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| 1 | 三苯双脒、青蒿琥酯、蒿甲醚和吡喹酮单剂、多剂或联合用药治疗大鼠华支睾吸虫感染的实验研究显示文摘目的观察三苯双脒、青蒿琥酯、蒿甲醚、或吡喹酮单剂、多剂给药,及其伍用治疗感染华支睾吸虫大鼠的疗效。方法147只SD大鼠各感染50个华支睾吸虫囊蚴,于感染后42~44d分组治疗。各药物采用灌胃给药。①60只感染大鼠随机分为11组(每组4~5只),分别为三苯双脒150mg/kg(顿服)、75mg/(kg·d)×2d、50mg/(kg·d)×3d和25mg/kg(tid)×2d组;吡喹酮150mg/kg(顿服)、75mg/(kg·d)×2d和25mg/kg(tid)×2d;青蒿琥酯或蒿甲醚75mg/kg(顿服)和37.5mg/(kg·d)×2d组。②另87只感染大鼠随机分为15组(每组4~6只),用青蒿琥酯或蒿甲醚(30mg/kg)分别与吡喹酮(150mg/kg)、三苯双脒(50mg/kg和75mg/kg)伍用组;三苯双脒(50mg/kg)与吡喹酮(150mg/kg)伍用组;三苯双脒(75mg/kg)与吡喹酮(187.5mg/kg)伍用组,及各药的单用组。并设同批感染未治疗对照组。受治鼠于治疗后2周剖杀,收集胆管和肝组织内的残留华支睾吸虫,计算各组的平均虫数和减虫率,用非参数统计方法(Mann-Whitney秩和检验)对相应组间的平均虫数进行分析。结果感染华支睾吸虫的大鼠口服单剂三苯双脒或吡喹酮(150mg/kg)的减虫率分别为57.2%和63.8%。三苯双脒各小剂量多次给药组的减虫率稍高,达77.1%~79.4%,而吡喹酮小剂量多次给药组的减虫率则为50.6%~54.2%。但两种药物各组间的平均虫数的差异无统计学意义。青蒿琥酯和蒿甲醚各单剂给药组与小剂量多次给药组的减虫率均较高,分别为90.4%~98.5%和100%。三苯双脒小剂量(50或75mg/kg)与吡喹酮(150mg/kg或187.5mg/kg)伍用治疗,减虫率为74.9%~100%,高于其各单药组的减虫率(26.9%~79.6%)。青蒿琥酯或蒿甲醚小剂量(30mg/kg)与吡喹酮(150mg/kg)或三苯双脒(50或75mg/kg)伍用治疗,减虫率为74.9%~97.9%,亦高于其各药组的减虫率(24.8%~79.6%)。结论青蒿琥酯、蒿甲醚、吡喹酮和三苯双脒均为有效的抗华支睾吸虫药物,各药物小剂量伍用具有增效作用。 | 肖树华 薛剑 Marcel TANNER 张永年 Jennifer KEISER Jug UTZINGER 强慧琴 刘晓云 | 2008 | 中国寄生虫学与寄生虫病杂志2008，26，5： | 10 |
| 2 | Controlling schistosomiasis with praziquantel:How much longer without a viable alternative?显示文摘The current approach of morbidity control of schistosomiasis,a helminth disease of poverty with considerable public health and socioeconomic impact,is based on preventive chemotherapy with praziquantel.There is a pressing need for new drugs against this disease whose control entirely depends on this single drug that has been widely used over the past 40 years.We argue that a broader anthelminthic approach supplementing praziquantel with new antischistosomals targeting different parasite development stages would not only increase efficacy but also reduce the risk for drug resistance.Repositioning drugs already approved for other diseases provides a shortcut to clinical trials,as it is expected that such drugs rapidly pass the regulatory authorities.The antischistosomal properties of antimalarial drugs(e.g.,semisynthetic artemisinins,synthetic trioxolanes,trioxaquines and mefloquine)and of drugs being developed or registered for other purposes(e.g.,moxidectin and miltefosin),administered alone or in combination with praziquantel,have been tested in the laboratory and clinical trials.Another avenue to follow is the continued search for new antischistosomal properties in plants.Here,we summarise recent progress made in schistosomiasis chemotherapy,placing particular emphasis on repositioning of existing drugs against schistosomiasis. | Robert Bergquist Jürg Utzinger Jennifer Keiser | 2017 | Infectious Diseases of Poverty2017，6，1： | 7 |
| 3 | 妊娠期高血压免疫因子、肿瘤坏死因子α、血管紧张素Ⅱ1型受体自身抗体对妊娠可溶性fms样酪氨酸1和可溶性Endoglin产物的影响显示文摘最近研究发现先兆子痫中血管新生因子、可溶性fms样酪氨酸激酶(sFlt-1)和可溶性Endoglin(sEn-doglin)不平衡;然而尚不清楚它们过度分泌的启动机制。方法:长期给予怀孕大鼠肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)或抗血管紧张素Ⅱ受体的自身抗体(AT1-AA),测定其循环和胎盘的sFlt-1和(或)sEndoglin以确定这些因素的免疫调节作用。 | Parrish MR Murphy SR Rutland S Wallace K Wenzel K Wallukat G Keiser S Ray LF Dechend R Martin JN Granger JP La Marca B 黄晓斌 | 2010 | 中华高血压杂志2010，18，12： | 5 |
| 4 | Nonlinear terahertz devices utilizing semiconducting plasmonic metamaterials显示文摘The development of responsive metamaterials has enabled the realization of compact tunable photonic devices capable of manipulating the amplitude,polarization,wave vector and frequency of light.Integration of semiconductors into the active regions of metallic resonators is a proven approach for creating nonlinear metamaterials through optoelectronic control of the semiconductor carrier density.Metal-free subwavelength resonant semiconductor structures offer an alternative approach to create dynamic metamaterials.We present InAs plasmonic disk arrays as a viable resonant metamaterial at terahertz frequencies.Importantly,InAs plasmonic disks exhibit a strong nonlinear response arising from electric field-induced intervalley scattering,resulting in a reduced carrier mobility thereby damping the plasmonic response.We demonstrate nonlinear perfect absorbers configured as either optical limiters or saturable absorbers,including flexible nonlinear absorbers achieved by transferring the disks to polyimide films.Nonlinear plasmonic metamaterials show potential for use in ultrafast terahertz(THz)optics and for passive protection of sensitive electromagnetic devices. | Huseyin R Seren Jingdi Zhang George R Keiser Scott J Maddox Xiaoguang Zhao Kebin Fan Seth R Bank Xin Zhang Richard D Averitt | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 5 | Sensing and lasing applications of whispering gallery mode microresonators显示文摘 | Yu Zheng Zhifang Wu Perry Ping Shum Zhilin Xu Gerd Keiser Georges Humbert Hailiang Zhang Shuwen Zeng Xuan Quyen Dinh | 2018 | Opto-Electronic Advances2018，1，9： | 3 |
| 6 | 信息素养行动计划实施战略显示文摘 | Barbie E. Keiser 程旭(翻译整理) 丰静(翻译整理) | 2009 | 图书情报知识2009，26，1： | 3 |
| 7 | The Drugs We Have and the Drugs We Need Against Major Helminth Infections显示文摘 | Jennifer Keiser Jürg Utzinger | 2010 | Advances in Parasitology2010，，： | 2 |
| 8 | Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk显示文摘 | Peter Steinmann Jennifer Keiser Robert Bos Marcel Tanner Jürg Utzinger | 2006 | The Lancet Infectious Diseases2006，，7： | 2 |
| 9 | Changes in thymic function with age and during the treatment of HIV infection显示文摘 | Douek DC McFarland RD Keiser PH | 1998 | Nature1998，396，6712： | 1 |
| 10 | Pheochromocytoma:evaluation,diagnosis,and treatment 显示文摘 | Walther MM Keiser HR Linehan WM | 1999 | World Journal of Urology1999，17，： | 1 |
| 11 | Past,present,and future of Japanese encephalitis显示文摘 | Erlanger TE Weiss S Keiser J | 2009 | Emerg Infect Dis2009，15，1： | 1 |
| 12 | Standardized mississippi protocol treatment of 190 patients with HELLP syndrome: Slowing disease progression and preventing new major maternal morbidity显示文摘 | Martin JN Jr Owens MY Keiser SD | 2012 | Hypertens Pregnancy2012，31，1： | 1 |
| 13 | Past, present and future of Japanese encephalitis 显示文摘 | Erlanger TE Weiss S Keiser J | 2009 | Emerg Infect Dis2009，15，1： | 1 |
| 14 | Multi-scale feature extraction on point-sampled surfaces 显示文摘 | PAULY M KEISER R GROSS M | 2003 | Computer Graphics Forum2003，22，3： | 1 |
| 15 | Schistosomiasis and water re sources development:systematic review,meta analysis,and esti mates of people at risk显示文摘 | Steinmann P Keiser J Bos R | 2006 | Lancet Infect Dis2006，6，7： | 1 |
| 16 | Changes in thymic function with age and during the treatment of HIV infection显示文摘 | Douek DC McFarland RD Keiser PH | 1998 | Nature1998，396，6712： | 1 |
| 17 | Schistosomiasis and water resources development, systematic review, meta-analysis, and es- timates of people at risk显示文摘 | Steinmann P Keiser J Bos R | 2006 | Lancet Infect Dis2006，6，7： | 1 |
| 18 | How Nalco revitalized its quality process for R&D 显示文摘 | Keiser Blake | 1996 | Research Technology Management1996，39，3： | 1 |
| 19 | 显示文摘 | Douek DC MeFarland RD Keiser PH | 1998 | Nature1998，396，17： | 1 |
| 20 | Past,present,and future of Japanese encephalitis显示文摘 | Erlanger T E Weiss S Keiser J | 2009 | Emerg Infect Dis2009，15，1： | 1 |
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