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| 1 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 2 | Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil 显示文摘 | Selbst MK Ahrens WA Robert ME | 2009 | Modem Pathology2009，22，6： | 1 |
| 3 | Transforming growth factorbeta and the initiation of chondrogenesis and osteegenesis in the rat femur显示文摘 | Joyce ME Roberts AB Sporn MB | 1990 | J Cell Biol1990，110，6： | 1 |
| 4 | Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution显示文摘 | Roberts Me | 1996 | FEMS Microbiology Reviews1996，19，1： | 1 |
| 5 | Olive oil mill effluent (OOME) : new substrate for biosurfactant production 显示文摘 | Mercade ME Manresa MA Robert M | 2003 | Bioresour Technol2003，43，1： | 1 |
| 6 | Associationbetween initial prescribed minute ventilation and post-resuscitationpartial pressure of arterial carbon dioxide in patients with post-cardiac arrest syndrome 显示文摘 | Roberts BW Kilgannon JH Chansky ME | 2014 | Ann Intensive Care2014，4，1： | 1 |
| 7 | Review : behaviour management techniques in paediatric dentistry显示文摘 | Roberts JF Curzon ME Koch G | 2010 | Eur Arch Paediatr Dent2010，11，4： | 1 |
| 8 | Reduction in hippocampal cholinergic innervation is unrelated to recognition memory impairment in aged rhesus monkeys显示文摘 | Calhoun ME Mao Y Roberts JA | 2004 | J Comp Neurol2004，475，2： | 1 |
| 9 | ABA,ethylene and the control of shoot and root growth under water stress 显示文摘 | Robert ES Le Noble ME | 2002 | J Exp Bot2002，53，： | 1 |
| 10 | Management of a ma- lignant pleural effusion: British Thoracic Society Pleural Disease Guideline 2010显示文摘 | Roberts ME Neville E Ben'isford RG | 2010 | Thorax2010，652，： | 1 |
| 11 | Pselectin activates integrin-mediated colon carcinoma cell adhesion to fibronectin显示文摘 | Reyes-Reyes ME George MD Roberts JD | | 0，，20： | 1 |
| 12 | Pathological stage does not alter the prognosis for renal lesions determined to be stage TI by computerized tomography显示文摘 | Roberts WW Bhayani SB Allaf ME | 2005 | J Urol2005，173，3： | 1 |
| 13 | Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1,Dnmt3L,SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo显示文摘 | Roberts AR Blewitt ME Youngson NA | | 0，，： | 1 |
| 14 | Source, transport and fluxes of Amazon River particulate organic carbon: Insights from river sediment depth-profiles显示文摘 | Julien Bouchez Valier Galy Robert G. Hilton Jér?me Gaillardet Patricia Moreira-Turcq Marcela Andrea Pérez Christian France-Lanord Laurence Maurice | 2014 | Geochimica et Cosmochimica Acta2014，，： | 1 |
| 15 | Transforming growth factor β and the initiation of chondrogenesis and osteogenesis in the rat femur显示文摘 | Joyce ME Robert AB Sporn AB | 1990 | Cell Biol1990，110，： | 1 |
| 16 | Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance显示文摘 | Chopra I Roberts Me | 2001 | Microbiology and Molecular Biology Reviews2001，65，2： | 1 |
| 17 | Modeling antibiotic tolerance in biofilms by accounting for nutrient limitation显示文摘 | Roberts ME Stewart PS | 2004 | Antimicrob Agents Chemother2004，48，1： | 1 |
| 18 | Acute gastroenteritis surveillance through the National Outbreak Reporting System, United States 显示文摘 | Hall AJ Wikswo ME Manikonda K Roberts VA Yoder JS Gould LH | 2013 | Emerg Infect Dis2013，19，8： | 1 |
| 19 | Groin lymphorrhea complicating revascularization involving the femoral vessels显示文摘 | Walters GK Zenilman ME | 1993 | Am J Surg1993，165，3： | 1 |
| 20 | Management of a malignant pleural effusion: British Thoracic Society Pleural Disease Guideline 2010显示文摘 | Roberts ME Neville E Berrisford RG | 2010 | Thorax2010，65，2： | 1 |
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