|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)显示文摘 | E.A. Eisenhauer P. Therasse J. Bogaerts L.H. Schwartz D. Sargent R. Ford J. Dancey S. Arbuck S. Gwyther M. Mooney L. Rubinstein L. Shankar L. Dodd R. Kaplan D. Lacombe J. Verweij | 2008 | European Journal of Cancer2008，，2： | 22 |
| 2 | 腹腔镜结肠癌切除术疗效并不亚于开腹手术——基于COST的5年完整随访资料显示文摘目的通过多中心随机对照试验比较腹腔镜结肠癌切除与开腹手术在切口复发率、无病生存率以及总体生存率等疗效指标上有无差异。方法来自48个不同中心的872名的结肠癌患者被随机分成腹腔镜组和开腹组,分别接受手术治疗。随访8年,其中90%的病例获随访5年以上。主要终点指标为复发时间,分析方法采⒚非劣效性检验,次要终点指标为无病生存率和总体生存率,统计方法采⒚Kaplan-Meier检验。结果截至2007年3月1日,共有170例复发,252例死亡。随访时间为5~10年(中位时间为7年),两组的5年无病生存率(开腹组68.4%,腹腔镜组69.2%,P=0.94)和5年总体生存率(开腹组74.6%,腹腔镜组76.4%,P=0.93)无统计学差异,两组总的复发率无统计学差异(开腹组21.8%,腹腔镜组19.4%,P=0.25)。复发位置分布相似(开腹组:切缘0.5%,肝5.8%,肺4.6%,其它组织8.4%;腹腔镜组:切口0.9%,肝5.5%,肺4.6%,其它组织6.1%)。结论对于可切除的结肠癌而言,腹腔镜手术的效果并不亚于开腹手术。 | 陈志辉 Fleshman J Sargent DJ Green E | 2009 | 中华普通外科学文献(电子版)2009，3，1： | 13 |
| 3 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 4 | Laparoscopic Colectomy for Cancer Is Not Inferior to Open Surgery Based on 5-Year Data From the COST Study Group Trial显示文摘 | James Fleshman Daniel J. Sargent Erin Green Mehran Anvari Steven J. Stryker Robert W. Beart Michael Hellinger Richard Flanagan Walter Peters Heidi Nelson | 2007 | Annals of Surgery2007，，4： | 7 |
| 5 | Molecular genetics and genomics of the Rosoideae: state of theart and future perspectives显示文摘The Rosoideae is a subfamily of the Rosaceae that contains a number of species of economic importance,including the soft fruit species strawberry(Fragaria 3ananassa),red(Rubus idaeus)and black(Rubus occidentalis)raspberries,blackberries(Rubus spp.)and one of the most economically important cut flower genera,the roses(Rosa spp.).Molecular genetics and genomics resources for the Rosoideae have developed rapidly over the past two decades,beginning with the development and application of a number of molecular marker types including restriction fragment length polymorphisms,amplified fragment length polymorphisms and microsatellites,and culminating in the recent publication of the genome sequence of the woodland strawberry,Fragaria vesca,and the development of high throughput single nucleotide polymorphism(SNP)-genotyping resources for Fragaria,Rosa and Rubus.These tools have been used to identify genes and other functional elements that control traits of economic importance,to study the evolution of plant genome structure within the subfamily,and are beginning to facilitate genomic-assisted breeding through the development and deployment of markers linked to traits such as aspects of fruit quality,disease resistance and the timing of flowering.In this review,we report on the developments that have been made over the last 20 years in the field of molecular genetics and structural genomics within the Rosoideae,comment on how the knowledge gained will improve the efficiency of cultivar development and discuss how these advances will enhance our understanding of the biological processes determining agronomically important traits in all Rosoideae species. | Sara Longhi Lara Giongo Matteo Buti Nada Surbanovski Roberto Viola Riccardo Velasco Judson AWard Daniel J Sargent | 2014 | Horticulture Research2014，1，1： | 7 |
| 6 | New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)显示文摘 | E.A. Eisenhauer P. Therasse J. Bogaerts L.H. Schwartz D. Sargent R. Ford J. Dancey S. Arbuck S. Gwyther M. Mooney L. Rubinstein L. Shankar L. Dodd R. Kaplan D. Lacombe J. Verweij | 2008 | European Journal of Cancer2008，，2： | 6 |
| 7 | Mapping QTL associated with Verticillium dahliae resistance in the cultivated strawberry(Fragaria×ananassa)显示文摘A biparental cross of octoploid strawberry segregating for resistance to Verticillium dahliae,the causative agent of Verticillium wilt,was screened under field conditions for three seasons.Average wilt scores were significantly associated with multiple QTL,which were mostly significant across all years.Markers significantly associated with the traits were used to screen material with known wilt resistance and susceptibility phenotypes.A clear and statistically significant relationship was observed between resistant,tolerant and susceptible material and the total number of markers present in the different resistance classes.In field situations resistance QTL appear to behave in an additive manner.These markers are abundant in the cultivated strawberry germplasm indicating that,despite the large number of markers,clear genetic gain is possible through marker-assisted breeding. | L Antanaviciute NŠurbanovski N Harrison K J McLeary D W Simpson F Wilson D J Sargent R J Harrison | 2015 | Horticulture Research2015，2，1： | 5 |
| 8 | Critical analysis of feeding jejunostomy following resection of upper gastrointestinal malignancies显示文摘AIM To assess nutritional recovery,particularly regarding feeding jejunostomy tube(FJT)utilization,following upper gastrointestinal resection for malignancy. METHODS A retrospective review was performed of a prospectively-maintained database of adult patients who underwent esophagectomy or gastrectomy(subtotal or total)for cancer with curative intent,from January 2001 to June 2014. Patient demographics,the approach to esophagectomy,the extent of gastrectomy,FJT placement and utilization at discharge,administration of parenteral nutrition(PN),and complications were evaluated. All patients were followed for at least ninety days or until death.RESULTS The 287 patients underwent upper GI resection,comprised of 182 esophagectomy(n=107 transhiatal,58.7%; n=56 Ivor-Lewis,30.7%)and 105 gastrectomy [n=63 subtotal(SG),60.0%; n=42 total(TG),40.0%]. 181 of 182 esophagectomy patients underwent FJT,compared with 47 of 105 gastrectomy patients(99.5% vs 44.8%,P < 0.0001),of whom most had undergone TG(n=39,92.9% vs n=8 SG,12.9%,P < 0.0001). Median length of stay was similar between esophagectomy and gastrectomy groups(14.7 d vs 17.1 d,P=0.076). Upon discharge,87 esophagectomy patients(48.1%)were taking enteral feeds,with 53(29.3%)fully and 34(18.8%)partially dependent. Meanwhile,20 of 39 TG patients(51.3%)were either fully(n=3,7.7%)or partially(n=17,43.6%)dependent on tube feeds,compared with 5 of 8 SG patients(10.6%),all of whom were partially dependent. Gastrectomy patients were significantly less likely to be fully dependent on tube feeds at discharge compared to esophagectomy patients(6.4% vs 29.3%,P=0.0006). PN was administered despite FJT placement more often following gastrectomy than esophagectomy(n=11,23.4% vs n=7,3.9%,P=0.0001). FJT-specific complications requiring reoperation within 30 d of resection occurred more commonly in the gastrectomy group(n=6),all after TG,compared to 1 esophagectomy patient(12.8% vs 0.6%,P=0.0003). Six of 7 patients(85.7%)who experienced tube-related complications required PN.CONCLUSION Nutritional recovery following esophagectomy and gastrectomy is distinct. Operations are associated with unique complication profiles. Nutritional supplementation alternative to jejunostomy should be considered in particular scenarios. | Andrew M Blakely Saad Ajmal Rachel E Sargent Thomas T Ng Thomas J Miner | 2017 | World Journal of Gastrointestinal Surgery2017，9，2： | 4 |
| 9 | Disease-Free Survival as a Surrogate for Overall Survival in Adjuvant Trials of Gastric Cancer: A Meta-Analysis显示文摘 | Koji Oba Xavier Paoletti Steven Alberts Yung-Jue Bang Jacqueline Benedetti Harry Bleiberg Paul Catalano Florian Lordick Stefan Michiels Satoshi Morita Yasuo Ohashi Jean-pierre Pignon Philippe Rougier Mitsuru Sasako Junichi Sakamoto Daniel Sargent Kohei Sh | 2013 | JNCI Journal of the National Cancer Institute2013，，21： | 3 |
| 10 | Additive QTLs on three chromosomes control flowering time in woodland strawberry(Fragaria vesca L.)显示文摘Flowering time is an important trait that affects survival,reproduction and yield in both wild and cultivated plants.Therefore,many studies have focused on the identification of flowering time quantitative trait locus(QTLs)in different crops,and molecular control of this trait has been extensively investigated in model species.Here we report the mapping of QTLs for flowering time and vegetative traits in a large woodland strawberry mapping population that was phenotyped both under field conditions and in a greenhouse after flower induction in the field.The greenhouse experiment revealed additive QTLs in three linkage groups(LG),two on both LG4 and LG7,and one on LG6 that explain about half of the flowering time variance in the population.Three of the QTLs were newly identified in this study,and one co-localized with the previously characterized FvTFL1 gene.An additional strong QTL corresponding to previously mapped PFRU was detected in both field and greenhouse experiments indicating that gene(s)in this locus can control the timing of flowering in different environments in addition to the duration of flowering and axillary bud differentiation to runners and branch crowns.Several putative flowering time genes were identified in these QTL regions that await functional validation.Our results indicate that a few major QTLs may control flowering time and axillary bud differentiation in strawberries.We suggest that the identification of causal genes in the diploid strawberry may enable fine tuning of flowering time and vegetative growth in the closely related octoploid cultivated strawberry. | Samia Samad Takeshi Kurokura Elli Koskela Tuomas Toivainen Vipul Patel Katriina Mouhu Daniel James Sargent Timo Hytönen | 2017 | Horticulture Research2017，4，1： | 3 |
| 11 | The conquest of US inflation: Learning and robustness to model uncertainty显示文摘 | Timothy Cogley Thomas J. Sargent | 2005 | Review of Economic Dynamics2005，，2： | 2 |
| 12 | Major-effect candidate genes identified in cultivated strawberry(Fragaria×ananassa Duch.)for ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside biosynthesis,key polyphenolic compounds显示文摘Strawberries are rich in polyphenols which impart health benefits when metabolized by the gut microbiome,including anti-inflammatory,neuroprotective,and antiproliferative effects.In addition,polyphenolic anthocyanins contribute to the attractive color of strawberry fruits.However,the genetic basis of polyphenol biosynthesis has not been extensively studied in strawberry.In this investigation,ripe fruits from three cultivated strawberry populations were characterized for polyphenol content using HPLC-DAD-MSn and genotyped using the iStraw35k array.GWAS and QTL analyses identified genetic loci controlling polyphenol biosynthesis.QTL were identified on four chromosomes for pelargonidin-3-O-malonylglucoside,pelargonidin-3-O-acetylglucoside,cinnamoyl glucose,and ellagic acid deoxyhexoside biosynthesis.Presence/absence of ellagic acid deoxyhexoside and pelargonidin-3-O-malonylglucoside was found to be under the control of major gene loci on LG1X2 and LG6b,respectively,on the F.×ananassa linkage maps.Interrogation of gene predictions in the F.vesca reference genome sequence identified a single candidate gene for ellagic acid deoxyhexoside biosynthesis,while seven malonyltransferase genes were identified as candidates for pelargonidin-3-O-malonylglucoside biosynthesis.Homologous malonyltransferase genes were identified in the F.×ananassa‘Camarosa’genome sequence but the candidate for ellagic acid deoxyhexoside biosynthesis was absent from the‘Camarosa’sequence.This study demonstrated that polyphenol biosynthesis in strawberry is,in some cases,under simple genetic control,supporting previous observations of the presence or absence of these compounds in strawberry fruits.It has also shed light on the mechanisms controlling polyphenol biosynthesis and enhanced the knowledge of these biosynthesis pathways in strawberry.The above findings will facilitate breeding for strawberries enriched in compounds with beneficial health effects. | Jahn Davik Kjersti Aaby Matteo Buti Muath Alsheikh NadaŠurbanovski Stefan Martens Dag Røen Daniel James Sargent | 2020 | Horticulture Research2020，7，1： | 2 |
| 13 | A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients显示文摘 | Sargent DJ Goldberg RM Jacobson SD | | New England Journal of Medicine0，，： | 2 |
| 14 | Chemosensitivity testing predicts survival in ovarian cancer 显示文摘 | Taylor CG Sargent JM Elgie AW | 2001 | Eur J Gynaecol Oncol2001，22，4： | 2 |
| 15 | The clinical relevance of chemosensitivity testing in ovarian cancer显示文摘 | Taylor CG Sargent JM Elgie AW | 1998 | Cancer Detection and Prevention1998，22，4： | 2 |
| 16 | Intraepithelial Effector (CD3 + )/Regulatory (FoxP3 + ) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma显示文摘 | Frank A. Sinicrope Rafaela L. Rego Stephen M. Ansell Keith L. Knutson Nathan R. Foster Daniel J. Sargent | 2009 | Gastroenterology2009，，4： | 2 |
| 17 | Assessment of the classical MDR phenotype in epithelial ovarian carcinoma using primary cultures: a feasibility study 显示文摘 | Coley HM Sargent JM Williamson CJ | 2002 | A nticancer Res2002，22，1： | 2 |
| 18 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Y M Dennis Lo Noemi Corbetta Paul F Chamberlain Vik Rai Ian L Sargent Christopher WG Redman James S Wainscoat | 1997 | The Lancet1997，，9076： | 2 |
| 19 | Molecular Markers Identify Subtypes of Stage III Colon Cancer Associated with Patient Outcomes显示文摘 | Frank A. Sinicrope Qian Shi Thomas C. Smyrk Stephen N. Thibodeau Rodrigo Dienstmann Justin Guinney Brian M. Bot Sabine Tejpar Mauro Delorenzi Richard M. Goldberg Michelle Mahoney Daniel J. Sargent Steven R. Alberts | 2014 | Gastroenterology2014，，： | 2 |
| 20 | Do Movie Stars Encourage Adolescents to Start Smoking? -Evidence from Californial 显示文摘 | Distefan JM Gilpin EA Sargent JD | 1999 | Preventive Medicine1999，28，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员