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| 1 | 新型重组腺病毒载体埃博拉疫苗完成1期临床试验显示文摘一种新型的重组5型腺病毒载体埃博拉疫苗完成了1期临床试验。研究结果显示了疫苗的安全性和免疫原型良好,特别是高剂量组在14d就可以产生高水平的特异性抗体和T细胞反应。此前的埃博拉疫苗毒株均来自1976年的扎伊尔(Zaire)埃博拉暴发疫情。来自中国的研究者首次评价了这种利用2014年埃博拉疫情流行毒株和重组5型腺病毒载体方法研制的新型埃博拉疫苗。 | Zhu FC Hou LH Li JX 索罗丹 | 2015 | 中华预防医学杂志2015，49，6： | 36 |
| 2 | 多发肝癌免疫基因组特征及免疫逃逸机制的探究显示文摘【据《J Hepatol》2020年5月报道】题:多发肝癌免疫基因组特征及免疫逃逸机制的探究(作者Dong LQ等)多灶性肿瘤是肝癌常见的一种临床特征,其基因起源可能是由肝内转移(IM)或多中心独立发生(MO)而来的。本研究旨在探究多发肝癌基因组结构、异质性基因组结构对其免疫浸润及特征的影响,以及不同病灶差异化的免疫逃逸机制,从而针对其多病灶开发覆盖个体化的免疫治疗策略。 | 高强 董良庆 PENG LH MA LJ | 2020 | 临床肝胆病杂志2020，36，6： | 17 |
| 3 | Microbial community structure of ethanol type fermentation in biohydrogen production显示文摘 | Ren NQ Xing DF Rittmann BE Zhao LH Xie TH Zhao X | 2007 | 中国生物学文摘2007，21，7： | 16 |
| 4 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 5 | 溶栓时间(入院到用药时间)的延迟及其对脑卒中治疗时间与预后的影响显示文摘尽管美国心脏协会/美国脑卒中协会关于脑卒中的治疗均提出了倡议,大量急性缺血性脑卒中患者仍然在到达就诊60min后才开始启动组织型纤溶酶原激活剂(阿替普酶)溶栓治疗。该研究旨在描述延迟的原因及其与患者预后之间的关系。 | 刘莉 叶鹏 Kamal N Sheng S Xian Y Matsouaka R Hill MD Bhatt DL Saver JL Reeves MJ Fonarow GC Schwamm LH Smith EE | 2017 | 中华高血压杂志2017，25，4： | 15 |
| 6 | Leaf orientation, photorespiration and xanthophyll cycle protect young soybean leaves against high irradiance in field显示文摘 | Jiang, CD Gao, HY Zou, Q Jiang, GM Li, LH | 2006 | 中国生物学文摘2006，20，2： | 12 |
| 7 | Picophytoplankton, nanophytoplankton, heterotrohpic bacteria and viruses in the Changjiang Estuary and adjacent coastal waters显示文摘 | Pan LA Zhang J Zhang LH | 2007 | 中国生物学文摘2007，21，7： | 11 |
| 8 | Isolation and Structure Elucidation of Autolytimycin, A New Compound Produced by Streptomyces Autolyticus JX-47显示文摘Autolytimycin 1 was isolated from the culture filtrate of Streptomyces autolyticus JX-47, together with two known compounds, lebstatin 2 and 17-O-demethyl-geldanamycin 3. These compounds showed the activities of anti-HSV-I. The structure of 1 was determined by spectral analysis. | Li, MG Wu, SH Zhao, LX Zhang, Q Li, WJ Cui, XL Xu, LH Wu, DG Jiang, CL | 2001 | Chinese Chemical Letters2001，12，10： | 10 |
| 9 | Short-term effect of Salvia miltiorhiza in treating rat acetic acid chronic gastric ulcer and long-term effect in preventing recurrence显示文摘ShorttermefectofSalviamiltiorhizaintreatingrataceticacidchronicgastriculcerandlongtermefectinpreventingrecurenceWANGGuoZho... | Wang, GZ Ru, X Ding, LH Li, HQ | 1998 | World Journal of Gastroenterology1998，4，2： | 8 |
| 10 | Regulation of Arabidopsis Early Anther Development by Putative Cell-Cell Signaling Molecules and Transcriptional Regulators显示文摘在 flowering 的花药开发包含几种房间类型的形成,包括 tapetal 和花粉母细胞。基因、分子的工具的使用导致了在 Arabidopsis 早花药开发为正常细胞分裂和区别是批评的基因的鉴定和描述。我们这里在这些基因上考察几最近的研究,包括通常认为的受体蛋白质家族 ases BAM1 和 BAM2together 玩的示范在早细胞分裂和区别的控制的必要角色。Inaddition,我们讨论 BAM1/2 可以形成的假设积极否定的反馈有一个以前识别的关键管理者的规章的循环, SPOROCYTELESS (也叫的嘴) ,到在在花药的 sporogenous 和体细胞类型之间的 controlthebalance。而且,我们在支持 propertapetal 细胞分化总结隔离和不正常的 TAPETUM1 (DYT1 ) 基因的功能的分析。我们发现那 DYT1 编码 thebHLH 家庭的一个通常认为的抄写因素,以及相关表示强烈分析支持 DYT1 作为在在上游的因素和为 normaltapetum 开发和功能是批评的下游的目标基因之间的一个批评连接为服务的一个模特儿。和另外的最近出版的工作,这些研究显示房间房间通讯和 transcriptional | Yu-Jin Sun Carey LH Hord Chang-Bin Chen Hong Ma | 2007 | Journal of Integrative Plant Biology2007，49，1： | 8 |
| 11 | Investigation of recombinant Schistosoma japonicum paramyosin fragments for immunogenicity and vaccine efficacy in mice显示文摘 | Zhang DM Pan WQ Qian L Duke M Shen LH McManus DP | 2006 | 第二军医大学学报2006，27，6： | 6 |
| 12 | 心肌梗塞危险因素的新概念显示文摘心肌梗塞危险因素的新概念[OpieLH.CardiovascDrugsTher,1995,9:479(英文)]近年对冠心病和心肌梗塞的传统危险因素有了一些新认识,并提出了一些新的危险因素。1对传统危险因素的新认识冠心病和心肌梗塞3个最主要的危险因素是... | Opie LH | 1996 | 心血管病学进展1996，17，5： | 6 |
| 13 | AFP特异性CD8^+ T/CD4^+ T肝癌疫苗体外杀伤肝癌细胞的实验研究显示文摘目的甲胎蛋白作为一种肿瘤特异性抗原,是临床上诊断肝癌的重要指标。本研究中,检测AFP特异性T细胞的体外抗肿瘤免疫活性。方法采用经过AFP抗原决定簇肽刺激或慢病毒转染的的树突状细胞(dendriticcells,DC),活化AFP特异性的CD4+T细胞和CD8+T细胞,并在体外检测这群T细胞对人肝癌细胞HepG2的杀伤活性。结果本研究结果显示,AFP特异性的CD4+T细胞和CD8+T细胞体外能有效杀伤HepG2细胞,上调培养体系中IL-2、IFN-γ、TNF-α、穿孔素、颗粒酶的水平,对于T细胞活化的负调控因子IL-10,具有显著的抑制作用。结论经DC活化后的AFP特异性T细胞具有显著的体外抗肿瘤免疫活性,有望成为肝细胞癌的免疫治疗新方法。 | 刘扬 宋振顺 周波 傅晓辉 吴孟超 Butterfield LH | 2011 | 同济大学学报(医学版)2011，32，1： | 6 |
| 14 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 15 | 咽鼓管功能障碍定义、类型、临床表现及诊断的共识声明显示文摘1引言 英国NIHR卫生技术评估(HTA)计划发表的咽鼓管功能障碍治疗的系统回顾性研究指出,目前缺乏咽鼓管功能障碍统一的定义和诊断标准,推进这一领域研究进展的关键是针对咽鼓管功能障碍的诊断标准和重要临床结果达成共识。因此,2014年06月21日在荷兰阿姆斯特丹召开了由咽鼓管功能障碍领域的医学专家和科学家们参加的研讨会,旨在针对咽鼓管功能障碍的定义、临床表现、诊断及未来研究领域等方面达成共识。本文针对本次会议讨论结果总结如下。 | Schilder AG Bhutta MF Butler CC Holy C Levine LH Kvaerner KJ Norman G Pennings RJ Poe D Silvola JT Sudhoff H Lund VJ 翻曲腾飞 龚树生 | 2015 | 中国医学文摘(耳鼻咽喉科学)2015，30，6： | 5 |
| 16 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 17 | Current status and prospects of clinical proteomics studies on detection of colorectal cancer:Hopes and fears显示文摘Colorectal adenocarcinoma (CRC) is the third most com-mon type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A fi eld of recent interest is clinical proteomics, which was reported to lead to high sensitivity and specifi cities for early detection of several solid tumors. This emerging fi eld uses mass spectrometry-based protein profi les/pat-terns of easy accessible body fluids to distinguish cancer from non-cancer patients. These discrepancies may be a result of: (1) proteins being abnormally produced or shed and added to the serum proteome, (2) proteins clipped or modified as a consequence of the disease process, or (3) proteins subtracted from the proteome owing to disease-related proteolytic degradation path-ways. Therefore, protein pattern diagnostics would pro-vide easy and reliable tools for detection of cancer. This paper focuses on the current status of clinical proteomics research in oncology and in colorectal cancer especially, and will re? ect on pitfalls and fears in this relatively new area of clinical medicine, which are reproducibility issues and pre-analytical factors, statistical issues, and identifi -cation and nature of discriminating proteins/peptides. | ME de Noo RAEM Tollenaar AM Deelder LH Bouwman | 2006 | World Journal of Gastroenterology2006，12，41： | 3 |
| 18 | 女性健康倡议单用雌激素试验中冠状动脉钙化与试验后心血管事件及死亡率的关系显示文摘参与女性健康倡议(women’s health initiative,WHI)单用雌激素(estrogen—alone,E—Alone)试验的年龄50~59岁的女性中,与安慰剂组相比,基线时随机使用合成雌激素的女性心肌梗死的风险和死亡率更低。 | 黄洁 叶鹏 Poornima IG Mackey RH Allison MA Manson JE Carr JJ LaMonte MJ Chang Y Kuller LH | 2017 | 中华高血压杂志2017，25，11： | 3 |
| 19 | Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome显示文摘Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory support.We aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this disease.Methods Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome Database.Intubation rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital groups.Results Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid commencement.Compared to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid rescue.There were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive ventilation.Conclusion Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality. | Loretta YC Yam Alfred YF Chan Thomas MT Cheung Eva LH Tsui Jane CK Chan Vivian CW Wong | 2005 | Chinese Medical Journal2005，，17： | 3 |
| 20 | The lipase monolayer film self-assembly on the negatively charged poly(ethylene terephthalate) substrate显示文摘The PET-CO2-film was prepared and the lipase was assembled on the surface of the PET-CO2- substrate The structure at the surface and activity of lipase/PET monolayer were studied by ATR-FTIR and AFM, and other methods. | Lin, XF He, L Xu, LH Lu, DS Chen, ZC | 2000 | Chinese Chemical Letters2000，11，3： | 3 |
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