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| 1 | 应用组织追踪法评价左室功能的研究显示文摘目的 用超声心动图组织追踪法评价左室功能。方法 对 90例具有不同左室收缩功能患者的心尖四腔心、心尖长轴和心尖二腔心切面 ,用组织追踪法和M型超声心动图法记录收缩期二尖瓣瓣环向心尖方向的运动位移。所有患者均用Simpson方法确定左室射血分数 ,其中 2 7例患者又做了左室造影。 结果 在 5 0例患者中 (包括 2 5例正常左室功能患者和 2 5例左室整体功能减退患者 ) ,组织追踪法从二尖瓣环的 6个位置测得的收缩期平均二尖瓣瓣环距离与M型测得的值非常接近 (r =0 .99,P <0 .0 0 1) ,与左室射血分数的相关性很匹配 (r =0 .97,P <0 .0 0 1)。用组织追踪法测定的收缩期二尖瓣瓣环下移距离 4.8mm作为一个切断点的值(cut ofvalue) ,预测左室射血分数≤ 30 %的敏感性为 98%,特异性为 78%。但在陈旧性心肌梗死患者中 ,组织追踪法从二尖瓣瓣环的 6个位置测得的收缩期平均二尖瓣瓣环下移的距离与左室射血分数的相关性是较低的 (r= 0 .87,P <0 .0 0 1)。结论 组织追踪法测收缩期二尖瓣瓣环下移距离可为临床提供一种简单快速和无创伤性评价左室功能的方法。 | 潘翠珍 舒先红 陈灏珠 Rainer Hoffmann Peter Hanrath | 2001 | 中华超声影像学杂志2001，10，12： | 58 |
| 2 | 组织追踪法快速而精确评价心梗患者左室功能显示文摘目的 :本研究旨在用一种新的超声心动图技术—组织追踪法评价心梗患者左室节段收缩功能。方法 :我们研究 4 0例陈旧性心梗患者和 2 5例左室收缩功能正常对照组 ,在心尖四腔心、三腔心和二腔心切面 ,用组织追踪法和 M型超声心动图法记录收缩期二尖瓣瓣环向心尖方向的运动位移。所有患者均用 Simpson s方法确定左室射血分数 ,其中 2 7例患者又做了对比造影。结果 :在陈旧性心梗患者中 ,组织追踪法从二尖瓣瓣环的 6个位置测得的收缩期平均二尖瓣瓣环下移的距离与 M- mode测得的距离相关性很匹配 (r=0 .98,P<0 .0 0 1) ,与左室射血分数的相关性很好 (r=0 .87,P<0 .0 0 1)。陈旧性心梗节段收缩减退患者与正常左室收缩功能患者的比较 ,收缩期二尖瓣瓣环下移距离在 6个位置都是有意义地减少 ,而且收缩期二尖瓣瓣环下移距离在 6个位置之间有较大的异质性。结论 :组织追踪法测收缩期二尖瓣瓣环下移距离为临床提供了一种简单的。 | 潘翠珍 Rainer Hoffmann Peter Hanrath 舒先红 陈灏珠 | 2002 | 中国超声医学杂志2002，18，2： | 22 |
| 3 | 藏毛窦发病率和远期复发率现况及其影响因素分析显示文摘目的调查德国部队中藏毛窦的发病率和术后远期复发率的现状及其发展变化趋势,分析不同手术治疗方法、体格状况和吸烟量等因素对藏毛窦的发病率和术后远期复发率的影响。方法对德国三家部队医院1980至1996年收治的所有藏毛窦患者的资料进行统计,随机抽取其中500例患者进行随访。结果德国部队中藏毛窦的发病率由1985年的0.3/1000上升到2007年的2.4/1000。随机抽取的500例患者中2例死亡,498例接受了随访。其术后复发率从1981年的33%,到1986年的23%,再到1996年的12%,呈明显下降趋势(P=0.01)。藏毛窦切除后行开放愈合的复发率为16.8%,显著低于行一期缝合的复发率31.0%(P〈0.01)。部队中人均体质量每十年增加1kg,德国国民人均体质量每十年增加1.9kg,但是体质量的增加与藏毛窦复发率之间无显著相关性(P=0.72)。每天吸烟20支以上者藏毛窦的复发率比吸烟≤20支者显著升高(P=0.015)。结论在藏毛窦的术后复发率下降,特别是切除后开放愈合的术后复发率下降的同时,藏毛窦的发病率上升了近十倍。 | Theo Evers Dietrich Doll Edouard Matevossian Sebastian Noe Konrad Neumann 李挥力 Norbert Huser Rainer Ludde Sebastian Hoffmann Bjorn Dirk Krapohl | 2011 | 中华外科杂志2011，49，9： | 14 |
| 4 | Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods显示文摘Neutralizing antibodies targeting the receptor-binding domain(RBD)of the SARS-CoV-2 spike(S)block severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)entry into cells via surface-expressed angiotensin-converting enzyme 2(ACE2).We used a surrogate virus neutralization test(sVNT)and SARS-CoV-2 S protein-pseudotyped vesicular stomatitis virus(VSV)vector-based neutralization assay(pVNT)to assess the degree to which serum antibodies from coronavirus disease 2019(COVID-19)convalescent patients interfere with the binding of SARS-CoV-2 S to ACE2.Both tests revealed neutralizing anti-SARS-CoV-2 S antibodies in the sera of ~90% of mildly and 100% of severely affected COVID-19 convalescent patients.Importantly,sVNT and pVNT results correlated strongly with each other and to the levels of anti-SARS-CoV-2 S1 IgG and IgA antibodies.Moreover,levels of neutralizing antibodies correlated with the duration and severity of clinical symptoms but not with patient age.Compared to pVNT,sVNT is less sophisticated and does not require any biosafety labs.Since this assay is also much faster and cheaper,sVNT will not only be important for evaluating the prevalence of neutralizing antibodies in a population but also for identifying promising plasma donors for successful passive antibody therapy. | Berislav Bosnjak Saskia Catherina Stein Stefanie Willenzon Anne Katrin Cordes Wolfram Puppe Gunter Bernhardt Inga Ravens Christiane Ritter Christian R.Schultze-Florey Nina Godecke Jorg Martens Hannah Kleine-Weber Markus Hoffmann Anne Cossmann Mustafa Yilmaz Isabelle Pink Marius M.Hoeper Georg M.N.Behrens Stefan Pohlm ann Rainer Blasczyk Thomas F.Schulz Reinhold Forster | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 5 | Preparation β-silicon nitride seeds for self-reinforced silicon nitride ceramics显示文摘 | Peelamedu D Ramesh Rainer Oberacker Michael J Hoffmann | | 0，，06： | 1 |
| 6 | Three-year follow-up after treatment of bare-metal stent restenosis with first-generation or second-generation drug-eluting stents显示文摘 | Mohammad Almalla J?rg W. Schr?der Verena Pross Nikolaus Marx Rainer Hoffmann | 2013 | Coronary Artery Disease2013，，2： | 1 |
| 7 | Patterns and mechanisms of in-stent restenosis: A serial intravascular ultrasound study 显示文摘 | Rainer Hoffmann Gary S Mintz Gaston R Dussaillant | 1996 | Circulation1996，94，： | 1 |
| 8 | Assessment of Myocardial Reperfusion by Intravenous Myocardial Contrast Echocardiography and Coronary Flow Reserve After Primary Percutaneous Transluminal Coronary Angiography in Patients With Acute Myocardial Infarction显示文摘 | Wolfgang Lepper Rainer Hoffmann Otto Kamp Andreas Franke Carel C. de Cock Harald P. Kühl Gertjan T. Sieswerda Jürgen vom Dahl Uwe Janssens Paolo Voci Cees A. Visser Peter Hanrath | 2000 | Circulation: Journal of the American Heart Association2000，，20： | 1 |
| 9 | 血管内超声评价冠心病患者冠状动脉支架功能显示文摘目的 :应用 IVUS显像评价 Multi L ink支架植入后 6个月追踪结果和对比 Multi L ink新、旧设计类型支架植入后的变化。方法 :75例植入 Multi L ink (Gaidant Corporation)支架后 6个月 IVUS进行检查。在支架植入前 ,之后立即和 6个月均进行冠状动脉造影。患者分成两组 :第一代 Multi L ink支架 40例 ;第二代 Multi L ink支架35例。结果 :第二代 Multi L ink支架最小内膜面积大于第一代 Multi L ink支架 (P=0 .0 0 5 3)。平均最小内膜直径两组具有明显差别 ,(2 .17± 0 .33) mm与 (2 .37± 0 .2 8) mm,P=0 .0 11。第二代 Multi L ink支架区新生内膜增殖面积和最大内膜增殖厚度均比第一代 Multi L ink支架小。第一代 Multi L ink支架具有较高的斑块面积百分数。结论 :新的设计类型 Multi L | 周维新 杨浣宜 Rainer Hoffmann Andreas Franke Harald Kuhl Peter Hanrat | 2001 | 中国超声医学杂志2001，17，8： | 1 |
| 10 | Effect of Statin Therapy Before Q-Wave Myocardial Infarction on Myocardial Perfusion显示文摘 | Rainer Hoffmann Philipp Haager Hasna Suliman Philipp Christott Peter Radke Rüdiger Blindt Malte Kelm | 2008 | The American Journal of Cardiology2008，，2： | 1 |
| 11 | Control of the morphology of CSD-prepared (Ba,Sr)TiO3 thin films 显示文摘 | Susanne Hoffmann and Rainer Waser | 1999 | Journal of the European Ceramic Society1999，19，： | 1 |
| 12 | Polymer-Based Paclitaxel -Eluting Stents Are Superior to Nonpolymer-Based Paclitaxel -Eluting Stents in the Treatment of De Novo Coronary Lesions显示文摘 | Ekaterina Iofina Roswitha Langenberg Rüdiger Blindt Harald Kühl Malte Kelm Rainer Hoffmann | 2006 | The American Journal of Cardiology2006，，8： | 1 |
| 13 | Stroke MRI in Intracerebral Hemorrhage: Is There a Perihemorrhagic Penumbra?显示文摘 | Peter D. Schellinger Jochen B. Fiebach Katrin Hoffmann Kristina Becker Berk Orakcioglu Rainer Kollmar Eric Jüttler Peter Schramm Stefan Schwab Klaus Sartor Werner Hacke | 2003 | Stroke: Journal of the American Heart Association2003，，7： | 1 |
| 14 | Correction of Mitral Regurgitation in Nonresponders to Cardiac Resynchronization Therapy by MitraClip Improves Symptoms and Promotes Reverse Remodeling显示文摘 | Angelo Auricchio Wolfgang Schillinger Sven Meyer Francesco Maisano Rainer Hoffmann Gian Paolo Ussia Giovanni B. Pedrazzini Jan van der Heyden Simona Fratini Catherine Klersy Jan Komtebedde Olaf Franzen | 2011 | Journal of the American College of Cardiology2011，，21： | 1 |
| 15 | Predictive value of markers of myocardial reperfusion in acute myocardial infarction for follow-up left ventricular function显示文摘 | Wolfgang Lepper Gertjan Tj Sieswerda Jean Louis Vanoverschelde Andreas Franke Carel C de Cock Otto Kamp Harald P Kühl Agnes Pasquet Paolo Voci Cees A Visser Peter Hanrath Rainer Hoffmann | 2001 | The American Journal of Cardiology2001，，12： | 1 |
| 16 | Real-time transesophageal three-dimensional echocardiography for guidance of percutaneous cardiac interventions: first experience显示文摘 | Jan Balzer MD Harald Kühl MD Tienush Rassaf MD Rainer Hoffmann MD Patrick Schauerte MD Malte Kelm MD Andreas Franke MD | 2008 | Clinical Research in Cardiology2008，，9： | 1 |
| 17 | Intravenous myocardial contrast echocardiography predicts left ventricular remodeling in patients with acute myocardial infarction显示文摘 | Wolfgang Lepper Otto Kamp Jean Louis Vanoverschelde Andreas Franke Gertjan Tj. Sieswerda Agnes Pasquet Harald P. Kühl Paolo Voci Cees A. Visser Peter Hanrath Rainer Hoffmann | 2002 | Journal of the American Society of Echocardiography2002，，： | 1 |
| 18 | Effect of different types of elemental sulfur on bioleaching of heavy metals from contaminated sediments 显示文摘 | SEIDEL Heinz WENNRICH Rainer HOFFMANN Petra LOSER Christian | 2006 | Chemosphere2006，62，9： | 1 |
| 19 | Association of aortic valve calcification severity with the degree of aortic regurgitation after transcatheter aortic valve implantation显示文摘 | Ralf Koos Andreas Horst Mahnken Guido Dohmen Kathrin Brehmer Rolf W. Günther Rüdiger Autschbach Nikolaus Marx Rainer Hoffmann | 2010 | International Journal of Cardiology2010，，： | 1 |
| 20 | Evaluation of aortic root for definition of prosthesis size by magnetic resonance imaging and cardiac computed tomography: Implications for transcatheter aortic valve implantation显示文摘 | Ralf Koos Ertunc Altiok Andreas Horst Mahnken Mirja Neizel Guido Dohmen Nikolaus Marx Harald Kühl Rainer Hoffmann | 2011 | International Journal of Cardiology2011，，3： | 1 |
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