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| 1 | 藏毛窦发病率和远期复发率现况及其影响因素分析显示文摘目的调查德国部队中藏毛窦的发病率和术后远期复发率的现状及其发展变化趋势,分析不同手术治疗方法、体格状况和吸烟量等因素对藏毛窦的发病率和术后远期复发率的影响。方法对德国三家部队医院1980至1996年收治的所有藏毛窦患者的资料进行统计,随机抽取其中500例患者进行随访。结果德国部队中藏毛窦的发病率由1985年的0.3/1000上升到2007年的2.4/1000。随机抽取的500例患者中2例死亡,498例接受了随访。其术后复发率从1981年的33%,到1986年的23%,再到1996年的12%,呈明显下降趋势(P=0.01)。藏毛窦切除后行开放愈合的复发率为16.8%,显著低于行一期缝合的复发率31.0%(P〈0.01)。部队中人均体质量每十年增加1kg,德国国民人均体质量每十年增加1.9kg,但是体质量的增加与藏毛窦复发率之间无显著相关性(P=0.72)。每天吸烟20支以上者藏毛窦的复发率比吸烟≤20支者显著升高(P=0.015)。结论在藏毛窦的术后复发率下降,特别是切除后开放愈合的术后复发率下降的同时,藏毛窦的发病率上升了近十倍。 | Theo Evers Dietrich Doll Edouard Matevossian Sebastian Noe Konrad Neumann 李挥力 Norbert Huser Rainer Ludde Sebastian Hoffmann Bjorn Dirk Krapohl | 2011 | 中华外科杂志2011，49，9： | 14 |
| 2 | Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5显示文摘Since late 2022, the share of infections caused by the SARS-CoV2 lineage XBB.1.5 has gradually increased in the United States,resulting in XBB.1.5 becoming the dominating SARS-CoV-2lineage in the United States and a similar trend is likely to soontake place also in European countries. However, information onthe virological properties of XBB.1.5 is scarce. Here, weconducted an initial virological assessment of the SARS-CoV-2XBB.1.5 lineage. | Markus Hoffmann Prerna Arora Inga Nehlmeier Amy Kempf Anne Cossmann Sebastian R.Schulz Gema Morillas Ramos Luis A.Manthey Hans-Martin Jäck Georg M.N.Behrens Stefan Pöhlmann | 2023 | Cellular & Molecular Immunology2023，20，4： | 2 |
| 3 | Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases显示文摘 | Sebastian M. Dieter Claudia R. Ball Christopher M. Hoffmann Ali Nowrouzi Friederike Herbst Oksana Zavidij Ulrich Abel Anne Arens Wilko Weichert Karsten Brand Moritz Koch Jürgen Weitz Manfred Schmidt Christof von Kalle Hanno Glimm | 2011 | Cell Stem Cell2011，，4： | 2 |
| 4 | Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases显示文摘 | Sebastian M. Dieter Claudia R. Ball Christopher M. Hoffmann Ali Nowrouzi Friederike Herbst Oksana Zavidij Ulrich Abel Anne Arens Wilko Weichert Karsten Brand Moritz Koch Jürgen Weitz Manfred Schmidt Christof von Kalle Hanno Glimm | 2011 | Cell Stem Cell2011，，4： | 1 |
| 5 | Biological degradation of pharmaceuticals in municipal wastewater treatment: Proposing a classification scheme显示文摘 | Adriano Joss Sebastian Zabczynski Anke G?bel Burkhard Hoffmann Dirk L?ffler Christa S. McArdell Thomas A. Ternes Angela Thomsen Hansruedi Siegrist | 2006 | Water Research2006，，8： | 1 |
| 6 | Results of higher power toric intraocular lens implantation显示文摘 | Peter C. Hoffmann Sebastian Auel Werner W. Hütz | 2011 | Journal of Cataract & Refractive Surgery2011，，8： | 1 |
| 7 | IGF-I pathway mutations and protein expression in resected non-small cell lung cancer显示文摘 | Niels Reinmuth Sebastian Kloos Arne Warth Angela Risch Thomas Muley Hans Hoffmann Michael Thomas Michael Meister | 2014 | Human Pathology2014，，： | 1 |
| 8 | The ECVAM International validation study on in vitro tests for acute skin irritation: report on the validity of the EpiSkin and EpiDerm assays and on the skin integrity function test 显示文摘 | Horst Spielmann Sebastian Hoffmann Manfred Liebsch | 2007 | Ahern Lab Anim2007，35，6： | 1 |
| 9 | Hardware-EfficientCoherent Digital Receiver Concept with Feedforward Carrier Recovery for M-QAM Constellations 显示文摘 | Pfau T Sebastian Hoffmann Reinhold Noe | 2009 | Journal of Lightwave Technology2009，27，： | 1 |
| 10 | Multiplier-free real-time phase tracking for coherent QPSK receivers显示文摘 | Sebastian Hoffmann | 2009 | PTL2009，21，3： | 1 |
| 11 | Prospectively gated axial CT coronary angiography: preliminary experiences with a novel low-dose technique显示文摘 | Oliver Klass Martin Jeltsch Sebastian Feuerlein Horst Brunner Hans-Dieter Nagel Matthew J. Walker Hans-Juergen Brambs Martin H. K. Hoffmann | 2009 | European Radiology2009，，4： | 1 |
| 12 | Delta variant(B.1.617.2)sublineages do not show increased neutralization resistance显示文摘The emergence of SARS-CoV-2 variants threatens efforts to control the COVID-19 pandemic.At present,the global spread of the Delta(B.1.617.2)variant is responsible for a rapid increase in COVID-19 cases and hospitalizations in many countries.The variant evades neutralizing antibodies and is believed to be more transmissible and pathogenic[1,2,3,4]. | Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Anzhalika Sidarovich Martin S.Winkler Sebastian Schulz Hans-Martin Jäck Metodi V.Stankov Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 13 | Efficient antibody evasion but reduced ACE2 binding by the emerging SARS-CoV-2 variant B.1.640.2显示文摘The SARS-CoV-2 spike(S)protein engages ACE2 for cell entry,and the S protein/ACE2 interface is an important target for neutralizing antibodies.In the course of the COVID-19 pandemic,SARS-CoV-2 variants have emerged that harbor mutations in the S protein,which confer neutralization resistance and allow viral spread in immunologically nonnaive populations.The most prominent example is the highly mutated Omicron variant,which infects convalescent or vaccinated individuals with unprecedented efficiency[1,2]. | Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Sebastian Schulz Anne Cossmann Alexandra Dopfer-Jablonka Martin S.Winkler Hans-Martin Jäck Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann | 2022 | Cellular & Molecular Immunology2022，19，9： | 0 |
| 14 | Wetting Behaviour of Glasses on Nanostructured Silicon Surfaces显示文摘 | Sebastian Gropp Michael Fischer Lars Dittrich Beate Capraro Jens Mtiller Martin Hoffmann | 2015 | Journal of Electrical Engineering2015，3，1： | 0 |
| 15 | The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency显示文摘The COVID-19 pandemic,caused by SARS-CoV-2,continues to rage in many countries,straining health systems and economies.Vaccines protect against severe disease and death and are considered central to ending the pandemic.COVID-19 vaccines(and SARS-CoV-2 infection)elicit antibodies that are directed against the viral spike(S)protein and neutralize the virus.However,the emergence of SARS-CoV-2 variants with S protein mutations that confer resistance to neutralization might compromise vaccine efficacy[1]. | Prerna Arora Cheila Rocha Amy Kempf Inga Nehlmeier Luise Graichen Martin S.Winkler Martin Lier Sebastian Schulz Hans-Martin Jäck Anne Cossmann Metodi V.Stankov Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann | 2021 | Cellular & Molecular Immunology2021，18，12： | 0 |
| 16 | No evidence for increased cell entry or antibody evasion by Delta sublineage AY.4.2显示文摘Since the beginning of the COVID-19 pandemic,multiple SARS-CoV-2 variants have emerged.While some variants spread only locally,others,referred to as variants of concern,disseminated globally and became drivers of the pandemic.All SARS-CoV-2 variants harbor mutations relative to the virus circulating early in the pandemic,and mutations in the viral spike(S)protein are considered of particular relevance since the S protein mediates host cell entry and constitutes the key target of the neutralizing antibody response.As a consequence,mutations in the S protein may increase SARS-CoV-2 infectivity and enable its evasion of neutralizing antibodies.Furthermore,mutations in the S protein can modulate viral transmissibility and pathogenicity. | Prerna Arora Amy Kempf Inga Nehlmeier Luise Graichen Martin S.Winkler Martin Lier Sebastian Schulz Hans-Martin Jäck Stefan Pöhlmann Markus Hoffmann | 2022 | Cellular & Molecular Immunology2022，19，3： | 0 |
| 17 | Implantable cardiac defibrillators in octogenarians显示文摘OBJECTIVE Implantable cardiac defibrillators(ICD)implantation in the very elderly remains controversial.We aimed to describe the experience and outcome of patients over 80 years old implanted with an ICD in Belgium.METHODS Data were extracted from the national QERMID-ICD registry.All implantations performed in octogenarians between February 2010 and March 2019 were analysed.Data on baseline patient characteristics,type of prevention,device configuration and all-cause mortality were available.To determine predictors of mortality,multivariable Cox proportional hazard regression modelling was performed.RESULTS Nationwide,704 primo ICD implantations were performed in octogenarians(median age 82,IQR 81-83 years;83% male and 45% secondary prevention).During a mean follow-up of 3.1±2.3 years,249(35%)patients died,of which 76(11%)within the first year after implantation.In multivariable Cox regression analysis age(HR=1.15,P=0.004),oncological history(HR=2.43,P=0.027)and secondary prevention(HR=2.23,P=0.001)were independently associated with 1-year mortality.A better preserved left ventricular ejection fraction(LVEF)was associated with a better outcome(HR=0.97,P=0.002).Regarding overall mortality multivariable analysis withheld age,history of atrial fibrillation,centre volume and oncological history as significant predictors.Higher LVEF was again protective(HR=0.99,P=0.008).CONCLUSIONS Primary ICD implantation in octogenarians is not often performed in Belgium.Among this population,11%died within the first year after ICD implantation.Advanced age,oncological history,secondary prevention and a lower LVEF were associated with an increased one-year mortality.Age,low LVEF,atrial fibrillation,centre volume and oncological history were indicative of higher overall mortality. | Maarten Pauwelyn Sebastian Ingelaere Ruben Hoffmann Johan Vijgen Georges H.Mairesse Ivan Blankoff Yves Vandekerckhove Jean-Benoit le Polain de Waroux Bert Vandenberk Rik Willems | 2023 | Journal of Geriatric Cardiology2023，20，1： | 0 |
| 18 | 图像导引介入治疗中可视化3D的2D/3D图像数据分析显示文摘三维成像对许多医学过程(根本上是对患者的健康)来说,是非常关键的。本文探讨了三维成像方法的与众不同之处,以及作为一种不断发展创新的技术,临床医生们对它的需求和期待。 | Kenneth R. Hoffmann Stephen Rudin Hui Meng Anant Gopal Alan Walczak Minsuok Kim Sebastian Schafer Peter B. Noel Snehal Kasodekar L. Nelson Hopkins 石琳 | 2007 | 现代显示2007，，1： | 0 |
| 19 | Host cell entry and neutralisation sensitivity of the SARS-CoV-2 XBB.1.16 lineage显示文摘Despite previous circulation of the highly transmissible and antibody evasive BA.2.75, BQ.1, XBB.1 and XBB.1.5 lineages, the share of infections caused by the SARS-CoV-2 lineage XBB.1.16 has gradually increased in India in early 2023, resulting in XBB.1.16 being the dominating SARS-CoV-2 lineage in India today. Since a similar trend may also take place in other countries and information on the biological properties of the XBB.1.16 lineage is scarce, we conducted a rapid assessment of the SARS-CoV-2 XBB.1.16 lineage with respect to its ability to enter cells and evade neutralisation by antibodies. | Inga Nehlmeier Amy Kempf Prerna Arora Anne Cossmann Alexandra Dopfer-Jablonka Metodi V.Stankov Sebastian R.Schulz Hans-Martin Jäck Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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