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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Gilbert's syndrome: High frequency of the (TA)_7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene显示文摘瞄准:在吉伯的症候群(GS ) 在 UDP-glucuronosyltransferase 1 (UGT1A1 ) 基因识别变体并且在印度在正常控制之中在 TA 插入和它的影响的印度,以及频率为 TA 插入和 GS 估计在纯合性之间的协会。方法:95 个 GS 盒子和 95 正常控制被选择。肝工作,另外的测试被做。倡导者和 UGT1A1 基因的所有 5 前 ons 被重新定序。对新奇 trinucleotide 插入的功能的评价被做由在 silico 分析并且由估计 UGT1A1,倡导者活动在 Hep G2 由适当构造的酶记者试金执行了房间线。结果:在 GS 病人之中, 80% 为 TA 插入是同型结合的,它比从另外的种族组的报告高好几倍。吝啬的 UCB 水平与仅仅这插入的一个拷贝在个人之中被提高,它不与有二个拷贝的那些显著地不同。在 UGT1A1 基因的许多新 DNA 变体被发现,包括在倡导者的插入在 GS 病人的一个子集(10%) 发现了的 trinucleotide (猫) ,然而并非在正常之中控制。In-silico 分析证明在倡导者和功能的分析的合拢 DNA 的显著变化在 UGT1A1 基因源于这插入的抄写效率显示出 20 褶层减小,显著地从而提高 UCB 水平。结论:GS 的基因传染病学越过种族组是可变的,在 UGT1A1 倡导者变体之中的上位相互作用调制胆红素 glucuronidation。 | Shabana Farheen Sanghamitra Sengupta Amal Santra Suparna Pal Gopal Krishna Dhali Meenakshi Chakravorty Partha P Majumder Abhijit Chowdhury | 2006 | World Journal of Gastroenterology2006，12，14： | 29 |
| 3 | Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice显示文摘Objective:To evaluate the hepatoprotective and immunotherapeutic effects of aqueous extract of turmeric rhizome in CCl_4 intoxicated Swiss albino mice.Methods:first group of mice(n=5) received CCl_4 treatment at a dose of 0.5 mL/kg bw(i.p.) for 7 days.Second group was fed orally the aqueous extract of turmeric at a dose of 50 mg/kg bw for IS days.The third group was given both the turmeric extract(for 15 days,orally) and CCl_4(for last 7 days,i.p.).The fourth group was kept as a control.To study the liver function,the transaminase enzymes(SGOT and SGPT) and bilirubin level were measured in the serum of respective groups.For assaying the immunotherapeutic action of Curcuma longa(C.longa),non specific host response parameters like morphological alteration,phagocytosis,nitric oxide release,myeloperoxidase release and intracellular killing capacity of peritoneal macrophages were studied from the respective groups.Results:The result of present study suggested that CCl_4 administration increased the level of SCOT and SGPT and bilirubin level in serum.However,the aqueous extract of turmeric reduced the level of SGOT, SCFT and bilirubin in CCl_4 intoxicated mice.Apart from damaging the liver system,CCl_4 also reduced non specific host response parameters like morphological alteration,phagocytosis, nitric oxide release,myeloperoxidase release and intracellular killing capacity of peritoneal macrophages.Administration of aqueous extract of C.longa offered significant protection from these damaging actions of CCl_4 on the non specific host response in the peritoneal macrophages of CCl_4 intoxicated mice.Conclusions:In conclusion,the present study suggests that C.longa has immunotherapeutic properties along with its ability to ameliorate hepatotoxicity. | Mahuya Sengupta Gauri Dutta Sharma Biswajit Chakraborty | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 11 |
| 4 | Performance of sand and shredded rubber tire mixture as a natural base isolator for earthquake protection显示文摘The performance of a well-designed layer of sand, and composites like layer of sand mixed with shredded rubber tire(RSM) as low cost base isolators, is studied in shake table tests in the laboratory. The building foundation is modeled by a 200 mm by 200 mm and 40 mm thick rigid plexi-glass block. The block is placed in the middle of a 1m by 1m tank filled with sand. The selected base isolator is placed between the block and the sand foundation. Accelerometers are placed on top of the footing and foundation sand layer. The displacement of the footing is also measured by LVDT. The whole setup is mounted on a shake table and subjected to sinusoidal motions with varying amplitude and frequency. Sand is found to be effective only at very high amplitude(> 0.65 g) of motions. The performance of a composite consisting of sand and 50% shredded rubber tire placed under the footing is found to be most promising as a low-cost effective base isolator. | Srijit Bandyopadhyay Aniruddha Sengupta G.R.Reddy | 2015 | Earthquake Engineering and Engineering Vibration2015，14，4： | 10 |
| 5 | RNAi-Mediated Silencing of ITPK Gene Reduces Phytic Acid Content,Alters Transcripts of Phytic Acid Biosynthetic Genes,and Modulates Mineral Distribution in Rice Seeds显示文摘Phytic acid is the principal storage form of phosphorus in plant seeds and an essential signalling molecule in several regulatory processes of plant development.However,it is known as an anti-nutrient compound owing to its potent chelating property.Thus,reducing the phytic acid content in crops is desirable.Studies involving regulation of MIPS and IPK1 genes to generate low phytate rice have been reported earlier.However,the functional significance of OsITPK and the effect of its down-regulation on phytic acid content and the associated pleiotropic effects on rice have not yet been investigated.In this study,tissue specific RNA interference(RNAi)-mediated down-regulation of a major ITPK homolog(OsITP5/6K-1)resulted in 46.2%decrease in phytic acid content of T2 transgenic seeds with a subsequent 3-fold enhancement in the inorganic phosphorus content.Silencing of OsITP5/6K-1 altered the transcript levels of essential phytic acid pathway genes,without significantly affecting the transcript levels of other OsITPK homologs.Furthermore,the mapping of elements through X-ray microfluorescence analysis revealed significant changes in the spatial distribution pattern and translocation of elements in low phytate seeds.Additionally,low phytate polished seeds exhibited 1.3-fold and 1.6-fold enhancement in iron and zinc content in the grain endosperm,respectively.Silencing of OsITP5/6K-1 also altered the amino acid and myo-inositol content of the transgenic seeds.Our results successfully established that RNAi-mediated silencing of OsITP5/6K-1 gene significantly reduced the phytate levels in seeds without hampering the germination potential of seeds and plant growth.The present study provided an insight into the mechanism of phytic acid biosynthesis pathway. | Aritra KARMAKAR Sananda BHATTACHARYA Shinjini SENGUPTA Nusrat ALI Sailendra Nath SARKAR Karabi DATTA Swapan K.DATTA | 2020 | Rice science2020，27，4： | 7 |
| 6 | Thioredoxin and glutaredoxin-mediated redox regulation of ribonucleotide reductase显示文摘Ribonucleotide reductase(RNR), the rate-limitingenzyme in DNA synthesis, catalyzes reduction of thedifferent ribonucleotides to their corresponding deoxyri-bonucleotides. The crucial role of RNR in DNA synthesishas made it an important target for the development ofantiviral and anticancer drugs. Taking account of the re-cent developments in this field of research, this reviewfocuses on the role of thioredoxin and glutaredoxin sys-tems in the redox reactions of the RNR catalysis. | Rajib Sengupta Arne Holmgren | 2014 | World Journal of Biological Chemistry2014，5，1： | 6 |
| 7 | Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study显示文摘AIM Toll like receptors plays a significant anti-viral role in different infections. The aim of this study was to look into the role of toll like receptor 4(TLR4) in hepatitis B virus(HBV) infection.METHODS Real time PCR was used to analyze the transcription of TLR4 signaling molecules, cell cycle regulators and HBV DNA viral load after triggering the Hep G2.2.15 cells with TLR4 specific ligand. Nuclear factor(NF)-κB translocation on TLR4 activation was analyzed using microscopic techniques. Protein and cell cycle analysis was done using Western Blot and FACS respectively.RESULTS The present study shows that TLR4 activation represses HBV infection. As a result of HBV suppression, there are several changes in host factors which include partial release in G1/S cell cycle arrest and changes in host epigenetic marks. Finally, it was observed that anti-viral action of TLR4 takes place through the NF-κB pathway.CONCLUSION The study shows that TLR4 activation in HBV infection brings about changes in hepatocyte microenvironment and can be used for developing a promising therapeutic target in future. | Dipanwita Das Neelakshi Sarkar Isha Sengupta Ananya Pal Debraj Saha Manikankana Bandopadhyay Chandrima Das Jimmy Narayan Shivram Prasad Singh Runu Chakravarty | 2016 | World Journal of Gastroenterology2016，22，47： | 4 |
| 8 | 印度Ganga-Meghna-Brahmaputra平原及周围地区与孟加拉国地下水砷污染及其对健康影响的19年研究显示文摘基于近19年对印度Ganga—Meghna—Brahmaputra(简称GMB)平原(面积569749km^2,人口超过5亿)地下水砷污染的调查,可以确定印度Ganga—Brahmaputra平原(包括北方邦、比哈尔邦、恰尔康得邦、西孟加拉邦、阿萨姆邦)和孟加拉国普遍受到砷的污染。近期的调查研究也表明,除米佐拉姆邦外,其他各邦的地下水也受到不同程度的砷污染。至今为止.已对印度各邦和孟加拧国的175000份和50808份压把井水样进行了含砷量检测。并组织了一支包括皮肤科、神经科和妇产科医生在内的有经验的专家组,对上述地区125000人进行了临床检查,其中9%患有砷导致的皮肤病损症状。至今共采集分析了60000份生物样品。包括发样、指甲、尿样及皮肤鳞屑,其中80%的样品含砷量超过允许值,很多人由此受到砷的亚临床损害。在上述砷暴露地区.19000名儿童经过检查,近1100人患有砷导致的皮肤病损。该调查结果表明.儿童比成人更容易受到砷的毒性损害。在这种状况下.应着力解决饮水安全问题来减轻砷的苊害. | Ahamed S Hossain MA Mukharjee A Sengupta MK Das B Nayak B Pal A Mukherjee SC Pati S Dutta RN Saha KC Quamruzzaman Q Chakraborti D 付松波(译) 孙殿军(审校) | 2007 | 中国地方病学杂志2007，26，1： | 3 |
| 9 | Golgi localization and dynamics of hyaluronan binding protein 1 (HABP1/p32/C1QBP) during the cell cycle显示文摘Hyaluronan binding protein 1 (HABP1) is a negatively charged multifunctional mammalian protein with a unique structural fold. Despite the fact that HABP1 possesses mitochondrial localization signal, it has also been localized to other cellular compartments. Using indirect immunofluorescence, we examined the sub-cellular localization of HABP1 and its dynamics during mitosis. We wanted to determine whether it distributes in any distinctive manner after mitotic nuclear envelope disassembly or is dispersed randomly throughout the cell. Our results reveal the golgi localization of HABP1 and demonstrate its complete dispersion throughout the cell during mitosis. This distinctive distribution pattern of HABP1 during mitosis resembles its ligand hyaluronan, suggesting that in concert with each other the two molecules play critical roles in this dynamic process. | Aniruddha SENGUPTA Bhaswati BANERJEE Rakesh K. TYAGI Kasturi DATTA | 2005 | Cell Research2005，15，3： | 3 |
| 10 | Nexus between polymer support and metal oxide nanoparticles in hybrid nanosorbent materials (HNMs) for sorption/desorption of target ligands显示文摘象含水的铁的氧化物(HFO ) 或含水的锆氧化物(HZrO ) 一样的金属氧化物 nanoparticles 是为象磷酸盐,砷,或氟化物一样的环境地重要的 ligands 的优秀吸着剂,在踪迹集中在场。因为吸着能力是为 HFO 和 HZrO 的表面依赖者, nanoscale 尺寸在性能提供重要改进。然而,由于他们的 miniscule 尺寸,低摩擦抵抗,和差的耐久性,他们是不能的在典型塞子流动列安装被过去常。同时离子交换树脂,没向 anionic ligands 有特定的亲密关系,持久、化学上稳定。由在聚合物支持内使金属氧化物 nanoparticles 妊娠,与或没有功能的组,混合 nanosorbent 材料(HNM ) 能被准备。HNM 持久、机械地强壮、化学上稳定。聚合支持的功能的组将影响 Donnan 膜效果施加的 ligands 的全面移动效率。例如,由 HFO 的砷的移动或由 HZrO 的氟化物的移动被使用阴离子交换树脂提高。HNM 能精确被调节在另一种类型上移开沾染物的一种类型。另外,支持材料,球形的祷告对离子交换纤维的物理形态学,在吸着和解吸附作用的动力学上有重要效果。HNM 也拥有双吸着地点并且能够也就是,移开多重沾染物砷酸盐和高氯酸盐并发地。 | Ryan C. SMITH Jinze LI Surapol PADUNGTHON Arup K. SENGUPTA | 2015 | Frontiers of Environmental Science & Engineering2015，9，5： | 3 |
| 11 | mmunomodulatory properties of silver nanoparticles ontribute to anticancer strategy for murine fibrosarcoma显示文摘 | Biswajit Chakraborty Ramkrishna Pal Mohammed Ali Leichombam Mohindro Singh Dewan Shahidur Rahman Sujit Kumar Ghosh Mahuya Sengupta | 2016 | Cellular & Molecular Immunology2016，13，2： | 3 |
| 12 | Genetic variation in relation to adaptability of three mangrove species from the Indian Sundarbans assessed with RAPD and ISSR markers显示文摘Rich genetic polymorphism is important for plants to adapt to changes because it enables the plant to make anatomical,physiological and biochemical changes in response to abiotic stress.Geomorphologic characteristics,demographic interference and a cumulative decrease in freshwater influx in the Indian Sundarbans region have proved detrimental to some economically important plants.In this study,genetic polymorphism of three mangrove species,Xylocarpus granatum,Excoecaria agallocha,and Phoenix paludosa,was assessed using RAPD and ISSR molecular markers.X.granatum,already in distress in the Sundarbans,had the least genetic polymorphism,14.56%in the RAPD analysis and 12.92% in the ISSR.Relatively higher genetic polymorphism was recorded for the profusely growing E.agallocha and P.paludosa: 24.66 and26.4% in RAPD; 24.87 and 20.32% in ISSR analysis respectively.A UPGMA dendrogram constructed using the similarity matrix from RAPD,ISSR and combined datashowed that for X.granatum,the least and highest salinity zones clustered together,whereas for E.agallocha and P.paludosa,higher and lower salinity areas clustered in different clades.Nei's genetic diversity,calculated from RAPD and ISSR data,was also in accordance with 0.0637 and 0.0583 for X.granatum,respectively,much lower than0.0794 and 0.0818 for E.agallocha and 0.0799 and 0.0688 for P.paludosa.This opposing degree of polymorphism might be attributed to the profusely growing E.agallocha and P.paludosa and precarious status of X.granatum throughout the Indian Sundarbans. | Nirjhar Dasgupta Paramita Nandy Chandan Sengupta Sauren Das | 2018 | Journal of Forestry Research2018，29，2： | 3 |
| 13 | 世界服务外包之都——班加罗尔的故事显示文摘作为现代服务业,服务外包产业近年来在我国发展迅猛,日益崛起。而服务外包产业对于转变经济增长方式和产业结构战略性调整,对于提高开放型经济发展水平和自主创新能力,对于充分发挥教育资源优势、拓宽就业渠道等重要作用也逐渐被中央和地方各级政府所认识到。特别是在商务部服务外包“千百十”工程和“中国服务外包示范城市”创建工程的推动下,各地方政府发展服务外包业可谓“八仙过海各显神通”,初步形成了百舸争流、良性互动的竞争格局。 | Saugata Sengupta 郭周明(编译) | 2010 | 中国外资2010，，5： | 3 |
| 14 | Impact of inflammatory bowel disease activity and thiopurine therapy on birth weight: A meta-analysis显示文摘AIM To investigate the effect of disease activity or thiopurine use on low birth weight and small for gestational age in women with inflammatory bowel disease(IBD).METHODS Selection criteria included all relevant articles on the effect of disease activity or thiopurine use on the risk of low birth weight(LBW) or small for gestational age(SGA) among pregnant women with IBD. Sixtynine abstracts were identified,35 papers were full text reviewed and,only 14 of them met inclusion criteria. Raw data were extracted to generate the relative risk of LBW or SGA. Quality was assessed using the Newcastle Ottawa Scale.RESULTS This meta-analysis is reported according to PRISMA guidelines. Fourteen studies met inclusion criteria,and nine reported raw data suitable for meta-analysis. We found an increased risk ratio of both SGA and LBW in women with active IBD,when compared with women in remission: 1.3 for SGA(4 studies,95%CI: 1.0-1.6,P = 0.04) and 2.0 for LBW(4 studies,95%CI: 1.5-2.7,P < 0.0001). Women on thiopurines during pregnancy had a higher risk of LBW(RR 1.4,95%CI: 1.1-1.9,P = 0.007) compared with non-treated women,but when adjusted for disease activity there was no significant effect on LBW(RR 1.2,95%CI: 0.6-2.2,P = 0.6). No differences were observed regarding SGA(2 studies; RR 0.9,95%CI: 0.7-1.2,P = 0.5). CONCLUSION Women with active IBD during pregnancy have a higher risk of LBW and SGA in their neonates. This should be considered in treatment decisions during pregnancy. | Begona Gonzalez-Suarez Shreyashee Sengupta Alan C Moss | 2017 | World Journal of Gastroenterology2017，23，45： | 3 |
| 15 | Structural basis of PP2A activation by PTPA, an ATP- dependent activation chaperone显示文摘蛋白质磷酸酶 2A (PP2A ) 的合适的激活催化子单元为复杂 PP2A 规定是中央的并且为细胞的功能的宽广方面是关键的。PP2A 的水晶结构跳了到 PP2A 磷酸酶使活跃之物(PTPA ) 和 ATPγ S 表明 PTPA 与包围 PP2A 的结构的元素做宽广接触活跃地点和 ATP 的腺嘌一半。PTPA 有约束力稳定为激活要求的 apo-PP2A 的蛋白质褶层,并且东方 ATP phosphoryl 组织直接绑在 PP2A 活跃地点。这允许 ATP 调制 PP2A 活跃地点的金属绑定偏爱并且利用 PP2A 为 ATP 水解作用的活跃地点。在 vitro, ATP 有选择地并且急速地提高内长的催化金属离子的绑定,它要求 ATP 水解作用并且为 pSer/Thr-specific 磷酸酶活动的获得是关键的。而且, PP2A 有约束力、 ATP 有约束力在房间增长和幸存为 PTPA 功能被要求。我们的结果与结构的经济和能潜在地用作一个特定的治疗学的目标的一个唯一的 ATP 有约束力的衣袋在 PP2A 激活建议 PTPA 的新奇机制。 | Feng Guo Vitali Stanevich Nathan Wlodarchak Ritupama Sengupta Li Jiang Kenneth A Satyshur Yongna Xing | 2014 | Cell Research2014，24，2： | 3 |
| 16 | A review on immobilization of phosphate containing high level nuclear wastes within glass matrix – Present status and future challenges显示文摘 | Pranesh Sengupta | 2012 | Journal of Hazardous Materials2012，，： | 2 |
| 17 | Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB显示文摘 | Dos D. Sarbassov Siraj M. Ali Shomit Sengupta Joon-Ho Sheen Peggy P. Hsu Alex F. Bagley Andrew L. Markhard David M. Sabatini | 2006 | Molecular Cell2006，，2： | 2 |
| 18 | Barium borosilicate glass – a potential matrix for immobilization of sulfate bearing high-level radioactive liquid waste显示文摘 | C.P. Kaushik R.K. Mishra P. Sengupta Amar Kumar D. Das G.B. Kale Kanwar Raj | 2006 | Journal of Nuclear Materials2006，，2： | 2 |
| 19 | Transient loads on buildings in microburst and tornado winds显示文摘 | Anindya Sengupta Fred L. Haan Partha P. Sarkar Vasanth Balaramudu | 2008 | Journal of Wind Engineering & Industrial Aerodynamics2008，，10： | 2 |
| 20 | Filamin A regulates cell spreading and survival via β1 integrins显示文摘 | Hugh Kim Anita Sengupta Michael Glogauer Christopher A. McCulloch | 2007 | Experimental Cell Research2007，，4： | 2 |
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