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| 1 | Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide显示文摘Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing positive and protective effects in several different tissues, including pancreas, heart or even brain. This gut secreted hormone plays a potent insulinotropic activity and an important role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a protective role against cognitive deficits. As GLP-1 receptors(GLP-1R) are expressed throughout the central nervous system and GLP-1 may cross the blood-brain-barrier, an emerging hypothesis suggests that they may be promising therapeutic targets against brain dysfunctional insulin signaling-related pathologies. Importantly, GLP-1 actions depend not only on the direct effect mediated by its receptor activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous physiological functions(e.g., energy homeostasis, glucose-dependent insulin secretion, as well as appetite and weight control). Amongst the incretin/GLP-1 mimetics class of anti-T2 D drugs with an increasingly described neuroprotective potential, the already marketed liraglutide emerged as a GLP-1R agonist highly resistant to dipeptidyl peptidase-4 degradation(thereby having an increased half-life) and whose systemic GLP-1R activity is comparable to that of native GLP-1. Importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in AD biomarkers. Herein, we discuss the GLP-1 action through the gut-brain axis, the hormone's regulation of some autonomic functions and liraglutide's neuroprotective potential. | Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia Catarina Correia Cristina Isabel Carvalho Ana Isabel Plácido Maria Sancha Santos Catarina Resende Oliveira Paula Isabel Moreira Ana Isabel Duarte | 2015 | World Journal of Diabetes2015，6，6： | 9 |
| 2 | Survey of infectious and parasitic diseases in stray cats at the Lisbon Metropolitan Area, Portugal显示文摘 | Ana Duarte Isabel Castro Isabel M. Pereira da Fonseca Virgilio Almeida Luis M. Madeira de Carvalho José Meireles Maria I. Fazendeiro Luis Tavares Yolanda Vaz | 2009 | Journal of Feline Medicine and Surgery2009，，6： | 1 |
| 3 | Lipidomic characterization of streptozotocin-induced heart mitochondrial dysfunction显示文摘 | Rita Ferreira Gabriela Guerra Ana Isabel Padr?o Tania Melo Rui Vitorino José Alberto Duarte Fernando Remi?o Pedro Domingues Francisco Amado M. Rosário Domingues | 2013 | Mitochondrion2013，，： | 1 |
| 4 | Intra-urban variation in tuberculosis and community socioeconomic deprivation in Lisbon metropolitan area:a Bayesian approach显示文摘Background:Multidrug resistant tuberculosis(MDR-TB)is a recognized threat to global eforts to TB control and remains a priority of the National Tuberculosis Programs.Additionally,social determinants and socioeconomic dep‑rivation have since long been associated with worse health and perceived as important risk factors for TB.This study aimed to analyze the spatial distribution of non-MDR-TB and MDR-TB across parishes of the Lisbon metropolitan area of Portugal and to estimate the association between non-MDR-TB and MDR-TB and socioeconomic deprivation.Methods:In this study,we used hierarchical Bayesian spatial models to analyze the spatial distribution of notifcation of non-MDR-TB and MDR-TB cases for the period from 2000 to 2016 across 127 parishes of the seven municipalities of the Lisbon metropolitan area(Almada,Amadora,Lisboa,Loures,Odivelas,Oeiras,Sintra),using the Portuguese TB Surveillance System(SVIG-TB).In order to characterise the populations,we used the European Deprivation Index for Portugal(EDI-PT)as an indicator of poverty and estimated the association between non-MDR-TB and MDR-TB and socioeconomic deprivation.Results:The notifcation rates per 10,000 population of non-MDR TB ranged from 18.95 to 217.49 notifcations and that of MDR TB ranged from 0.83 to 3.70.We identifed 54 high-risk areas for non-MDR-TB and 13 high-risk areas for MDR-TB.Parishes in the third[relative risk(RR)=1.281,95% credible interval(CrI):1.021-1.606],fourth(RR=1.786,95%CrI:1.420-2.241)and ffth(RR=1.935,95%CrI:1.536-2.438)quintile of socioeconomic deprivation presented higher non-MDR-TB notifcations rates.Parishes in the fourth(RR=2.246,95%CrI:1.374-3.684)and ffth(RR=1.828,95%CrI:1.049-3.155)quintile of socioeconomic deprivation also presented higher MDR-TB notifcations rates.Conclusions:We demonstrated signifcant heterogeneity in the spatial distribution of both non-MDR-TB and MDRTB at the parish level and we found that socioeconomically disadvantaged parishes are disproportionally afected by both non-MDR-TB and MDR-TB.Our fndings suggest that the emergence of MDR-TB and transmission are specifc from each location and often diferent from the non-MDR-TB settings.We identifed priority areas for intervention for a more efcient plan of control and prevention of non-MDR-TB and MDR-TB. | Olena Oliveira Ana Isabel Ribeiro Raquel Duarte Margarida Correia‑Neves Teresa Rito | 2022 | Infectious Diseases of Poverty2022，11，2： | 1 |
| 5 | G-308A TNF-α polymorphism is associated with an increased risk of invasive cervical cancer显示文摘 | Isabel Duarte Alexandra Santos Hugo Sousa Raquel Catarino Daniela Pinto Ana Matos Deolinda Pereira José Moutinho Paulo Canedo José Carlos Machado Rui Medeiros | 2005 | Biochemical and Biophysical Research Communications2005，，2： | 1 |
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