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| 1 | α-葡萄糖苷酶抑制剂治疗2型糖尿病的系统评价(英文)显示文摘目的评价α-葡萄糖苷酶抑制剂治疗2型糖尿病患者的效果。方法检索Cochrane图书馆、MEDLINE、EMBASE、CurrentContents、LILACS在研试验数据库,主题为α-葡萄糖苷酶抑制剂的综述的参考文献,并联系纳入试验的专家与实施者。最近检索日期为2003年月12月(CurrentContents)和2003年4月(其他数据库)。纳入α-葡萄糖苷酶抑制剂单一疗法与其它干预比较,治疗2型糖尿病疗程至少12周的随机对照试验,并且试验至少包括以下结局之一:病死率、患病率、生活质量、血糖控制、血脂、胰岛素水平、体重、不良事件。两名评价者独立阅读所有摘要,评价质量并提取数据,分歧通过协商解决或由第三位评价者裁决。由一位统计学家在对提取数据输入数据库时进行检查。我们尽量联系所有作者以核实数据。结果共纳入41个试验、8130例受试者,其中30个针对阿卡波糖,7个针对米格列醇,1个针对优格列波糖,还有3个为不同α-葡萄糖苷酶抑制剂间的比较。绝大多数研究疗程为24周,仅有2个研究超过1年。与安慰剂相比,阿卡波糖血糖控制效果更好:糖化血红蛋白–0.8%[95%CI(–0.9,–0.7)],空腹血糖–1.1mmol/L[95%CI(–1.4,–0.9)],负荷血糖–2.3mmol/L[95%CI(–2.7,–1.9)],阿卡波糖对糖化血红蛋白的作用呈非剂量依赖。我们发现其可降低负荷胰岛素,但对血脂和体重未见临床相关的作用。不良反应主要来自胃肠道且与剂量相关。相对于磺脲,阿卡波糖将空腹和负荷胰岛素水平分别降低至–24.8pmol/L[95%CI(–43.3,–6.3)]和–133.2pmol/L[95%CI(–184.5,–81.8)],但阿卡波糖引起的不良反应更多。结论关于α-葡萄糖苷酶抑制剂是否影响2型糖尿病患者的病死率和患病率仍不清楚。相反,其对血糖控制或胰岛素水平作用明显,对血脂和体重的作用差异无统计学意义。α-葡萄糖苷酶抑制剂更长疗程的效果仍不确定。阿卡波糖剂量超过50mg(TID)时不能进一步影响糖化血红蛋白水平,不良反应反而更多,与磺脲相比,α-葡萄糖苷酶抑制剂降低了空腹和负荷胰岛素水平,但在血糖控制和不良反应方面存在不利影响。 | VandeLaarFA Lucassen PLBJ Akkermans RP Van de Lisdonk EH Rutten GEHM Van Weel C 陈耀龙(译) 孙丁(审校) | 2006 | 中国循证医学杂志2006，6，5： | 9 |
| 2 | The TME Trial After a Median Follow-up of 6 Years: Increased Local Control But No Survival Benefit in Irradiated Patients With Resectable Rectal Carcinoma显示文摘 | Koen C.M.J. Peeters Corrie A.M. Marijnen Iris D. Nagtegaal Elma Klein Kranenbarg Hein Putter Theo Wiggers Harm Rutten Lars Pahlman Bengt Glimelius Jan Willem Leer Cornelis J.H. van de Velde | 2007 | Annals of Surgery2007，，5： | 3 |
| 3 | The peroxisome proliferator-activated receptor-α (PPAR-α) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats显示文摘 | Wolfgang LINZ Paulus WOHLFART Manuel BAADE Kristin BREITSCHOPF EugenFALK Hans-Ludwig SCHAFER Martin GERL Werner KRAMER Hartmut RUTTEN | 2009 | Acta Pharmacologica Sinica2009，30，7： | 3 |
| 4 | Reduction of Postoperative Ileus by Early Enteral Nutrition in Patients Undergoing Major Rectal Surgery: Prospective, Randomized, Controlled Trial显示文摘 | Petra G. Boelens Fanny F. B. M. Heesakkers Misha D. P. Luyer Kevin W. Y. van Barneveld Ignace H. J. T. de Hingh Grard A. P. Nieuwenhuijzen Arnout N. Roos Harm J. T. Rutten | 2014 | Annals of Surgery2014，，4： | 2 |
| 5 | Outcome and prognostic factors in 110 consecutive patients with primary uterine leiomyosarcoma:A Rare Cancer Network study显示文摘Objective: Primary uterine leiomyosarcomas(ULMS) are rare,and the optimal treatment is controversial.We aimed to assess the outcome and prognostic factors in a multicenter population of women treated for primary ULMS.Methods: We retrospectively collected data of 110 women treated in 19 institutions of the Rare Cancer Network(RCN).Inclusion criteria consisted of a pathology report confirming the diagnosis of ULMS,aged 18–80 years,complete International Federation of Gynecology and Obstetrics(FIGO) stage information,complete information on treatment,and a minimum follow-up of 6 months.Local control(LC) and locoregional control(LRC),overall survival(OS) and disease-free survival(DFS) rates were computed using the Kaplan-Meier method.Univariate analysis was implemented using the log rank test,and multivariate analysis using the Cox model.Results: All patients underwent surgery.Seventy-five patients(68%) received adjuvant radiotherapy(RT),including brachytherapy in 18(16%).Seventeen patients(15%) received adjuvant chemotherapy.Median follow-up was 58(range,6–240) months.Five-year OS and DFS rates were 50% and 34%,and LC and LRC rates were 88%and 72%,respectively.On multivariate analysis,independent favorable prognostic factors were younger age,FIGO stage I,small tumor size,previous uterine disease,and no vascular invasion for OS and DFS.FIGO stage was the only favorable factor influencing LRC.Adjuvant local or systemic treatments did not improve the outcomes.Eight patients treated with RT presented a grade 3 acute toxicity,and only one patient with grade 3 late toxicity.Conclusions: In this large population of primary ULMS patients,we found good results in terms of LC and LRC.Nevertheless,OS remains poor,mainly due to the occurrence of distant metastases.An early diagnosis seemed to improve the prognosis of the patients.Adjuvant local or systemic treatments,or more aggressive surgicalprocedures such as the Wertheim procedure,did not seem to impact the outcome. | Alessandra Franzetti Pellanda Berardino De Bari Elisabeth Deniaud-Alexandre MarcoKrengli Paul Van Houtte Antonella Riehetti Salvador Villa Hadassah Goldberg EwaSzutowiez-Zielifiska Michel Bolla Heidi Rutten Marc Van Eijkeren Philip Poortmans Guido Henke Yavuz Anaeak Steve Chan Christine Landmann Carine Kirkove LueianoScandolaro Jacques Bernier Rene-Olivier Mirimanof Mahmut Ozsahin | 2017 | Chinese Journal of Cancer Research2017，29，6： | 2 |
| 6 | Controlling the gelation temperature of biomimetic polyisocyanides显示文摘Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature(LCST) is often sharp, which allows for a wide range of smart material applications.At the LCST, oligo(ethylene glycol)-substituted polyisocyanides(PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol(EG) tails; every EG group increases the LCSTand thus the gelation temperature by nearly 30 ℃. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 ℃ and 60 ℃and, consequently, tune the mechanical properties of the PIC gels. | Paul H.J. Kouwer Paula de Almeida Onno ven den Boomen Zaskia H. Eksteen-Akeroyd Roel Hammink Maarten Jaspers Stijn Kragt Mathijs F.J. Mabesoone RoelandJ.M. Nolte Alan E. Rowan Martin G.T.A. Rutten Vincent A.A. Le Sage Daniel C. Schoenmakers Chengfen Xing Jialiang xu | 2018 | Chinese Chemical Letters2018，29，2： | 2 |
| 7 | Diabetes, hyperglycaemia, and acute ischaemic stroke显示文摘 | Merel JA Luitse Geert Jan Biessels Guy EHM Rutten L Jaap Kappelle | 2012 | Lancet Neurology2012，，3： | 2 |
| 8 | Detection of coronary calcifications from computed tomography scans for automated risk assessment of coronary artery disease显示文摘 | Isgum I Rutten A Prokop M | 2007 | Med Phys2007，34，4： | 1 |
| 9 | HLA-DP as specific target for cellular immunotherapy in HLA class Ⅱ-ex- pressing B-cell leukemia 显示文摘 | Rutten CE van Luxemburg-Heijs SA Griffioen M | 2008 | Leukemia2008，22，7： | 1 |
| 10 | Investigating membrane breakdown of neuronal cells exposed to nonuniform electric fields by finite-element modeling and experiments 显示文摘 | Heida T Wagenaar JB Rutten WL | 2002 | IEEE Trans BME2002，49，10： | 1 |
| 11 | Autoregulation of subtilin biosynthesis in Bacillus subtilis: the role of the spa-box in subtilin-responsive promoters 显示文摘 | Kleerebezem M Bongers R Rutten G | 2004 | Peptides2004，25，9： | 1 |
| 12 | Regional social capital: Embeddedness, innovation networks and regional economic development 显示文摘 | Rutten Roel Boekema Frans | 2007 | Technological forecasting and social change2007，74，： | 1 |
| 13 | Effect of a dietary n-6 polyunsaturated fatty acid supplement on distinct immune functions of goats显示文摘 | Thanasak J Rutten V P Schonewille J T | 2004 | J Vet Med A Physiol Pathol Clin Med2004，51，1： | 1 |
| 14 | Regional social capital: Embeddedness, innovation networks and regional economic development显示文摘 | Roel Rutten Frans Boekema | 2007 | Technological Forecasting & Social Change2007，，9： | 1 |
| 15 | A Novel Experimental Approach for Three-Dimensional Geometry Assessment of Calcified Human Stenotic Arteries In Vitro显示文摘 | Renate W. Boekhoven Richard G.P. Lopata Marc R. van Sambeek Frans N. van de Vosse Marcel C.M. Rutten | 2013 | Ultrasound in Medicine & Biology2013，，： | 1 |
| 16 | Autoregulation of subtilin biosynthesis in Bacillus subtilis: the role of the spa-box in subtilin-responsive promoters 显示文摘 | Kleerebezem M Bongers R Rutten G | 2004 | Peptides2004，25，： | 1 |
| 17 | Inflammation of unknown origin versus fever of unknown origin:two of a kind显示文摘 | Vanderschueren S Del Biondo E Ruttens D | | 0，，04： | 1 |
| 18 | Recursive track-before-detect with target amplitude fluctuations显示文摘 | RUTTEN M G GORDON N J MASKELL S | 2005 | IEE Proceedings of Radar Sonar and Navigation2005，152，2： | 1 |
| 19 | B typenatriuretie peptideassays for detecting heart failure in the elderly: same value as those in the younge显示文摘 | Rutten F Hoes A | 2008 | Int J Cardiol2008，125，2： | 1 |
| 20 | Surgical intervention in patients with necrotizing pancreatitis显示文摘 | Besselink MG de Bruijn MT Rutten JP | 2006 | Br J Surg2006，93，5： | 1 |
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