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| 1 | Different risk factors influence peptic ulcer disease development in a Brazilian population显示文摘AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU. | Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic Márcia Aparecida Sperana | 2012 | World Journal of Gastroenterology2012，18，38： | 8 |
| 2 | 紫外分光光度法测定PAN纤维中的DMSO含量(英文)显示文摘用蒸馏水为萃取剂萃取出聚丙烯腈纤维中的DMSO,然后用紫外分光光度法测定其含量。测定的最佳线性浓度为:4.5× 10-10~1.6×10-9mol/L,DMSO最大吸收波长为208 nm, 检测限为1.9×10-9 mol/L,相关系数为0.999 8,相对标准偏差小于0.5%;与其它常用的测定方法相比,解决了从纤维中分离DMSO的难题,具有简便、快速、准确和低成本的特点。 | 曾小梅 Jan Ellinger 张幼维 赵炯心 潘鼎 | 2006 | 合成纤维工业2006，29，3： | 5 |
| 3 | Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation显示文摘AIM To investigate the relation of two different mutations to the outcome of partial external biliary diversion(PEBD)in severe bile salt export pump(BSEP) deficiency.METHODS Mutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney(HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatographytandem mass spectrometry. Wild-type and mutant BSEP transport of [~3H]-labeled taurocholate(TC) and taurochenodeoxycholate(TCDC) was assessed by vesicular transport assays.RESULTS A girl(at 2 mo) presented with pruritus, jaundice and elevated serum bile salts(BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919 del and the nonsense mutation p.R1235 X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy(age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032 R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives(< 5%). The patients' native liver biopsies showed canalicular BSEP expression. Both BSEP p.T919 del and p.G1032 R were localized in the plasma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecules per wild-type BSEP transporter per minute, respectively.CONCLUSION In summary, our findings suggest that residual function of BSEP as well as substrate specificity influence the therapeutic effectiveness of PEBD in progressive familial intrahepatic cholestasis type 2(PFIC-2). | Philipp Ellinger Jan Stindt Carola Droge Katharina Sattler Claudia Stross Stefanie Kluge Diran Herebian Sander HJ Smits Martin Burdelski Sebastian Schulz-Jürgensen Antje Ballauff Jan Schulte am Esch Ertan Mayatepek Dieter Haussinger Ralf Kubitz Lutz Schmitt | 2017 | World Journal of Gastroenterology2017，23，29： | 4 |
| 4 | Soy isoflavone genistein in prevention and treatment of prostate cancer 显示文摘 | Perabo FG Von EC Ellinger J | 2008 | Prostate Cancer Prostatic Dis2008，11，： | 1 |
| 5 | Cell free circulating DNA:Diagnositc value in patients with renal cell cancer显示文摘 | Hauser S Zahalka T Ellinger J | 2010 | Anticancer Res2010，30，7： | 1 |
| 6 | Leveraging logistics/distribution capabilities:the effect of logistics service on marketshare显示文摘 | Daugherty P Stank T Ellinger A | 1998 | Journal of Business Logistics1998，19，2： | 1 |
| 7 | Cell-free circulating DNA: diagnostic value in patients with testicular germ cell cancer 显示文摘 | Ellinger J Wittkamp V Albers P | 2009 | JUrol2009，181，1： | 1 |
| 8 | Fraud in Documentary Credit Transactions显示文摘 | E P Ellinger | 1981 | Journal of Business Law1981，，3： | 1 |
| 9 | Cell-free circulating DNA:Diagnostic value in patients with testicular germ cell cancer显示文摘 | Ellinger J Wittkamp V Albers P | 2009 | J Urol2009，181，1： | 1 |
| 10 | Examination of concrete by computerized tomography显示文摘 | MORGAN I L ELLINGER H KLINKSIEK R | 1980 | ACI Journal1980，77，1： | 1 |
| 11 | Demand and supply integration: a conceptual framework of value creation through knowledge management显示文摘 | Esper L Ellinger A E Stank T P | 2010 | Journal of the Academy of Marketing Science2010，38，1： | 1 |
| 12 | An ab initio and DFT study of (N2)2 dimers显示文摘 | Couronne O Ellinger Y | | 0，，： | 1 |
| 13 | Die neue Rolle der Rettungsleitstelle: Medical Call Center显示文摘 | Ellinger K Genzworker H | 2002 | Notfall&Rettungsmedizin2002，5，7： | 1 |
| 14 | Supervisory coaching behavior, employee satisfaction, and warehouse employee performance: A dyadic perspective in the distribution industry显示文摘 | Ellinger A D Ellinger A E Keller S B | 2003 | Human Resource Development Quarterly2003，14，4： | 1 |
| 15 | Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci 显示文摘 | Bastian PJ Ellinger J Wellmann A | 2005 | Clin Cancer Res2005，11，11： | 1 |
| 16 | Approach for a Novel Control Strategy for Simultaneous Nitrification/Denitrification in Activated Sludge Reactors显示文摘 | Fuerhacker M Bauer H Ellinger R | 2000 | Water Research2000，34，9： | 1 |
| 17 | Circulating microRNAs (miRNA) in Serum of Patients With Prostate Cancer显示文摘 | Robert Mahn Lukas C. Heukamp Sebastian Rogenhofer Alexander von Ruecker Stefan C. Müller J?rg Ellinger | 2011 | Urology2011，，5： | 1 |
| 18 | 26~42 GHz SOI CMOS Low Noise Amplifier显示文摘 | Frank Ellinger | 2004 | IEEE Journal of Solid-State Circuits2004，39，3： | 1 |
| 19 | Mapping Patterns of Support for Privatization in the Mass Public显示文摘 | Thompson L Elling R | | 0，，60： | 1 |
| 20 | Supervisory Coaching Behavior, Employee Satisfaction, and Warehouse Employee Performance: A Dyadic Perspective in the Distribution Industry 显示文摘 | Ellinger A D Ellinger A E Keller S B | 2003 | Human Resource Development Quarterly2003，14，4： | 1 |
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