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| 1 | MicroRNA-21 as a potential colon and rectal cancer biomarker显示文摘Colorectal cancer(CRC)is one of the most common malignant diseases worldwide and the prognosis is still poor although much progress has been achieved in recent years.In order to reduce CRC-related deaths,many studies are aimed at identifying novel screeningand prognosis-related biomarkers.MicroRNAs(miRNAs)are a class of 18-27-nucleotide single-stranded RNA molecules that regulate gene expression at the posttranscriptional level.It has been demonstrated that miRNAs regulate a variety of physiological functions,including development,cell differentiation,proliferation,and apoptosis.They play important roles in various physiologic and developmental processes and in the initiation and progression of various human cancers.It has been shown that miRNAs can critically regulate tumor cell gene expression,and evidence suggests that they may function as both oncogenes and tumor suppressor genes.In CRC,miRNAs-21 is one of the most important miRNAs and is rapidly emerging as a novel biomarker in CRC,with good potential as a diagnostic and therapeutic target.In this review,we summarize the latest research findings of the clinicopathological relevance of miRNAs-21 in CRC initiation,development,and progress,highlighting its potential diagnostic,prognostic,and therapeutic application,as well as discuss-ing future prospects. | Tao Li Mei Ha Leong Bruce Harms Gregory Kennedy Lin Chen | 2013 | World Journal of Gastroenterology2013，19，34： | 16 |
| 2 | FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC显示文摘Over recent years,[18F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography(FDG-PET/CT)has proven its role as a staging modality in patients with non-small cell lung cancer(NSCLC).The purpose of this review was to present the evidence to use FDG-PET/CT for response evaluation in patients with NSCLC,treated with epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKI).All published articles from 1November 2003 to 1 November 2013 reporting on 18FFDG-PET response evaluation during EGFR-TKI treatment in patients with NSCLC were collected.In total 7studies,including data of 210 patients were eligible for analyses.Our report shows that FDG-PET/CT responseduring EGFR-TKI therapy has potential in targeted treatment for NSCLC.FDG-PET/CT response is associated with clinical and radiologic response and with survival.Furthermore FDG-PET/CT response monitoring can be performed as early as 1-2 wk after initiation of EGFR-TKI treatment.Patients with substantial decrease of metabolic activity during EGFR-TKI treatment will probably benefit from continued treatment.If metabolic response does not occur within the first weeks of EGFR-TKI treatment,patients may be spared(further)unnecessary toxicity of ineffective treatment.Refining FDG-PET response criteria may help the clinician to decide on continuation or discontinuation of targeted treatment. | Matthijs H van Gool Tjeerd S Aukema Koen J Hartemink Renato A Valdés Olmos Houke M Klomp Harm van Tinteren | 2014 | World Journal of Radiology2014，6，7： | 8 |
| 3 | 超重力法合成纳米碳酸钙的研究(Ⅰ)最佳反应时间的确定显示文摘采用红外光谱法动态跟踪研究在超重力法下合成纳米碳酸钙的整个碳化过程。实验表明 ,该方法得到的结果符合常规 pH计与电导仪记录的转化点 ,并与电镜形貌分析观察到晶形完全转化为立方型的反应时间相吻合。 | 朱开明 刘春光 饶国瑛 王玉红 陈建峰 Harm Wiese | 2001 | 北京化工大学学报(自然科学版)2001，28，3： | 8 |
| 4 | 纳米CaCO_3合成及原位改性的研究显示文摘在旋转填充床反应器中合成了纳米CaCO3悬浮液,利用pH计跟踪Ca(OH)2碳化反应过程, 研究了碳化反应过程原理。结果表明:旋转填充床能极大地强化相间传质与微观混合,提高体系中CaCO3的过饱和度,增大其成核及生长速率。加入适当的添加剂对纳米CaCO3进行原位改性; 利用TEM照片研究了原位改性过程中纳米CaCO3的成核生长机理,并考察了添加剂的作用机理。 | 刘春光 朱开明 王玉红 陈建峰 饶国英 Harm Wiese | 2001 | 高校化学工程学报2001，15，5： | 6 |
| 5 | Complicated small-bowel diverticulosis: A case report and review of the literature显示文摘当 jejunoileal 憩室稀罕、经常无征状时,他们可以导致长期的非特定或尖锐的症状。与类似于阑尾炎,胆汁或结肠的憩室炎而是他们的急腹症在场的复杂并发症的大多数可以也与不正常的症状出现。作为结果,复杂 jejunoileal 憩室形成的诊断能是相当困难的,并且可以完全取决于外科的探索的结果。当禁止徵候不在时,诊断腹腔镜检查有腹的内容和帮助的彻底的检查的利益到达绝对诊断。有主要吻合的深奥小肠的片断的外科的切除术是在有征兆的复杂 jejunoileal 的病人的比较喜欢的治疗憩室的疾病。与与腹腔镜检查诊断并且与外科的切除术对待的 S 字形的憩室炎一起的复杂空肠憩室炎的一个不正常的演讲被介绍。 | Woubet T Kassahun Josef Fangmann Jens Harms Michael Bartels Johann Hauss | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 6 | Landscape fragmentation by urbanization in the Netherlands: options and ecological consequences显示文摘1Introduction:thestudyareaFig1ThestudyareaTheeconomicactivitiesoftheNetherlandsareconcentratedinthewestofthecountry,thesoca... | W. Bert. Harms Department of Landscape Ecology, Winand Staring Centre DLO, Wageningen, The Netherlands | 1999 | Journal of Environmental Sciences1999，11，2： | 5 |
| 7 | Induction of desiccation tolerance in desiccation sensitive Citrus limon seeds显示文摘Many economically important perennial species bear recalcitrant seeds, including tea, coffee, cocoa, mango,citrus, rubber, oil palm and coconut. Orthodox seeds can be dried almost completely without losing viability, but so-called recalcitrant seeds have a very limited storage life and die upon drying below a higher critical moisture content than orthodox seeds. As a result, the development of longterm storage methods for recalcitrant seeds is compromised.Lowering this critical moisture content would be very valuable since dry seed storage is the safest, most convenient and cheapest method for conserving plant genetic resources.Therefore, we have attempted to induce desiccation tolerance(DT) in the desiccation sensitive seeds of Citrus limon. We show that DT can be induced by paclobutrazol(an inhibitor of gibberellin biosynthesis) and we studied its associated transcriptome to delineate the molecular mechanisms underlying this induction of DT. Paclobutrazol not only interfered with gibberellin related gene expression but also caused extensive changes in expression of genes involved in the biosynthesis and signaling of other hormones. Paclobutrazol induced a transcriptomic switch encompassing suppression of biotic-and induction of abiotic responses.We hypothesize that this is the main driver of the induction of DT by paclobutrazol in C. limon seeds. | Alexandre Marques Harm Nijveen Charles Somi Wilco Ligterink Henk Hilhorst | 2019 | Journal of Integrative Plant Biology2019，61，5： | 5 |
| 8 | 荷兰高等教育质量保障体系的演变、特点及其启示显示文摘本文总结了荷兰高等教育质量保障体系的演变历程,分析了荷兰现有质量保障体系的特点,并对其与荷兰高校、学科发展之间的关系进行了探析。通过比较研究,以期对我国高等教育如何结合'双一流'推进质量保障体系建设提供参考与借鉴。 | 成协设 Harm J.A Biemans | 2017 | 国家教育行政学院学报2017，，6： | 4 |
| 9 | MgO的外逸电子发射在PDP中作用显示文摘MgO外逸电子发射特性的获得是实现PDP高分辨率显示的关要技术之一,对MgO外逸电子发射的产生机理、测试方法及形成MgO外逸电子发射的方式进行了详细阐述,对该特性缩短PDP器件的统计延迟时间及提高放电稳定性等作用做了深入讨论,为合理利用MgO外逸电子发射特性,改善PDP特性提供了有力的理论基础。 | 李青 朱笛 Harm Tolner | 2009 | 光电子技术2009，29，1： | 3 |
| 10 | The TME Trial After a Median Follow-up of 6 Years: Increased Local Control But No Survival Benefit in Irradiated Patients With Resectable Rectal Carcinoma显示文摘 | Koen C.M.J. Peeters Corrie A.M. Marijnen Iris D. Nagtegaal Elma Klein Kranenbarg Hein Putter Theo Wiggers Harm Rutten Lars Pahlman Bengt Glimelius Jan Willem Leer Cornelis J.H. van de Velde | 2007 | Annals of Surgery2007，，5： | 3 |
| 11 | 8-Year Follow-up of Randomized Trial: Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy in Patients with Peritoneal Carcinomatosis of Colorectal Cancer显示文摘 | Vic J. Verwaal MD PhD Sjoerd Bruin MD Henk Boot MD PhD Gooike Slooten MD Harm Tinteren ScM | 2008 | Annals of Surgical Oncology2008，，9： | 3 |
| 12 | Effects of therapeutic horseback riding on post-traumatic stress disorder in military veterans显示文摘Background:Large numbers of post-deployment U.S.veterans are diagnosed with post-traumatic stress disorder(PTSD)and/or traumatic brain injury(TBI),leading to an urgent need for effective interventions to reduce symptoms and increase veterans’coping.PTSD includes anxiety,flashbacks,and emotional numbing.The symptoms increase health care costs for stress-related illnesses and can make veterans’civilian life difficult.Methods:We used a randomized wait-list controlled design with repeated measures of U.S.military veterans to address our specific aim to test the efficacy of a 6-week therapeutic horseback riding(THR)program for decreasing PTSD symptoms and increasing coping self-efficacy,emotion regulation,social and emotional loneliness.Fiftyseven participants were recruited and 29 enrolled in the randomized trial.They were randomly assigned to either the horse riding group(n=15)or a wait-list control group(n=14).The wait-list control group experienced a 6-week waiting period,while the horse riding group began THR.The wait-list control group began riding after 6 weeks of participating in the control group.Demographic and health history information was obtained from all the participants.PTSD symptoms were measured using the standardized PTSD Checklist-Military Version(PCL-M).The PCL-M as well as other instruments including,The Coping Self Efficacy Scale(CSES),The Difficulties in Emotion Regulation Scale(DERS)and The Social and Emotional Loneliness Scale for Adults-short version(SELSA)were used to access different aspects of individual well-being and the PTSD symptoms.Results:Participants had a statistically significant decrease in PTSD scores after 3 weeks of THR(P≤0.01)as well as a statistically and clinically significant decrease after 6 weeks of THR(P≤0.01).Logistic regression showed that participants had a 66.7%likelihood of having lower PTSD scores at 3 weeks and 87.5%likelihood at 6 weeks.Under the generalized linear model(GLM),our ANOVA findings for the coping self-efficacy,emotion regulation,and social and emotional loneliness did not reach statistical significance.The results for coping self-efficacy and emotion regulation trended in the predicted direction.Results for emotional loneliness were opposite the predicted direction.Logistic regression provided validation that outcome effects were caused by riding longer.Conclusion:The findings suggest that THR may be a clinically effective intervention for alleviating PTSD symptoms in military veterans. | Rebecca A.Johnson David L.Albright James R.Marzolf Jessica L.Bibbo Hayley D.Yaglom Sandra M.Crowder Gretchen K.Carlisle Amy Willard Cynthia L.Russell Karen Grindler Steven Osterlind Marita Wassman Nathan Harms | 2018 | Military Medical Research2018，5，1： | 3 |
| 13 | 8-Year Follow-up of Randomized Trial: Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy in Patients with Peritoneal Carcinomatosis of Colorectal Cancer显示文摘 | Vic J. Verwaal Sjoerd Bruin Henk Boot Gooike Slooten Harm Tinteren | 2008 | Annals of Surgical Oncology2008，，： | 3 |
| 14 | Reduction of Postoperative Ileus by Early Enteral Nutrition in Patients Undergoing Major Rectal Surgery: Prospective, Randomized, Controlled Trial显示文摘 | Petra G. Boelens Fanny F. B. M. Heesakkers Misha D. P. Luyer Kevin W. Y. van Barneveld Ignace H. J. T. de Hingh Grard A. P. Nieuwenhuijzen Arnout N. Roos Harm J. T. Rutten | 2014 | Annals of Surgery2014，，4： | 2 |
| 15 | Causes and consequences of ischemic-type biliary lesions after liver transplantation显示文摘 | Carlijn I. Buis Harm Hoekstra Robert C. Verdonk Robert J. Porte | 2006 | Journal of Hepato - Biliary - Pancreatic Surgery2006，，6： | 2 |
| 16 | Geospatial decision support for drought risk management显示文摘 | Steve Goddard Sherri K. Harms Stephen E. Reichenbach Tsegaye Tadesse William J. Waltman | 2003 | Communications of the ACM2003，，1： | 2 |
| 17 | Softening by fluidized bed crystallizers 显示文摘 | Willard D Harms Jr Robinson R Brace | 1992 | J Environ Eng1992，118，4： | 2 |
| 18 | Pancreatic cancer–Neoadjuvant therapy显示文摘In spite of the high mortality in pancreatic cancer, significant progress is being made. This review discusses multimodality therapy for patients with pancreatic cancer. Surgical therapy currently offers the only potential monomodal cure for pancreatic adenocarcinoma. However only 10%–20% of patients present with tumors that are amenable to resection, and even after resection of localized cancers, long term survival is rare. The addition of chemoradiation therapy significantly increases median survival. To achieve long-term success in treating this disease it is therefore increasingly important to identify effective neoadjuvant/adjuvant multimodality therapies. Preoperative chemoradiation for potentially resectable pancreatic cancer has the following advantages: (1) neoadjuvant treatment would eliminate the delay of adjuvant treatment due to postoperative complications; (2) neoadjuvant treatment could avoid unnecessary surgery for patients with metastatic disease evident on restaging after neoadjuvant therapy; (3) downstaging after neoadjuvant therapy may increase the likelihood for negative surgical margins; and (4) neoadjuvant treatment could prevent peritoneal tumor cell implantation and dissemination caused during surgery. This review systematically summarizes the current status, controversies, and prospects of neoadjuvant treatment of pancreatic cancer. | R. Krempien M. W. Munter W. Harms J. Debus | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，2： | 2 |
| 19 | Developing convective heat transfer in deep rectangular microchannels显示文摘 | Harms T M Kazmierczak M J | 1999 | Heat and Fluid Flow1999，20，： | 1 |
| 20 | Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons 显示文摘 | Nakayama AY Harms MB Luo L | 2000 | J Neurosci2000，20，14： | 1 |
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