an increase in postoperative mortality and a lower overall long-term survival for patients aged ≥ 70 years old, it should be considered that, even in the elderly group, a signif icant number of patients is alive 5 years after CRC resection. | Corrado Pedrazzani Guido Cerullo Giovanni De Marco Daniele Marrelli Alessandro Neri Alfonso De Stefano Enrico Pinto Franco Roviello | 2009 | World Journal of Gastroenterology2009，15，45： | 5 |
| 6 | Follow-up after gastrectomy for cancer:results of an international web round table显示文摘Oncological follow-up after radical gastrectomy for cancer still represents a discrepancy in the field,with many retrospective series demonstrating that early diagnosis of recurrence does not result in an improvement in patient survival;yet,many centers with high quality of care still provide routine patient follow-up after surgery by clinical and instrumental controls.This was the topic for a web round table entitled'Rationale and limits of oncological follow-up after gastrectomy for cancer'that was launched one year before the 10th International Gastric Cancer Congress.Authors having specific expertise were invited to comment on their previous publications to provide the subject for an open debate.During a three-month-long discussion,32 authors from 12 countries participated,and 2299people visited the dedicated web page.Substantial differences emerged between the participants:authors from Japan,South Korea,Italy,Brazil,Germany and France currently engage in instrumental follow-up,whereas authors from Eastern Europe,Peru and India do not,and British and American surgeons practice it in a rather limited manner or in the context of experimental studies.Although endoscopy is still considered useful by most authors,all the authors recognized that computed tomography scanning is the method of choice to detect recurrence;however,many limit follow-up to clinical and biochemical examinations,and acknowledge the lack of improved survival with early detection. | Gian Luca Baiocchi Yasuhiro Kodera Daniele Marrelli Fabio Pacelli Paolo Morgagni Franco Roviello Giovanni De Manzoni | 2014 | World Journal of Gastroenterology2014，20，34： | 4 |
| 7 | Prognostic Value of the 7th AJCC/UICC TNM Classification of Noncardia Gastric Cancer: Analysis of a Large Series From Specialized Western Centers显示文摘 | Daniele Marrelli Paolo Morgagni Giovanni de Manzoni Arianna Coniglio Alberto Marchet Luca Saragoni Guido Tiberio Franco Roviello | 2012 | Annals of Surgery2012，，3： | 3 |
| 8 | Treatment of Peritoneal Carcinomatosis by Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemoperfusion (IHCP): Postoperative Outcome and Risk Factors for Morbidity显示文摘 | Franco Roviello Daniele Marrelli Alessandro Neri Daniela Cerretani Giovanni Manzoni Corrado Pedrazzani MD Tommaso Cioppa MD Giacomo Nastri MD Giorgio Giorgi Enrico Pinto | 2006 | World Journal of Surgery2006，，11： | 3 |
| 9 | CA19-9 serum levels in obstructive jaundice: clinical value in benign and malignant conditions显示文摘 | Daniele Marrelli Stefano Caruso Corrado Pedrazzani Alessandro Neri Eduardo Fernandes Mario Marini Enrico Pinto Franco Roviello | 2009 | The American Journal of Surgery2009，，3： | 3 |
| 10 | Presacral ganglioneuroma: A case report and review of literature显示文摘骶骨前 ganglioneuromas 是仅仅 17 个案例在文学被报导了的那么稀罕的良性瘤。他们是慢慢地成长的腹的群众并且微分诊断不得不被考虑。因为它代表唯一的治疗学的选择,外科的切除术为权威的诊断是重要的。因为神经节瘤的良性的性质,辅助化学或放射疗法没被显示,但是常规后续为潜在的本地复发的早诊断是必要的。我们与一个骶骨前神经节瘤报导一个 64 岁的人的一个案例。 | Guido Cerullo Daniele Marrelli Bernardino Rampone Clelia Miracco Stefano Caruso Di Martino Marianna Maria Antonietta Mazzei Franco Roviello | 2007 | World Journal of Gastroenterology2007，13，14： | 3 |
| 11 | Recurrence in node-negative advanced gastric cancer:Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series显示文摘AIM To analyze the clinicopathological characteristics of patients with both node-negative gastric carcinoma and diagnosis of recurrence during follow-up. METHODS We enrolled 41 patients treated with curative gastrectomy for p T2-4 a N0 gastric carcinoma between 1992 and 2010,who developed recurrence(Group 1). We retrospectively selected this group from the prospectively collected database of 4 centers belonging to the Italian Research Group for Gastric Cancer,and compared them with 437 p T2-4 a N0 patients without recurrence(Group 2). We analyzed lymphatic embolization,microvascular infiltration,perineural infiltration,and immunohistochemical determination of p53,Ki67,and HER2 in Group 1 and in a subgroup of Group 2(Group 2 bis) of 41 cases matched with Group 1 according to demographic and pathological characteristics. RESULTS T4 a stage and diffuse histotype were associated with recurrence in the group of p N0 patients. In-depth pathological analysis of two homogenous groups of p N0 patients,with and without recurrence during longterm follow-up(groups 1 and 2 bis),revealed two striking patterns: lymphatic embolization and perineural infiltration(two parameters that pathologists can easily report),and p53 and Ki67,represent significant factors for recurrence.CONCLUSION The reported pathological features should be considered predictive factors for recurrence and could be useful to stratify node-negative gastric cancer patients for adjuvant treatment and tailored follow-up. | Gian Luca Baiocchi Sarah Molfino Carla Baronchelli Simone Giacopuzzi Daniele Marrelli Paolo Morgagni Maria Bencivenga Luca Saragoni Carla Vindigni Nazario Portolani Maristella Botticini Giovanni De Manzoni | 2017 | World Journal of Gastroenterology2017，23，45： | 3 |
| 12 | Super-extended (D3) lymphadenectomy in advanced gastric cancer显示文摘 | F. Roviello C. Pedrazzani D. Marrelli A. Di Leo S. Caruso S. Giacopuzzi G. Corso G. de Manzoni | 2010 | European Journal of Surgical Oncology2010，，： | 2 |
| 13 | A Multicentric Western Analysis of Prognostic Factors in Advanced, Node-Negative Gastric Cancer Patients显示文摘 | Gian Luca Baiocchi Guido A. Tiberio Anna Maria Minicozzi Paolo Morgagni Daniele Marrelli Lorenzo Bruno Fausto Rosa Alberto Marchet Arianna Coniglio Luca Saragoni Marco Veltri Fabio Pacelli Franco Roviello Donato Nitti Stefano M. Giulini Giovanni De Manzon | 2010 | Annals of Surgery2010，，1： | 2 |
| 14 | Different Patterns of Recurrence in Gastric Cancer Depending on Lauren’s Histological Type: Longitudinal Study显示文摘 | Daniele Marrelli Franco Roviello Giovanni de Manzoni Paolo Morgagni Alberto Di Leo Luca Saragoni Alfonso De Stefano Secondo Folli Claudio Cordiano Enrico Pinto | 2002 | World Journal of Surgery2002，，9： | 2 |
| 15 | Total inhibin is a potential serum marker for epithelial ovarian cancer显示文摘 | Tsigkou A Marrelli D Reis FM | 2007 | J Clin Endocrinol Metab2007，92，7： | 1 |
| 16 | Numberof lymph nodemetastases and its prognostic significance in early gastric cancer: multicenter Italian study显示文摘 | Roviello F Rossi S Marrelli D | 2006 | J Surg Oncol2006，94，4： | 1 |
| 17 | Acute serum amyloid A induces migration, angiogenesis, and inflammation in synovial cells in vitro and in a human rheumatoid arthritis/SCm mouse chimera model显示文摘 | Connolly M Marrelli A Blades M | 2010 | J Immunol2010，184，11： | 1 |
| 18 | Preoperative positivity of serum tumor markers in a stron predictor of hem atogenous recurrence of gastric cancer显示文摘 | Marrelli D Pinto E De Stefano A | 2001 | J Surg Oncol2001，78，4： | 1 |
| 19 | Lymph Node Involvement in Gastric Cancer for Different Tumor Sites and T Stage显示文摘 | Alberto Leo Daniele Marrelli Franco Roviello Marco Bernini AnnaMaria Minicozzi Simone Giacopuzzi Corrado Pedrazzani Luca Gian Baiocchi Giovanni Manzoni | 2007 | Journal of Gastrointestinal Surgery2007，，9： | 1 |
| 20 | CA19-9 serum levels in obstructive jaundice: clinical value in benign and malignant conditions显示文摘 | Daniele Marrelli Stefano Caruso Corrado Pedrazzani Alessandro Neri Eduardo Fernandes Mario Marini Enrico Pinto Franco Roviello | 2009 | The American Journal of Surgery2009，，3： | 1 |
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