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| 1 | Strategies to reduce pulmonary complications after esophagectomy显示文摘Esophagectomy,the surgical removal of all or part of the esophagus,is a surgical procedure that is associated with high morbidity and mortality.Pulmonary complications are an especially important postoperative problem.Therefore,many perioperative strategies to prevent pulmonary complications after esophagectomy have been investigated and introduced in daily clinical practice.Here,we review these strategies,including improvement of patient performance and technical advances such as minimally invasive surgery that have been implemented in recent years.Furthermore,interventions such as methylprednisolone,neutrophil elastase inhibitor and epidural analgesia,which have been shown to reduce pulmonary complications,are discussed.Benefits of the commonly applied routine nasogastric decompression,delay of oral intake and prophylactic mechanical ventilation are unclear,and many of these strategies are also evaluated here.Finally,we will discuss recent insights and new developments aimed to improve pulmonary outcomes after esophagectomy. | Teus J Weijs Jelle P Ruurda Grard AP Nieuwenhuijzen Richard van Hillegersberg Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，39： | 17 |
| 2 | Diagnostic value of drain amylase for detecting intrathoracic leakage after esophagectomy显示文摘AIM:To investigate the value of elevated drain amylase concentrations for detecting anastomotic leakage(AL) after minimally invasive Ivor-Lewis esophagectomy(MIILE).METHODS:This was a retrospective analysis of prospectively collected data in two hospitals in the Netherlands. Consecutive patients undergoing MI-ILE were included. A Jackson-Pratt drain next to the dorsal side of the anastomosis and bilateral chest drains were placed at the end of the thoracoscopic procedure. Amylase levels in drain fluid were determined in all patients during at least the first four postoperative days. Contrast computed tomography scans and/or endoscopic imaging were performed in cases of a clinically suspected AL. Anastomotic leakage was defined as any sign of leakage of the esophago-gastric anastomosis on endoscopy,re-operation,radiographic investigations,post mortal examination or when gastro-intestinal contents were found in drain fluid. Receiver operator characteristic curves were used to determine the cut-off values. Sensitivity,specificity,positive predictive value,negative predictive value,risk ratio and overall test accuracy were calculated for elevated drain amylase concentrations.RESULTS:A t o t a l o f 8 9 p a t ie n t s w e re in c lu d e d between March 2013 and August 2014. No differences in group characteristics were observed between patients with and without AL,except for age. Patients with AL were older than were patients without AL(P = 0.01). One patient(1.1%) without AL died within 30 d after surgery due to pneumonia and acute respiratory distress syndrome. Anastomotic leakage that required any intervention occurred in 15 patients(16.9%). Patients with proven anastomotic leakage had higher drain amylase levels than patients without anastomotic leakage [median 384 IU/L(IQR 34-6263) vs median 37 IU/L(IQR 26-66),P = 0.003]. Optimal cut-off values on postoperative days 1,2,and 3 were 350 IU/L,200 IU/L and 160 IU/L,respectively. An elevated amylase level was found in 9 of the 15 patients with AL. Five of these 9 patients had early elevations of their amylase levels,with a median of 2 d(IQR 2-5) before signs and symptoms occurred.CONCLUSION:Measurement of drain amylase levels is an inexpensive and easy tool that may be used to screen for anastomotic leakage soon after MI-ILE. However,clinical validation of this marker is necessary. | Gijs HK Berkelmans Ewout A Kouwenhoven Boudewijn JJ Smeets Teus J Weijs Luis C Silva Corten Marc J van Det Grard AP Nieuwenhuijzen Misha DP Luyer | 2015 | World Journal of Gastroenterology2015，21，30： | 3 |
| 3 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 4 | Reduction of Postoperative Ileus by Early Enteral Nutrition in Patients Undergoing Major Rectal Surgery: Prospective, Randomized, Controlled Trial显示文摘 | Petra G. Boelens Fanny F. B. M. Heesakkers Misha D. P. Luyer Kevin W. Y. van Barneveld Ignace H. J. T. de Hingh Grard A. P. Nieuwenhuijzen Arnout N. Roos Harm J. T. Rutten | 2014 | Annals of Surgery2014，，4： | 2 |
| 5 | Extensive mesenteric venous thrombosis treatment by regional thmmbolysis显示文摘 | ESPEEL B GRARD C MANSVELT B | 2005 | Ann Fr Anesth Reanim2005，24，3： | 1 |
| 6 | Intraoperative radiation therapy in recurrent carcinoma of the uterine cervix:report of the French intraoperative group on 70 patients 显示文摘 | Mah MA Grard JP DUbois JB | 1996 | Int J Radiat Oneol Biol Phys1996，34，1： | 1 |
| 7 | Enhancement of second-migrating enatiomer peak symmetry of basic drugs by using dual-cyclodextrin system in capillary electrophoresis显示文摘 | Grard S Morin P Dreux M | 2000 | Electrophoresis2000，21，14： | 1 |
| 8 | Optical interaction between a dielectric tip and a nanometric lattice:implications for near field microscopy显示文摘 | Labani B Grard C Courjon D | 1990 | J Opt Soc A m B1990，7，6： | 1 |
| 9 | Influence of cracking on the diffusion properties of cement-based materials Part Ⅰ: Influence of continuous cracks on the steady-state regime 显示文摘 | Grard B Marchand J | 2000 | Cement and Concrete Research2000，30，1： | 1 |
| 10 | Structural effects of diacidie andglycolicmoieties on physicochemical properties of aromatic polyesterdiols from glycolysis/ esterification of poly ( ethylene terephthalate) wastes显示文摘 | MYFIAM BL GRARD D GILLES T | 2002 | Polymer2002，43，： | 1 |
| 11 | Spacecraft Charging Effects 显示文摘 | Grard R Knott K Pedersen | 1983 | Space Science Reviews1983，34，3： | 1 |
| 12 | A 2 years follow up study of endovenous 980 nm laser treatment of the great saphenous vein: role of the blood content in the GSV显示文摘 | Desmyttere J Grard C Mordon S | 2005 | Medical laser application2005，20，4： | 1 |
| 13 | Inflammation of the atherosclerotic cap and shulder of the plaque is a common and locally observed feature in unrupture plaques of femoral and coronary arteries 显示文摘 | Grard P Arjan H Schoneveld | 1999 | Ateriosler Thromb Vasc Biol1999，19，： | 1 |
| 14 | Music decreases sedative requirements during spinal anesthesia 显示文摘 | Lepage C Drolet P Grard M | 2001 | Anesth Analg2001，93，： | 1 |
| 15 | Prognostic im- pact of matrix metafloproteinase gene polymorphisma in patients with heart failure according to the aetiology of left ventricular sys- tolic dysfunction显示文摘 | Mizon- Grard F de Groote P Lamblin N | 2004 | Eur Heart J2004，25，8： | 1 |
| 16 | Zika virus in Gabon (Central Africa)-2007:a new threat from Aedes albopictus? 显示文摘 | Grard G Caron M Mombo IM | 2014 | PLoS Negl Trop Dis2014，8，2： | 1 |
| 17 | Zika virus in Gabon(Central Africa)-2007:a new threat from Aedes albopictus?显示文摘 | Grard G Mélanie C Illich Manfred M DieudonnéN Statiana MO Davy J Didier F Christophe P Eric Maurice L | 2014 | PLoS Negl Trop Dis2014，8，2： | 1 |
| 18 | Endovenous laser ablation (980 nm) of the small saphenous vein in a series of 147 limbs with a 3-year follow-up显示文摘 | Desmytt-re J Grard C Stalnikiewicz G | 2010 | Eur J Wasc Endovasc Surg2010，39，1： | 1 |
| 19 | Prognostic factors for medium‐ and long‐term survival of esophageal cancer patients in the Netherlands显示文摘 | Pauline Bus Valery E. Lemmens Martijn G. van Oijen Geert‐Jan Creemers Grard A. Nieuwenhuijzen Jantine W. van Baal Peter D. Siersema | 2014 | J Surg Oncol2014，，5： | 1 |
| 20 | '? Incumbency, size, and radical product innovation 显示文摘 | Rajesh K Chandy Grard J TeUis The incumbent' s curse | 2000 | Journal of Marketing2000，，64： | 1 |
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