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| 1 | Surveillance-response systems: the key to elimination of tropical diseases显示文摘Tropical diseases remain a major cause of morbidity and mortality in developing countries.Although combined health efforts brought about significant improvements over the past 20 years,communities in resource-constrained settings lack the means of strengthening their environment in directions that would provide less favourable conditions for pathogens.Still,the impact of infectious diseases is declining worldwide along with progress made regarding responses to basic health problems and improving health services delivery to the most vulnerable populations.The London Declaration on Neglected Tropical Diseases(NTDs),initiated by the World Health Organization’s NTD roadmap,set out the path towards control and eventual elimination of several tropical diseases by 2020,providing an impetus for local and regional disease elimination programmes.Tropical diseases are often patchy and erratic,and there are differing priorities in resources-limited and endemic countries at various levels of their public health systems.In order to identify and prioritize strategic research on elimination of tropical diseases,the‘First Forum on Surveillance-Response System Leading to Tropical Diseases Elimination’was convened in Shanghai in June 2012.Current strategies and the NTD roadmap were reviewed,followed by discussions on how to identify and critically examine prevailing challenges and opportunities,including inter-sectoral collaboration and approaches for elimination of several infectious,tropical diseases.A priority research agenda within a‘One Health-One World’frame of global health was developed,including(i)the establishment of a platform for resource-sharing and effective surveillance-response systems for Asia Pacific and Africa with an initial focus on elimination of lymphatic filariasis,malaria and schistosomiasis;(ii)development of new strategies,tools and approaches,such as improved diagnostics and antimalarial therapies;(iii)rigorous validation of surveillance-response systems;and(iv)designing pilot studies to transfer Chinese experiences of successful surveillance-response systems to endemic countries with limited resources. | Ernest Tambo Lin Ai Xia Zhou Jun-Hu Chen Wei Hu Robert Bergquist Jia-Gang Guo Jürg Utzinger Marcel Tanner Xiao-Nong Zhou | 2014 | Infectious Diseases of Poverty2014，3，1： | 14 |
| 2 | Surveillance and response systems for elimination of tropical diseases: summary of a thematic series in Infectious Diseases of Poverty显示文摘The peer-reviewed journal Infectious Diseases of Poverty provides a new platform to engage with,and disseminate in an open-access format,science outside traditional disciplinary boundaries.The current piece reviews a thematic series on surveillance-response systems for elimination of tropical diseases.Overall,22 contributions covering a broad array of diseases are featured–i.e.clonorchiasis,dengue,hepatitis,human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS),H7N9 avian influenza,lymphatic filariasis,malaria,Middle East respiratory syndrome(MERS),rabies,schistosomiasis and tuberculosis(TB).There are five scoping reviews,a commentary,a letter to the editor,an opinion piece and an editorial pertaining to the theme“Elimination of tropical disease through surveillance and response”.The remaining 13 articles are original contributions mainly covering(i)drug resistance;(ii)innovation and validation in the field of mathematical modelling;(iii)elimination of infectious diseases;and(iv)social media reports on disease outbreak notifications released by national health authorities.Analysis of the authors’affiliations reveals that scientists from the People’s Republic of China(P.R.China)are prominently represented.Possible explanations include the fact that the 2012 and 2014 international conferences pertaining to surveillance-response mechanisms were both hosted by the National Institute of Parasitic Diseases(NIPD)in Shanghai,coupled with P.R.China’s growing importance with regard to the control of infectious diseases.Within 4 to 22 months of publication,three of the 22 contributions were viewed more than 10000 times each.With sustained efforts focusing on relevant and strategic information towards control and elimination of infectious diseases,Infectious Diseases of Poverty has become a leading journal in the field of surveillance and response systems in infectious diseases and beyond. | Xia Zhou Peiling Yap Marcel Tanner Robert Bergquist Jürg Utzinger Xiao-Nong Zhou | 2016 | Infectious Diseases of Poverty2016，5，1： | 12 |
| 3 | Controlling schistosomiasis with praziquantel:How much longer without a viable alternative?显示文摘The current approach of morbidity control of schistosomiasis,a helminth disease of poverty with considerable public health and socioeconomic impact,is based on preventive chemotherapy with praziquantel.There is a pressing need for new drugs against this disease whose control entirely depends on this single drug that has been widely used over the past 40 years.We argue that a broader anthelminthic approach supplementing praziquantel with new antischistosomals targeting different parasite development stages would not only increase efficacy but also reduce the risk for drug resistance.Repositioning drugs already approved for other diseases provides a shortcut to clinical trials,as it is expected that such drugs rapidly pass the regulatory authorities.The antischistosomal properties of antimalarial drugs(e.g.,semisynthetic artemisinins,synthetic trioxolanes,trioxaquines and mefloquine)and of drugs being developed or registered for other purposes(e.g.,moxidectin and miltefosin),administered alone or in combination with praziquantel,have been tested in the laboratory and clinical trials.Another avenue to follow is the continued search for new antischistosomal properties in plants.Here,we summarise recent progress made in schistosomiasis chemotherapy,placing particular emphasis on repositioning of existing drugs against schistosomiasis. | Robert Bergquist Jürg Utzinger Jennifer Keiser | 2017 | Infectious Diseases of Poverty2017，6，1： | 7 |
| 4 | Comparison of novel and standard diagnostic tools for the detection of Schistosoma mekongi infection in Lao People’s Democratic Republic and Cambodia显示文摘Background:Given the restricted distribution of Schistosoma mekongi in one province in Lao People’s Democratic Republic(Lao PDR)and two provinces in Cambodia,together with progress of the national control programmes aimed at reducing morbidity and infection prevalence,the elimination of schistosomiasis mekongi seems feasible.However,sensitive diagnostic tools will be required to determine whether elimination has been achieved.We compared several standard and novel diagnostic tools in S.mekongi-endemic areas.Methods:The prevalence and infection intensity of S.mekongi were evaluated in 377 study participants from four villages in the endemic areas in Lao PDR and Cambodia using Kato-Katz stool examination,antibody detection based on an enzyme-linked immunosorbent assay(ELISA)and schistosome circulating antigen detection by lateral-flow tests.Two highly sensitive test systems for the detection of cathodic and anodic circulating antigens(CCA,CAA)in urine and serum were utilized.Results:Stool microscopy revealed an overall prevalence of S.mekongi of 6.4%(one case in Cambodia and 23 cases in Lao PDR),while that of Opisthorchis viverrini,hookworm,Trichuris trichiura,Ascaris lumbricoides and Taenia spp.were 50.4%,28.1%,3.5%,0.3%and 1.9%,respectively.In the urine samples,the tests for CCA and CAA detected S.mekongi infections in 21.0%and 38.7%of the study participants,respectively.In the serum samples,the CAA assay revealed a prevalence of 32.4%,while a combination of the CAA assay in serum and in urine revealed a prevalence of 43.2%.There was a difference between the two study locations with a higher prevalence reached in the samples from Lao PDR.Conclusions:The CCA,CAA and ELISA results showed substantially higher prevalence estimates for S.mekongi compared to Kato-Katz thick smears.Active schistosomiasis mekongi in Lao PDR and Cambodia might thus have been considerably underestimated previously.Hence,sustained control efforts are still needed to break transmission of S.mekongi.The pivotal role of highly sensitive diagnostic assays in areas targeting elimination cannot be overemphasised. | Youthanavanh Vonghachack Somphou Sayasone Virak Khieu Robert Bergquist Govert Jvan Dam Pytsje THoekstra Paul L.A.M.Corstjens Beatrice Nickel Hanspeter Marti Jürg Utzinger Sinuon Muth Peter Odermatt | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 5 | Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk显示文摘 | Peter Steinmann Jennifer Keiser Robert Bos Marcel Tanner Jürg Utzinger | 2006 | The Lancet Infectious Diseases2006，，7： | 2 |
| 6 | Equivalent dose measurement using a single aliquot of quartz 显示文摘 | Murray AS Roberts RG Wintle AG | 1997 | Radiat Megs1997，27，： | 2 |
| 7 | Optical dating of single and multiple grains of quartz from Jinmium rock shelter,northern Australia: Part Ⅰ, Experimental design and statistical models 显示文摘 | Galbraith RF Roberts RG Laslett GM | 1999 | Archaeometry1999，41，： | 2 |
| 8 | Single-aliquot and single-grain optical dating confirm thermoluminescence age estimates at Malakunanja Ⅱ rock shelter in northern Australia 显示文摘 | Roberts RG Yoshida H Galbraith RF | 1998 | Ancient TL1998，16，： | 2 |
| 9 | Phosphodiesterase type 5 inhi- bitors as adjunctive therapy in the management of systolic heart fail- ure显示文摘 | Cvelich RG Roberts SC Brown JN | 2011 | Anrt Pharmacother2011，45，12： | 1 |
| 10 | Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex显示文摘 | Jürg Müller Craig M. Hart Nicole J. Francis Marcus L. Vargas Aditya Sengupta Brigitte Wild Ellen L. Miller Michael B. O’Connor Robert E. Kingston Jeffrey A. Simon | 2002 | Cell2002，，2： | 1 |
| 11 | Characterization of DRP2, a novel human dystrophin homologue显示文摘 | ROBERTS RG FREEMAN TC KENDALL E | 1996 | Nat Genet1996，13，2： | 1 |
| 12 | Etomidate,adrenal dysfuncti-on and critical care显示文摘 | Roberts RG Redman JW | 2002 | Anaesthesia2002，57，4： | 1 |
| 13 | Circulating microRNAs (miRNA) in Serum of Patients With Prostate Cancer显示文摘 | Robert Mahn Lukas C. Heukamp Sebastian Rogenhofer Alexander von Ruecker Stefan C. Müller J?rg Ellinger | 2011 | Urology2011，，5： | 1 |
| 14 | Intrahepatic IL-8 producing Foxp3 + CD4 + regulatory T cells and fibrogenesis in chronic hepatitis C<!-- Doctopic: VH -->显示文摘 | Bettina Langhans Benjamin Kr?mer Marcell Louis Hans Dieter Nischalke Robert Hüneburg Andrea Staratschek-Jox Margarethe Odenthal Steffen Manekeller Michael Schepke J?rg Kalff Hans-Peter Fischer Joachim L. Schultze Ulrich Spengler | 2013 | Journal of Hepatology2013，，2： | 1 |
| 15 | Management of a ma- lignant pleural effusion: British Thoracic Society Pleural Disease Guideline 2010显示文摘 | Roberts ME Neville E Ben'isford RG | 2010 | Thorax2010，652，： | 1 |
| 16 | The identification of poit mutations in Duchenne muscular dystrophy patients by using reverse-transcription PCR and the protefin truncation test显示文摘 | Gardner TJ Bobrow M Roberts RG | 1995 | Am J Hum Genet1995，57，： | 1 |
| 17 | The human colonisation of Australia:optical dates of 53,000 and 60,000 years bracket human arrival at Deaf Adder Gorge,Northern Territory显示文摘 | Roberts RG Jones R Spooner NA | 1994 | Quaternary Science Reviews1994，13，5： | 1 |
| 18 | Altered patterns of caediac intercellular junction distribution in hypertrophic cardiomyopathy 显示文摘 | Robert S Severs NJ Gourdie RG | 1996 | Heart1996，76，5： | 1 |
| 19 | Imporoved recovery in aevtivities of dalily living with remission of poststroke depression 显示文摘 | Chemerisk E Robert G Robinson RG | 2001 | Stroke2001，26，： | 1 |
| 20 | Stereologi- cal estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat 显示文摘 | Nair - Roberts RG Chatelain - Badie SD Benson E | 2008 | Neuroscience2008，152，4： | 1 |
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