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| 1 | 美国密歇根大学护理学博士课程及教学介绍显示文摘我国护理博士教育刚刚起步,而美国十分成熟。本文介绍了美国护理研究生教育排名前六的密歇根大学护理专业博士课程及教学情况,包括培养目标、课程设置、教学与评价方法等,对其特色进行了分析,提出了如何借鉴相关经验发展我国护理博士教育的设想。 | 刘义兰 Richard W. Redman | 2009 | 中华护理教育2009，6，2： | 11 |
| 2 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 3 | 子痫前期:病理生理学和临床意义显示文摘子痫前期是一种常见疾病,尤其影响首次妊娠。其临床表现多样,但通常表现为高血压和蛋白尿。这些全身症状是由于在合体滋养细胞的压力作用下,胎盘释放了可溶性因子。子痫前期主要有早发型和迟发型2种亚型,其他几种亚型目前尚未确定。早发型子痫前期是由于胎盘缺陷而出现,而迟发型子痫前期可能是由于胎盘的正常衰老,以及母体对心血管和代谢疾病的遗传易感性交互产生。子痫前期因胎盘和母体因素产生的原因因人而异。最近的研究主要集中在早孕期的胎盘-子宫相互作用。本文旨在对关于子痫前期的预测、预防和治疗方法的最新文献进行归纳综述。 | Graham J Burton Christopher W Redman James M Roberts Ashley Moffett 秦萌(译) 金滢 潘凌亚(校 | 2019 | 英国医学杂志中文版2019，22，11： | 6 |
| 4 | Fiber Bragg grating monitors for thermal and stress of the composite insulators in transmission lines显示文摘Running composite insulators are prone to failure due to their harsh surrounding work environment, which directly affects the safe operation of transmission lines. This paper puts forward the method of using fiber Bragg grating(FBG) as the monitors to parameters correlated with thermal and stress of the composite insulators in transmission lines at working status. Firstly, monitoring points are found out by the mechanical test on composite insulator samples. Secondly, based on the monitoring theory, this paper introduces the feasibility design frame of the composite insulator with FBG implanted in the rod and the online monitor system. At last, it describes applications of this monitor system in the field of transmission lines. | Heming Deng Wei Cai You Song Jinsong Liu Christopher Redman Qiandong Zhuang | 2018 | Global Energy Interconnection2018，1，3： | 6 |
| 5 | Infectious hypodermal and hematopoietic necrosis, a newly recognized virus disease of penaeid shrimp显示文摘 | Lightner D V Redman R M Bell T A | 1983 | Invertebrate Pathology1983，42，： | 2 |
| 6 | Women with Preeclampsia Have Increased Serum Levels of Pregnancy‐Associated Plasma Protein A (PAPP‐A), Inhibin A, Activin A and Soluble E‐selectin显示文摘 | Nick A. Bersinger Alexander K. Smárason Shanthi Muttukrishna Nigel P. Groome Christopher W. Redman | 2003 | Hypertension in Pregnancy2003，，1： | 2 |
| 7 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 8 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Y M Dennis Lo Noemi Corbetta Paul F Chamberlain Vik Rai Ian L Sargent Christopher WG Redman James S Wainscoat | 1997 | The Lancet1997，，9076： | 2 |
| 9 | 一株耐盐植物内生真菌的筛选与鉴定显示文摘[目的]研究盐田原生态系统中的耐盐植物内生真菌。[方法]对38株从海南省莺歌海盐场和东方盐场分离的菌株进行耐盐生长测试。[结果]发现了1株在8%Na Cl浓度下生长较好的真菌,并根据其形态特征,ITS扩增序列聚类进化树分析,显示其分类地位为黑酵母菌(Hortaea werneckii)。经过高效液相色谱分析其代谢产物,发现该真菌在0、2%、4%、8%Na Cl浓度下的发酵产物均有所不同。[结论]盐田生境中存在特殊的植物内生真菌区系,其中黑酵母菌Hortaea werneckii具有一定代表性,有深入研究的价值。 | 孙海彦 尹慧祥 陈惠琴 王琪 Marilyn Roossinck Regina S Redman Rusty Rodriguez 包晓东 | 2018 | 安徽农业科学2018，46，19： | 2 |
| 10 | A new RNA-friendly fixative for the preservation of penaeid shrimp samples for virological detection using eDNA genomie probes显示文摘 | Hasson K W Hasson J Aubert H Redman R M Lightner D V | 1997 | J Virol Methods1997，66，2： | 1 |
| 11 | Analysis of mutations in father-son pairs with 17 Y-STR loci显示文摘 | Decker AE Kline MC Redman JW | 2008 | Forensic Sci Int Genet2008，2，3： | 1 |
| 12 | Activity of SUl1248, a muhitargeted inhibitor of vascular endothelial growth faclor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma 显示文摘 | Motzer R J Michaelson MD Redman BG | 2006 | J Clin Oncol2006，24，1： | 1 |
| 13 | Preeclampsia: an excessive maternal inflammatory response to pregnancy 显示文摘 | Redman CW Sacks GP Sargent IL | 1999 | Am J Obstet Gynecol1999，180，21： | 1 |
| 14 | Competency assessment: methods for development and implementation in nursing education 显示文摘 | Redman R W Lenburg C B Hinton Walker P | 1999 | Online Journal of Issues in Nursing1999，4，2： | 1 |
| 15 | Cancer antigen CA125 in epithelial ovarian cancer: immunohistochemical expression before and after chemotherapy显示文摘 | REDMAN C BRADGATE MG ROLLASON TP | 1988 | Enr J Cancer Clin Oncol1988，24，8： | 1 |
| 16 | Current strategies {or articular cartilage repair显示文摘 | REDMAN S N OLDFIELD S F ARCHER C W | 2005 | European Cells b- Materials2005，9，： | 1 |
| 17 | An overview of the VISTA triM: newly diagnosed, untreated patients with multiple myeloma ineligible for stem cell transplantation 显示文摘 | Spicka I Mateos MV Redman K | 2011 | Immunotherapy2011，3，9： | 1 |
| 18 | Reversed diurnal blood pressure rhythm in hypertensive pregnancies显示文摘 | Redman CW Beilin LJ Bonnar J | 1976 | Clin Sci Mol Med Suppl1976，3，： | 1 |
| 19 | Expressian of irrflammatory cytokines in placentas from women with preeclampsia显示文摘 | Benyo DF Smarason A Redman CW | 2001 | J Clin Endocrinol Metab2001，86，6： | 1 |
| 20 | The development of synovial joints显示文摘 | Khan IM Redman SN Williams R | 2007 | Curr Top Dev Biol2007，79，： | 1 |
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