|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neo-adjuvant radiotherapy in rectal cancer显示文摘In rectal cancer treatment,attention has focused on the local primary tumour and the regional tumour cell deposits to diminish the risk of a loco-regional recurrence.Several large randomized trials have also shown that combinations of surgery,radiotherapy and chemotherapy have markedly reduced the risk of a locoregional recurrence,but this has not yet had any major influence on overall survival.The best results have been achieved when the radiotherapy has been given preoperatively.Preoperative radiotherapy improves loco-regional control even when surgery has been optimized to improve lateral clearance,i.e.,when a total mesorectal excision has been performed.The relative reduction is then 50%-70%.The value of radiotherapy has not been tested in combination with more extensive surgery including lateral lymph node clearance,as practised in some Asian countries.Many details about how the radiotherapy is performed are still open for discussion,and practice varies between countries.A highly fractionated radiation schedule(5 Gy×5),proven efficacious in many trials,has gained much popularity in some countries,whereas a conventionally fractionated regimen(1.8-2.0 Gy×25-28),often combined with chemotherapy,is used in other countries.The additional therapy adds morbidity to the morbidity that surgery causes,and should therefore be administered only when the risk of loco-regional recurrence is sufficiently high.The best integration of the weakest modality,to date the drugs(conventional cytotoxics and biologicals)is not known.A new generation of trials exploring the best sequence of treatments is required.Furthermore,there is a great need to develop predictors of response,so that treatment can be further individualized and not solely based upon clinical factors and anatomic imaging. | Bengt Glimelius | 2013 | World Journal of Gastroenterology2013，19，46： | 7 |
| 2 | The TME Trial After a Median Follow-up of 6 Years: Increased Local Control But No Survival Benefit in Irradiated Patients With Resectable Rectal Carcinoma显示文摘 | Koen C.M.J. Peeters Corrie A.M. Marijnen Iris D. Nagtegaal Elma Klein Kranenbarg Hein Putter Theo Wiggers Harm Rutten Lars Pahlman Bengt Glimelius Jan Willem Leer Cornelis J.H. van de Velde | 2007 | Annals of Surgery2007，，5： | 3 |
| 3 | Improved survival in cancer of the colon and rectum in Sweden显示文摘 | H. Birgisson M. Talb?ck U. Gunnarsson L. P?hlman B. Glimelius | 2005 | European Journal of Surgical Oncology2005，，8： | 2 |
| 4 | Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer显示文摘 | Glimelius B Ekstorm K Hoffman K | 1997 | Ann Oncol1997，8，2： | 1 |
| 5 | Substantial changese in life percep tions in patients with newly diagnosed advanced cancer and their spouses显示文摘 | Winterling J Wasteson E Glimelius B | 2004 | Cancer Nursing2004，27，5： | 1 |
| 6 | Prediction of iri-notecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer显示文摘 | Glimelius B Garmo H Berglund A | | 0，，01： | 1 |
| 7 | Random- ized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer 显示文摘 | GLIMELIUS B EKSTROM K HOFFMAN K | 1997 | Ann Oncol1997，8，2： | 1 |
| 8 | Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer显示文摘 | Glimelius B Ekstrom K Hoffman K | 1997 | AnnOncol1997，8，2： | 1 |
| 9 | Phase Ⅲ trial of cetuximab with continuous or intermittent fluorouracil,leucovorin,and oxaliplatin (Nordic FLOX) versus FLOX alone in first-line treatment of metastatic colorectal cancer:the NORDIC-Ⅶ study显示文摘 | Tveit KM Guren T Glimelius B | 2012 | J Clin Oncol2012，30，15： | 1 |
| 10 | A systematic overview of chemotherapy effects in non - small cell lung cancer显示文摘 | Sorenson S Glimelius B Nygren P | 2001 | Acta Oncol2001，40，23： | 1 |
| 11 | Perioperative chemotherapy with FOLFOX 4 and surgery versus surgery alone for respectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983):a randomized controlled trial显示文摘 | Nordlinger B Sorbye H Glimelius B | 2008 | Lancet2008，371，9617： | 1 |
| 12 | Preoperative or postoperative irradiation in adenocarcinoma of the rectum:final treatment results of a randomized trial and an evaluation of late secondary effects显示文摘 | Frykholm GJ Glimelius B Pahlman L | 1993 | Dis Colon Rectum1993，36，： | 1 |
| 13 | Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer显示文摘 | Glimelius B Ekstrom K Hoffman K | 1997 | Ann Oncol1997，8，： | 1 |
| 14 | Brassica napus lines with rearranged Arabidopsis mitochondria display CMS and a range of developmental aberrations显示文摘 | M. Leino R. Teixeira M. Landgren K. Glimelius | 2003 | Theoretical and Applied Genetics2003，，7： | 1 |
| 15 | Rectal cancer: ESMO clinical practice guidelines for diagnosis, treat- ment and follow-up显示文摘 | Glimelius B Tiret E Cervantes A | 2013 | Ann Oncol2013，24，6： | 1 |
| 16 | Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up 显示文摘 | Glimelius B Tiret E Cervantes A | 2013 | Ann Oncol2013，24，6： | 1 |
| 17 | Anorectal malignant melanoma in Sweden: report of 49 patients 显示文摘 | Goldman S Glimelius B Pahlman L | 1990 | Dis Colon Rectum1990，33，10： | 1 |
| 18 | Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial 显示文摘 | Nordlinger B Sorbye H Glimelius B | 2008 | Lancet2008，371，9617： | 1 |
| 19 | Improved Survival and Reduction in Local Failure Rates After Preoperative Radiotherapy: Evidence for the Generalizability of the Results of Swedish Rectal Cancer Trial显示文摘 | Michael Dahlberg Bengt Glimelius Lars P?hlman | 1999 | Annals of Surgery1999，，4： | 1 |
| 20 | Fertile somatic hybrids between brassica nap us and Arabidopsis thaliana 显示文摘 | Forsberg J Landgren M Glimelius K | 1994 | Plant Science1994，95，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员